Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model

Authors: J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: immunotherapy, resistance, mouse model, cancer, antigen presentation machinery, glioblastoma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1297932/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Authors: Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel

Source: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e78e979f7f9a43d280222791ea6273df

p66ShcA functions as a contextual promoter of breast cancer metastasis

Authors: Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel

Source: Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)

Subject Terms: Breast cancer, Lung metastasis, p66ShcA, Reactive oxygen species, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/3438a5e4c9ae4d46bf14a48ac898942d

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors

Authors: Eduardo Cepeda Cañedo, Stephanie Totten, Ryuhjin Ahn, Paul Savage, Deanna MacNeil, Jesse Hudson, Chantal Autexier, Genevieve Deblois, Morag Park, Michael Witcher, Josie Ursini-Siegel

Source: JCI Insight, Vol 6, Iss 4 (2021)

Subject Terms: Cell biology, Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/96aa4977e46346acb779cdd5bbcf3cf3

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Authors: Ryuhjin Ahn, Valérie Sabourin, Alicia M. Bolt, Steven Hébert, Stephanie Totten, Nicolas De Jay, Maria Carolina Festa, Yoon Kow Young, Young Kyuen Im, Tony Pawson, Antonis E. Koromilas, William J. Muller, Koren K. Mann, Claudia L. Kleinman, Josie Ursini-Siegel

Source: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4564af3090224e7180bdbbc6e315baaa

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.

Authors: Iorgulescu, J. Bryan, Ruthen, Neil, Ryuhjin Ahn, Panagioti, Eleni, Gokhale, Prafulla C., Neagu, Martha, Speranza, Maria C., Eschle, Benjamin K., Soroko, Kara M., Piranlioglu, Raziye, Datta, Meenal, Krishnan, Shanmugarajan, Yates, Kathleen B., Baker, Gregory J., Jain, Rakesh K., Suvà, Mario L., Neuberg, Donna, White, Forest M., Chiocca, E. Antonio, Freeman, Gordon J.

Source: Frontiers in Immunology; 2024, p01-18, 18p

Subject Terms: ANTIGEN presentation, HUMAN biology, RAS oncogenes, IMMUNOTHERAPY, PROTEIN analysis

The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.

Authors: Kiepas, Alex^1,2, Voorand, Elena^2,3, Senecal, Julien^2,4, Ryuhjin Ahn^4,5, Annis, Matthew G.^2,6, Jacquet, Kévin⁷, Tali, George¹, Bisson, Nicolas^7,8, Ursini-Siegel, Josie^3,5,9, Siegel, Peter M.^2,3,6 peter.siegel@mcgill.ca, Brown, Claire M.^1,10 claire.brown@mcgill.ca

Source: Journal of Biological Chemistry. 7/31/2020, Vol. 295 Issue 31, p10535-10559. 25p.

Subject Terms: *ADAPTOR proteins, *METASTATIC breast cancer, *CANCER cell migration, *TRANSFORMING growth factors, *ADHESION, *CYTOSKELETAL proteins