Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study

Authors: Joaquina C. Baranda, Debbie Robbrecht, Ryan Sullivan, Bernard Doger, Armando Santoro, Minal Barve, Jean‐Jacques Grob, Oliver Bechter, Maria Vieito, Maria Jose deMiguel, Dirk Schadendorf, Melissa Johnson, Clemence Pouzin, Cathy Cantalloube, Rui Wang, Jooyun Lee, Xiaofei Chen, Brigitte Demers, Amele Amrate, Giovanni Abbadessa, F. Stephen Hodi

Source: Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/0d7ccfe237a8402d86c3353c80fd2923

541 Diabetes and glucose level as metabolic determinants of immune checkpoint inhibitors response in melanoma

Authors: Ryan Sullivan, Kerry Reynolds, Soravis Osataphan, Yu Jen A Jan, Cho Han Chiang

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c92660ebd96547c28858113d354d5121

152 Immuno-oncology protein biomarker panels provide greater biological insights and improved patient stratification

Authors: Nir Hacohen, Keith Flaherty, Ryan Sullivan, Genevieve M Boland, Marijana Rucevic, Arnav Mehta, Katarina Horneaus, Emmett Sprecher, Alexis Schneider, Russell W Jenkins, William Michaud, Benchun Miao

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/34c96c3ac03845f59ad475f3a1b54491

628 Circulatory plasma proteomic biomarkers combined with high-throughput proteomic screen of patient-derived organotypic tumor spheroids predict responses to immunotherapy in melanoma patients

Authors: Yi Sun, Nir Hacohen, Keith Flaherty, Ryan Sullivan, Michelle Kim, Gyulnara Kasumova, Dennie Frederick, Michael Förster, Genevieve M Boland, Ryan Park, Marijana Rucevic, Arnav Mehta, Alexis Schneider, Russell W Jenkins, William Michaud, Benchun Miao, Or-Yam Revach, Angelina Cicerchia, Amrita Kar

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/6480203bf79b44488f4a2d8ddf846143

669 Durable responses with triple blockade of the DNAM-1 axis with COM701 + BMS-986207 + nivolumab in patients with platinum resistant ovarian cancer

Authors: Gady Cojocaru, Inbal Barbiro, Amita Patnaik, Manish Sharma, Drew Rasco, Benjamin Izar, Kyriakos P Papadopoulos, Eran Ophir, Ryan Sullivan, Pierre Ferre, Stéphanie Gaillard, Daniel Vaena, Oladapo Yeku, John Moroney, Adeboye H Adewoye

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/a3c445d3d8fe4f368bee37e0d51c9c49

1255 Single cell dissection of human checkpoint inhibitor hepatitis reveals insights into liver immune tolerance

Authors: Nir Hacohen, Ryan Sullivan, Molly Thomas, John McGuire, Dejan Juric, Leyre Zubiri, Kerry Reynolds, Genevieve M Boland, Alexandra-Chloe Villani, Mazen Nasrallah, Neal Smith, Kasidet Manakongtreecheep, Jessica Tantivit, Alice Tirard, Swetha Ramesh, Tos Chan, Marc Sherman, Georg Lauer, Shreyash Sonthalia

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/f5ca302d2b4240459d1f4e1aeb96ea81

736 A phase 1/2 open-label, dose-escalation study of ST-067, a decoy-resistant IL-18 cytokine, given as a monotherapy and with pembrolizumab in advanced solid tumor malignancies

Authors: Mario Sznol, Harriet Kluger, Igor Puzanov, Gerald S Falchook, Ryan Sullivan, Matthew H Taylor, Justin C Moser, Aaron M Ring, Virginia E Paton, David Chonzi, Brage Garofalo, Mark Sonnemann, Hirdesh Uppal, Jeremy Barton, Beatrice Y McQueen

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c9d6a589d3ec4c688bdb430c28cf8a3d

Multiple sclerosis lesion segmentation: revisiting weighting mechanisms for federated learning

Authors: Dongnan Liu, Mariano Cabezas, Dongang Wang, Zihao Tang, Lei Bai, Geng Zhan, Yuling Luo, Kain Kyle, Linda Ly, James Yu, Chun-Chien Shieh, Aria Nguyen, Ettikan Kandasamy Karuppiah, Ryan Sullivan, Fernando Calamante, Michael Barnett, Wanli Ouyang, Weidong Cai, Chenyu Wang

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: deep learning, federated learning, multiple sclerosis, segmentation, MRI, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.1167612/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/114eca7e05d64d5b81f0d42092bb00a0

Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma

Authors: Bart Neyns, Lisa Zimmer, Caroline Robert, Celeste Lebbe, Olivier Michielin, Omid Hamid, Anne Zaremba, Oliver Klein, Ruth Plummer, Joanna Mangana, Paolo A Ascierto, Katharina C Kähler, Georgina V Long, Ryan Sullivan, Grant A McArthur, Michael Weichenthal, Egle Ramelyte, Meghan J Mooradian, Douglas B Johnson, Alexander Shoushtari, Christian U Blank, Judith M Versluis, Prachi Bhave, Claudia Trojanello, Lu Si, Inderjit Mehmi, Tasnia Ahmed, Alexander M Menzies, Adnan Khattak, Severine Roy, Matteo S Carlino, Paul C Lorigan, Clara Allayous, Rachel Roberts-Thomson, Florentia Dimitriou, Kathleen Batty, Thierry Lesimple, Serigne N Lo, Alexandre Wicky, Richard Heywood, Lena Tran, Anna Stansfeld, Julia K Schwarze, Andrea Maurichi, Hui-Ling Yeoh, Mario Santinami, Andrew M Haydon

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/7/e004668.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/0b1c2b670e1e4ec1b95b97b6b085c47b

Real-world incidence and impact of pneumonitis in patients with lung cancer treated with immune checkpoint inhibitors: a multi-institutional cohort study

Authors: Jarushka Naidoo, Ryan Sullivan, Meghan J Mooradian, Leyre Zubiri, Vartan Pahalyants, Nicholas Theodosakis, Kerry L Reynolds, Yevgeniy R Semenov, Meghan E Sise, James Iheke, Pearl Ugwu-Dike, Jayhyun Seo, Kimberly Tang, Bruce C Tiu

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/6/e004670.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e69c94c662834802beab88009e05effd

Phase 1 Clinical Trial Evaluating the Safety and Anti-Tumor Activity of ADP-A2M10 SPEAR T-Cells in Patients With MAGE-A10+ Head and Neck, Melanoma, or Urothelial Tumors

Authors: David S. Hong, Marcus O. Butler, Russell K. Pachynski, Ryan Sullivan, Partow Kebriaei, Sarah Boross-Harmer, Armin Ghobadi, Matthew J. Frigault, Ecaterina E. Dumbrava, Amy Sauer, Francine Brophy, Jean-Marc Navenot, Svetlana Fayngerts, Zohar Wolchinsky, Robyn Broad, Dzmitry G. Batrakou, Ruoxi Wang, Luisa M. Solis, Dzifa Yawa Duose, Joseph P. Sanderson, Andrew B. Gerry, Diane Marks, Jane Bai, Elliot Norry, Paula M. Fracasso

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: HNSCC, melanoma, urothelial carcinoma, ADP-A2M10, MAGE-A10, adoptive cellular therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.818679/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/4c808abbb2f84a2ab7ad3e5e7de8a030

804 Real-world incidence and impact of pneumonitis in lung cancer patients treated with immune checkpoint inhibitors

Authors: Ryan Sullivan, Leyre Zubiri, Kerry Reynolds, Vartan Pahalyants, Nicholas Theodosakis, Yevgeniy Semenov, Bruce Tiu, James Iheke, Pearl Ugwu-Dike, Jayhyun Seo, Kimberly Tang, Meghan Mooradian

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/26a45125332a4e3b99b4c76fcc4b3498

478 COM701 in combination with BMS-986207 (anti-TIGIT antibody) and nivolumab – preliminary results of safety, tolerability and pharmacokinetics in patients with advanced solid tumors (NCT04570839)

Authors: Inbal Barbiro, Amita Patnaik, Manish Sharma, Drew Rasco, Ryan Sullivan, Ecaterina Dumbrava, Pierre Ferre, Gini Fleming, Kyriakos Papadopoulos, Daniel Vaena, Adam ElNaggar, Adeboye Adewoye, Robina Smith, Emerson Lim

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/79090e9b14894f908bab8530154d36f2

Immune checkpoint inhibitors in patients with pre-existing psoriasis: safety and efficacy

Authors: Andrew Haydon, Jessica C Hassel, Jeffrey A Sosman, Sunandana Chandra, Ryan Sullivan, Mario E Lacouture, Meghan J Mooradian, Alexander Menzies, Douglas B Johnson, Fei Ye, Prachi Bhave, Steven T Chen, Georgina Long, Briana Rose Halle, Farzana Y Zaman, Anna K Dewan, Rebecca Irlmeier, Paras Mehta, Nicholas R Kurtansky, Jacob S Choi, Tracey S Otto, Florentia Dimitriou, Veronica M Rotemberg

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/10/e003066.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/2404ddf91eb64426ad24a0c1ae12dd85

Pericardial disease in patients treated with immune checkpoint inhibitors

Authors: Anju Nohria, Vineet K Raghu, Jingyi Gong, Ryan Sullivan, Leyre Zubiri, Tomas G Neilan, Amna Zafar, Raza M Alvi, Sarah Hartmann, Hannah K Gilman, Meghan E Sise, Zsofia Dora Drobni, Thiago Quinaglia, Carlos Gongora, Daniel Zlotoff

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/6/e002771.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/414e41e43c864f2b9158c3868fd87280

Electrocardiographic features of immune checkpoint inhibitor associated myocarditis

Authors: Anju Nohria, Alexander R Lyon, Stephane Ederhy, Franck Thuny, Michael Mahmoudi, Magid Awadalla, Dahlia Banerji, Merna Armanious, Dipti Gupta, Sarju Ganatra, Paaladinesh Thavendiranathan, Gagan Sahni, Ryan Sullivan, Lili Zhang, Tomas G Neilan, Daniel A Zlotoff, Malek Z O Hassan, Amna Zafar, Raza M Alvi, Syed S Mahmood, Carol L Chen, Ana Barac, Maeve Jones-O'Connor, Sean P Murphy, Brian J Forrestal, Michael C Kirchberger, Otavio R Coelho-Filho, Muhammad A Rizvi, Anant Mandawat, Carlo G Tocchetti, Sarah Hartmann, Hannah K Gilman, Eduardo Zatarain-Nicolás, Lucie M Heinzerling, Justine V Cohen, John Groarke, Michael G Fradley

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/3/e002007.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e0d49c053cc347dfa4d4fbdd78de84e0

488 The impact of education on novel concepts in metastatic melanoma: triplet therapy

Authors: Ryan Sullivan, Kinjal Parikh, Sara Fagerlie, Patrick Kugel, Richard Caracio

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c6ee87f14cf14e878f7c4b1837259a12

194 A multicenter characterization of chronic toxicities following adjuvant anti-PD-1 therapy for high risk resected melanoma

Authors: Andrew Haydon, Rebecca Johnson, Iman Osman, Janice Mehnert, Suthee Rapisuwon, Douglas Johnson, Ryan Sullivan, Matteo Carlino, Alexander Menzies, Prachi Bhave, James Patrinely, Aleigha Lawless, Amelia Sawyers, Maya Dimitrova, Hui Yeohc, Marisa Palmeri, Elizabeth Davis, Georgina Long

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b2afcd48507b46a58a5169e0c18c2d0a

285 Phase I clinical trial evaluating the safety of ADP-A2M10 in patients with MAGE-A10+ head and neck, melanoma, or urothelial tumors

Authors: Marcus Butler, David Hong, Ryan Sullivan, Matthew Frigault, Sarah Boross-Harmer, Ecaterina Dumbrava, Jean-Marc Navenot, Svetlana Fayngerts, Jane Bai, Elliot Norry, Paula Fracasso, Russell Pachynski, Partow Kebriaei, Amy Sauer, Francine Brophy

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/3cc3704b6a2e45a5bc9da899afd13797

Ipilimumab plus nivolumab for patients with metastatic uveal melanoma: a multicenter, retrospective study

Authors: Arun Singh, Richard Carvajal, Yana G Najjar, Igor Puzanov, Marc Ernstoff, Shailender Bhatia, Katy Tsai, Fei Ding, Zeynep Eroglu, Douglas Johnson, Pauline Funchain, Sunandana Chandra, Ryan Sullivan, Roma Bhatia, Kristina Navrazhina, Kelly Abbate, Barbara Durden, Song Park, Akansha Chowdhary, Jonathan Kennedy, Pankit Vachhani, Joseph Drabick, Tan Xu, Jessica Yang, Daniel Manson, John M Kirkwood, Justine Cohen, Alexander Shoushtari

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000331.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/af78c8c4442f42e39c146dd7aedcf3ad