Insights into heart failure metabolite markers through explainable machine learning

Authors: Baron, Cantin ^{a, b, c}, Mehanna, Pamela ^b, Daneault, Caroline ^b, Hausermann, Leslie ^b, Busseuil, David ^b, Tardif, Jean-Claude ^{b, d}, Dupuis, Jocelyn ^{b, d}, Des Rosiers, Christine ^{b, e}, Ruiz, Matthieu ^{b, e, ⁎}, Hussin, Julie G. ^{a, b, c, d, ⁎⁎}

Source: In Computational and Structural Biotechnology Journal 2025 27:1012-1022

Right Ventricular Remodeling in Complex Congenital Heart Disease

Authors: Demonceaux, Marilee ^{a, §}, Benseba, Juva ^{b, §}, Ruiz, Matthieu ^{a, c}, Mongeon, François-Pierre ^{a, b}, Khairy, Paul ^{a, b}, Mital, Seema ^d, Dore, Annie ^b, Mondésert, Blandine ^{a, b}, Gravel, Maxime Tremblay ^{a, e}, Dib, Nabil ^b, Tan, Stéphanie ^f, Poirier, Nancy ^b, Ibrahim, Réda ^b, Chaix, Marie-A. ^{a, b, ∗}

Source: In Canadian Journal of Cardiology January 2025

Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides

Authors: Robb, Josephine Louise ^{a, b}, Boisjoly, Frédérick ^{a, c}, Machuca-Parra, Arturo Israel ^{a, b}, Coursan, Adeline ^e, Manceau, Romane ^{a, c}, Majeur, Danie ^{a, c}, Rodaros, Demetra ^a, Bouyakdan, Khalil ^a, Greffard, Karine ^f, Bilodeau, Jean-François ^{f, g}, Forest, Anik ^h, Daneault, Caroline ^h, Ruiz, Matthieu ^{d, h}, Laurent, Cyril ^{a, c}, Arbour, Nathalie ^{a, c}, Layé, Sophie ^{e, i}, Fioramonti, Xavier ^{e, i}, Madore, Charlotte ^{e, i}, Fulton, Stephanie ^{a, d, i, 1}, Alquier, Thierry ^{a, b, i, 1, ⁎}

Source: In Brain Behavior and Immunity January 2025 123:315-333

PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease

Authors: Sachan, Vatsal, Le Dévéhat, Maïlys, Roubtsova, Anna, Essalmani, Rachid, Laurendeau, Jean-Francois, Garçon, Damien, Susan-Resiga, Delia, Duval, Stéphanie, Mikaeeli, Sahar, Hamelin, Josée, Evagelidis, Alexandra, Chong, Michael, Paré, Guillaume, Chernetsova, Elizabeta, Gao, Zu-Hua, Robillard, Isabelle, Ruiz, Matthieu, Trinh, Vincent Quoc-Huy, Estall, Jennifer L., Faraj, May, Austin, Richard C., Sauvageau, Martin, Prat, Annik, Kiss, Robert S., Seidah, Nabil G.

Source: In Metabolism January 2024 150

Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results

Authors: Baron, Cantin ^{1, 2}, Cherkaoui, Sarah ^{2, 3, 4}, Therrien-Laperriere, Sandra ², Ilboudo, Yann ^{1, 2}, Poujol, Raphaël ², Mehanna, Pamela ², Garrett, Melanie E. ⁵, Telen, Marilyn J. ⁶, Ashley-Koch, Allison E. ⁵, Bartolucci, Pablo ^{7, 8}, Rioux, John D. ^{1, 2, 9}, Lettre, Guillaume ^{2, 9}, Rosiers, Christine Des ^{1, 2, 10}, Ruiz, Matthieu ^{2, 10}, Hussin, Julie G. ^{2, 9, 11, ∗}

Source: In iScience 15 December 2023 26(12)

Remodeling of lipid landscape in high fat fed very-long chain acyl-CoA dehydrogenase null mice favors pro-arrhythmic polyunsaturated fatty acids and their downstream metabolites

Authors: Lefort, Bruno, Gélinas, Roselle, Forest, Anik, Bouchard, Bertrand, Daneault, Caroline, Robillard Frayne, Isabelle, Roy, Jérôme, Oger, Camille, Greffard, Karine, Galano, Jean-Marie, Durand, Thierry, Labarthe, François, Bilodeau, Jean-François, Ruiz, Matthieu, Des Rosiers, Christine

Source: In BBA - Molecular Basis of Disease December 2023 1869(8)

Cryo-EM structure of the Agrobacterium tumefaciens T-pilus reveals the importance of positive charges in the lumen

Authors: Amro, Jaafar, Black, Corbin, Jemouai, Zakaria, Rooney, Nathan, Daneault, Caroline, Zeytuni, Natalie, Ruiz, Matthieu, Bui, Khanh Huy, Baron, Christian

Source: In Structure 6 April 2023 31(4):375-384

MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke–Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFκB (Nuclear Factor κB)-CaSR (Calcium-Sensing Receptor) Cascade

Authors: Su, Yuan, Tan, Rubin, Sun, Mengxiang, Yuan, Linbo, Ruiz, Matthieu, Dupuis, Jocelyn, Hu, Qinghua, Zhu, Liping

Source: Hypertension. 79(12):2721-2732

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172924524.0x000001&indx=1&recIds=ETOCvdc_100172924524.0x000001

Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility

Authors: Liu, Bingxun, Wei, Yun-Peng, Fan, Xiaohang, Hu, Xiaoyi, Chen, Zeshuai, Liu, Xiaoyuan, Xu, Yan, Wang, Lu, Wang, Tao, Ruiz, Matthieu, Dupuis, Jocelyn, Yuan, Ping, Liu, Jinming, Huang, Songling, Zhu, Liping, Jing, Zhi-Cheng, Hu, Qinghua

Source: Hypertension. 79(7):1348-1360

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168787670.0x000001&indx=1&recIds=ETOCvdc_100168787670.0x000001

Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel

Authors: Samman, Karla N., Mehanna, Pamela, Takla, Emad, Grenier, Jean-Christophe, Chan, Mark Y., Lopes, Renato D., Neely, Megan Lee, Wang, Tracy Y., Newby, L. Kristin, Becker, Richard C., Lordkipanidzé, Marie, Ruiz, Matthieu, Hussin, Julie G., Jolicœur, E. Marc

Source: In Cell Reports Medicine 15 June 2021 2(6)

Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension

Authors: Zhu, Liping, Liu, Fangbo, Hao, Qiang, Feng, Tian, Chen, Zeshuai, Luo, Shengquan, Xiao, Rui, Sun, Mengxiang, Zhang, Ting, Fan, Xiaohang, Zeng, Xianqin, He, Jianguo, Yuan, Ping, Liu, Jinming, Ruiz, Matthieu, Dupuis, Jocelyn, Hu, Qinghua

Source: Circulation. 143(18):1775-1792

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188867882.0x000001&indx=1&recIds=ETOCvdc_100188867882.0x000001

Peptide Blocking Self-Polymerization of Extracellular Calcium-Sensing Receptor Attenuates Hypoxia-Induced Pulmonary Hypertension

Authors: Xiao, Rui, Luo, Shengquan, Zhang, Ting, Lv, Yankai, Wang, Tao, Zhang, Jiwei, Su, Yuan, Ruiz, Matthieu, Dupuis, Jocelyn, Zhu, Liping, Hu, Qinghua

Source: Hypertension. 78(5):1605-1616

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176825225.0x000001&indx=1&recIds=ETOCvdc_100176825225.0x000001

Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling

Authors: Schmeisser, Sebastian, Li, Shaolin, Bouchard, Bertrand, Ruiz, Matthieu, Des Rosiers, Christine, Roy, Richard

Source: In Cell Reports 24 December 2019 29(13):4540-4552

Identification of Noncoding Functional Regulatory Variants of STIM1 Gene in Idiopathic Pulmonary Arterial Hypertension.

Authors: Bingxun Liu, Cen-Jin Wen, Guangyuan Zhou, Yun-Peng Wei, Zeang Wu, Ting Zhang, Yudan Zhou, Shuyi Qiu, Tao Wang, Ruiz, Matthieu, Dupuis, Jocelyn, Ping Yuan, Jinming Liu, Liping Zhu, Zhi-Cheng Jing, Qinghua Hu

Source: Hypertension (0194911X); Sep2024, Vol. 81 Issue 9, p1895-1909, 15p

Au-modified ceria nanozyme prevents and treats hypoxia-induced pulmonary hypertension with greatly improved enzymatic activity and safety.

Authors: Xiao, Rui, Liu, Jia, Shi, Lin, Zhang, Ting, Liu, Jie, Qiu, Shuyi, Ruiz, Matthieu, Dupuis, Jocelyn, Zhu, Liping, Wang, Lin, Wang, Zheng, Hu, Qinghua

Source: Journal of Nanobiotechnology; 8/19/2024, Vol. 22 Issue 1, p1-16, 16p

Subject Terms: CALCIUM-sensing receptors, PULMONARY hypertension, REACTIVE oxygen species, INTRACELLULAR calcium, PULMONARY artery, CERIUM oxides

Platelet extracellular vesicles preserve lymphatic endothelial cell integrity and enhance lymphatic vessel function.

Authors: Vachon, Laurent, Jean, Gabriel, Milasan, Andreea, Babran, Sara, Lacroix, Elizabeth, Guadarrama Bello, Dainelys, Villeneuve, Louis, Rak, Janusz, Nanci, Antonio, Mihalache-Avram, Teodora, Tardif, Jean-Claude, Finnerty, Vincent, Ruiz, Matthieu, Boilard, Eric, Tessier, Nolwenn, Martel, Catherine

Source: Communications Biology; 8/11/2024, Vol. 7 Issue 1, p1-15, 15p

Subject Terms: EXTRACELLULAR vesicles, LYMPHATICS, BLOOD vessels, BLOOD platelets, CAPACITY (Law)

Corrigendum to “PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease” [Metabolism Volume 150, January 2024, 155736, PMID: 7967646]

Authors: Sachan, Vatsal, LeDévéhat, Maïlys, Roubtsova, Anna, Essalmani, Rachid, Laurendeau, Jean-Francois, Garçon, Damien, Susan-Sesiga, Delia, Duval, Stéphanie, Mikaeeli, Sahar, Hamelin, Josée, Evagelidis, Alexandra, Chong, Michael, Paré, Guillaume, Chernetsova, Elizabeta, Gao, Zu-Hua, Robillard, Isabelle, Ruiz, Matthieu, Trinh, Vincent Quoc-Huy, Estall, Jennifer L., Faraj, May, Austin, Richard C., Sauvageau, Martin, Prat, Annik, Kiss, Robert S., Seidah, Nabil G.

Source: In Metabolism December 2024 161

Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism

Authors: Ruiz, Matthieu, Coderre, Lise, Allen, Bruce Gordon, Des Rosiers, Christine

Source: In BBA - Molecular Basis of Disease May 2018 1864(5) Part B:1914-1922

PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure

Authors: Nguyen, Quang T, Nsaibia, Mohamed J, Sirois, Martin G, Calderone, Angelino, Tardif, Jean-Claude, Fen Shi, Yan, Ruiz, Matthieu, Daneault, Caroline, Gagnon, Lyne, Grouix, Brigitte, Laurin, Pierre, Dupuis, Jocelyn

Source: Cardiovascular research. 116(1):171-182

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097307071.0x000001&indx=1&recIds=ETOCvdc_100097307071.0x000001

Sexual Dimorphism in Response to Vitamins B3, B9 and B12, Used in Combination, in a Mice Model of Heart Failure Induced by Pressure Overload

Authors: David, Chloé, Deschêches, Sonia, Bouchard, Bertrand, Robillard, Isabelle, Shi, Yan Fen, Higgins, Marie‐Eve, Tardif, Jean‐Claude, Ruiz, Matthieu

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196440671.0x000001&indx=1&recIds=ETOCvdc_100196440671.0x000001