Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice

Authors: Jia He, Chaoyu Wang, Xiao Fang, Junyao Li, Xueying Shen, Junxia Zhang, Cheng Peng, Hongjian Li, Sai Li, Jeffrey M. Karp, Rui Kuai

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c5a92375cb394ab6964fb80bae62e3d1

Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity

Authors: Chaoyu Wang, Ruoshi Zhang, Jia He, Lvshan Yu, Xinyan Li, Junxia Zhang, Sai Li, Conggang Zhang, Jonathan C. Kagan, Jeffrey M. Karp, Rui Kuai

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/47ef2dad2b6e4c9d8e6cb22518e29c64

Clathrin light chain‐conjugated drug delivery for cancer

Authors: Sungwook Jung, Liwei Jiang, Jing Zhao, Leonard D. Shultz, Dale L. Greiner, Munhyung Bae, Xiaofei Li, Farideh Ordikhani, Rui Kuai, John Joseph, Vivek Kasinath, David R. Elmaleh, Reza Abdi

Source: Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)

Subject Terms: cancer, drug delivery, fluorescence imaging, targeted therapy, Chemical engineering, TP155-156, Biotechnology, TP248.13-248.65, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2380-6761

Access URL: https://doaj.org/article/6d669f23ea8149e9a0f338ab025c1c27

Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

Authors: Jutaek Nam, Sejin Son, Lukasz J. Ochyl, Rui Kuai, Anna Schwendeman, James J. Moon

Source: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7800d99405614f2f897441abe369621c

Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression

Authors: Yanhong Guo, Wenmin Yuan, Bilian Yu, Rui Kuai, Wenting Hu, Emily E. Morin, Minerva T. Garcia-Barrio, Jifeng Zhang, James J. Moon, Anna Schwendeman, Y. Eugene Chen

Source: EBioMedicine, Vol 28, Iss C, Pp 225-233 (2018)

Subject Terms: Atherosclerosis, Liver X receptors, High-density lipoprotein, Reverse cholesterol transport, Macrophage, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396417305029; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/89afab47033c408bb318ca4350a4dd10

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy.

Authors: Rui Kuai^1,2, Wenmin Yuan^1,2, Sejin Son^1,2, Jutaek Nam^1,2, Yao Xu^1,2, Yuchen Fan^1,2, Schwendeman, Anna^1,2 annaschw@umich.edu, Moon, James J.^1,2,3 moonjj@umich.edu

Source: Science Advances. 8/9/2024, Vol. 10 Issue 32, p1-13. 13p.

Subject Terms: *T cells, *IMMUNE checkpoint proteins, *CANCER cells, *COLON tumors, *CELL death, *DISEASE relapse, *T cell receptors

Shattering barriers toward clinically meaningful MSC therapies.

Authors: Levy, Oren¹, Rui Kuai^1,2, Siren, Erika M. J.¹, Bhere, Deepak^2,3, Milton, Yuka¹, Nissar, Nabeel³, De Biasio, Michael¹, Heinelt, Martina¹, Reeve, Brock⁴, Abdi, Reza⁵, Alturki, Meshael^6,7, Fallatah, Mohanad⁷, Almalik, Abdulaziz^6,7, Alhasan, Ali H.^6,7, Shah, Khalid^2,3,4, Karp, Jeffrey M.^1,2,4,8 jmkarp@bwh.harvard.edu

Source: Science Advances. 7/24/2020, Vol. 6 Issue 30, p1-18. 18p.

Subject Terms: *CRYOPRESERVATION of cells, *GENE transfection, *MESENCHYMAL stem cells, *GLIAL cell line-derived neurotrophic factor, *BONE marrow cells, *THERMORESPONSIVE polymers

High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme.

Authors: Kadiyala, Padma, Dan Li, Nuñez, Fernando M., Altshuler, David, Doherty, Robert, Rui Kuai, Minzhi Yu, Neha Kamran, Edwards, Marta, Moon, James J., Lowenstein, Pedro R., Castro, Maria G., Schwendeman, Anna

Source: ACS Nano; 2/26/2019, Vol. 13 Issue 2, p1365-1384, 20p

Subcutaneous Nanodisc Vaccination with Neoantigens for Combination Cancer Immunotherapy.

Authors: Rui Kuai, Xiaoqi Sun, Wenmin Yuan, Yao Xu, Schwendeman, Anna, Moon, James J.

Source: Bioconjugate Chemistry; 3/21/2018, Vol. 29 Issue 3, p771-775, 5p

Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy.

Authors: Yuchen Fan^1,2, Rui Kuai^1,2, Yao Xu^1,2, Ochyl, Lukasz J.^1,2, Irvine, Darrell J.^3,4,5,6,7, Moon, James J.^1,2,8 moonjj@umich.edu

Source: Nano Letters. 12/13/2017, Vol. 17 Issue 12, p7387-7393. 7p.

Subject Terms: *CELL death, *CANCER immunotherapy, *CANCER cells, *COLON cancer, *IRRADIATION, *CANCER chemotherapy

Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma.

Authors: Rui Kuai, Subramanian, Chitra, White, Peter T., Timmermann, Barbara N., Moon, James J., Cohen, Mark S., Schwendeman, Anna

Source: International Journal of Nanomedicine; Sep2017, Vol. 12, p6581-6594, 14p

Lupus high-density lipoprotein induces proinflammatory responses in macrophages by binding lectin-like oxidised low-density lipoprotein receptor 1 and failing to promote activating transcription factor 3 activity.

Authors: Smith, Carolyne K., Seto, Nickie L., Vivekanandan-Giri, Anuradha, Wenmin Yuan, Playford, Martin P., Manna, Zerai, Hasni, Sarfaraz A., Rui Kuai, Mehta, Nehal N., Schwendeman, Anna, Pennathur, Subramaniam, Kaplan, Mariana J., Yuan, Wenmin, Kuai, Rui

Source: Annals of the Rheumatic Diseases; Mar2017, Vol. 76 Issue 3, p602-611, 10p, 6 Graphs

Subject Terms: PROTEIN metabolism, RNA metabolism, AMIDES, ANIMAL experimentation, ANIMALS, BIOLOGICAL transport, CELL culture, CELL receptors, CYTOKINES, HIGH density lipoproteins, LECITHIN, MACROPHAGES, MICE, OXIDATION-reduction reaction, PEPTIDES, PHOSPHOTRANSFERASES, PROTEINS, PYRIDINE, RNA, SPLEEN, SYSTEMIC lupus erythematosus, DNA-binding proteins, PROTEIN kinase inhibitors, PHARMACODYNAMICS

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Precise modulation and use of reactive oxygen species for immunotherapy.

Authors: Xinyan Li^1,2, Jingjing Gao^3,4, Chengcheng Wu^1,2, Chaoyu Wang^1,2, Ruoshi Zhang^1,2, Jia He^1,2, Ziting Judy Xia³, Joshi, Nitin³ njoshi@bwh.harvard.edu, Karp, Jeffrey M.³ jmkarp@bwh.harvard.edu, Rui Kuai^1,2 ruikuai@tsinghua.edu.cn

Source: Science Advances. 5/17/2024, Vol. 10 Issue 20, p1-17. 17p.

Subject Terms: *IMMUNOTHERAPY, *REACTIVE oxygen species, *BIOMATERIALS, *IMMUNE system, *AUTOIMMUNE diseases, *COMMUNICABLE diseases, *CANCER cells