Assay for the quantification of abemaciclib, its metabolites, and olaparib in human plasma by liquid chromatography-tandem mass spectrometry

Authors: Hill, Kasey L., Abbott, Nicole L., Na, Joo Young, Rudek, Michelle, Moore, Kathleen, Lee, Eudocia Q., Phelps, Mitch A.

Source: In Journal of Pharmaceutical and Biomedical Analysis 15 January 2025 253

DNA methyltransferase inhibitor exposure–response: Challenges and opportunities

Authors: Kagan, Amanda B., Garrison, Dominique A., Anders, Nicole M., Webster, Jonathan A., Baker, Sharyn D., Yegnasubramanian, Srinivasan, Rudek, Michelle A.

Source: Clinical and translational science. 16(8):1309-1322

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192970811.0x000001&indx=1&recIds=ETOCvdc_100192970811.0x000001

Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

Authors: Talebi, Zahra ^a, Garrison, Dominique A. ^b, Eisenmann, Eric D. ^a, Parmar, Kalindi ^c, Shapiro, Geoffrey I. ^{c, d}, Rudek, Michelle A. ^{b, e}, Sparreboom, Alex ^{a, ∗∗}, Jin, Yan ^{a, ∗}

Source: In Heliyon November 2023 9(11)

Brentuximab vedotin with AVD for stage II–IV HIV-related Hodgkin lymphoma (AMC 085): phase 2 results from an open-label, single arm, multicentre phase 1/2 trial

Authors: Barta, Stefan K., Hamdan, Ayad, Boué, François, Delobel, Pierre, Galicier, Lionel, Coppo, Paul, Ghesquières, Hervé, Rubinstein, Paul G ^*, Moore, Page C, Bimali, Milan, Lee, Jeanette Y, Rudek, Michelle A, Chadburn, Amy, Ratner, Lee, Henry, David H, Cesarman, Ethel, DeMarco, Camille E, Costagliola, Dominique, Taoufik, Yassine, Ramos, Juan Carlos, Sharon, Elad, Reid, Erin G, Ambinder, Richard F, Mitsuyasu, Ronald, Mounier, Nicolas, Besson, Caroline, Noy, Ariela

Source: In The Lancet Haematology August 2023 10(8):e624-e632

Quantitation of Cabozantinib in Human Plasma by LC–MS/MS

Authors: Jones, Reyna, Holleran, Julianne, Parise, Robert A, Rudek, Michelle A, Chan, Jennifer, Wen, Yujia, Gobburu, Joga, Lewis, Lionel D, Beumer, Jan H

Source: Journal of chromatographic science. 60(3):274-279

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144894815.0x000001&indx=1&recIds=ETOCvdc_100144894815.0x000001

A phase 1 study of the combination of BH3-mimetic, navitoclax, and mTORC1/2 inhibitor, vistusertib, in patients with advanced solid tumors.

Authors: Scott, Susan C., Farago, Anna, Lai, W. Victoria, Zahurak, Marianna, Rudek, Michelle A., Murray, Judy, Carducci, Michael A., Uziel, Tamar, Takebe, Naoko, Gore, Steven D., Rudin, Charles M., Hann, Christine L.

Source: Cancer Chemotherapy & Pharmacology; 2/25/2025, Vol. 95 Issue 1, p1-9, 9p

Subject Terms: SMALL cell lung cancer, PHARMACOKINETICS, THROMBOCYTOPENIA

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.

Authors: Rendo, Veronica, Lee, Eudocia Q., Bossi, Connor, Khuu, Nicholas, Rudek, Michelle A., Pal, Sangita, Azazmeh, Narmen, Rashid, Rumana, Lin, Jia-Ren, Cusick, Margaret, Reynolds, Abigail R. N., Fassinou, Auriole C. R., Ayoub, Georges, Malinowski, Seth, Lapinskas, Emily, Pisano, William, Jeang, John, Stopka, Sylwia A., Regan, Michael S., Spetz, Johan

Source: Science Translational Medicine; 2/19/2025, Vol. 17 Issue 786, p1-18, 18p

Subject Terms: BONE marrow cells, PROGRESSION-free survival, OVERALL survival, CELL death, DNA sequencing

A phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome.

Authors: Maher, Keri R., Shafer, Danielle, Schaar, Dale, Bandyopadhyay, Dipankar, Deng, Xiaoyan, Wright, John, Piekarz, Richard, Rudek, Michelle A., Harvey, R. Donald, Grant, Steven

Source: Cancer Chemotherapy & Pharmacology; 2025, Vol. 95 Issue 1, p1-9, 9p

High-dose administration of tyrosine kinase inhibitors to improve clinical benefit: A systematic review

Authors: Gerritse, Sophie L., Janssen, Jorien B.E., Labots, Mariette, de Vries, Ralph, Rudek, Michelle, Carducci, Michael, van Erp, Nielka P., Verheul, Henk M.W.

Source: In Cancer Treatment Reviews June 2021 97

Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax

Authors: Moses, Blake S., McCullough, Samantha, Fox, Jennifer M., Mott, Bryan T., Bentzen, Søren M., Kim, MinJung, Tyner, Jeffrey W., Lapidus, Rena G., Emadi, Ashkan, Rudek, Michelle A., Kingsbury, Tami J., Civin, Curt I.

Source: In Blood Advances 9 February 2021 5(3):711-724

Targeting the Hedgehog Pathway Using Itraconazole to Prevent Progression of Barrett's Esophagus to Invasive Esophageal Adenocarcinoma

Authors: Kelly, Ronan J., Ansari, Amir M., Miyashita, Tomoharu, Zahurak, Marianna, Lay, Frank, Ahmed, A. Karim, Born, Louis J., Pezhouh, Maryam K., Salimian, Kevan J., Ng, Christopher, Matsangos, Aerielle E., Stricker-Krongrad, Anne-Heloise, Mukaisho, Ken-ichi, Marti, Guy P., Chung, Christine H., Canto, Marcia I., Rudek, Michelle A., Meltzer, Stephen J., Harmon, John W.

Source: Annals of surgery. 273(6):e206-e213

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121718132.0x000001&indx=1&recIds=ETOCvdc_100121718132.0x000001

Treatment of advanced AIDS-associated Kaposi sarcoma in resource-limited settings: a three-arm, open-label, randomised, non-inferiority trial

Authors: Moses, Agnes, Kanyama, Cecilia, Mukwekwerere, Pamela, Gudza, Ivy, Chauwa, Felluna, Ulaya, Godwin, Kutto, Irene, Cheruiyot, Priscilla, Okello, Clement, Nakaganda, Annet, Koskei, Geoffrey, Keter, Winnie, Netto, Juliana, Baião, Tamiris, Govender, Iveshni, O'Connell-Maritz, Jessica, Cain, Kevin, Okanda, John, Cornelissen, Lynne, Van Schalkwyk, Marije, Sikhosana, Rejoice, Ngcobo, Minenhle, Lee, Jeannette Y., Harrison, Taylor, Wachsman, William, Shin, Katherine, Evans, Scott, Rothenberg, Jennifer, Hosey, Lara, McCarthy, Sean, Martinez-Maza, Otoniel, Rinaldo, Charles, Dittmer, Dirk, Fletcher, Courtney, Rudek, Michelle, Asmelash, Aida, Hughes, Valery, Schouten, Jeffrey, Shugarts, David, Kujinga, Tapiwanashe, Zadzilka, Amanda, Kerui, Fredrick, Robertson, Debora, Rooney, James, Sewal, Krishna, Gottshall, Brian, Krown, Susan E ^*, Moser, Carlee B, MacPhail, Patrick, Matining, Roy M, Godfrey, Catherine, Caruso, Stephanie R, Hosseinipour, Mina C, Samaneka, Wadzanai, Nyirenda, Mulinda, Busakhala, Naftali W, Okuku, Fred M, Kosgei, Josphat, Hoagland, Brenda, Mwelase, Noluthando, Oliver, Vincent O, Burger, Henriette, Mngqibisa, Rosie, Nokta, Mostafa, Campbell, Thomas B, Borok, Margaret Z

Source: In The Lancet 11-17 April 2020 395(10231):1195-1207

A Prospective Study of Peritransplant Sorafenib for Patients with FLT3-ITD Acute Myeloid Leukemia Undergoing Allogeneic Transplantation

Authors: Pratz, Keith W., Rudek, Michelle A., Smith, B. Douglas, Karp, Judith, Gojo, Ivana, Dezern, Amy, Jones, Richard J., Greer, Jackie, Gocke, Christopher, Baer, Maria R., Duong, Vu H., Rosner, Gary, Zahurak, Marianna, Wright, John J., Emadi, Ashkan, Levis, Mark

Source: In Biology of Blood and Marrow Transplantation February 2020 26(2):300-306

A Phase I Study of Dinaciclib in Combination With MK‐2206 in Patients With Advanced Pancreatic Cancer

Authors: Murphy, Adrian G., Zahurak, Marianna, Shah, Mirat, Weekes, Colin D., Hansen, Aaron, Siu, Lillian L., Spreafico, Anna, LoConte, Noelle, Anders, Nicole M., Miles, Tearra, Rudek, Michelle A., Doyle, L. Austin, Nelkin, Barry, Maitra, Anirban, Azad, Nilofer S.

Source: Clinical and translational science. 13(6):1178-1188

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112199796.0x000001&indx=1&recIds=ETOCvdc_100112199796.0x000001

Successful gene therapy requires targeting the vast majority of cancer cells

Authors: Sagara, Takuya, Debeljak, Marija, Wright, Chapman M., Anders, Nicole M., Liang, Hong, Rudek, Michelle A., Ostermeier, Marc, Eshleman, James R., Matsushita, Yoshihisa

Source: Cancer biology & therapy. 21(10):946-953

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110828404.0x000001&indx=1&recIds=ETOCvdc_100110828404.0x000001

Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer.

Authors: Anchoori, Ravi K., Tseng, Ssu-Hsueh, Tsai, Hua-Ling, Palande, Vikrant, Rudek, Michelle A., Roden, Richard B. S.

Source: PLoS ONE; 7/11/2024, Vol. 19 Issue 7, p1-26, 26p

Subject Terms: OVARIAN cancer, OVARIAN epithelial cancer, CANCER treatment, PACLITAXEL, GUANIDINES, LEG muscles, BIOCHEMICAL substrates, BLOOD-brain barrier

Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-risk HIV-associated Non-Hodgkin's Lymphoma (AMC-075)

Authors: Ramos, Juan C., Sparano, Joseph A., Rudek, Michelle A., Moore, Page C., Cesarman, Ethel, Reid, Erin G., Henry, David, Ratner, Lee, Aboulafia, David, Lee, Jeanette Y., Ambinder, Richard F., Mitsuyasu, Ronald, Noy, Ariela

Source: In Clinical Lymphoma Myeloma and Leukemia March 2018 18(3):180-190

A multicenter, phase 1, Adult Brain Tumor Consortium trial of oral terameprocol for patients with recurrent high-grade glioma (GATOR)

Authors: Ahluwalia, Manmeet S., Ozair, Ahmad, Rudek, Michelle, Ye, Xiaobu, Holdhoff, Matthias, Lieberman, Frank S., Piotrowski, Anna F., Nabors, Burt, Desai, Arati, Lesser, Glenn, Huang, Ru Chih, Glenn, Steve, Khosla, Atulya A., Peereboom, David M., Wen, Patrick Y., Grossman, Stuart A.

Source: In Cell Reports Medicine 16 July 2024 5(7)

Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia

Authors: Sharma, Anirudh, Özayral, Sanem, Caserto, Julia S., ten Cate, Rosemarie, Anders, Nicole M., Barnett, James D., Kandala, Sri Kamal, Henderson, Elizabeth, Stewart, Jacqueline, Liapi, Eleni, Rudek, Michelle A., Franken, Nicolaas A.P., Oei, Arlene L., Korangath, Preethi, Bunz, Fred, Ivkov, Robert

Source: International journal of hyperthermia. 36(1):711-719

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094876606.0x000001&indx=1&recIds=ETOCvdc_100094876606.0x000001

A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors

Authors: Gaillard, Stéphanie L., Zahurak, Marianna, Sharma, Anup, Durham, Jennifer N., Reiss, Kim A., Sartorius‐Mergenthaler, Susan, Downs, Melinda, Anders, Nicole M., Ahuja, Nita, Rudek, Michelle A., Azad, Nilofer

Source: Cancer. 125(16):2837-2845

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085856046.0x000001&indx=1&recIds=ETOCvdc_100085856046.0x000001