De novo generation of multi-target compounds using deep generative chemistry

Authors: Brenton P. Munson, Michael Chen, Audrey Bogosian, Jason F. Kreisberg, Katherine Licon, Ruben Abagyan, Brent M. Kuenzi, Trey Ideker

Source: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/55b169129e9145c5abf476bbec8ac7f5

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic Flaviviridae

Authors: Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

Source: Viruses, Vol 17, Iss 1, p 6 (2024)

Subject Terms: Zika virus, protease inhibitors, mutation rates, allosteric druggable pockets, Dengue, Yellow Fever, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/17/1/6; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/dc3fa0fa34134556ac21ad98ce62e998

Hepatic injury and hepatic failure adverse events in 3,4-methylenedioxymethamphetamine users reported to the FDA Adverse Event Reporting System

Authors: Tigran Makunts, Ruben Abagyan

Source: Frontiers in Psychiatry, Vol 15 (2024)

Subject Terms: DILI (drug-induced liver injury), MDMA, DDI (drug-drug interaction), FAERS, adverse events, MDMA (3,4-methylenedioxymethamphetamine), Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1414622/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/d63850a0cdca4e8db7b4e5d8d7fe4361

Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis

Authors: Tigran Makunts, Haroutyun Joulfayan, Ruben Abagyan

Source: JMIRx Med, Vol 5, Pp e55976-e55976 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://xmed.jmir.org/2024/1/e55976; https://doaj.org/toc/2563-6316

Access URL: https://doaj.org/article/d16281af39c74487a370da31b05ad63f

Authors’ Response to Peer Reviews of 'Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis'

Authors: Tigran Makunts, Haroutyun Joulfayan, Ruben Abagyan

Source: JMIRx Med, Vol 5, Pp e58273-e58273 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://xmed.jmir.org/2024/1/e58273; https://doaj.org/toc/2563-6316

Access URL: https://doaj.org/article/bf6df77328f041d8aad6243b242a8d04

Depression Events Associated with Proton-Pump Inhibitors in Postmarketing Drug Surveillance Data

Authors: Tigran Makunts, Haroutyun Joulfayan, Kenneth Ta, Ruben Abagyan

Source: Pharmacoepidemiology, Vol 2, Iss 3, Pp 272-282 (2023)

Subject Terms: proton-pump inhibitors, PPIs, FAERS, depression, drug safety, adverse events, Therapeutics. Pharmacology, RM1-950, Other systems of medicine, RZ201-999, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://www.mdpi.com/2813-0618/2/3/23; https://doaj.org/toc/2813-0618

Access URL: https://doaj.org/article/a0c3b89a05184c309f3e046af9d2268b

Anti-TNF-α therapy induced psoriasis in rheumatoid arthritis patients according to FDA postmarketing surveillance data

Authors: Haroutyun Joulfayan, Tigran Makunts, Ruben Abagyan

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/91f6ab19a7e3417e963945c46f129575

Concomitant medications associated with ischemic, hypertensive, and arrhythmic events in MDMA users in FDA adverse event reporting system

Authors: Tigran Makunts, Diane Dahill, Lisa Jerome, Alberdina de Boer, Ruben Abagyan

Source: Frontiers in Psychiatry, Vol 14 (2023)

Subject Terms: 3,4-methylenedioxymethamphetamine, MDMA, adverse events, cardiovascular, schaemia, hypertension, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1149766/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/91692d656f5a46a3ba35f4ec0194d9fe

Postmarketing safety surveillance data reveals protective effects of botulinum toxin injections against incident anxiety

Authors: M. Axel Wollmer, Tigran Makunts, Tillmann H. C. Krüger, Ruben Abagyan

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/929c0971c2234a46a2163e2802818440

Common osteoporosis drug associated with increased rates of depression and anxiety

Authors: Dro Keshishi, Tigran Makunts, Ruben Abagyan

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3a0f2bd629644aef8fb8c38b036794c0

Myocarditis occurrence with cancer immunotherapy across indications in clinical trial and post-marketing data

Authors: Tigran Makunts, Ila M. Saunders, Isaac V. Cohen, Mengxing Li, Talar Moumedjian, Masara A. Issa, Keith Burkhart, Peter Lee, Sandip Pravin Patel, Ruben Abagyan

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f9e5c40ece6d4172afc9cd95cfa7fd22

Elucidation of transient protein-protein interactions within carrier protein-dependent biosynthesis

Authors: Thomas G. Bartholow, Terra Sztain, Ashay Patel, D. John Lee, Megan A. Young, Ruben Abagyan, Michael D. Burkart

Source: Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/93abe143c4514ee6b3184a5151b517f0

Concomitant drugs associated with increased mortality for MDMA users reported in a drug safety surveillance database

Authors: Isaac V. Cohen, Tigran Makunts, Ruben Abagyan, Kelan Thomas

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b5fcb5c6d48f493398295aa1b6997412

Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in 'Super-Open' Conformation

Authors: Ittipat Meewan, Sergey A. Shiryaev, Julius Kattoula, Chun-Teng Huang, Vivian Lin, Chiao-Han Chuang, Alexey V. Terskikh, Ruben Abagyan

Source: Viruses, Vol 15, Iss 5, p 1106 (2023)

Subject Terms: Zika virus protease inhibitors, allosteric inhibitors, Zika virus NS2B-NS3 protease, super-open conformation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/5/1106; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/d82dfc16c47e4ce8a8d1bcd1aada43df

Mapping the gene network landscape of Alzheimer's disease through integrating genomics and transcriptomics.

Authors: Sara Brin Rosenthal, Hao Wang, Da Shi, Cin Liu, Ruben Abagyan, Linda K McEvoy, Chi-Hua Chen

Source: PLoS Computational Biology, Vol 18, Iss 2, p e1009903 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/a2ec64c1dede42b08994ad8da998a0f1

Retrospective analysis of clinical trial safety data for pembrolizumab reveals the effect of co-occurring infections on immune-related adverse events.

Authors: Tigran Makunts, Keith Burkhart, Ruben Abagyan, Peter Lee

Source: PLoS ONE, Vol 17, Iss 2, p e0263402 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/29b78c5e769a42ec856c155c34b46a99

Reported Cases of Serotonin Syndrome in MDMA Users in FAERS Database

Authors: Tigran Makunts, Lisa Jerome, Ruben Abagyan, Alberdina de Boer

Source: Frontiers in Psychiatry, Vol 12 (2022)

Subject Terms: serotonin syndrome, MDMA (3, 4- methylenedioxymethamphetamine), FAERS database, surveillance system, case reports [publication type], Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.824288/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/1a874c8ec2a243d7a006fa41ab159435

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant

Authors: Ittipat Meewan, Xingquan Zhang, Suchismita Roy, Carlo Ballatore, Anthony J. O’Donoghue, Robert T. Schooley, Ruben Abagyan

Source: ACS Omega, Vol 4, Iss 16, Pp 16999-17008 (2019)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/031cd9edd34b4ffc82d9547db618b6a8

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery

Authors: Martina Maccesi, Pedro H. N. Aguiar, Valérian Pasche, Melody Padilla, Brian M. Suzuki, Sandro Montefusco, Ruben Abagyan, Jennifer Keiser, Marina M. Mourão, Conor R. Caffrey

Source: Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)

Subject Terms: Schistosoma, Schistosomiasis, Drug discovery, Phenotypic screen, Pathogen Box, MMV, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13071-019-3747-6; https://doaj.org/toc/1756-3305

Access URL: https://doaj.org/article/409ebe9371c34ff0b5f701fa37ac4641

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge.

Authors: Zhaoping Xiong, Minji Jeon, Robert J Allaway, Jaewoo Kang, Donghyeon Park, Jinhyuk Lee, Hwisang Jeon, Miyoung Ko, Hualiang Jiang, Mingyue Zheng, Aik Choon Tan, Xindi Guo, Multi-Targeting Drug DREAM Challenge Community, Kristen K Dang, Alex Tropsha, Chana Hecht, Tirtha K Das, Heather A Carlson, Ruben Abagyan, Justin Guinney, Avner Schlessinger, Ross Cagan

Source: PLoS Computational Biology, Vol 17, Iss 9, p e1009302 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/760d14f1687d40cc99f25eb1a90cecb7