Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma

Authors: Marta Zalacain, María Bunuales, Lucía Marrodan, Sara Labiano, Marisol Gonzalez-Huarriz, Naiara Martinez-Vélez, Virginia Laspidea, Montse Puigdelloses, Marc García-Moure, Manuela Gonzalez-Aparicio, Rubén Hernandez-Alcoceba, Marta M. Alonso, Ana Patiño-García

Source: Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 23-33 (2021)

Subject Terms: Pediatric solid tumors, therapy, osteosarcoma, high capacity adenoviral vectors, immunotherapy, IL-12, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770520301686; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/31c2c8191c8240cdb76ac36ee4d1b26d

Broad virus inactivation using inorganic micro/nano-particulate materials

Authors: Sergio Rius-Rocabert, Javier Arranz-Herrero, Adolfo Fernández-Valdés, Marzia Marciello, Sandra Moreno, Francisco Llinares-Pinel, Jesus Presa, Rubén Hernandez-Alcoceba, Roberto López-Píriz, Ramón Torrecillas, Antonia García, Alejandro Brun, Marco Filice, José S. Moya, Belen Cabal, Estanislao Nistal-Villan

Source: Materials Today Bio, Vol 13, Iss , Pp 100191- (2022)

Subject Terms: Virucidal materials, Virus inactivation, Virus clearance, Glass-based virucidal, Kaolinbased virucidal, Virus elimination, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006421000995; https://doaj.org/toc/2590-0064

Access URL: https://doaj.org/article/526ccdb7affb4a5db2c2d56c7c4e8548

Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome

Authors: Soraya Martín-Suárez, Oihane Abiega, Ana Ricobaraza, Rubén Hernandez-Alcoceba, Juan Manuel Encinas

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: neural stem cells, aberrant neurogenesis, gliosis, Dravet syndrome, SCN1A, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00654/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/cd5b3ba7cb7040268384019b7be7b62e

Preclinical model for phenotypic correction of dystrophic epidermolysis bullosa by in vivo CRISPR-Cas9 delivery using adenoviral vectors

Authors: Marta García, Jose Bonafont, Jesús Martínez-Palacios, Rudan Xu, Giandomenico Turchiano, Stina Svensson, Adrian J. Thrasher, Fernando Larcher, Marcela Del Rio, Rubén Hernández-Alcoceba, Marina I. Garín, Ángeles Mencía, Rodolfo Murillas

Source: Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 96-108 (2022)

Subject Terms: gene editing, epidermolysis bullosa, RDEB, adenoviral vector, CRISPR-Cas, in vivo gene therapy, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122001309; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/d7c843aebbdf4538b32d4bed782a099b

Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma

Authors: Guillermo Herrador-Cañete, Marta Zalacain, Sara Labiano, Virginia Laspidea, Montserrat Puigdelloses, Lucía Marrodan, Marc Garcia-Moure, Marisol Gonzalez-Huarriz, Javier Marco-Sanz, Iker Ausejo-Mauleon, Daniel de la Nava, Reyes Hernández-Osuna, Javier Martínez-García, Noelia Silva-Pilipich, Elisabeth Gurucega, Ana Patiño-García, Rubén Hernández-Alcoceba, Cristian Smerdou, Marta M. Alonso

Source: Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 246-264 (2022)

Subject Terms: Galectin-3, Semliki Forest virus, virotherapy, immunotherapy, osteosarcoma, pediatric cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770522000936; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/aa6be58f880644d78c5e92d41cf868e1

High value of 64Cu as a tool to evaluate the restoration of physiological copper excretion after gene therapy in Wilson’s disease

Authors: Oihana Murillo, Maria Collantes, Cristina Gazquez, Daniel Moreno, Ruben Hernandez-Alcoceba, Miren Barberia, Margarita Ecay, Blanche Tamarit, Anne Douar, Veronica Ferrer, Jean Philippe Combal, Ivan Peñuelas, Bernard Bénichou, Gloria Gonzalez-Aseguinolaza

Source: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 98-106 (2022)

Subject Terms: Wilson’s disease, radiocopper, AAV, ATP7B, copper metabolism, gene transfer, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122000791; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/afe87d2e90484e9ca008bbd452940d81

Viral vector–mediated expression of NaV1.1, after seizure onset, reduces epilepsy in mice with Dravet syndrome

Authors: Saja Fadila, Bertrand Beucher, Iria González Dopeso-Reyes, Anat Mavashov, Marina Brusel, Karen Anderson, Caroline Ismeurt, Ethan M. Goldberg, Ana Ricobaraza, Ruben Hernandez-Alcoceba, Eric J. Kremer, Moran Rubinstein

Source: The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)

Subject Terms: Neuroscience, Therapeutics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/2ad9803b50ee4a45bf9f3b05e52e1d3d

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations

Authors: Lucia Mora-Jimenez, Miguel Valencia, Rocio Sanchez-Carpintero, Jan Tønnesen, Saja Fadila, Moran Rubinstein, Manuela Gonzalez-Aparicio, Maria Bunuales, Eva Fernandez-Pierola, Maria Jesus Nicolas, Elena Puerta, Cristina Miguelez, Paula Gimenez Minguez, Sara Lumbreras, Gloria Gonzalez-Aseguinolaza, Ana Ricobaraza, Ruben Hernandez-Alcoceba

Source: Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 585-602 (2021)

Subject Terms: SCN1A, Nav1.1., Dravet syndrome, epilepsy, encephalopathy, adenovirus, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253121001979; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/d8a21f6b96294c4686222a2f4ad8317e

Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis

Authors: Sara Lumbreras, Ana Ricobaraza, Lucia Baila-Rueda, Manuela Gonzalez-Aparicio, Lucia Mora-Jimenez, Iker Uriarte, Maria Bunuales, Matias A. Avila, Maria J. Monte, Jose J.G. Marin, Ana Cenarro, Gloria Gonzalez-Aseguinolaza, Ruben Hernandez-Alcoceba

Source: Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 210-221 (2021)

Subject Terms: cerebrotendinous xanthomatosis, CTX, adeno-associated virus, gene therapy, chenodeoxycholic acid, cholestanol, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050121001194; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/dbca431b41004c1fa3d3a6751b4526b2

Gene therapies and COVID-19 vaccines: a necessary discussion in relation with viral vector-based approaches

Authors: Angel Aledo-Serrano, Antonio Gil-Nagel, Julian Isla, Ana Mingorance, Fernando Mendez-Hermida, Ruben Hernandez-Alcoceba

Source: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-3 (2021)

Subject Terms: SARS-CoV-2, Adenovirus, AAV, Genetic diseases, Rare diseases, Pandemic, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/693f95cb49044abbacb22bcfef793a34

Author Correction: Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation

Authors: Ana Ricobaraza, Lucia Mora-Jimenez, Elena Puerta, Rocio Sanchez-Carpintero, Ana Mingorance, Julio Artieda, Maria Jesus Nicolas, Guillermo Besne, Maria Bunuales, Manuela Gonzalez-Aparicio, Noemi Sola-Sevilla, Miguel Valencia, Ruben Hernandez-Alcoceba

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3becad7f781e4292b660db2d7710c5e8

A Versatile Vector for In Vivo Monitoring of Type I Interferon Induction and Signaling.

Authors: Estanislao Nistal-Villan, Joanna Poutou, Estefania Rodríguez-Garcia, Maria Buñuales, Beatriz Carte-Abad, Jesus Prieto, Gloria Gonzalez-Aseguinolaza, Ruben Hernandez-Alcoceba, Esther Larrea

Source: PLoS ONE, Vol 11, Iss 3, p e0152031 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4805199?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/08947cd823fe461dbe7af45220631911

Gene therapy of liver cancer

Authors: Rubén Hernández-Alcoceba, Bruno Sangro, Jesús Prieto

Source: Annals of Hepatology, Vol 6, Iss 1, Pp 5-14 (2007)

Subject Terms: Gene therapy, cancer, liver, hepatocellular carcinoma, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1665268119319489; https://doaj.org/toc/1665-2681

Access URL: https://doaj.org/article/5860aa01ee324d828d37f4ceaea34790