ExplantAnalyzer: An advanced automated neurite outgrowth analysis evaluated by means of organotypic auditory neuron explant cultures

Authors: Schmidbauer, Dominik, Fink, Stefan, Rousset, Francis, Senn, Pascal, Müller, Marcus, Adel, Youssef, Glueckert, Rudolf

Source: In Journal of Neuroscience Methods 1 November 2021 363

Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss

Authors: Rousset, Francis, Nacher-Soler, German, Coelho, Marta, Ilmjarv, Sten, Kokje, Vivianne Beatrix Christina, Marteyn, Antoine, Cambet, Yves, Perny, Michael, Roccio, Marta, Jaquet, Vincent, Senn, Pascal, Krause, Karl Heinz

Source: In Redox Biology February 2020 30

Transmembrane Nox4 topology revealed by topological determination by Ubiquitin Fusion Assay, a novel method to uncover membrane protein topology

Authors: Rousset, Francis, Zhang, Leilei, Lardy, Bernard, Morel, Françoise, Nguyen, Minh Vu Chuong

Source: Biochemical and biophysical research communications. 521(2):383-388

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094775717.0x000001&indx=1&recIds=ETOCvdc_100094775717.0x000001

Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown

Authors: Rousset, Francis, Salmon, Patrick, Bredl, Simon, Cherpin, Ophélie, Coelho, Marta, Myburgh, Renier, Alessandrini, Marco, Perny, Michael, Roccio, Marta, Speck, Roberto F., Senn, Pascal, Krause, Karl Heinz

Source: In Molecular Therapy - Nucleic Acids 1 March 2019 14:351-363

WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro.

Authors: Rousset, Francis¹ (AUTHOR) francis.rousset@unige.ch, Schilardi, Giulia² (AUTHOR), Sgroi, Stéphanie¹ (AUTHOR), Nacher-Soler, German¹ (AUTHOR), Sipione, Rebecca¹ (AUTHOR), Kleinlogel, Sonja² (AUTHOR), Senn, Pascal^1,3 (AUTHOR)

Source: Cells (2073-4409). Aug2022, Vol. 11 Issue 15, p2431-2431. 20p.

Subject Terms: *AUDITORY neurons, *HAIR cells, *INNER ear, *SENSORINEURAL hearing loss, *PROGENITOR cells, *HIGH throughput screening (Drug development)

Poly-Lactic Acid-Based Biopolymer Formulations Are Safe for Sustained Intratympanic Dexamethasone Delivery

Authors: Rousset, Francis, Kokje, Vivianne Beatrix Christina, Coelho, Marta Da Costa, Mugnier, Thibault, Belissa, Emilie, Gabriel, Doris, Gurny, Robert, Krause, Karl Heinz, Senn, Pascal

Source: Otology & neurotology. 40(7):e739-e746

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181944917.0x000001&indx=1&recIds=ETOCvdc_100181944917.0x000001

Phoenix auditory neurons as 3R cell model for high throughput screening of neurogenic compounds

Authors: Rousset, Francis, Schmidbauer, Dominik, Fink, Stefan, Adel, Youssef, Obexer, Benjamin, Müller, Marcus, Glueckert, Rudolf, Löwenheim, Hubert, Senn, Pascal

Source: Hearing research. 414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153443721.0x000001&indx=1&recIds=ETOCvdc_100153443721.0x000001

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Authors: Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–Butuner, Bilge, Dias, Irundika H.K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., Di Lisa, Fabio, Daiber, Andreas

Source: In Redox Biology October 2017 13:94-162

La NADPH oxydase Nox4, une cible thérapeutique potentielle dans l’arthrose

Alternate Title: NADPH oxidase Nox4, a putative therapeutic target in osteoarthritis (English)

Authors: Morel, Françoise ^*, Rousset, Francis ^**, Vu Chuong Nguyen, Minh ^*, Trocme, Candice ^***, Grange, Laurent ^*, Lardy, Bernard ^*

Source: In Bulletin de l'Académie Nationale de Médecine April-May 2015 199(4-5):673-687

Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4

Authors: Nguyen, Minh Vu Chuong, Lardy, Bernard, Rousset, Francis, Hazane-Puch, Florence, Zhang, Leilei, Trocmé, Candice, Serrander, Lena, Krause, Karl-Heinz, Morel, Françoise

Source: In Biochemical Pharmacology 1 June 2013 85(11):1644-1654

NOX3-Targeted Therapies for Inner Ear Pathologies

Authors: Rousset, Francis, Carnesecchi, Stephanie, Senn, Pascal, Krause, Karl-Heinz

Source: Current pharmaceutical design. 21(41):5977-5987

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083497706.0x000001&indx=1&recIds=ETOCvdc_100083497706.0x000001

NADPH oxidase Nox4, a putative therapeutic target in osteoarthritis

Authors: Morel, Françoise, Rousset, Francis, Nguyen, Minh Vu Chuong, Trocme, Candice, Grange, Laurent, Lardy, Bernard

Source: Bulletin de l'Académie nationale de médecine.é. 199(4/5):673-688

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606790605&indx=1&recIds=ETOCRN606790605

NADPH oxidases, Nox: new isoenzymes family

Authors: Nguyen, Minh Vu Chuong, Lardy, Bernard, Paclet, Marie-Hélène, Rousset, Francis, Berthier, Sylvie, Baillet, Athan, Grange, Laurent, Gaudin, Philippe, Morel, Françoise

Source: M/S. 31(1):43-52

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600763877&indx=1&recIds=ETOCRN600763877

Axonal Regrowth of Olfactory Sensory Neurons In Vitro.

Authors: Sipione, Rebecca, Liaudet, Nicolas, Rousset, Francis, Landis, Basile N., Hsieh, Julien Wen, Senn, Pascal

Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 16, p12863, 15p

Subject Terms: OLFACTORY receptors, EXTRACELLULAR matrix proteins, BRAIN-derived neurotrophic factor, FIBROBLAST growth factors, TRANSFORMING growth factors, FIBROBLAST growth factor 2, SENSORY neurons

New insight into the Nox4 subcellular localization in HEK293 cells: First monoclonal antibodies against Nox4

Authors: Zhang, Leilei, Nguyen, Minh Vu Chuong, Lardy, Bernard, Jesaitis, Algirdas J., Grichine, Alexei, Rousset, Francis, Talbot, Monique, Paclet, Marie-Hélène, Qian, GuanXiang, Morel, Françoise

Source: In Biochimie March 2011 93(3):457-468

Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?

Authors: Schmidbauer, Dominik, Fink, Stefan, Rousset, Francis, Löwenheim, Hubert, Senn, Pascal, Glueckert, Rudolf

Source: International Journal of Molecular Sciences; Feb2023, Vol. 24 Issue 3, p2013, 31p

Subject Terms: COCHLEAR implants, ELECTRIC stimulation, AUDITORY neurons, ACOUSTIC nerve, NEUROTROPHINS, NEURONS

Development and in vivo validation of small interfering RNAs targeting NOX3 to prevent sensorineural hearing loss.

Authors: Nacher-Soler, German, Marteyn, Antoine, Barenzung, Natasha, Sgroi, Stéphanie, Krause, Karl-Heinz, Senn, Pascal, Rousset, Francis

Source: Frontiers in Neurology; 9/16/2022, Vol. 13, p1-18, 18p

Subject Terms: SENSORINEURAL hearing loss, SMALL interfering RNA, NOISE-induced deafness, INNER ear, SEMICIRCULAR canals, SPIRAL ganglion

Local Cisplatin Delivery in Mouse Reliably Models Sensorineural Ototoxicity Without Systemic Adverse Effects.

Authors: Nacher-Soler, German, Lenglet, Sébastien, Coelho, Marta, Thomas, Aurélien, Voruz, François, Krause, Karl-Heinz, Senn, Pascal, Rousset, Francis

Source: Frontiers in Cellular Neuroscience; 7/14/2021, Vol. 15, p1-12, 12p

Subject Terms: LABORATORY mice, OTOTOXICITY, AUDITORY neurons, WEIGHT loss, ANIMAL welfare, CISPLATIN, HAIR cells

Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes.

Authors: Rousset, Francis¹ francisrousset@yahoo.fr, Nguyen, Minh Vu Chuong¹, Grange, Laurent^1,2, Morel, Françoise¹, Lardy, Bernard^1,3

Source: PLoS ONE. Jun2013, Vol. 8 Issue 6, p1-12. 12p.

Subject Terms: *HEME oxygenase regulation, *MATRIX metalloproteinases, *MINNESOTA Multiphasic Personality Inventory, *SECRETION, *CARTILAGE cells, *CELL death, *NADPH oxidase

Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons.

Authors: Rousset, Francis, B. C. Kokje, Vivianne, Sipione, Rebecca, Schmidbauer, Dominik, Nacher-Soler, German, Ilmjärv, Sten, Coelho, Marta, Fink, Stefan, Voruz, François, El Chemaly, Antoun, Marteyn, Antoine, Löwenheim, Hubert, Krause, Karl-Heinz, Müller, Marcus, Glückert, Rudolf, Senn, Pascal

Source: Frontiers in Cellular Neuroscience; 12/9/2020, Vol. 14, pN.PAG-N.PAG, 15p

Subject Terms: INNER ear, AUDITORY neurons, SPIRAL ganglion, FREEZE-thaw cycles, NEUROGLIA, PROGENITOR cells, GENETIC transformation