Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone

Authors: Hodgson, Kirsty, Orozco-Moreno, Margarita, Goode, Emily Archer, Fisher, Matthew, Garnham, Rebecca, Beatson, Richard, Turner, Helen, Livermore, Karen, Zhou, Yuhan, Wilson, Laura, Visser, Eline A., Pijnenborg, Johan FA., Eerden, Nienke, Moons, Sam J., Rossing, Emiel, Hysenaj, Gerald, Krishna, Rashi, Peng, Ziqian, Nangkana, Kyla Putri, Schmidt, Edward N., Duxfield, Adam, Dennis, Ella P., Heer, Rakesh, Lawson, Michelle A., Macauley, Matthew, Elliott, David J., Büll, Christian, Scott, Emma, Boltje, Thomas J., Drake, Richard R., Wang, Ning, Munkley, Jennifer

Source: In eBioMedicine June 2024 104

Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides

Authors: Rossing, Emiel, Pijnenborg, Johan F. A., Boltje, Thomas J.

Source: Chemical communications. 58(87):12139-12150

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163540498.0x000001&indx=1&recIds=ETOCvdc_100163540498.0x000001

Structure—Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents

Authors: Moons, Sam J., Rossing, Emiel, Janssen, Mathilde A. C. H., Heise, Torben, Büll, Christian, Adema, Gosse J., Boltje, Thomas J.

Source: ACS chemical biology. 17(3):590-597

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628905471&indx=1&recIds=ETOCRN628905471

Cellular Fucosylation Inhibitors Based on Fluorinated Fucose‐1‐phosphates**

Authors: Pijnenborg, Johan F. A., Visser, Eline A., Noga, Marek, Rossing, Emiel, Veizaj, Raisa, Lefeber, Dirk J., Büll, Christian, Boltje, Thomas J.

Source: Chemistry. 27(12):4022-4027

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115855559.0x000001&indx=1&recIds=ETOCvdc_100115855559.0x000001

Structure—Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation

Authors: Moons, Sam J., Rossing, Emiel, Heming, Jurriaan J. A., Janssen, Mathilde A. C. H., van Scherpenzeel, Monique, Lefeber, Dirk J., de Jonge, Marien I., Langereis, Jeroen D., Boltje, Thomas J.

Source: Bioconjugate chemistry. 32(6):1047-1051

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631435589&indx=1&recIds=ETOCRN631435589

Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

Authors: van Scherpenzeel, Monique, Conte, Federica, Büll, Christian, Ashikov, Angel, Hermans, Esther, Willems, Anke, van Tol, Walinka, Kragt, Else, Noga, Marek, Moret, Ed E, Heise, Torben, Langereis, Jeroen D, Rossing, Emiel, Zimmermann, Michael, Rubio-Gozalbo, M Estela, de Jonge, Marien I, Adema, Gosse J, Zamboni, Nicola, Boltje, Thomas, Lefeber, Dirk J

Source: Glycobiology. 32(3):239-250

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100145238290.0x000001&indx=1&recIds=ETOCvdc_100145238290.0x000001

Sialylation Inhibition Can Partially Revert Acquired Resistance to Enzalutamide in Prostate Cancer Cells.

Authors: Goode, Emily Archer, Orozco-Moreno, Margarita, Hodgson, Kirsty, Nabilah, Amirah, Murali, Meera, Peng, Ziqian, Merx, Jona, Rossing, Emiel, Pijnenborg, Johan F. A., Boltje, Thomas J., Wang, Ning, Elliott, David J., Munkley, Jennifer

Source: Cancers; Sep2024, Vol. 16 Issue 17, p2953, 16p

Subject Terms: DRUG resistance in cancer cells, RESEARCH funding, GLYCOSYLATION, RADICAL prostatectomy, PROSTATE tumors, CELL lines, POLYSACCHARIDES, HORMONE therapy, TRANSFERASES, PROGRESSION-free survival, OVERALL survival

Geographic Terms: UNITED Kingdom

Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c9ob00108e

Authors: Elferink, Hidde, Rossing, Emiel, Huang, Chiung-Hui, Lee, Bee Wah, Cao, Linqiu, Delsing, Dianne J., Groeneveld, Andre, Boltje, Thomas J.

Source: Organic & biomolecular chemistry. 17(12):3108-3112

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078381431.0x000001&indx=1&recIds=ETOCvdc_100078381431.0x000001

Luminescent Assay for the Screening of SARS‐CoV‐2 MPro Inhibitors

Authors: Sondag, Daan, Merx, Jona, Rossing, Emiel, Boltje, Thomas J., Löwik, Dennis W. P. M., Nelissen, Frank H. T., Geffen, Mark, Veer, Cornelis, Heerde, Waander L., Rutjes, Floris P. J. T.

Source: Chembiochem. 23(15)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157750425.0x000001&indx=1&recIds=ETOCvdc_100157750425.0x000001

Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction

Authors: Heise, Torben, Büll, Christian, Beurskens, Daniëlle M., Rossing, Emiel, de Jonge, Marien I., Adema, Gosse J., Boltje, Thomas J., Langereis, Jeroen D.

Source: Bioconjugate chemistry. 28(7):1811-1815

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631358625&indx=1&recIds=ETOCRN631358625

Two Receptor Binding Strategy of SARS-CoV‑2 Is Mediated by Both the N‑Terminal and Receptor-Binding Spike Domain.

Authors: Monti, Michele, Milanetti, Edoardo, Frans, Myrthe T., Miotto, Mattia, Di Rienzo, Lorenzo, Baranov, Maksim V., Gosti, Giorgio, Somavarapu, Arun Kumar, Nagaraj, Madhu, Golbek, Thaddeus W., Rossing, Emiel, Moons, Sam J., Boltje, Thomas J., van den Bogaart, Geert, Weidner, Tobias, Otzen, Daniel E., Tartaglia, Gian Gaetano, Ruocco, Giancarlo, Roeters, Steven J.

Source: Journal of Physical Chemistry B; 1/18/2024, Vol. 128 Issue 2, p451-464, 14p

Targeting aberrant sialylation and fucosylation in prostate cancer cells using potent metabolic inhibitors.

Authors: Orozco-Moreno, Margarita, Visser, Eline A, Hodgson, Kirsty, Ederveen, Agnes L Hipgrave, Bastian, Kayla, Goode, Emily Archer, Öztürk, Özden, Pijnenborg, Johan F A, Eerden, Nienke, Moons, Sam J, Rossing, Emiel, Wang, Ning, Haan, Noortje de, Büll, Christian, Boltje, Thomas J, Munkley, Jennifer

Source: Glycobiology; Dec2023, Vol. 33 Issue 12, p1155-1171, 17p

Subject Terms: ENZYME inhibitors, ANDROGEN receptors, FUCOSYLATION, PROSTATE cancer, CANCER cell growth, CANCER cells

Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus influenzae Abrogates Serum Resistance

Authors: Heise, Torben, Langereis, Jeroen D., Rossing, Emiel, de Jonge, Marien I., Adema, Gosse J., Büll, Christian, Boltje, Thomas J.

Source: Cell chemical biology. 25(10):1279-1285.e8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131276868.0x000001&indx=1&recIds=ETOCvdc_100131276868.0x000001

Luminescent Assay for the Screening of SARS‐CoV‐2 M^Pro Inhibitors.

Authors: Sondag, Daan, Merx, Jona, Rossing, Emiel, Boltje, Thomas J., Löwik, Dennis W. P. M., Nelissen, Frank H. T., van Geffen, Mark, van 't Veer, Cornelis, van Heerde, Waander L., Rutjes, Floris P. J. T.

Source: ChemBioChem; 8/3/2022, Vol. 23 Issue 15, p1-5, 5p

Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs.

Authors: Scherpenzeel, Monique van, Conte, Federica, Büll, Christian, Ashikov, Angel, Hermans, Esther, Willems, Anke, Tol, Walinka van, Kragt, Else, Noga, Marek, Moret, Ed E, Heise, Torben, Langereis, Jeroen D, Rossing, Emiel, Zimmermann, Michael, Rubio-Gozalbo, M Estela, Jonge, Marien I de, Adema, Gosse J, Zamboni, Nicola, Boltje, Thomas, Lefeber, Dirk J

Source: Glycobiology; Mar2022, Vol. 39 Issue 3, p239-250, 12p

Subject Terms: TANDEM mass spectrometry, GLYCOCONJUGATES, SUGARS, SUGAR, SIALIC acids

Fluorinated rhamnosides inhibit cellular fucosylation.

Authors: Pijnenborg, Johan F. A., Rossing, Emiel, Merx, Jona, Noga, Marek J., Titulaer, Willem H. C., Eerden, Nienke, Veizaj, Raisa, White, Paul B., Lefeber, Dirk J., Boltje, Thomas J.

Source: Nature Communications; 12/2/2021, Vol. 12 Issue 1, p1-9, 9p

Subject Terms: FUCOSYLATION, FUCOSE, GLYCOCONJUGATES, RHAMNOSE, ENZYME inhibitors