Phosphodiesterase-4 Inhibitors Increase Pigment Cell Proliferation and Melanization in Cultured Melanocytes and within a 3-Dimensional Skin Equivalent Model

Authors: Goldstein, Nathaniel B. ¹, Berk, Zachary B.K. ¹, Tomb, Landon C. ¹, Hu, Junxiao ², Hoaglin, Laura G. ^{1, 3}, Roop, Dennis R. ^{1, 3}, Adiri, Roni ⁴, Zhuang, Yonghua ², Canosa, Juliana M. ⁵, Sanders, Paul ⁶, Norris, David A. ¹, Nocka, Karl ⁷, Cha, Amy ⁸, Birlea, Stanca A. ^{1, 3, ∗}

Source: In Journal of Investigative Dermatology April 2025 145(4):883-896

Loricrin and NRF2 Coordinate Cornification

Authors: Ishitsuka, Yosuke, Ogawa, Tatsuya, Nakamura, Yoshiyuki, Kubota, Noriko, Fujisawa, Yasuhiro, Watanabe, Rei, Okiyama, Naoko, Fujimoto, Manabu, Roop, Dennis R., Ishida-Yamamoto, Akemi

Source: In JID Innovations January 2022 2(1)

Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling

Authors: Goldstein, Nathaniel B., Steel, Andrea, Barbulescu, Chauncey C., Koster, Maranke I., Wright, Michael J., Jones, Kenneth L., Gao, Bifeng, Ward, Brian, Woessner, Brian, Trottier, Zachary, Pakieser, Jen, Hu, Junxiao, Lambert, Karoline A., Shellman, Yiqun G., Fujita, Mayumi, Robinson, William A., Roop, Dennis R., Norris, David A., Birlea, Stanca A.

Source: In Journal of Investigative Dermatology March 2021 141(3):638-647

Ancestral patterns of recessive dystrophic epidermolysis bullosa mutations in Hispanic populations suggest sephardic ancestry

Authors: Warshauer, Emily Mira, Brown, Adam, Fuentes, Ignacia, Shortt, Jonathan, Gignoux, Chris, Montinaro, Francesco, Metspalu, Mait, Youssefian, Leila, Vahidnezhad, Hassan, Jacków, Joanna, Christiano, Angela M., Uitto, Jouni, Fajardo‐Ramírez, Óscar R., Salas‐Alanis, Julio C., McGrath, John A., Consuegra, Liliana, Rivera, Carolina, Maier, Paul A., Runfeldt, Goran, Behar, Doron M., Skorecki, Karl, Sprecher, Eli, Palisson, Francis, Norris, David A., Bruckner, Anna L., Kogut, Igor, Bilousova, Ganna, Roop, Dennis R.

Source: American journal of medical genetics.Part A. 185(11):3390-3400

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134458671.0x000001&indx=1&recIds=ETOCvdc_100134458671.0x000001

Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal Intravital Imaging

Authors: Kubick, Bradley J., Fan, Xiying, Crouch, Acacia, McCarthy, Riley, Roop, Dennis R.

Source: In Journal of Investigative Dermatology April 2020 140(4):891-900

Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata

Authors: Barbulescu, Chauncey C., Goldstein, Nathaniel B., Roop, Dennis R., Norris, David A., Birlea, Stanca A.

Source: In Journal of Investigative Dermatology January 2020 140(1):29-37

NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy

Authors: Ogawa, Tatsuya, Ishitsuka, Yosuke, Nakamura, Yoshiyuki, Kubota, Noriko, Saito, Akimasa, Fujisawa, Yasuhiro, Watanabe, Rei, Okiyama, Naoko, Suga, Yasushi, Roop, Dennis R.

Source: Journal of immunology. 205(4):907-914

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624313973&indx=1&recIds=ETOCRN624313973

Montagna Symposium on the Biology of Skin 70th Anniversary: Visualizing the Future!

Authors: Roop, Dennis R., Krieg, Thomas, Werner, Sabine, Yuspa, Stuart, Diehl, Kyra, Seervai, Riyad, Harris-Tryon, Tamia, Leachman, Sancy A.

Source: In Journal of Investigative Dermatology October 2024 144(10):2120-2124

Repigmentation of Human Vitiligo Skin by NBUVB Is Controlled by Transcription of GLI1 and Activation of the β-Catenin Pathway in the Hair Follicle Bulge Stem Cells

Authors: Goldstein, Nathaniel B., Koster, Maranke I., Jones, Kenneth L., Gao, Bifeng, Hoaglin, Laura G., Robinson, Steven E., Wright, Michael J., Birlea, Smaranda I., Luman, Abigail, Lambert, Karoline A., Shellman, Yiqun G., Fujita, Mayumi, Robinson, William A., Roop, Dennis R., Norris, David A., Birlea, Stanca A.

Source: In Journal of Investigative Dermatology March 2018 138(3):657-668

Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b

Authors: Wojcik, Sonja M., Longley, Mary A., Roop, Dennis R.

Source: The Journal of Cell Biology, 2001 Aug 01. 154(3), 619-630.

Access URL: https://www.jstor.org/stable/1620550

An Inducible Mouse Model for Epidermolysis Bullosa Simplex: Implications for Gene Therapy

Authors: Cao, Tongyu, Longley, Mary Ann, Wang, Xiao-Jing, Roop, Dennis R.

Source: The Journal of Cell Biology, 2001 Feb 01. 152(3), 651-656.

Access URL: https://www.jstor.org/stable/1620320

Focal Activation of a Mutant Allele Defines the Role of Stem Cells in Mosaic Skin Disorders

Authors: Arin, Meral J., Longley, Mary Ann, Wang, Xiao-Jing, Roop, Dennis R.

Source: The Journal of Cell Biology, 2001 Feb 01. 152(3), 645-649.

Access URL: https://www.jstor.org/stable/1620319

Loricrin at the Boundary between Inside and Outside.

Authors: Ishitsuka, Yosuke¹ (AUTHOR) ishitsuka@derma.med.osaka-u.ac.jp, Roop, Dennis R.² (AUTHOR) dennis.roop@cuanschutz.edu

Source: Biomolecules (2218-273X). May2022, Vol. 12 Issue 5, p673. 20p.

Subject Terms: *CAPPING proteins, *SYMPTOMS, *SKIN diseases, *NUCLEAR factor E2 related factor, *CELLULAR signal transduction, *CELL metabolism, *BOTANICAL nomenclature

Vitiligo non‐responding lesions to narrow band UVB have intriguing cellular and molecular abnormalities that may prevent epidermal repigmentation.

Authors: Goldstein, Nathaniel B., Steel, Andrea, Tomb, Landon, Berk, Zachary, Hu, Junxiao, Balaya, Velmurugan, Hoaglin, Laura, Ganuthula, Kavya, Patel, Meet, Mbika, Erica, Robinson, William A., Roop, Dennis R., Norris, David A., Birlea, Stanca A.

Source: Pigment Cell & Melanoma Research; May2024, Vol. 37 Issue 3, p378-390, 13p

Subject Terms: VITILIGO, CYTOTOXIC T cells, KERATINOCYTE differentiation, IN situ hybridization, HUMAN abnormalities

Transgenic Mice Expressing a Mutant Form of Loricrin Reveal the Molecular Basis of the Skin Diseases, Vohwinkel Syndrome and Progressive Symmetric Erythrokeratoderma

Authors: Suga, Yasushi, Jarnik, Michal, Attar, Paul S., Longley, Mary A., Bundman, Donnie, Steven, Alasdair C., Koch, Peter J., Roop, Dennis R.

Source: The Journal of Cell Biology, 2000 Oct . 151(2), 401-412.

Access URL: https://www.jstor.org/stable/1620197

Lessons from Loricrin-Deficient Mice: Compensatory Mechanisms Maintaining Skin Barrier Function in the Absence of a Major Cornified Envelope Protein

Authors: Koch, Peter J., de Viragh, Pierre A., Scharer, Elisabeth, Bundman, Donnie, Longley, Mary Ann, Bickenbach, Jackie, Kawachi, Yasuhiro, Suga, Yasushi, Zhou, Zhijian, Huber, Marcel, Hohl, Daniel, Kartasova, Tonja, Jarnik, Michal, Steven, Alasdair C., Roop, Dennis R.

Source: The Journal of Cell Biology, 2000 Oct . 151(2), 389-400.

Access URL: https://www.jstor.org/stable/1620196

Development of Gene-Switch Transgenic Mice That Inducibly Express Transforming Growth Factor β 1 in the Epidermis

Authors: Wang, Xiao-Jing, Liefer, Kristin M., Tsai, Sophia, O'Malley, Bert W., Roop, Dennis R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1999 Jul . 96(15), 8483-8488.

Access URL: https://www.jstor.org/stable/48512

Expression of a Dominant-Negative Type II Transforming Growth Factor β (TGF-β ) Receptor in the Epidermis of Transgenic Mice Blocks TGF-β -Mediated Growth Inhibition

Authors: Wang, Xiao-Jing, Greenhalgh, David A., Bickenbach, Jackie R., Jiang, Aibo, Bundman, Donnie S., Krieg, Thomas, Derynck, Rik, Roop, Dennis R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1997 Mar . 94(6), 2386-2391.

Access URL: https://www.jstor.org/stable/41647

Loricrin Confers Photoprotective Function against UVB in Corneocytes

Authors: Ishitsuka, Yosuke, Roop, Dennis R.

Source: Journal of investigative dermatology. 138(12):2684-2687

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088879233.0x000001&indx=1&recIds=ETOCvdc_100088879233.0x000001

Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin

Authors: Ishitsuka, Yosuke, Huebner, Aaron J., Rice, Robert H., Koch, Peter J., Speransky, Vladislav V., Steven, Alasdair C., Roop, Dennis R.

Source: In Journal of Investigative Dermatology August 2016 136(8):1656-1663