Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice

Authors: Roni F. Kunst, Isabelle Bolt, Rychon D.J. van Dasselaar, Bart A. Nijmeijer, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf

Source: JHEP Reports, Vol 6, Iss 1, Pp 100917- (2024)

Subject Terms: ASBT, IBAT, Intestine-restricted ASBT inhibitors, OCA, Cilofexor, NGM282, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923002483; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/9b3c1ec91c60416aac41d256534c3c20

Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

Authors: Roni F. Kunst, Dirk R. de Waart, Frank Wolters, Suzanne Duijst, Esther W. Vogels, Isabelle Bolt, Joanne Verheij, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf

Source: JHEP Reports, Vol 4, Iss 11, Pp 100573- (2022)

Subject Terms: Apical sodium-dependent bile acid transporter (ASBT), IBAT, NTCP, BSEP, PFIC, Alagille, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555922001458; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/44bd0d993371444b94902a2e94c0bc06

Housing Temperature Influences Atypical Antipsychotic Drug‐Induced Bone Loss in Female C57BL/6J Mice

Authors: Roni F Kunst, Audrie L Langlais, Deborah Barlow, Karen L Houseknecht, Katherine J Motyl

Source: JBMR Plus, Vol 5, Iss 10, Pp n/a-n/a (2021)

Subject Terms: ANIMAL MODELS, PRECLINICAL STUDIES, SYSTEMS BIOLOGY—BONE INTERACTORS, BONE‐BRAIN‐NERVOUS SYSTEM INTERACTIONS, BONE‐FAT INTERACTIONS, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2473-4039

Access URL: https://doaj.org/article/377baabe70224c96bc6ba75ffa29d884