Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitis [version 2; peer review: 2 approved, 1 approved with reservations]

Authors: Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

Source: Wellcome Open Research, Vol 9 (2025)

Subject Terms: tuberculous meningitis, corticosteroids, clinical trial, analysis plan, leukotriene A4 hydrolase (LTA4H), personalised medicine, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/9-695/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/99df0b0d17f54fa49384a7006f80d183

Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tuberculous meningitis [version 1; peer review: 2 approved, 1 approved with reservations]

Authors: Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

Source: Wellcome Open Research, Vol 9 (2024)

Subject Terms: tuberculous meningitis, corticosteroids, clinical trial, analysis plan, leukotriene A4 hydrolase (LTA4H), personalised medicine, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/9-695/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/595ea5cdd06e40d0b2ae4b3dc6095491

Two biases in incubation time estimation related to exposure

Authors: Vera H. Arntzen, Marta Fiocco, Ronald B. Geskus

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-12 (2024)

Subject Terms: Differential recall, Left truncation, Incubation time, SARS-CoV-2, Interval censoring, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/cbda2346a0db4e479eed9a89f6967d5e

A novel diagnostic model for tuberculous meningitis using Bayesian latent class analysis

Authors: Trinh Huu Khanh Dong, Joseph Donovan, Nghiem My Ngoc, Do Dang Anh Thu, Ho Dang Trung Nghia, Pham Kieu Nguyet Oanh, Nguyen Hoan Phu, Vu Thi Ty Hang, Nguyen Van Vinh Chau, Nguyen Thuy Thuong Thuong, Le Van Tan, Guy E. Thwaites, Ronald B. Geskus

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-13 (2024)

Subject Terms: Tuberculosis, Tuberculous meningitis, Diagnosis, Latent class model, Gold standard, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/37362129d3004cc6911f5d8f62d8354d

Metformin as adjunctive therapy in combination with multidrug treatment for multibacillary leprosy: A protocol for a randomized double-blind, controlled Phase 2 trial in Indonesia (MetLep Trial) [version 2; peer review: 2 approved]

Authors: Dian E. Hasvitasari, Nelly Imbiri, Nico Tarino, Dwi R. Fajrianti, Stephen L. Walker, Fitri Wulandari, Raph L. Hamers, Nindya N. Utami, Annemieke Geluk, Marlous L. Grijsen, Duc H. Du, Hardyanto Soebono, Khairunnisa Puspatriani, Ronald B. Geskus, Reinout van Crevel, Evelyne Kestelyn, Hana Krismawati, Mutia Rahardjani, Sri V. Muchtar, Syamsiah ., Margareta Oktaviani

Source: Wellcome Open Research, Vol 8 (2024)

Subject Terms: leprosy, Morbus Hansen, multibacillary leprosy, leprosy reactions, type 1 reaction, reversal reaction, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/8-289/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/64427f2e37bc440388b375cb5d04e8ac

Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus

Authors: Duc Hong Du, Nguyen Quan Nhu Hao, Nguyen Van Hao, Tran Tan Thanh, Huynh Thi Loan, Lam Minh Yen, Tran Thi Diem Thuy, Duong Bich Thuy, Nguyen Thanh Nguyen, Nguyen Thi Phuong Dung, Evelyne Kestelyn, Ha Thi Hai Duong, Nguyen Thanh Phong, Pham Thi Tuyen, Nguyen Hoan Phu, Ho Dang Trung Nghia, Bui Thi Bich Hanh, Pham Kieu Nguyet Oanh, Phan Vinh Tho, Phung Tran Huy Nhat, Phan Nguyen Quoc Khanh, Duncan Wyncoll, Nicholas P. J. Day, Nguyen Van Vinh Chau, H. Rogier van Doorn, Le Van Tan, Ronald B. Geskus, C. Louise Thwaites

Source: Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-6 (2023)

Subject Terms: Catecholamine, Tetanus, Infectious diseases, Cardiovascular, Mechanical ventilation, Autonomic nervous system dysfunction, Arctic medicine. Tropical medicine, RC955-962

File Description: electronic resource

Relation: https://doaj.org/toc/1349-4147

Access URL: https://doaj.org/article/cf80d55694944988ade9b4949dad3efc

Biphasic pattern in the effect of severe measles infection; the difference between additive and multiplicative scale

Authors: Nhat Thanh Hoang Le, Nhan Thi Ho, Bryan Grenfell, Stephen Baker, Ronald B. Geskus

Source: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)

Subject Terms: Measles, Immunosuppression, Hospitalization, Infectious diseases, Multiplicative scale, Additive scale, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/07a1055fe2b44608b6355eddb636f130

Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

Authors: Jordi Cortés Martínez, Ronald B. Geskus, KyungMann Kim, Guadalupe Gómez Melis

Source: BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-14 (2021)

Subject Terms: Treatment Effect, Composite endpoint, Randomized Controlled Trial, Progression-Free Survival, Simulation, Copula, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/aa22fa4454fe4319b7edd28878ce3711

A statistical analysis plan for the Adjunctive Corticosteroids for Tuberculous meningitis in HIV-positive adults (ACT HIV) clinical trial [version 2; peer review: 3 approved]

Authors: Ronald B. Geskus, Joseph Donovan, Guy E. Thwaites, Trinh Dong Huu Khanh

Source: Wellcome Open Research, Vol 6 (2022)

Subject Terms: Tuberculous meningitis, human immunodeficiency virus, corticosteroids, clinical trial, analysis plan, eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/6-280/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/7b5d79d5dbbb44b3a37d96ca5135eff7

A statistical analysis plan for the Adjunctive Corticosteroids for Tuberculous meningitis in HIV-positive adults (ACT HIV) clinical trial [version 1; peer review: 2 approved]

Authors: Joseph Donovan, Trinh Dong Huu Khanh, Guy E. Thwaites, Ronald B. Geskus, ACT HIV investigators

Source: Wellcome Open Research, Vol 6 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/6-280/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/5e2ecc06a5a8473cba32bb3e6a9aa60a

Metformin as adjunctive therapy for dengue in overweight and obese patients: a protocol for an open-label clinical trial (MeDO) [version 2; peer review: 2 approved, 1 approved with reservations]

Authors: Nguyet Minh Nguyen, Ho Quang Chanh, Dong Thi Hoai Tam, Nguyen Lam Vuong, Nguyen Thi Xuan Chau, Nguyen Van Vinh Chau, Nguyen Thanh Phong, Huynh Trung Trieu, Tai Luong Thi Hue, Tam Cao Thi, Trung Dinh The, Huynh Thi Le Duyen, Ninh Thi Thanh Van, Quyen Nguyen Than Ha, Laura Rivino, Peter Gallagher, Nick K. Jones, Ronald B. Geskus, Evelyne Kestelyn, Sophie Yacoub

Source: Wellcome Open Research, Vol 5 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/5-160/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/76fc8bb69165486b97e32824e8de030a

Metformin as adjunctive therapy for dengue in overweight and obese patients: a protocol for an open-label clinical trial (MeDO) [version 1; peer review: 2 approved, 1 approved with reservations]

Authors: Nguyet Minh Nguyen, Ho Quang Chanh, Dong Thi Hoai Tam, Nguyen Lam Vuong, Nguyen Thi Xuan Chau, Nguyen Van Vinh Chau, Nguyen Thanh Phong, Huynh Trung Trieu, Tai Luong Thi Hue, Tam Cao Thi, Trung Dinh The, Huynh Thi Le Duyen, Ninh Thi Thanh Van, Quyen Nguyen Than Ha, Laura Rivino, Peter Gallagher, Nick K. Jones, Ronald B. Geskus, Evelyne Kestelyn, Sophie Yacoub

Source: Wellcome Open Research, Vol 5 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/5-160/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/7455192305464eb3bbf777690aee4c38

A multi centre randomized open label trial of chloroquine for the treatment of adults with SARS-CoV-2 infection in Vietnam [version 1; peer review: 1 approved, 2 approved with reservations]

Authors: Evelyne Kestelyn, Nguyen Thi Phuong Dung, Yen Lam Minh, Le Manh Hung, Nguyen Minh Quan, Nguyen Thanh Dung, Ngo Ngoc Quang Minh, Tran Chanh Xuan, Nguyen Thanh Phong, Van Ninh Thi Thanh, Joseph Donovan, Tran Nguyen Hoang Tu, Le Thanh Hoang Nhat, Nguyen Thanh Truong, Dinh Nguyen Huy Man, Huynh Phuong Thao, Nghiêm My Ngoc, Vo Thanh Lam, Huynh Hong Phat, Phan Minh Phuong, Ronald B. Geskus, Vo Thi Nhi Ha, Nguyen Ngo Quang, Hien Tran Tinh, Le Van Tan, Guy E. Thwaites, Jeremy N. Day, Nguyen Van Vinh Chau, OUCRU COVID-19 Research Group

Source: Wellcome Open Research, Vol 5 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/5-141/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/8a52f3780de345b3840906eac988e5e9

Continuous versus intermittent endotracheal cuff pressure control for the prevention of ventilator-associated respiratory infections in Vietnam: study protocol for a randomised controlled trial

Authors: Vu Quoc Dat, Ronald B. Geskus, Marcel Wolbers, Huynh Thi Loan, Lam Minh Yen, Nguyen Thien Binh, Le Thanh Chien, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Nguyen Phu Huong Lan, Nguyen Van Hao, Hoang Bao Long, Tran Phuong Thuy, Nguyen Van Kinh, Nguyen Vu Trung, Vu Dinh Phu, Nguyen Trung Cap, Dao Tuyet Trinh, James Campbell, Evelyne Kestelyn, Heiman F. L. Wertheim, Duncan Wyncoll, Guy Edward Thwaites, H. Rogier van Doorn, C. Louise Thwaites, Behzad Nadjm

Source: Trials, Vol 19, Iss 1, Pp 1-10 (2018)

Subject Terms: Intensive care unit, Ventilator-associated pneumonia, Intubation, Tracheal tube cuff pressure, Hospital-acquired infection, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-018-2587-6; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/2d341fba04fc4d44ae8642e4401dd975

Increase in the prevalence of mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates collected from early to late pregnancy in Nanoro, Burkina Faso

Authors: Esmée Ruizendaal, Marc C. Tahita, Ronald B. Geskus, Inge Versteeg, Susana Scott, Umberto d’Alessandro, Palpouguini Lompo, Karim Derra, Maminata Traore-Coulibaly, Menno D. de Jong, Henk D. F. H. Schallig, Halidou Tinto, Petra F. Mens

Source: Malaria Journal, Vol 16, Iss 1, Pp 1-15 (2017)

Subject Terms: Plasmodium falciparum, Pregnancy, Sulfadoxine–pyrimethamine, Resistance, Mutations, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-017-1831-y; https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/3d5158ebbf2c4c57958cb221bc6e5cb9

Risk and Temporal Changes of Heart Failure Among 5‐Year Childhood Cancer Survivors: a DCOG‐LATER Study

Authors: E. A. M. (Lieke) Feijen, Anna Font‐Gonzalez, Helena J. H. Van der Pal, Wouter E. M. Kok, Ronald B. Geskus, Cécile M. Ronckers, Dorine Bresters, Elvira C. van Dalen, Eline van Dulmen‐den Broeder, Marleen H. van den Berg, Margriet van der Heiden‐van der Loo, Marry M. van den Heuvel‐Eibrink, Flora E. van Leeuwen, Jacqueline J. Loonen, Sebastian J. C. M. M. Neggers, A. B. (Birgitta) Versluys, Wim J. E. Tissing, Leontien C. M. Kremer

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 1 (2019)

Subject Terms: childhood cancer survivors, heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/10e422f8522e417dbb55c1d0cc39a988

Intrathecal Immunoglobulin for treatment of adult patients with tetanus: A randomized controlled 2x2 factorial trial [version 2; referees: 2 approved]

Authors: Huỳnh Thị Loan, Lam Minh Yen, Evelyne Kestelyn:, Nguyen Van Hao, Tran Tan Thanh, Nguyen Thi Phuong Dung, Hugo C. Turner, Ronald B. Geskus, Marcel Wolbers, Le Van Tan, H. Rogier Van Doorn, Nicholas P. Day, Duncan Wyncoll, Tran Tinh Hien, Guy E. Thwaites, Nguyen Van Vinh Chau, C. Louise Thwaites

Source: Wellcome Open Research, Vol 3 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/3-58/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/00f8f6aaf6a14c9e8486356a6261409b

Adjunctive dexamethasone for the treatment of HIV-infected adults with tuberculous meningitis (ACT HIV): Study protocol for a randomised controlled trial [version 2; referees: 1 approved, 2 approved with reservations]

Authors: Joseph Donovan, Nguyen Hoan Phu, Nguyen Thi Hoang Mai, Le Tien Dung, Darma Imran, Erlina Burhan, Lam Hong Bao Ngoc, Nguyen Duc Bang, Do Chau Giang, Dang Thi Minh Ha, Jeremy Day, Le Thi Phuong Thao, Nguyen TT Thuong, Nguyen Nang Vien, Ronald B. Geskus, Marcel Wolbers, Raph L Hamers, Reinout van Crevel, Mugi Nursaya, Kartika Maharani, Tran Tinh Hien, Kevin Baird, Nguyen Huu Lan, Evelyne Kestelyn, Nguyen Van Vinh Chau, Guy E. Thwaites

Source: Wellcome Open Research, Vol 3 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/3-31/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/ac29a6757e1442f5a7efee484ed1bec4

Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial [version 1; referees: 2 approved]

Authors: Joseph Donovan, Nguyen Hoan Phu, Le Thi Phuong Thao, Nguyen Huu Lan, Nguyen Thi Hoang Mai, Nguyen Thi Mai Trang, Nguyen Thi Thu Hiep, Tran Bao Nhu, Bui Thi Bich Hanh, Vu Thi Phuong Mai, Nguyen Duc Bang, Do Chau Giang, Dang Thi Minh Ha, Jeremy Day, Nguyen TT Thuong, Nguyen Nang Vien, Ronald B. Geskus, Tran Tinh Hien, Evelyne Kestelyn, Marcel Wolbers, Nguyen Van Vinh Chau, Guy E. Thwaites

Source: Wellcome Open Research, Vol 3 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/3-32/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/bd382c45cf5b426b83e940671677d58d

Correction: HIV-Infected Men Who Have Sex with Men Who Identify Themselves as Belonging to Subcultures Are at Increased Risk for Hepatitis C Infection.

Authors: Amy Matser, Joost Vanhommerig, Maarten F. Schim van der Loeff, Ronald B. Geskus, Henry J. C. de Vries, Jan M. Prins, Maria Prins, Sylvia M. Bruisten

Source: PLoS ONE, Vol 8, Iss 4 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3623561; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ac9089e7dc2a42799f1e818bdab1e857