Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding

Authors: Lee, Olivia W., Rodrigues, Calvin, Lin, Shu-Hong, Luo, Wen, Jones, Kristine, Brown, Derek W., Zhou, Weiyin, Karlins, Eric, Khan, Sairah M., Baulande, Sylvain, Raynal, Virginie, Surdez, Didier, Reynaud, Stephanie, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetête, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Pierron, Gaelle, Gaspar, Nathalie, Corradini, Nadège, Marec-Bérard, Perrine, Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Manning, Michelle, Wyatt, Kathleen, Yeager, Meredith, Chari, Raj, Leisenring, Wendy M., Kulozik, Andreas E., Kriebel, Jennifer, Meitinger, Thomas, Strauch, Konstantin, Kirchner, Thomas, Dirksen, Uta, Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Armstrong, Gregory T., Bhatia, Smita, Robison, Leslie L., Yasui, Yutaka, Romero-Pérez, Laura, Hartmann, Wolfgang, Metzler, Markus, Diver, W. Ryan, Lori, Adriana, Freedman, Neal D., Hoover, Robert N., Morton, Lindsay M., Chanock, Stephen J., Grünewald, Thomas G.P., Delattre, Olivier, Machiela, Mitchell J.

Source: American journal of human genetics. 110(3):427-441

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184723849.0x000001&indx=1&recIds=ETOCvdc_100184723849.0x000001

Western Blot Analysis in Ewing Sarcoma

Authors: Marchetto, Aruna, Romero-Pérez, Laura

Source: Methods in molecular biology. 2226:15-26

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625350837&indx=1&recIds=ETOCRN625350837

Tissue Preservation and FFPE Samples: Optimized Nucleic Acids Isolation in Ewing Sarcoma

Authors: Romero-Pérez, Laura, Grünewald, Thomas G. P.

Source: Methods in molecular biology. 2226:27-38

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625350849&indx=1&recIds=ETOCRN625350849

Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients

Authors: Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.

Source: In EBioMedicine September 2019 47:156-162

STAG Mutations in Cancer

Authors: Romero-Pérez, Laura, Surdez, Didier, Brunet, Erika, Delattre, Olivier, Grünewald, Thomas G.P.

Source: In Trends in Cancer August 2019 5(8):506-520

Hippo pathway effectors YAP1/TAZ induce an EWS–FLI1‐opposing gene signature and associate with disease progression in Ewing sarcoma

Authors: Rodríguez‐Núñez, Pablo, Romero‐Pérez, Laura, Amaral, Ana T, Puerto‐Camacho, Pilar, Jordán, Carmen, Marcilla, David, Grünewald, Thomas GP, Alonso, Javier, Alava, Enrique, Díaz‐Martín, Juan

Source: Journal of pathology. 250(4):374-386

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111911131.0x000001&indx=1&recIds=ETOCvdc_100111911131.0x000001

Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma

Authors: Gerke, Julia S., Orth, Martin F., Tolkach, Yuri, Romero‐Pérez, Laura, Wehweck, Fabienne S., Stein, Stefanie, Musa, Julian, Knott, Maximilian M.L., Hölting, Tilman L.B., Li, Jing, Sannino, Giuseppina, Marchetto, Aruna, Ohmura, Shunya, Cidre‐Aranaz, Florencia, Müller‐Nurasyid, Martina, Strauch, Konstantin, Stief, Christian, Kristiansen, Glen, Kirchner, Thomas, Buchner, Alexander, Grünewald, Thomas G.P.

Source: International journal of cancer. 146(7):2036-2046

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107741382.0x000001&indx=1&recIds=ETOCvdc_100107741382.0x000001

A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas

Authors: Orth, Martin F., Buecklein, Veit Leonhard, Kampmann, Eric, Subklewe, Marion, Noessner, Elfriede, Cidre-Aranaz, Florencia, Romero-Pérez, Laura, Wehweck, Fabienne Sophie, Lindner, Lars, Issels, Rolf, Kirchner, Thomas, Altendorf-Hofmann, Annelore, Grünewald, Thomas G. P., Knösel, Thomas

Source: Cancer immunology, immunotherapy. 69(7):1353-1362

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167889425.0x000001&indx=1&recIds=ETOCvdc_100167889425.0x000001

DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics

Authors: Kommoss, Felix K. F., Stichel, Damian, Schrimpf, Daniel, Kriegsmann, Mark, Tessier-Cloutier, Basile, Talhouk, Aline, McAlpine, Jessica N., Chang, Kenneth T. E., Sturm, Dominik, Pfister, Stefan M., Romero-Pérez, Laura, Kirchner, Thomas, Grünewald, Thomas G. P., Buslei, Rolf, Sinn, Hans-Peter, Mechtersheimer, Gunhild, Schirmacher, Peter, Schmidt, Dietmar, Lehr, Hans-Anton, Sahm, Felix, Huntsman, David G., Gilks, C. Blake, Kommoss, Friedrich, von Deimling, Andreas, Koelsche, Christian

Source: Journal of cancer research and clinical oncology. 146(1):97-104

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124160875.0x000001&indx=1&recIds=ETOCvdc_100124160875.0x000001

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1–NFATc2 fusion from Ewing sarcoma

Authors: Koelsche, Christian, Kriegsmann, Mark, Kommoss, Felix K. F., Stichel, Damian, Kriegsmann, Katharina, Vokuhl, Christian, Grünewald, Thomas G. P., Romero-Pérez, Laura, Kirchner, Thomas, de Alava, Enrique, Diaz-Martin, Juan, Hartmann, Wolfgang, Baumhoer, Daniel, Antonescu, Cristina R., Szuhai, Karoly, Flucke, Uta, Dirksen, Uta, Pfister, Stefan M., Jones, David T. W., Mechtersheimer, Gunhild, von Deimling, Andreas

Source: Journal of cancer research and clinical oncology. 145(5):1273-1281

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118335239.0x000001&indx=1&recIds=ETOCvdc_100118335239.0x000001

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Authors: Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin, Boon, Ruben, Kerstens, Axelle, Kwan, Suet, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte, Chen, Ting, Fernandez-Garcia, Juan, Duarte, João, Schmitz, Arndt, Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Ginderachter, Jo, Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph, Swinnen, Johannes, Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas, Fendt, Sarah-Maria

Source: Nature. 566(7744):403-406

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114652803.0x000001&indx=1&recIds=ETOCvdc_100114652803.0x000001

Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma

Authors: Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela, Hölting, Tilman, Musa, Julian, Knott, Max, Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne, Romero-Pérez, Laura, Gerke, Julia, Orth, Martin, Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas

Source: Cell death and disease. 10(2):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112265523.0x000001&indx=1&recIds=ETOCvdc_100112265523.0x000001

A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer

Authors: Romero-Pérez, Laura, Garcia-Sanz, Pablo, Mota, Alba, Leskelä, Susanna, Hergueta-Redondo, Marta, Díaz-Martín, Juan, López-García, M Angeles, Castilla, M Angeles, Martínez-Ramírez, Angel, Soslow, Robert A, Matias-Guiu, Xavier, Moreno-Bueno, Gema, Palacios, Jose

Source: In Modern Pathology November 2015 28(11):1492-1503

Sarcoma classification by DNA methylation profiling

Authors: Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sill, Martin, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Heilig, Christoph E., Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Ecker, Jonas, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Sievers, Philipp, Ebrahimi, Azadeh, Suwala, Abigail, Fernández-Klett, Francisco, Casalini, Belén, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Pérez, Laura, Grünewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Abdollahi, Amir, Debus, Jürgen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Jürgen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Mentzel, Thomas, Griewank, Klaus, de Álava, Enrique, Martín, Juan Díaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schüller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Büttner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjær, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Heining, Christoph, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, Alonso, Javier, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Vokuhl, Christian, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Capper, David, Jones, David T. W., Fröhling, Stefan, Pfister, Stefan M., von Deimling, Andreas

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193178892.0x000001&indx=1&recIds=ETOCvdc_100193178892.0x000001

ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma

Authors: Romero-Pérez, Laura, López-García, M Ángeles, Díaz-Martín, Juan, Biscuola, Michele, Castilla, M Ángeles, Tafe, Laura J, Garg, Karuna, Oliva, Esther, Matias-Guiu, Xavier, Soslow, Robert A, Palacios, José

Source: In Modern Pathology November 2013 26(11):1514-1524

Oncogene alterations in endometrial carcinosarcomas

Authors: Biscuola, Michele, Van de Vijver, Koen, Castilla, María Ángeles, Romero-Pérez, Laura, López-García, María Ángeles, Díaz-Martín, Juan, Matias-Guiu, Xavier, Oliva, Esther, Calvo, José Palacios

Source: In Human Pathology May 2013 44(5):852-859

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Authors: Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187166072.0x000001&indx=1&recIds=ETOCvdc_100187166072.0x000001

Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Authors: Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187150030.0x000001&indx=1&recIds=ETOCvdc_100187150030.0x000001

Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis

Authors: Romero-Pérez, Laura, Castilla, María Ángeles, López-García, María Ángeles, Díaz-Martín, Juan, Biscuola, Michele, Ramiro-Fuentes, Susana, Oliva, Esther, Matias-Guiu, Xavier, Prat, Jaime, Cano, Amparo, Moreno-Bueno, Gema, Palacios, José

Source: In Human Pathology February 2013 44(2):244-254

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

Authors: Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130627619.0x000001&indx=1&recIds=ETOCvdc_100130627619.0x000001