Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption

Authors: Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

Source: Breast Cancer Research, Vol 27, Iss 1, Pp 1-15 (2025)

Subject Terms: Hormone-receptor positive breast cancer, ESR1 mutation, Specific immune responses, Neoantigen, T cell, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/cd7fe7f04fd44ab482196aa4e103444c

Decoding mutational signatures in breast cancer: Insights from a multi-cohort study

Authors: Margaux Betz, Andréa Witz, Julie Dardare, Cassandra Michel, Vincent Massard, Romain Boidot, Pauline Gilson, Jean-Louis Merlin, Alexandre Harlé

Source: Translational Oncology, Vol 53, Iss , Pp 102315- (2025)

Subject Terms: Mutational signature, Breast cancer, Next generation sequencing, Genomic database, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523325000464; https://doaj.org/toc/1936-5233

Access URL: https://doaj.org/article/6368a0c471ed4e7ea71fd0027e6c064b

Nanopore adaptive sampling accurately detects nucleotide variants and improves the characterization of large‐scale rearrangement for the diagnosis of cancer predisposition

Authors: Sandy Chevrier, Corentin Richard, Marie Mille, Denis Bertrand, Romain Boidot

Source: Clinical and Translational Medicine, Vol 15, Iss 1, Pp n/a-n/a (2025)

Subject Terms: adaptive sampling, germline variants, large‐scale rearrangements, single nucleotide variation, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/50f9dfc2efd34922bffd675bf8d61fac

The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers

Authors: Meriem Messaoudene, Stéphanie Ferreira, Nathalie Saint-Lu, Mayra Ponce, Caroline Truntzer, Romain Boidot, Clément Le Bescop, Thomas Loppinet, Tanguy Corbel, Céline Féger, Karine Bertrand, Arielle Elkrief, Morten Isaksen, Fabien Vitry, Frédérique Sablier-Gallis, Antoine Andremont, Lloyd Bod, François Ghiringhelli, Jean de Gunzburg, Bertrand Routy

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/654c4f9e81204f8999feefb9a049aabe

New leads to enhance tagraxofusp efficacy in pDC-AML

Authors: Morgane Boichut, Margaux Poussard, Xavier Roussel, Imane Belakri, Sabeha Biichlé, Maxime Fredon, Florian Renosi, Romain Boidot, Olivier Adotevi, Christopher Brooks, Francine Garnache-Ottou, Fanny Angelot Delettre

Source: Blood Neoplasia, Vol 2, Iss 2, Pp 100066- (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950328025000019; https://doaj.org/toc/2950-3280

Access URL: https://doaj.org/article/aed201e929a94e21a41b1d9ad6307c36

Targeting mTOR signaling for the treatment of intrahepatic cholangiocarcinoma with TSC1/ARID1A mutations: a case report with an unexpected response

Authors: Clémentine Daugan, Romain Boidot, François Ghiringhelli, Christophe Borg, Angélique Vienot

Source: Therapeutic Advances in Medical Oncology, Vol 16 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/51c99f82ed53476c90515933212ae6e6

Case report: Immune response characterization of a pseudoprogression in a PD-L1-negative, TMB-low, KEAP1/STK11 co-mutated metastatic NSCLC

Authors: Nicolas Roussot, Marion Thibaudin, Jean-David Fumet, Susy Daumoine, Léa Hampe, Cédric Rébé, Emeric Limagne, Aurélie Lagrange, Victor Herreros, Julie Lecuelle, Hugo Mananet, Alis Ilie, David Rageot, Romain Boidot, Vincent Goussot, Anthony Comte, Pierre Jacob, Françoise Beltjens, Anthony Bergeron, Céline Charon-Barra, Laurent Arnould, Valentin Derangère, Sylvain Ladoire, Caroline Truntzer, François Ghiringhelli

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: case report, NSCLC, pseudoprogression, chemoimmunotherapy, neoantigen, cold tumor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1437961/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/720f9ebdb12b41d5a9b653e489118e2d

Advancing precision oncology through systematic germline and tumor genetic analysis: The oncogenetic point of view on findings from a prospective multicenter clinical trial of 666 patients

Authors: Benoit Mazel, Geoffrey Bertolone, Amandine Baurand, Elodie Cosset, Caroline Sawka, Marion Robert, Elodie Gautier, Allan Lançon, Manon Réda, Laure Favier, Valentin Dérangère, Corentin Richard, Christine Binquet, Romain Boidot, Vincent Goussot, Juliette Albuisson, François Ghiringhelli, Laurence Faivre, Sophie Nambot

Source: Cancer Medicine, Vol 12, Iss 18, Pp 18786-18796 (2023)

Subject Terms: genetic counseling, incidental findings, information, oncogenetic, theranostic exome sequencing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/1d715b84577b4084b82c16565b999548

Durable response of lung carcinoma patients to EGFR tyrosine kinase inhibitors is determined by germline polymorphisms in some immune-related genes

Authors: Lorraine Dalens, Julie Niogret, Corentin Richard, Sandy Chevrier, Pascal Foucher, Bruno Coudert, Aurélie Lagrange, Laure Favier, Virginie Westeel, Stefano Kim, Olivier Adotevi, Caroline Chapusot, Laurent Martin, Laurent Arnould, Courèche-Guillaume Kaderbhai, Romain Boidot

Source: Molecular Cancer, Vol 22, Iss 1, Pp 1-9 (2023)

Subject Terms: Lung carcinoma, Exome analysis, SNPs, Innate immunity, EGFR TKI, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/fae01f6d6f6245acad2b87dbc4464121

PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy

Authors: Zoé Tharin, Corentin Richard, Valentin Derangère, Alis Ilie, Laurent Arnould, François Ghiringhelli, Romain Boidot, Sylvain Ladoire

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/549ad5585730463788e76a11767d4dba

Molecular intrinsic subtypes, genomic, and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancers

Authors: Elise Ballot, Loïck Galland, Hugo Mananet, Romain Boidot, Laurent Arnould, Isabelle Desmoulins, Didier Mayeur, Courèche Kaderbhai, Silvia Ilie, Audrey Hennequin, Anthony Bergeron, Valentin Derangère, François Ghiringhelli, Caroline Truntzer, Sylvain Ladoire

Source: Breast Cancer Research, Vol 24, Iss 1, Pp 1-16 (2022)

Subject Terms: Early breast cancer, ER-positive breast cancer, BRCA, Exome, NGS, HRD score, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/aae1a74ab7764d138f14f99a0499bf34

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization

Authors: Marion Ciudad, Sethi Ouandji, Baptiste Lamarthée, Claudie Cladière, Thibault Ghesquière, Martin Nivet, Marine Thébault, Romain Boidot, Agnès Soudry-Faure, Sandy Chevrier, Corentin Richard, Thibault Maillet, François Maurier, Hélène Greigert, Coraline Genet, André Ramon, Malika Trad, Valérie Predan, Philippe Saas, Maxime Samson, Bernard Bonnotte, Sylvain Audia

Source: Haematologica, Vol 109, Iss 2 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11188; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/91111fd73e6244f8b2a6f13f971b6c7a

Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency

Authors: Antonin Schmitt, Bernard Royer, Romain Boidot, Joseph Berthier, François Ghiringhelli

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: uracilemia, DPD deficiency, 5-Fu (5-Fluorouracil), esophageal cancer, therapeutic drug monitoring, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1187052/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/fb43c09a336148f89968870d2201a771

Efficacy of platinum-based chemotherapy in metastatic breast cancer and HRD biomarkers: utility of exome sequencing

Authors: Loïck Galland, Elise Ballot, Hugo Mananet, Romain Boidot, Julie Lecuelle, Juliette Albuisson, Laurent Arnould, Isabelle Desmoulins, Didier Mayeur, Courèche Kaderbhai, Silvia Ilie, Audrey Hennequin, Anthony Bergeron, Valentin Derangère, François Ghiringhelli, Caroline Truntzer, Sylvain Ladoire

Source: npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/8c75168bd84843898eaa4679c7af4e30

OncoSNIPE® Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients

Authors: Sébastien Vachenc, Jessica Gobbo, Sarah El Moujarrebe, Isabelle Desmoulins, Marine Gilabert, Michelle Beau-Faller, Emmanuel Mitry, Nicolas Girard, Aurélie Bertaut, Nelson Dusetti, Juan L. Iovanna, Rahima Yousfi, Fabien Pierrat, Roman Bruno, Adèle Cueff, Romain Boidot, Philippe Genne

Source: BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)

Subject Terms: Early/ late resistance marker, NGS, Immunological profile, Triple negative breast or Luminal Breast Cancer, Non small-cell lung cancer, Pancreatic ductal adenocarcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/c0d3b85ada7445039f9d9e0a54d385a5

Impact of proton therapy on antitumor immune response

Authors: Céline Mirjolet, Anaïs Nicol, Emeric Limagne, Carole Mura, Corentin Richard, Véronique Morgand, Marc Rousseau, Romain Boidot, François Ghiringhelli, Georges Noel, Hélène Burckel

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6c06ec6e3d0548fbbddd6f3023616eb5

Is There a Role for Large Exome Sequencing in the Management of Metastatic Non-Small Cell Lung Cancer: A Brief Report of Real Life

Authors: Lorraine Dalens, Julie Niogret, Courèche Guillaume Kaderbhai, Romain Boidot

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: lung adenocarcinoma, small NGS panel, large NGS panel, exome analysis, utility, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.863057/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/3ba6b19973334495ac6a2528a7d2f954

MER4 endogenous retrovirus correlated with better efficacy of anti-PD1/PD-L1 therapy in non-small cell lung cancer

Authors: Francois Ghiringhelli, Romain Boidot, Caroline Truntzer, Bertrand Routy, Philippe Joubert, Julie Lecuelle, Laure Favier, Cléa Fraisse, Aurélie Lagrange, Coureche Kaderbhai, Sandy Chevrier

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/3/e004241.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/28eb9d9b877048be85b905e79ee79501

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells

Authors: Pauline Soulas-Sprauel, Bernhard Ryffel, Corentin Richard, Romain Boidot, Elise Jacquin, Raphael Carapito, Richard A Flavell, Frederique Vegran, Tiffany Martin, Isis Benoit-Lizon, Thaiz Rivera Vargas, Aurélie Roussey, Ludivine Dal Zuffo, Andréa Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stéphane Giorgiutti, Eric R Nelson, Toby Lawrence, Lionel Apetoh

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/1/e003459.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/010efbccc7be494cbe7e79e2e8c14071

Somatic substitution signature as an innovative tool in lung cancer diagnosis

Authors: Stéphane Busca, Julia Salleron, Romain Boidot, Jean-Louis Merlin, Alexandre Harlé

Source: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b87948ed20474dea8a6fabbf8e342a86