Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism

Authors: Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang-Bo Wei, Jiang Hu, Ava DiStefano-Forti, Valeria Salerno Gonzales, Tadataka Tsuji, Siying Wei, Matthias Blüher, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni

Source: Nature Communications, Vol 16, Iss 1, Pp 1-19 (2025)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression

Authors: Shota Okagawa, Masaji Sakaguchi, Yuma Okubo, Yuri Takekuma, Motoyuki Igata, Tatsuya Kondo, Naoki Takeda, Kimi Araki, Bruna Brasil Brandao, Wei-Jun Qian, Yu-Hua Tseng, Rohit N. Kulkarni, Naoto Kubota, C. Ronald Kahn, Eiichi Araki

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/73c07eb1857940b0846feaa4ba14f245

Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice

Authors: Xuanchun Wang, Yanliang Li, Guifen Qiang, Kaihua Wang, Jiarong Dai, Maximilian McCann, Marcos D. Munoz, Victoria Gil, Yifei Yu, Shengxian Li, Zhihong Yang, Shanshan Xu, Jose Cordoba-Chacon, Dario F. De Jesus, Bei Sun, Kuangyang Chen, Yahao Wang, Xiaoxia Liu, Qing Miao, Linuo Zhou, Renming Hu, Qiang Ding, Rohit N. Kulkarni, Daming Gao, Matthias Blüher, Chong Wee Liew

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells

Authors: Kanako Iwasaki, Benjamin Lalani, Jiho Kahng, Priscila Carapeto, Stephanie Sanjines, Francesko Hela, Cristian Abarca, Tadataka Tsuji, Justin Darcy, Andrzej Bartke, Yu-Hua Tseng, Rohit N. Kulkarni, Cristina Aguayo-Mazzucato

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: senescence, SASP, IGF-1, insulin, Dwarf, diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

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Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1203534/full; https://doaj.org/toc/1664-2392

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Stress and human health in diabetes: A report from the 19th Chicago Biomedical Consortium symposium

Authors: Raghavendra G. Mirmira, Rohit N. Kulkarni, Pingwen Xu, Tina Drossos, Krista Varady, Kristen L. Knutson, Sirimon Reutrakul, Pamela Martyn-Nemeth, Robert M. Sargis, Amisha Wallia, Arleen M. Tuchman, Jill Weissberg-Benchell, Kirstie K. Danielson, Scott A. Oakes, Celeste C. Thomas, Brian T. Layden, Sarah C. May, Michelle Burbea Hoffmann, Eleonora Gatta, Julian Solway, Louis H. Philipson

Source: Journal of Clinical and Translational Science, Vol 7 (2023)

Subject Terms: Diabetes, stress, beta cells, metabolic syndrome, diabetes technology, healthcare, community, Medicine

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2059866123006465/type/journal_article; https://doaj.org/toc/2059-8661

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ROCK1 regulates insulin secretion from β-cells

Authors: Byung-Jun Sung, Sung-Bin Lim, Won-Mo Yang, Jae Hyeon Kim, Rohit N. Kulkarni, Young-Bum Kim, Moon-Kyu Lee

Source: Molecular Metabolism, Vol 66, Iss , Pp 101625- (2022)

Subject Terms: ROCK1, Insulin secretion, Beta cells, Hyperglycemia, Pyruvate kinase, Diabetes, Internal medicine, RC31-1245

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Relation: http://www.sciencedirect.com/science/article/pii/S2212877822001946; https://doaj.org/toc/2212-8778

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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

Authors: Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F. De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M. Dreyfuss, A.M. James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N. Kulkarni

Source: Cell Reports, Vol 41, Iss 1, Pp 111436- (2022)

Subject Terms: CP: Metabolism, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124722012773; https://doaj.org/toc/2211-1247

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Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets

Authors: Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni

Source: Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)

Subject Terms: Transplanted human islets, Single-nucleus RNA-sequencing, Single-cell RNA-sequencing, Human β-cells, Frozen samples, Archived tissue, Medicine, Genetics, QH426-470

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Relation: https://doaj.org/toc/1756-994X

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Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance

Authors: Ercument Dirice, Giorgio Basile, Sevim Kahraman, Danielle Diegisser, Jiang Hu, Rohit N. Kulkarni

Source: JCI Insight, Vol 7, Iss 16 (2022)

Subject Terms: Development, Endocrinology, Medicine

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Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/b5b54765f6be496aa5205bd9295767c8

Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER

Authors: Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A.M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa

Source: iScience, Vol 25, Iss 7, Pp 104603- (2022)

Subject Terms: Endocrinology, cell biology, Functional aspects of cell biology, Science

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Relation: http://www.sciencedirect.com/science/article/pii/S2589004222008756; https://doaj.org/toc/2589-0042

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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Authors: Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld

Source: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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RADAR: differential analysis of MeRIP-seq data with a random effect model

Authors: Zijie Zhang, Qi Zhan, Mark Eckert, Allen Zhu, Agnieszka Chryplewicz, Dario F. De Jesus, Decheng Ren, Rohit N. Kulkarni, Ernst Lengyel, Chuan He, Mengjie Chen

Source: Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)

Subject Terms: N 6-adenosine methylation (m6A), Differential methylation, MeRIP-seq, Biology (General), QH301-705.5, Genetics, QH426-470

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Relation: https://doaj.org/toc/1474-760X

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HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Authors: Natasha Hui Jin Ng, Joanita Binte Jasmen, Chang Siang Lim, Hwee Hui Lau, Vidhya Gomathi Krishnan, Juned Kadiwala, Rohit N. Kulkarni, Helge Ræder, Ludovic Vallier, Shawn Hoon, Adrian Kee Keong Teo

Source: iScience, Vol 16, Iss , Pp 192-205 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004219301695; https://doaj.org/toc/2589-0042

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Essential roles of insulin and IGF-1 receptors during embryonic lineage development

Authors: Erin R. Okawa, Manoj K. Gupta, Sevim Kahraman, Praneeth Goli, Masaji Sakaguchi, Jiang Hu, Kaiti Duan, Brittany Slipp, Jochen K. Lennerz, Rohit N. Kulkarni

Source: Molecular Metabolism, Vol 47, Iss , Pp 101164- (2021)

Subject Terms: Insulin/IGF-1 receptors, Pluripotency, Lineage development, Signaling, Apoptosis, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877821000041; https://doaj.org/toc/2212-8778

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Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation

Authors: Manoj K. Gupta, Dario F. De Jesus, Sevim Kahraman, Ivan A. Valdez, Farnaz Shamsi, Lian Yi, Adam C. Swensen, Yu-Hua Tseng, Wei-Jun Qian, Rohit N. Kulkarni

Source: Molecular Metabolism, Vol 18, Iss , Pp 153-163 (2018)

Subject Terms: Internal medicine, RC31-1245

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Relation: http://www.sciencedirect.com/science/article/pii/S2212877818306999; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/ed089cc8fe424187a8b0aa0f368d3df0

Sex differences underlying pancreatic islet biology and its dysfunction

Authors: Maureen Gannon, Rohit N. Kulkarni, Hubert M. Tse, Franck Mauvais-Jarvis

Source: Molecular Metabolism, Vol 15, Iss , Pp 82-91 (2018)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877818305209; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/b3e58fedd55541b2981de218940005ca

'Omics' and 'epi-omics' underlying the β-cell adaptation to insulin resistance

Authors: Dario F. De Jesus, Rohit N. Kulkarni

Source: Molecular Metabolism, Vol 27, Iss , Pp S42-S48 (2019)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877819305630; https://doaj.org/toc/2212-8778

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A Systematic Comparison of Protocols for Recovery of High-Quality RNA from Human Islets Extracted by Laser Capture Microdissection

Authors: Chiara M. A. Cefalo, Teresa Mezza, Andrea Giaccari, Rohit N. Kulkarni

Source: Biomolecules, Vol 11, Iss 5, p 625 (2021)

Subject Terms: laser capture microdissection, RNA extraction, human islets, Microbiology, QR1-502

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Relation: https://www.mdpi.com/2218-273X/11/5/625; https://doaj.org/toc/2218-273X

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Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

Authors: Ivan Achel Valdez, Ercument Dirice, Manoj K. Gupta, Jun Shirakawa, Adrian Kee Keong Teo, Rohit N. Kulkarni

Source: Cell Reports, Vol 15, Iss 3, Pp 460-470 (2016)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124716302923; https://doaj.org/toc/2211-1247

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Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

Authors: Adrian Kee Keong Teo, Hwee Hui Lau, Ivan Achel Valdez, Ercument Dirice, Erling Tjora, Helge Raeder, Rohit N. Kulkarni

Source: Stem Cell Reports, Vol 6, Iss 3, Pp 357-367 (2016)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213671116000242; https://doaj.org/toc/2213-6711

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