Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2MUT ovarian cancer models

Authors: Biegała, Łukasz, Statkiewicz, Małgorzata, Gajek, Arkadiusz, Szymczak-Pajor, Izabela, Rusetska, Natalia, Śliwińska, Agnieszka, Marczak, Agnieszka, Mikula, Michał, Rogalska, Aneta

Source: In BBA - Molecular Basis of Disease February 2025 1871(2)

Folate Receptor Alpha—A Secret Weapon in Ovarian Cancer Treatment?

Authors: Bukowski, Karol¹ (AUTHOR) aneta.rogalska@biol.uni.lodz.pl, Rogalska, Aneta¹ (AUTHOR), Marczak, Agnieszka¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p11927. 25p.

Subject Terms: *OVARIAN epithelial cancer, *CHIMERIC antigen receptors, *PATIENT experience, *DISEASE relapse, *DRUG target, *MONOCLONAL antibodies

MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model.

Authors: Bębenek, Wiktoria, Gajek, Arkadiusz, Marczak, Agnieszka, Malý, Jan, Smejkal, Jiří, Statkiewicz, Małgorzata, Rusetska, Natalia, Bryś, Magdalena, Rogalska, Aneta

Source: International Journal of Molecular Sciences; Jan2025, Vol. 26 Issue 2, p834, 21p

Subject Terms: CHECKPOINT kinase 1, LIVER cancer, HEPATOCELLULAR carcinoma, THERAPEUTICS, OVARIAN cancer

Olaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in TP53 -Mutated Epithelial Ovarian Cancer Cell Lines.

Authors: Gralewska, Patrycja, Biegała, Łukasz, Gajek, Arkadiusz, Szymczak-Pajor, Izabela, Marczak, Agnieszka, Śliwińska, Agnieszka, Rogalska, Aneta

Source: International Journal of Molecular Sciences; Jan2025, Vol. 26 Issue 2, p693, 17p

Subject Terms: GENE expression, OVARIAN epithelial cancer, RNA regulation, GYNECOLOGIC cancer, CELL cycle

Geographic Terms: GERMANY (East)

PARP inhibitor resistance in ovarian cancer: Underlying mechanisms and therapeutic approaches targeting the ATR/CHK1 pathway

Authors: Biegała, Łukasz, Gajek, Arkadiusz, Marczak, Agnieszka, Rogalska, Aneta

Source: In BBA - Reviews on Cancer December 2021 1876(2)

Suppression of autophagy enhances preferential toxicity of epothilone A and epothilone B in ovarian cancer cells

Authors: Rogalska, Aneta, Gajek, Arkadiusz, Marczak, Agnieszka

Source: In Phytomedicine August 2019 61

Aclarubicin in subtoxic doses reduces doxorubicin cytotoxicity in human non-small cell lung adenocarcinoma (A549) and human hepatocellular carcinoma (HepG2) cells by decreasing DNA damage

Authors: Gajek, Arkadiusz, Rogalska, Aneta, Koceva-Chyła, Aneta

Source: In Toxicology in Vitro March 2019 55:140-150

Targeted Nanocarrier-Based Drug Delivery Strategies for Improving the Therapeutic Efficacy of PARP Inhibitors against Ovarian Cancer.

Authors: Gralewska, Patrycja, Gajek, Arkadiusz, Marczak, Agnieszka, Rogalska, Aneta

Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 15, p8304, 29p

Subject Terms: CELL receptors, CELL adhesion molecules, VASCULAR endothelial growth factors, EPIDERMAL growth factor, DRUG delivery systems, POLY ADP ribose

Therapeutic potential of patupilone in epithelial ovarian cancer and future directions

Authors: Rogalska, Aneta, Marczak, Agnieszka

Source: In Life Sciences 15 July 2018 205:38-44

Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells

Authors: Rogalska, Aneta, Bukowska, Barbara, Marczak, Agnieszka

Source: In Toxicology in Vitro March 2018 47:48-62

Antileukemic activity of novel adenosine derivatives

Authors: Poczta, Anastazja, Rogalska, Aneta, Łukawska, Małgorzata, Marczak, Agnieszka

Source: Scientific reports. 9(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190816350.0x000001&indx=1&recIds=ETOCvdc_100190816350.0x000001

Ruthenium dendrimers against acute promyelocytic leukemia: in vitro studies on HL-60 cells

Authors: Michlewska, Sylwia, Ionov, Maksim, Maroto-Díaz, Marta, Szwed, Aleksandra, Ihnatsyeu-Kachan, Aliaksei, Abashkin, Viktar, Dzmitruk, Volha, Rogalska, Aneta, Denel, Marta, Gapinska, Magdalena, Shcharbin, Dzmitry, Gomez Ramirez, Rafael, de la Mata, Francisco Javier, Bryszewska, Maria

Source: Future medicinal chemistry. 11(14):1741-1756

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186790479.0x000001&indx=1&recIds=ETOCvdc_100186790479.0x000001

Uncovering miRNA–mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of BRCA2 MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors.

Authors: Biegała, Łukasz, Kołat, Damian, Gajek, Arkadiusz, Płuciennik, Elżbieta, Marczak, Agnieszka, Śliwińska, Agnieszka, Mikula, Michał, Rogalska, Aneta

Source: Cells (2073-4409); May2024, Vol. 13 Issue 10, p867, 31p

Subject Terms: POLY ADP ribose, OLAPARIB, OVARIAN cancer, CELL cycle regulation, GENE expression, BRCA genes

Identification of the key pathway of oxazolinoanthracyclines mechanism of action in cells derived from human solid tumors

Authors: Denel-Bobrowska, Marta, Łukawska, Małgorzata, Rogalska, Aneta, Forma, Ewa, Bryś, Magdalena, Oszczapowicz, Irena, Marczak, Agnieszka

Source: In Toxicology and Applied Pharmacology 15 December 2016 313:159-169

New potential chemotherapy for ovarian cancer — Combined therapy with WP 631 and epothilone B

Authors: Bukowska, Barbara, Rogalska, Aneta, Marczak, Agnieszka

Source: In Life Sciences 15 April 2016 151:86-92

Metformin, but not sitagliptin, enhances WP 631-induced apoptotic HepG2 cell death

Authors: Sliwinska, Agnieszka, Rogalska, Aneta, Marczak, Agnieszka, Kasznicki, Jacek, Drzewoski, Jozef

Source: In Toxicology in Vitro August 2015 29(5):1116-1123

Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway

Authors: Rogalska, Aneta, Marczak, Agnieszka

Source: In Environmental Toxicology and Pharmacology March 2015 39(2):700-712

Tumour protein 53 is linked with type 2 diabetes mellitus

Authors: Sliwinska, Agnieszka, Kasznicki, Jacek, Kosmalski, Marcin, Mikolajczyk, Melania, Rogalska, Aneta, Przybylowska, Karolina, Majsterek, Ireneusz, Drzewoski, Jozef

Source: Indian journal of medical research. 146(2):237-243

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088326838.0x000001&indx=1&recIds=ETOCvdc_100088326838.0x000001

Cytotoxicity and induction of apoptosis by formamidinodoxorubicins in comparison to doxorubicin in human ovarian adenocarcinoma cells

Authors: Marczak, Agnieszka, Denel-Bobrowska, Marta, Rogalska, Aneta, Łukawska, Małgorzata, Oszczapowicz, Irena

Source: In Environmental Toxicology and Pharmacology January 2015 39(1):369-383

Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells

Authors: Rogalska, Aneta, Gajek, Arkadiusz, Marczak, Agnieszka

Source: In Toxicology in Vitro June 2014 28(4):675-683