Framework of the strengths and challenges of clinically integrated trials: An expert panel report

Authors: Peters, Anthony E., Jones, W. Schuyler, Anderson, Brian, Bramante, Carolyn T., Broedl, Uli, Hornik, Christoph P., Kehoe, Lindsay, Knowlton, Kirk U., Krofah, Esther, Landray, Martin, Locke, Trevan, Patel, Manesh R., Psotka, Mitchell, Rockhold, Frank W., Roessig, Lothar, Rothman, Russell L., Schofield, Lesley, Stockbridge, Norman, Trontell, Anne, Curtis, Lesley H., Tenaerts, Pamela, Hernandez, Adrian F.

Source: In American Heart Journal September 2024 275:62-73

Drug development for major chronic health conditions—aligning with growing public health needs: Proceedings from a multistakeholder think tank

Authors: Krychtiuk, Konstantin A., Andersson, Tomas LG, Bodesheim, Ulrike, Butler, Javed, Curtis, Lesley H., Elkind, Mitchell, Hernandez, Adrian F., Hornik, Christoph, Lyman, Gary H., Khatri, Pooja, Mbagwu, Michael, Murakami, Masahiro, Nichols, Gwen, Roessig, Lothar, Young, Anne Quinn, Schilsky, Richard L., Pagidipati, Neha

Source: In American Heart Journal April 2024 270:23-43

Electronic health record characterization and outcomes of heart failure with preserved ejection fraction

Authors: Rao, Vishal N., Cyr, Derek D., Wruck, Lisa M., Sanders, Gretchen, Hofmann, Paul, Rössig, Lothar, Siedentop, Harald, Evers, Thomas, Meyer, Michaela, Paraschin, Karen, Nkulikiyinka, Richard, Parikh, Kishan, Felker, G. Michael

Source: In American Heart Journal September 2023 263:1-14

Classification of Heart Failure Events by Severity: Insights From the VICTORIA Trial

Authors: Felker, G. MICHAEL, NORTH, REBECCA, MULDER, HILLARY, JONES, W. SCHUYLER, ANSTROM, KEVIN J., PATEL, MAHESH J., BUTLER, JAVED, EZEKOWITZ, JUSTIN A., LAM, CAROLYN S.P., O'CONNOR, CHRISTOPHER M., ROESSIG, LOTHAR, HERNANDEZ, ADRIAN F., ARMSTRONG, PAUL W.

Source: In Journal of Cardiac Failure August 2023 29(8):1113-1120

Patient-Reported Frailty and Functional Status in Heart Failure With Preserved Ejection Fraction: Insights From VITALITY-HFpEF

Authors: Kaul, Padma, Rathwell, Sarah, Lam, Carolyn S.P., Westerhout, Cynthia M., Spertus, John A., Anstrom, Kevin J., Blaustein, Robert O., Ezekowitz, Justin A., Pieske, Burkert, Roessig, Lothar, Butler, Javed, Armstrong, Paul W.

Source: In JACC: Heart Failure April 2023 11(4):392-403

Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure With Reduced Ejection Fraction: The VICTORIA Biomarker Substudy

Authors: DEFILIPPI, CHRISTOPHER R., ALEMAYEHU, WENDIMAGEGN G., VOORS, ADRIAAN A., KAYE, DAVID, BLAUSTEIN, ROBERT O., BUTLER, JAVED, EZEKOWITZ, JUSTIN A., HERNANDEZ, ADRIAN F., LAM, CAROLYN S.P., ROESSIG, LOTHAR, SELIGER, STEPHEN, SHAH, PALAK, WESTERHOUT, CYNTHIA M., ARMSTRONG, PAUL W., O'CONNOR, CHRISTOPHER M.

Source: In Journal of Cardiac Failure April 2023 29(4):448-458

CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research

Authors: Kotecha, Dipak ^*, Asselbergs, Folkert W ^*, Achenbach, Stephan, Anker, Stefan D, Atar, Dan, Baigent, Colin, Banerjee, Amitava, Beger, Birgit, Brobert, Gunnar, Casadei, Barbara, Ceccarelli, Cinzia, Cowie, Martin R, Crea, Filippo, Cronin, Maureen, Denaxas, Spiros, Derix, Andrea, Fitzsimons, Donna, Fredriksson, Martin, Gale, Chris P, Gkoutos, Georgios V, Goettsch, Wim, Hemingway, Harry, Ingvar, Martin, Jonas, Adrian, Kazmierski, Robert, Løgstrup, Susanne, Lumbers, R Thomas, Lüscher, Thomas F, McGreavy, Paul, Piña, Ileana L, Roessig, Lothar, Steinbeisser, Carl, Sundgren, Mats, Tyl, Benoît, Thiel, Ghislaine van, Bochove, Kees van, Vardas, Panos E, Villanueva, Tiago, Vrana, Marilena, Weber, Wim, Weidinger, Franz, Windecker, Stephan, Wood, Angela, Grobbee, Diederick E

Source: In The Lancet Digital Health October 2022 4(10):e757-e764

Sequential Evaluation of NT-proBNP in Heart Failure: Insights Into Clinical Outcomes and Efficacy of Vericiguat

Authors: Armstrong, Paul W., Zheng, Yinggan, Troughton, Richard W., Lund, Lars H., Zhang, Jian, Lam, Carolyn S.P., Westerhout, Cynthia M., Blaustein, Robert O., Butler, Javed, Hernandez, Adrian F., Roessig, Lothar, O’Connor, Christopher M., Voors, Adrian A., Ezekowitz, Justin A.

Source: In JACC: Heart Failure September 2022 10(9):677-688

Medical Therapy During Hospitalization for Heart Failure With Reduced Ejection Fraction: The VICTORIA Registry

Authors: Greene, STEPHEN J., EZEKOWITZ, JUSTIN A., ANSTROM, KEVIN J., DEMYANENKO, VLADIMIR, GIVERTZ, MICHAEL M., PIÑA, ILEANA L., O'CONNOR, CHRISTOPHER M., KOGLIN, JOERG, ROESSIG, LOTHAR, HERNANDEZ, ADRIAN F., ARMSTRONG, PAUL W., MENTZ, ROBERT J.

Source: In Journal of Cardiac Failure July 2022 28(7):1063-1077

Drug Development in Kidney Disease: Proceedings From a Multistakeholder Conference

Authors: Edmonston, Daniel L., Roe, Matthew T., Block, Geoffrey, Conway, Paul T., Dember, Laura M., DiBattiste, Peter M., Greene, Tom, Hariri, Ali, Inker, Lesley A., Isakova, Tamara, Montez-Rath, Maria E., Nkulikiyinka, Richard, Polidori, David, Roessig, Lothar, Tangri, Navdeep, Wyatt, Christina, Chertow, Glenn M., Wolf, Myles

Source: In American Journal of Kidney Diseases December 2020 76(6):842-850

N-Terminal Pro-B-Type Natriuretic Peptide and Clinical Outcomes: Vericiguat Heart Failure With Reduced Ejection Fraction Study

Authors: Ezekowitz, Justin A., O’Connor, Christopher M., Troughton, Richard W., Alemayehu, Wendimagegn G., Westerhout, Cynthia M., Voors, Adriaan A., Butler, Javed, Lam, Carolyn S.P., Ponikowski, Piotr, Emdin, Michele, Patel, Mahesh J., Pieske, Burkert, Roessig, Lothar, Hernandez, Adrian F., Armstrong, Paul W.

Source: In JACC: Heart Failure November 2020 8(11):931-939

Soluble GC stimulators and activators: Past, present and future.

Authors: Sandner, Peter, Follmann, Markus, Becker‐Pelster, Eva, Hahn, Michael G., Meier, Christian, Freitas, Cecilia, Roessig, Lothar, Stasch, Johannes‐Peter

Source: British Journal of Pharmacology; Nov2024, Vol. 181 Issue 21, p4130-4151, 22p

Subject Terms: CHRONIC kidney failure, DIABETIC retinopathy, PULMONARY hypertension, HEART failure

Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial.

Authors: Tromp, Jasper, Lam, Carolyn S.P., Alemayehu, Wendimagegn, de Filippi, Christopher R., Melenovský, Vojtěch, Sliwa, Karen, Lopatin, Yuri, Arango, Juan Luis, Bahit, M. Cecilia, Roessig, Lothar, O'Connor, Christopher M., Shah, Palak, Westerhout, Cynthia M., Voors, Adriaan A., Pieske, Burkert, Armstrong, Paul W.

Source: European Journal of Heart Failure; Oct2024, Vol. 26 Issue 10, p2231-2239, 9p

Subject Terms: VENTRICULAR remodeling, HEART metabolism, BODY surface area, HEART failure patients, VENTRICULAR ejection fraction

Proteomics Identify Clinical Phenotypes and Predict Functional Outcomes in Heart Failure With Preserved Ejection Fraction: Insights From VITALITY-HFpEF.

Authors: deFilippi, Christopher R., Shah, Palak, Shah, Sanjiv J., Alemayehu, Wendimagegn, Lam, Carolyn S. P., Butler, Javed, Roessig, Lothar, O’Connor, Christopher M., Westerhout, Cynthia M., Armstrong, Paul W.

Source: Circulation: Heart Failure; Sep2024, Vol. 17 Issue 9, p854-863, 10p

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator: The VICTORIA Trial

Authors: Armstrong, Paul W., Roessig, Lothar, Patel, Mahesh J., Anstrom, Kevin J., Butler, Javed, Voors, Adriaan A., Lam, Carolyn S.P., Ponikowski, Piotr, Temple, Tracy, Pieske, Burkert, Ezekowitz, Justin, Hernandez, Adrian F., Koglin, Joerg, O'Connor, Christopher M.

Source: In JACC: Heart Failure February 2018 6(2):96-104

Clinical Pharmacokinetic and Pharmacodynamic Profile of Vericiguat.

Authors: Fritsch, Achim, Meyer, Michaela, Blaustein, Robert O., Trujillo, Maria E., Kauh, Eunkyung, Roessig, Lothar, Boettcher, Michael, Becker, Corina

Source: Clinical Pharmacokinetics; Jun2024, Vol. 63 Issue 6, p751-771, 21p

Subject Terms: LEFT ventricular dysfunction, CYCLIC guanylic acid, PHOSPHODIESTERASE inhibitors, CHILD patients, HEART failure patients, BLOOD pressure

Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps

Authors: Mentz, Robert J., Roessig, Lothar, Greenberg, Barry H., Sato, Naoki, Shinagawa, Kaori, Yeo, Daniel, Kwok, Bernard W.K., Reyes, Eugenio B., Krum, Henry, Pieske, Burkert, Greene, Stephen J., Ambrosy, Andrew P., Kelly, Jacob P., Zannad, Faiez, Pitt, Bertram, Lam, Carolyn S.P.

Source: In JACC: Heart Failure June 2016 4(6):419-427

Using Natriuretic Peptides for Selection of Patients in Acute Heart Failure Clinical Trials

Authors: Smith, Sakima A., Mentz, Robert J., Roessig, Lothar, Mebazza, Alexandre, Longrois, Dan, Gheorghiade, Mihai, Pitt, Bertram, Zannad, Faiez, Butler, Javed, Abraham, William T.

Source: In The American Journal of Cardiology 15 October 2015 116(8):1304-1310

Improving cardiovascular clinical trials conduct in the United States: Recommendation from clinicians, researchers, sponsors, and regulators

Authors: Butler, Javed, Fonarow, Gregg C., O’Connor, Christopher, Adams, Kirkwood, Bonow, Robert O., Cody, Robert J., Collins, Sean P., Dunnmon, Preston, Dinh, Wilfried, Fiuzat, Mona, Georgiopoulou, Vasiliki V., Grant, Stephen, Kim, So-Young, Kupfer, Stuart, Lefkowitz, Martin, Mentz, Robert J., Misselwitz, Frank, Pitt, Bertram, Roessig, Lothar, Schelbert, Erik, Shah, Monica, Solomon, Scott, Stockbridge, Norman, Yancy, Clyde, Gheorghiade, Mihai

Source: In American Heart Journal March 2015 169(3):305-314

Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study

Authors: Bonderman, Diana, Pretsch, Ingrid, Steringer-Mascherbauer, Regina, Jansa, Pavel, Rosenkranz, Stephan, Tufaro, Caroline, Bojic, Andja, Lam, Carolyn S. P, Frey, Reiner, Ochan Kilama, Michael, Unger, Sigrun, Roessig, Lothar, Lang, Irene M

Source: In Chest November 2014 146(5):1274-1285