Efficacy and Safety of 4-Month Rifapentine-Based Tuberculosis Treatments in Persons with Diabetes

Authors: Ekaterina V. Kurbatova, William C. Whitworth, Lakshmi Praveena Peddareddy, Patrick P.J. Phillips, Nigel A. Scott, Kia E. Bryant, Rodney Dawson, Sandra Wagner Cardoso, Wadzanai Samaneka, Melissa Engle, Ziyaad Waja, Erin Sizemore, Wendy Carr, Kelly E. Dooley, Radojka Savic, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, Payam Nahid, Nhung V. Nguyen

Source: Emerging Infectious Diseases, Vol 31, Iss 3, Pp 467-476 (2025)

Subject Terms: tuberculosis and other mycobacteria, diabetes, phase 3 clinical trial, rifapentine, moxifloxacin, antimicrobial resistance, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/31/3/24-1634_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/741a0ed9af8348169ec0d113889d5597

Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

Authors: Vincent K. Chang, Marjorie Z. Imperial, Patrick P. J. Phillips, Gustavo E. Velásquez, Payam Nahid, Andrew Vernon, Ekaterina V. Kurbatova, Susan Swindells, Richard E. Chaisson, Susan E. Dorman, John L. Johnson, Marc Weiner, Erin E. Sizemore, William Whitworth, Wendy Carr, Kia E. Bryant, Deron Burton, Kelly E. Dooley, Melissa Engle, Pheona Nsubuga, Andreas H. Diacon, Nguyen Viet Nhung, Rodney Dawson, Radojka M. Savic, AIDS Clinical Trial Group, Tuberculosis Trials Consortium

Source: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/de940f5d4bbc4e00aaa1dfc2d65e721a

Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) studyResearch in context

Authors: Nigel Garrett, Asa Tapley, Aaron Hudson, Sufia Dadabhai, Bo Zhang, Nyaradzo M. Mgodi, Jessica Andriesen, Azwidihwi Takalani, Leigh H. Fisher, Jia Jin Kee, Craig A. Magaret, Manuel Villaran, John Hural, Erica Andersen-Nissen, Guido Ferarri, Maurine D. Miner, Bert Le Roux, Eduan Wilkinson, Richard Lessells, Tulio de Oliveira, Jackline Odhiambo, Parth Shah, Laura Polakowski, Margaret Yacovone, Taraz Samandari, Zvavahera Chirenje, Peter James Elyanu, Joseph Makhema, Ethel Kamuti, Harriet Nuwagaba-Biribonwoha, Sharlaa Badal-Faesen, William Brumskine, Soritha Coetzer, Rodney Dawson, Sinead Delany-Moretlwe, Andreas Henri Diacon, Samantha Fry, Katherine Margaret Gill, Zaheer Ahmed Ebrahim Hoosain, Mina C. Hosseinipour, Mubiana Inambao, Craig Innes, Steve Innes, Dishiki Kalonji, Margaret Kasaro, Priya Kassim, Noel Kayange, William Kilembe, Fatima Laher, Moelo Malahleha, Vongane Louisa Maluleke, Grace Mboya, Kirsten McHarry, Essack Mitha, Kathryn Mngadi, Pamela Mda, Tumelo Moloantoa, Cissy Kityo Mutuluuza, Nivashnee Naicker, Vimla Naicker, Anusha Nana, Annet Nanvubya, Maphoshane Nchabeleng, Walter Otieno, Elsje Louise Potgieter, Disebo Potloane, Zelda Punt, Jamil Said, Yashna Singh, Mohammed Siddique Tayob, Yacoob Vahed, Deo Ogema Wabwire, M. Juliana McElrath, James G. Kublin, Linda-Gail Bekker, Peter B. Gilbert, Lawrence Corey, Glenda E. Gray, Yunda Huang, Philip Kotze, Kagisho Baepanye, Veronique Bailey, Katekani Baloyi-Oseh, Mumtaz Booley, Johannes Louis Botha, Yolande Brown, Valerie Brown, Lisa Bunts, Myron Cohen, Shirley Collie, Pallabi Deb, Hana El Sahly, Jill El-Khorazaty, Andries Engelbrecht, Marianne Gildea, Dhevium Govender, Jen Hanke, Jayla Harris, Simone Hendricks, Nick Hopkinson, Haley Howell, Nzeera Ketter, Kentse Khuto, Faatima Laher Omar, Leolin Katsidzira, Kim Linton, James Ludwig, Bongile Mabilane, Matshidiso Malefo, Ndiitwani Mamushiana, Daciana Margineantu, Jeanine May, Fatima Mayat, Cindy Molitor, Yeshnee Naidoo, Michelle Nebergall, Alan Nguyen, Sarah Nikles, Bianca Noronha, Melissa Peda, Tamara Phiri, Shanthie Pillay, Sureshnee Pillay, Lori Proulx-Burns, Laurie Rinn, Lisa Sanders, Carrie Sopher, Smitha Sripathy, Michael Stirewalt, Houriiyah Tegally, Sara Thiebaud, Alicia Toledano, Stephanie Van Wyk, Shamaya Whitby, Stephany Wilcox, Haven Wilvich, Charles Wiysonge, Nelisiwe Xaba, Ntokozo Xulu

Source: EClinicalMedicine, Vol 80, Iss , Pp 103054- (2025)

Subject Terms: People living with HIV, SARS-CoV-2, mRNA-1273, Hybrid immunity, Vaccine immunity, COVID-19, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024006333; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/312fbb1df2dc4adba1e3c906cf2f4809

Quabodepistat in combination with delamanid and bedaquiline in participants with drug-susceptible pulmonary tuberculosis: protocol for a multicenter, phase 2b/c, open-label, randomized, dose-finding trial to evaluate safety and efficacy

Authors: Rodney Dawson, Andreas H. Diacon, Simbarashe Takuva, Yongge Liu, Bo Zheng, Vatsala Karwe, Jeffrey Hafkin

Source: Trials, Vol 25, Iss 1, Pp 1-12 (2024)

Subject Terms: Antituberculosis agent, Bedaquiline, Delamanid, DprE1 inhibitor, Drug-sensitive tuberculosis, Quabodepistat, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/e09144f4018641fda1b5b86c2867dd4b

High rifampicin peak plasma concentrations accelerate the slow phase of bacterial decline in tuberculosis patients: Evidence for heteroresistance.

Authors: Antal Martinecz, Martin J Boeree, Andreas H Diacon, Rodney Dawson, Colin Hemez, Rob E Aarnoutse, Pia Abel Zur Wiesch

Source: PLoS Computational Biology, Vol 19, Iss 4, p e1011000 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/744d2eb58e5f4f758753e7eb9536c66a

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Authors: Rami Ayoun Alsoud, Robin J. Svensson, Elin M. Svensson, Stephen H. Gillespie, Martin J. Boeree, Andreas H. Diacon, Rodney Dawson, Rob E. Aarnoutse, Ulrika S. H. Simonsson

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: rifampicin, TTP, CFU, tuberculosis, biomarker, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1067295/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1e7e34c9287b4aedb8b78bb3b1c57875

Brief psychotherapy administered by non-specialised health workers to address risky substance use in patients with multidrug-resistant tuberculosis: a feasibility and acceptability study

Authors: Gregory L. Calligaro, Zani de Wit, Jacqui Cirota, Catherine Orrell, Bronwyn Myers, Sebastian Decker, Dan J. Stein, Katherine Sorsdahl, Rodney Dawson

Source: Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-10 (2021)

Subject Terms: Tuberculosis, Adherence, Counselling, Substance use, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5784

Access URL: https://doaj.org/article/66e7c8a846c647a6a0e5521e68596cd1

Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status

Authors: Conor D. Tweed, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Lerato Mohapi, Michael E. Murphy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Stephen H. Gillespie

Source: BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)

Subject Terms: Tuberculosis, Clinical trials, HIV, Adverse events, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12890-019-0907-6; https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/d4f6503cd6b943dbb18e73105c9b0eb8

Assessing whether isoniazid is essential during the first 14 days of tuberculosis therapy: a phase 2a, open-label, randomised controlled trial

Authors: Andreas Diacon, ProfPhD, Sachiko Miyahara, PhD, Rodney Dawson, PhD, Xin Sun, PhD, Evelyn Hogg, Kathleen Donahue, MA, Michael Urbanowski, PhD, Veronique De Jager, MD, Courtney V Fletcher, ProfPharmD, Richard Hafner, MD, Susan Swindells, ProfMBBS, William Bishai, ProfMD

Source: The Lancet Microbe, Vol 1, Iss 2, Pp e84-e92 (2020)

Subject Terms: Medicine (General), R5-920, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666524720300112; https://doaj.org/toc/2666-5247

Access URL: https://doaj.org/article/18657402e09d414b9438792656058339

Toxicity associated with tuberculosis chemotherapy in the REMoxTB study

Authors: Conor D. Tweed, Angela M. Crook, Evans I. Amukoye, Rodney Dawson, Andreas H. Diacon, Madeline Hanekom, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Michael E. Murphy, Saraswathi E. Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Genevieve H. Wills, Stephen H. Gillespie

Source: BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)

Subject Terms: Tuberculosis, Toxicity, Clinical trials, Adverse events, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12879-018-3230-6; https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/87ffe9cc14bf494197dd9d05a700110f

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

Authors: Conor Duncan Tweed, Genevieve Helen Wills, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Cheryl E. Louw, Timothy D. McHugh, Carl Mendel, Sarah Meredith, Lerato Mohapi, Michael E. Murphy, Stephen Murray, Sara Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha Singh, M. Spigelman, S. H. Gillespie

Source: BMC Medicine, Vol 16, Iss 1, Pp 1-10 (2018)

Subject Terms: Tuberculosis, Hepatotoxicity, Drug-induced liver injury, Treatment monitoring, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12916-018-1033-7; https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/9c5b8d40012f497db02bc3f9607be6f2

Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial [version 1; referees: 3 approved]

Authors: Ray Y. Chen, Laura E. Via, Lori E. Dodd, Gerhard Walzl, Stephanus T. Malherbe, André G. Loxton, Rodney Dawson, Robert J. Wilkinson, Friedrich Thienemann, Michele Tameris, Mark Hatherill, Andreas H. Diacon, Xin Liu, Jin Xing, Xiaowei Jin, Zhenya Ma, Shouguo Pan, Guolong Zhang, Qian Gao, Qi Jiang, Hong Zhu, Lili Liang, Hongfei Duan, Taeksun Song, David Alland, Michael Tartakovsky, Alex Rosenthal, Christopher Whalen, Michael Duvenhage, Ying Cai, Lisa C. Goldfeder, Kriti Arora, Bronwyn Smith, Jill Winter, Clifton E. Barry III, Predict TB Study Group

Source: Gates Open Research, Vol 1 (2017)

Subject Terms: Antimicrobials & Drug Resistance, Bacterial Infections, Immunological Biomarkers, Medicine

File Description: electronic resource

Relation: https://gatesopenresearch.org/articles/1-9/v1; https://doaj.org/toc/2572-4754

Access URL: https://doaj.org/article/2e9744f070dd42cc8f0373c77478494c

Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages.

Authors: Michael D Weiden, Satomi Hoshino, David N Levy, Yonghua Li, Rajnish Kumar, Sean A Burke, Rodney Dawson, Catarina E Hioe, William Borkowsky, William N Rom, Yoshihiko Hoshino

Source: PLoS ONE, Vol 9, Iss 10, p e108476 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4182706?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4fb004f7ba614f2fae400c761c402fce

Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis.

Authors: Robert S Wallis, Rodney Dawson, Sven O Friedrich, Amour Venter, Darcy Paige, Tong Zhu, Annette Silvia, Jason Gobey, Craig Ellery, Yao Zhang, Kathleen Eisenach, Paul Miller, Andreas H Diacon

Source: PLoS ONE, Vol 9, Iss 4, p e94462 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3986205?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1d2f4c6c83044d40877fbbf4225b55e9

Development of a simple reliable radiographic scoring system to aid the diagnosis of pulmonary tuberculosis.

Authors: Lancelot M Pinto, Keertan Dheda, Grant Theron, Brian Allwood, Gregory Calligaro, Richard van Zyl-Smit, Jonathan Peter, Kevin Schwartzman, Dick Menzies, Eric Bateman, Madhukar Pai, Rodney Dawson

Source: PLoS ONE, Vol 8, Iss 1, p e54235 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3548832?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e72072c53523489c87d17ac891673d96

Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum.

Authors: Anna Nolan, Elaine Fajardo, Maryann L Huie, Rany Condos, Anil Pooran, Rodney Dawson, Keertan Dheda, Eric Bateman, William N Rom, Michael D Weiden

Source: PLoS ONE, Vol 8, Iss 3, p e59461 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3603887?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/67f098f57b5f4b51a3f1364ea0ef1d2f

Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples.

Authors: Keertan Dheda, Virginia Davids, Laura Lenders, Teri Roberts, Richard Meldau, Daphne Ling, Laurence Brunet, Richard van Zyl Smit, Jonathan Peter, Clare Green, Motasim Badri, Leonardo Sechi, Surendra Sharma, Michael Hoelscher, Rodney Dawson, Andrew Whitelaw, Jonathan Blackburn, Madhukar Pai, Alimuddin Zumla

Source: PLoS ONE, Vol 5, Iss 3, p e9848 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2844421?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/670128ab3cc74ad0ba8b1ed316592365

Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting.

Authors: Keertan Dheda, Richard N Van-Zyl Smit, Leonardo A Sechi, Motasim Badri, Richard Meldau, Gregory Symons, Hoosein Khalfey, Igshaan Carr, Alice Maredza, Rodney Dawson, Helen Wainright, Andrew Whitelaw, Eric D Bateman, Alimuddin Zumla

Source: PLoS ONE, Vol 4, Iss 3, p e4689 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19277111/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/baa4d0fe7fd24b198853321c1f77e24b

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