Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis

Authors: Arantza Lamas-Paz, Alejandro Hionides-Gutiérrez, Feifei Guo, Gonzalo Jorquera, Laura Morán-Blanco, Raquel Benedé-Ubieto, Mariana Mesquita, Olga Estévez-Vázquez, Kang Zheng, Marina Mazariegos, Elena Vázquez-Ogando, Elena Blázquez-López, Iris Asensio, Beste Mutlu, Beatriz Gomez-Santos, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Teresa C. Delgado, María Luz Martínez-Chantar, Eduardo Martínez-Naves, Carlos Sanz-García, Mohamed Ramadan Mohamed, Sofía Tesolato, Pilar Iniesta, Rocío Gallego-Durán, Douglas Maya-Miles, Javier Ampuero, Manuel Romero-Gómez, Ana Martínez-Alcocer, David Sanfeliu-Redondo, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andrea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, Matías A. Ávila, Maria Dolores Frutos, Carlos Manuel Martínez-Cáceres, Bruno Ramos-Molina, Patricia Aspichueta, Pere Puigserver, Yulia A. Nevzorova, Francisco Javier Cubero

Source: JHEP Reports, Vol 7, Iss 1, Pp 101230- (2025)

Subject Terms: CDKN1A, Steatotic liver disease (SLD), Hepatocyte, Senescence, Metabolic dysregulation, Palbociclib, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924002349; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/4e2f28ede80d4cfa8f3201c467cc1073

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis

Authors: Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José R. Regueiro, Eduardo Martínez-Naves, Mohamed Ramadan Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andreea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, María Dolores Frutos, Bruno Ramos Molina, José María Herranz, Matías A. Ávila, Yulia A. Nevzorova, Edgar Fernández-Malavé, Francisco Javier Cubero

Source: Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/01a591f664c741c59cc9c983321052fd

Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis

Authors: Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón, Águeda González-Rodríguez

Source: Biomarker Research, Vol 11, Iss 1, Pp 1-14 (2023)

Subject Terms: Liver fibrosis, Bone morphogenetic proteins, BMP8A, Non-invasive diagnosis, Hepatic stellate cells, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/8bdf154a44f54c48aa9adb7e918626e3

Bone morphogenetic protein 2 is a new molecular target linked to non-alcoholic fatty liver disease with potential value as non-invasive screening tool

Authors: Patricia Marañón, Carlos Ernesto Fernández-García, Stephania C. Isaza, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Manuel Romero-Gómez, Carmelo García-Monzón, Águeda González-Rodríguez

Source: Biomarker Research, Vol 10, Iss 1, Pp 1-10 (2022)

Subject Terms: Non-alcoholic fatty liver disease, Bone morphogenetic proteins, BMP2, Non-invasive diagnosis, Hepatocytes, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/205b4344f61f456098437edb33a7af9e

Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation

Authors: Rocío Gallego-Durán, Javier Ampuero, Helena Pastor-Ramírez, Leticia Álvarez-Amor, Jose Antonio del Campo, Douglas Maya-Miles, Rocío Montero-Vallejo, Antonio Cárdenas-García, Mª Jesús Pareja, Sheila Gato-Zambrano, Raquel Millán, María del Carmen Rico, Amparo Luque-Sierra, Antonio Gil-Gómez, Ángela Rojas, Rocío Muñoz-Hernández, María García-Lozano, Rocío Aller, Raúl J. Andrade, Carmelo García-Monzón, Fausto Andreola, Francisco Martín, Rajiv Jalan, Manuel Romero-Gómez

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6b0034b1492945a5bad81e9db024ea51

Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitis

Authors: Leticia Álvarez-Amor, Amparo Luque Sierra, Antonio Cárdenas, Lucía López-Bermudo, Javier López-Beas, Eloísa Andújar, Mónica Pérez-Alegre, Rocío Gallego-Durán, Lourdes M. Varela, Alejandro Martin-Montalvo, Genoveva Berná, Anabel Rojas, Mª José Robles-Frías, Abdelkrim Hmadcha, Manuel Romero-Gómez, Robert Kleemann, Franz Martín

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/98018cb0ec61418692f64df0f9c6509c

Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver

Authors: Lucía López-Bermudo, Amparo Luque-Sierra, Douglas Maya-Miles, Rocío Gallego-Durán, Javier Ampuero, Manuel Romero-Gómez, Genoveva Berná, Franz Martín

Source: Frontiers in Endocrinology, Vol 13 (2022)

Subject Terms: β-cell, pancreatic islets, liver, hepatokines, crosstalk, type 2 diabetes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.892672/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/321c6c4067f74947abc72993e272154c

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Authors: Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly, James Clark, Heather J. Cordell, Rebecca Darlay, Christopher P. Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M. Bossuyt, Adriaan G. Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss

Source: JHEP Reports, Vol 4, Iss 2, Pp 100409- (2022)

Subject Terms: MicroRNA, Non-alcoholic fatty liver disease, Biomarker, Sequencing, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555921001853; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/bf7c90fd285b4e33a8d02523458d147c

Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases

Authors: Rocío Gallego-Durán, Rocío Montero-Vallejo, Douglas Maya-Miles, Ana Lucena, Franz Martin, Javier Ampuero, Manuel Romero-Gómez

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: NAFLD, NASH, immunology, fibrosis, biomarkers, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.667354/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8d9c6696eb054d378c7a6d45a6dbe999

Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype

Authors: Ángela Rojas, Paloma Gallego, Antonio Gil-Gómez, Rocío Muñoz-Hernández, Lourdes Rojas, Rosario Maldonado, Rocío Gallego-Durán, Marta García-Valdecasas, José A. Del Campo, Juan D. Bautista, Manuel Romero-Gómez

Source: Annals of Hepatology, Vol 17, Iss 2, Pp 242-249 (2018)

Subject Terms: Steatosis, Lipid droplets, Triglycerides, Quercetin, Cynara scolymus, Agaricus Bisporus, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1665268119301565; https://doaj.org/toc/1665-2681

Access URL: https://doaj.org/article/17c712c32499428ca65457d82ec0708f

Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy.

Authors: José A Del Campo, Marta García-Valdecasas, Antonio Gil-Gómez, Ángela Rojas, Paloma Gallego, Javier Ampuero, Rocío Gallego-Durán, Helena Pastor, Lourdes Grande, Francisco J Padillo, Jordi Muntané, Manuel Romero-Gómez

Source: PLoS ONE, Vol 13, Iss 1, p e0191805 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5791999?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e71c48ea98b143af984c9058bbb92e34

Thalidomide with peginterferon alfa-2b and ribavirin in the treatment of non-responders genotype 1 chronic hepatitis C patients: proof of concept Talidomida, peginterferón alfa-2b y ribavirina en el tratamiento de pacientes no respondedores con hepatitis crónica C genotipo 1: estudio piloto

Authors: Benjamín Pardo-Yules, Rocío Gallego-Durán, Mohammed Eslam, Carlos García-Collado, Lourdes Grande, Carmen Paradas, Ramón Morillo, Benito Dorantes, Manuel Romero-Gómez

Source: Revista Espanola de Enfermedades Digestivas, Vol 103, Iss 12, Pp 619-625 (2011)

Subject Terms: Hepatitis C, Factores del huésped, Talidomia, Factor de necrosis tumoral, Gammaglutamil transpeptidasa, Host factors, Thalidomide, TNF-&alpha, Clinical trial, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082011001200003; https://doaj.org/toc/1130-0108

Access URL: https://doaj.org/article/90fa290915384836bceda97d071fd458

Association of NAFLD with subclinical atherosclerosis and coronary-artery disease: meta-analysis

Authors: Javier Ampuero, Rocío Gallego-Durán, Manuel Romero-Gómez

Source: Revista Espanola de Enfermedades Digestivas, Vol 107, Iss 1, Pp 10-16

Subject Terms: non-alcoholic fatty liver disease, cardiovascular disease, subclinical atherosclerosis, steatohepatitis, nash, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000100003&lng=en&tlng=en; https://doaj.org/toc/1130-0108

Access URL: https://doaj.org/article/1573e132760c46248e6eb8d7101a4d42

Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy

Authors: Antonio Gil-Gómez, Ana-Isabel Gómez-Sotelo, Isidora Ranchal, Ángela Rojas, Marta García-Valdecasas, Rocío Muñoz-Hernández, Rocío Gallego-Durán, Javier Ampuero, Manuel Romero-Gómez

Source: Revista Espanola de Enfermedades Digestivas, Vol 110, Iss 7, Pp 427-433

Subject Terms: Hepatic encephalopathy, Metformin, Ammonia, Glutaminase, Glutamine, Cirrhosis, ASCT2, mTOR, Porto-caval anastomosis, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082018000700004&lng=en&tlng=en; https://doaj.org/toc/1130-0108

Access URL: https://doaj.org/article/3fbc16d5de1e43f1aa42afc020cad1d4

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Authors: Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A. Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha EL Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam

Source: EBioMedicine, Vol 70, Iss , Pp 103521- (2021)

Subject Terms: MAFLD, XPO4, Fibrosis, TGFβ, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421003145; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/a06ae1d89aea4d04a07d0e81cd7b368f

Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus

Authors: Ali Bayoumi, Asmaa Elsayed, Shuanglin Han, Salvatore Petta, Leon A. Adams, Rocio Aller, Anis Khan, Carmelo García‐Monzón, María Teresa Arias‐Loste, Luca Miele, Olivier Latchoumanin, Shafi Alenizi, Rocio Gallego‐Durán, Janett Fischer, Thomas Berg, Antonio Craxì, Mayada Metwally, Liang Qiao, Christopher Liddle, Hannele Yki‐Järvinen, Elisabetta Bugianesi, Manuel Romero‐Gomez, Jacob George, Mohammed Eslam

Source: Advanced Science, Vol 8, Iss 11, Pp n/a-n/a (2021)

Subject Terms: fibroblast growth factor 21, genetics, metabolic, metabolic associated fatty liver disease, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/ea7ae1ca7cda4ad490227a4f90944bd6

Genetic variation in the TLL1 gene is not associated with fibrosis in patients with metabolic associated fatty liver disease.

Authors: Ali Bayoumi, Ismail Jalil, Mayada Metwally, Leon A Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Luca Miele, Salvatore Petta, Antonio Craxì, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Liang Qiao, Christopher Liddle, Elisabetta Bugianesi, Manuel Romero-Gomez, Jacob George, Mohammed Eslam

Source: PLoS ONE, Vol 15, Iss 12, p e0243590 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/aecb6cb0d78d41dcb9b75a5642c82492