Opportunistic genomic screening has clinical utility: An interventional cohort study

Authors: Bombard, Yvonne, Armel, Susan Randall, Aronson, Melyssa, Baxter, Nancy N., Bond, Kenneth, Capo-Chichi, José-Mario, Carroll, June C., Caulfield, Timothy, Clausen, Marc, Clifford, Tammy J., Cohn, Iris, Dhalla, Irfan, Earle, Craig C., Eisen, Andrea, Elser, Christine, Evans, Michael, Glogowski, Emily, Graham, Tracy, Greenfeld, Elena, Hamilton, Jada G., Isaranuwatchai, Wanrudee, Kastner, Monika, Kim, Raymond H., Lerner-Ellis, Jordan, Morel, Chantal F., Mujoomdar, Michelle, Noor, Abdul, Offit, Kenneth, Panchal, Seema, Robson, Mark E., Scherer, Stephen W., Scheer, Adena, Schrader, Kasmintan A., Sullivan, Terrence, Thorpe, Kevin E., Mighton, Chloe ^{1, 2}, Kodida, Rita ², Shickh, Salma ^{1, 2}, Reble, Emma ², Sam, Jordan ², Grewal, Sonya ², Hirjikaka, Daena ², Piccinin, Carolyn ^{3, 4}, Ward, Thomas ⁵, Hofstedter, Renee ⁶, Mancuso, Talia ⁷, Forster, Nicole ⁸, Glogowksi, Emily ¹⁶, Chan, Kelvin K.W. ^{1, 19}

Source: In Genetics in Medicine February 2025 27(2)

Deep Interactive Learning-based ovarian cancer segmentation of H&E-stained whole slide images to study morphological patterns of BRCA mutation

Authors: Ho, David Joon, Chui, M. Herman, Vanderbilt, Chad M., Jung, Jiwon, Robson, Mark E., Park, Chan-Sik, Roh, Jin, Fuchs, Thomas J.

Subject Terms: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition

Access URL: http://arxiv.org/abs/2203.15015

The impact of previous therapy on overall-survival in registration clinical trials for 1st line metastatic breast cancer a systemic review

Authors: Remilah, Areen Abu, Krayim, Bilal, Amir, Eitan, Tibau, Ariadna, Robson, Mark E., Abuhadra, Nour, Chen, Yuan, Shepshelovich, Daniel, Goldvaser, Hadar

Source: In Critical Reviews in Oncology / Hematology October 2024 202

Validation of a clinical breast cancer risk assessment tool combining a polygenic score for all ancestries with traditional risk factors

Authors: Mabey, Brent, Hughes, Elisha, Kucera, Matthew, Simmons, Timothy, Hullinger, Brooke, Pederson, Holly J., Yehia, Lamis, Eng, Charis, Garber, Judy, Gary, Monique, Gordon, Ora, Klemp, Jennifer R., Mukherjee, Semanti, Vijai, Joseph, Offit, Kenneth, Olopade, Olufunmilayo I., Pruthi, Sandhya, Kurian, Allison, Robson, Mark E., Whitworth, Pat W., Pal, Tuya, Ratzel, Sarah, Wagner, Susanne, Lanchbury, Jerry S., Taber, Katherine Johansen, Slavin, Thomas P., Gutin, Alexander

Source: In Genetics in Medicine July 2024 26(7)

Invasive lobular breast cancer: Focus on prevention, genetics, diagnosis, and treatment

Authors: Corso, Giovanni, Fusco, Nicola, Guerini-Rocco, Elena, Leonardi, Maria Cristina, Criscitiello, Carmen, Zagami, Paola, Nicolò, Eleonora, Mazzarol, Giovanni, La Vecchia, Carlo, Pesapane, Filippo, Zanzottera, Cristina, Tarantino, Paolo, Petitto, Salvatore, Bianchi, Beatrice, Massari, Giulia, Boato, Anthony, Sibilio, Andrea, Polizzi, Andrea, Curigliano, Giuseppe, De Scalzi, Alessandra Margherita, Lauria, Federica, Bonanni, Bernardo, Marabelli, Monica, Rotili, Anna, Nicosia, Luca, Albini, Adriana, Calvello, Mariarosaria, Mukhtar, Rita A., Robson, Mark E., Sacchini, Virgilio, Rennert, Gad, Galimberti, Viviana, Veronesi, Paolo, Magnoni, Francesca

Source: In Seminars in Oncology June-August 2024 51(3-4):106-122

Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study

Authors: Berger, Michael, Bromberg, Jacqueline, Chen, Linda, Dang, Chau, Das, Jeeban P, Drullinsky, Pamela, Eng, Julianna, Flynn, Jessica, Gelblum, Daphna Y, Gillespie, Erin F, Girshman, Jeffrey, Gomez, Daniel R, Gucalp, Ayca, Guttmann, David, Hajj, Carla, Higginson, Daniel, Iqbal, Afsheen, Khan, Atif J, LaPlant, Quincey, Lee, Nancy Y, Mann, Justin M, Modi, Shanu, Namakydoust, Azadeh, Ng, Kenneth, Patel, Juber, Powell, Simon N, Preeshagul, Isabel, Reis-Filho, Jorge S, Reyngold, Marsha, Riaz, Nadeem, Rimner, Andreas, Robson, Mark E, Rudin, Charles M, Sanford, Rachel, Seidman, Andrew D, Shah, Ronak, Shaverdian, Narek, Shepherd, Annemarie F, Shin, Jacob Y, Sugarman, Steven, Traina, Tiffany A, Tsai, Chiaojung Jillian, Wu, Abraham J, Xu, Amy J, Yang, Jonathan T, Yeh, Randy, Zhang, Zhigang, Zhi, Wanqing, Eng, Juliana, Seidman, Andrew, Traina, Tiffany

Source: In The Lancet 13-19 January 2024 403(10422):171-182

OlympiAD extended follow-up for overall survival and safety: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer

Authors: Robson, Mark E., Im, Seock-Ah, Senkus, Elzbieta, Xu, Binghe, Domchek, Susan M., Masuda, Norikazu, Delaloge, Suzette, Tung, Nadine, Armstrong, Anne, Dymond, Mike, Fielding, Anitra, Allen, Allison, Conte, Pierfranco

Source: European journal of cancer. 184:39-47

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192375224.0x000001&indx=1&recIds=ETOCvdc_100192375224.0x000001

Clinical Impact of a Rapid Genetic Testing Model for Advanced Prostate Cancer Patients

Authors: Breen, Kelsey E., Symecko, Heather, Spielman, Kelsey, Gebert, Rebecca, Shah, Ibrahim H., Pundock, Stacy, Batson, Melissa, Narayan, Vivek K., Stadler, Zsofia K., Autio, Karen A., Abida, Wassim, Danila, Daniel C., Scher, Howard I., Morris, Michael J., Hamilton, Jada G., Robson, Mark E., Domchek, Susan M., Carlo, Maria I.

Source: Journal of urology. 209(5):918-927

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189918855.0x000001&indx=1&recIds=ETOCvdc_100189918855.0x000001

Summary of the experiences, knowledge, medical management, and family communication of monoallelic MUTYH carriers

Authors: McKenna, Danielle B., Sanchez, Pauleen, Powers, Jacquelyn, Brower, Jamie, Wang, Louise, Mueller, Rebecca, Symecko, Heather, Hamilton, Jada G., Wildman, Temima, Domchek, Susan M., Couch, Fergus J., Garber, Judy E., Offit, Kenneth, Robson, Mark E., Katona, Bryson W.

Source: Journal of genetic counseling. 32(2):342-350

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182212722.0x000001&indx=1&recIds=ETOCvdc_100182212722.0x000001

Gene-based Confirmatory Germline Testing Following Tumor-only Sequencing of Prostate Cancer

Authors: Truong, Hong, Breen, Kelsey, Nandakumar, Subhiksha, Sjoberg, Daniel D., Kemel, Yelena, Mehta, Nikita, Lenis, Andrew T., Reisz, Peter A., Carruthers, Jessica, Benfante, Nicole, Joseph, Vijai, Khurram, Aliya, Gopalan, Anuradha, Fine, Samson W., Reuter, Victor E., Vickers, Andrew J., Birsoy, Ozge, Liu, Ying, Walsh, Michael, Latham, Alicia, Mandelker, Diana, Stadler, Zsofia K., Pietzak, Eugene, Ehdaie, Behfar, Touijer, Karim A., Laudone, Vincent P., Slovin, Susan F., Autio, Karen A., Danila, Daniel C., Rathkopf, Dana E., Eastham, James A., Chen, Yu, Morris, Michael J., Offit, Kenneth, Solit, David B., Scher, Howard I., Abida, Wassim, Robson, Mark E., Carlo, Maria I.

Source: European urology. 83(1):29-38

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177521954.0x000001&indx=1&recIds=ETOCvdc_100177521954.0x000001

“I don’t need any more unknowns hanging over my head”: Views of patients with cancer on variants of uncertain significance and low/moderate risk results from genomic sequencing

Authors: Bombard, Yvonne, Armel, Susan Randall, Aronson, Melyssa, Baxter, Nancy N., Bond, Kenneth, Capo-Chichi, José-Mario, Carroll, June C., Caulfield, Timothy, Clausen, Marc, Clifford, Tammy J., Cohn, Iris, Dhalla, Irfan, Earle, Craig C., Eisen, Andrea, Elser, Christine, Evans, Michael, Glogowski, Emily, Graham, Tracy, Greenfeld, Elena, Hamilton, Jada G., Isaranuwatchai, Wanrudee, Kastner, Monika, Kim, Raymond H., Laupacis, Andreas, Lerner-Ellis, Jordan, Morel, Chantal F., Mujoomdar, Michelle, Noor, Abdul, Offit, Kenneth, Panchal, Seema, Robson, Mark E., Scherer, Stephen W., Scheer, Adena, Schrader, Kasmintan A., Sullivan, Terrence, Thorpe, Kevin E., Shickh, Salma, Mighton, Chloe, Kodida, Rita, Adi-Wauran, Ella, Hirjikaka, Daena, Krishnapillai, Suvetha, Reble, Emma, Sam, Jordan

Source: In Genetics in Medicine December 2023 25(12)

Development of a novel measure of advanced cancer patients’ perceived utility of secondary germline findings from tumor genomic profiling

Authors: Hamilton, Jada G., Shah, Ibrahim H., Salafia, Caroline, Schofield, Elizabeth, Garzon, Margaux Genoff, Cadet, Kechna, Stadler, Zsofia K., Hay, Jennifer L., Offit, Kenneth, Robson, Mark E.

Source: In PEC Innovation December 2023 2

Deep Interactive Learning-based ovarian cancer segmentation of H&E-stained whole slide images to study morphological patterns of BRCA mutation

Authors: Ho, David Joon, Chui, M. Herman, Vanderbilt, Chad M., Jung, Jiwon, Robson, Mark E., Park, Chan-Sik, Roh, Jin, Fuchs, Thomas J.

Source: In Journal of Pathology Informatics 2023 14

Disparities in cancer genetics care by race/ethnicity among pan‐cancer patients with pathogenic germline variants

Authors: Liu, Ying L., Maio, Anna, Kemel, Yelena, Salo‐Mullen, Erin E., Sheehan, Margaret, Tejada, Prince Ray, Trottier, Magan, Arnold, Angela G., Fleischut, Megan Harlan, Latham, Alicia, Carlo, Maria I., Murciano‐Goroff, Yonina R., Walsh, Michael F., Mandelker, Diana, Mehta, Nikita, Bandlamudi, Chaitanya, Arora, Kanika, Zehir, Ahmet, Berger, Michael F., Solit, David B., Aghajanian, Carol, Diaz, Luis A., Robson, Mark E., Brown, Carol L., Offit, Kenneth, Hamilton, Jada G., Stadler, Zsofia K.

Source: Cancer. 128(21):3870-3879

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185441593.0x000001&indx=1&recIds=ETOCvdc_100185441593.0x000001

Targeted BRCA1/2 population screening among Ashkenazi Jewish individuals using a web-enabled medical model: An observational cohort study

Authors: Morgan, Kelly M., Hamilton, Jada G., Symecko, Heather, Kamara, Daniella, Jenkins, Colby, Lester, Jenny, Spielman, Kelsey, Pace, Lydia E., Gabriel, Camila, Levin, Jeffrey D., Tejada, Prince Rainier, Braswell, Anthony, Marcell, Vanessa, Wildman, Temima, Devolder, Bryan, Baum, Robin Camhi, Block, Jeremy N., Fesko, Yuri, Boehler, Kylin, Howell, Victoria, Heitler, Jacob, Robson, Mark E., Nathanson, Katherine L., Tung, Nadine, Karlan, Beth Y., Domchek, Susan M., Garber, Judy E., Offit, Kenneth

Source: In Genetics in Medicine March 2022 24(3):564-575

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

Authors: Nguyen, Bastien, Fong, Christopher, Luthra, Anisha, Smith, Shaleigh A., DiNatale, Renzo G., Nandakumar, Subhiksha, Walch, Henry, Chatila, Walid K., Madupuri, Ramyasree, Kundra, Ritika, Bielski, Craig M., Mastrogiacomo, Brooke, Donoghue, Mark T.A., Boire, Adrienne, Chandarlapaty, Sarat, Ganesh, Karuna, Harding, James J., Iacobuzio-Donahue, Christine A., Razavi, Pedram, Reznik, Ed, Rudin, Charles M., Zamarin, Dmitriy, Abida, Wassim, Abou-Alfa, Ghassan K., Aghajanian, Carol, Cercek, Andrea, Chi, Ping, Feldman, Darren, Ho, Alan L., Iyer, Gopakumar, Janjigian, Yelena Y., Morris, Michael, Motzer, Robert J., O’Reilly, Eileen M., Postow, Michael A., Raj, Nitya P., Riely, Gregory J., Robson, Mark E., Rosenberg, Jonathan E., Safonov, Anton, Shoushtari, Alexander N., Tap, William, Teo, Min Yuen, Varghese, Anna M., Voss, Martin, Yaeger, Rona, Zauderer, Marjorie G., Abu-Rustum, Nadeem, Garcia-Aguilar, Julio, Bochner, Bernard, Hakimi, Abraham, Jarnagin, William R., Jones, David R., Molena, Daniela, Morris, Luc, Rios-Doria, Eric, Russo, Paul, Singer, Samuel, Strong, Vivian E., Chakravarty, Debyani, Ellenson, Lora H., Gopalan, Anuradha, Reis-Filho, Jorge S., Weigelt, Britta, Ladanyi, Marc, Gonen, Mithat, Shah, Sohrab P., Massague, Joan, Gao, Jianjiong, Zehir, Ahmet, Berger, Michael F., Solit, David B., Bakhoum, Samuel F., Sanchez-Vega, Francisco, Schultz, Nikolaus

Source: In Cell 3 February 2022 185(3):563-575

Uptake and acceptability of a mainstreaming model of hereditary cancer multigene panel testing among patients with ovarian, pancreatic, and prostate cancer

Authors: Hamilton, Jada G., Symecko, Heather, Spielman, Kelsey, Breen, Kelsey, Mueller, Rebecca, Catchings, Amanda, Trottier, Magan, Salo-Mullen, Erin E., Shah, Ibrahim, Arutyunova, Anna, Batson, Melissa, Gebert, Rebecca, Pundock, Stacy, Schofield, Elizabeth, Offit, Kenneth, Stadler, Zsofia K., Cadoo, Karen, Carlo, Maria I., Narayan, Vivek, Reiss, Kim A., Robson, Mark E., Domchek, Susan M.

Source: In Genetics in Medicine November 2021 23(11):2105-2113

The role of digital tools in the delivery of genomic medicine: enhancing patient-centered care

Authors: Shickh, Salma, Rafferty, Sara A., Clausen, Marc, Kodida, Rita, Mighton, Chloe, Panchal, Seema, Lorentz, Justin, Ward, Thomas, Watkins, Nicholas, Elser, Christine, Eisen, Andrea, Carroll, June C., Glogowski, Emily, Schrader, Kasmintan A., Lerner-Ellis, Jordan, Kim, Raymond H., Chitayat, David, Shuman, Cheryl, Bombard, Yvonne, Armel, Susan, Aronson, Melyssa, Baxter, Nancy, Bond, Kenneth, Capo-Chichi, José-Mario, Caulfield, Timothy, Clifford, Tammy, Cohn, Iris, Dhalla, Irfan, Earle, Craig C., Evans, Mike, Graham, Tracy, Hamilton, Jada G., Isaranuwatchai, Wanrudee, Kastner, Monika, Laupacis, Andreas, Morel, Chantal F., Mujoomdar, Michelle, Offit, Kenneth, Robson, Mark E., Scheer, Adena, Scherer, Stephen W., Sullivan, Terrence, Thorpe, Kevin E.

Source: In Genetics in Medicine June 2021 23(6):1086-1094

Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer

Authors: Ingle, James N., Kalari, Krishna R., Barman, Poulami, Shepherd, Lois E., Ellis, Matthew J., Goss, Paul E., Buzdar, Aman U., Robson, Mark E., Cairns, Junmei, Carlson, Erin E., Eyman Casey, Abraham, Hoskin, Tanya L., Goodnature, Barbara A., Haddad, Tufia C., Goetz, Matthew P., Weinshilboum, Richard M., Wang, Liewei

Source: Pharmaocogenetics and genomics. 31(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188335774.0x000001&indx=1&recIds=ETOCvdc_100188335774.0x000001

PD-L1 Expression in Metaplastic Breast Carcinoma Using the PD-L1 SP142 Assay and Concordance Among PD-L1 Immunohistochemical Assays

Authors: Grabenstetter, Anne, Jungbluth, Achim A., Frosina, Denise, Hoda, Raza, Dos Anjos, Carlos H., Patil, Sujata, Sevilimedu, Varadan, Weigelt, Britta, Reis-Filho, Jorge S., Zhang, Hong, Traina, Tiffany, Robson, Mark E., Brogi, Edi, Wen, Hannah Y.

Source: American journal of surgical pathology. 45(9):1274-1281

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185885850.0x000001&indx=1&recIds=ETOCvdc_100185885850.0x000001