Final analysis of the phase 1b Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT)

Authors: Chua, Chong Chyn ^{1, 2, 3, 4}, Loo, Sun ^{2, 3, 5}, Fong, Chun Yew ^{6, 7}, Ting, Stephen B. ⁸, Tiong, Ing Soo ^{5, 9}, Fleming, Shaun ⁴, Anstee, Natasha S. ^{2, 10}, Ivey, Adam ⁴, Ashby, Michael ⁴, Teh, Tse-Chieh ^{4, 8}, Reynolds, John ⁴, Roberts, Andrew W. ^{2, 5, 11}, Wei, Andrew H. ^{2, 5, 10, ∗}

Source: In Blood Advances January 2025

Venetoclax dose escalation rapidly activates a BAFF/BCL-2 survival axis in chronic lymphocytic leukemia

Authors: Luo, Meng-Xiao ^{1, 2}, Tan, Tania ^{1, 2}, Trussart, Marie ^{1, 2}, Poch, Annika ^{2, 3}, Nguyen, Thi Minh Hanh ^{2, 3}, Speed, Terence P. ^{1, 2}, Hicks, Damien G. ⁴, Bandala-Sanchez, Esther ^{1, 2}, Peng, Hongke ^{1, 2}, Chappaz, Stéphane ⁵, Slade, Charlotte ^{1, 2}, Utzschneider, Daniel T. ^{2, 3}, Koldej, Rachel M. ^{2, 6}, Ritchie, David ^{2, 6, 7}, Strasser, Andreas ^{1, 2}, Thijssen, Rachel ^{1, 2}, Ritchie, Matthew E. ^{1, 2}, Tam, Constantine S. ^{5, 8}, Lindeman, Geoffrey J. ^{1, 2, 9}, Huang, David C. S. ^{1, 2}, Lew, Thomas E. ^{1, 2, 7, 9}, Anderson, Mary Ann ^{1, 2, 7, 9}, Roberts, Andrew W. ^{1, 2, 7, 9}, Teh, Charis E. ^{1, 2, ∗}, Gray, Daniel H. D. ^{1, 2, ∗∗}

Source: In Blood 26 December 2024 144(26):2748-2761

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

Authors: Diepstraten, Sarah T., Yuan, Yin, La Marca, John E., Young, Savannah, Chang, Catherine, Whelan, Lauren, Ross, Aisling M., Fischer, Karla C., Pomilio, Giovanna, Morris, Rhiannon, Georgiou, Angela, Litalien, Veronique, Brown, Fiona C., Roberts, Andrew W., Strasser, Andreas, Wei, Andrew H., Kelly, Gemma L.

Source: In Cancer Cell 13 May 2024 42(5):850-868

Six-year follow-up and subgroup analyses of a phase 2 trial of venetoclax for del(17p) chronic lymphocytic leukemia

Authors: Stilgenbauer, Stephan, Tausch, Eugen, Roberts, Andrew W., Davids, Matthew S., Eichhorst, Barbara, Hallek, Michael, Hillmen, Peter, Schneider, Christof, Schetelig, Johannes, Böttcher, Sebastian, Kater, Arnon P., Jiang, Yanwen, Boyer, Michelle, Popovic, Relja, Ghanim, Majd T., Moran, Michael, Sinai, Wendy J., Wang, Xifeng, Mukherjee, Nabanita, Chyla, Brenda, Wierda, William G., Seymour, John F.

Source: In Blood Advances 23 April 2024 8(8):1992-2004

Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG

Authors: Loo, Sun, Roberts, Andrew W., Anstee, Natasha S., Kennedy, Glen A., He, Simon, Schwarer, Anthony P., Enjeti, Anoop K., D’Rozario, James, Marlton, Paula, Bilmon, Ian A., Taper, John, Cull, Gavin, Tiley, Campbell, Verner, Emma, Hahn, Uwe, Hiwase, Devendra K., Iland, Harry J., Murphy, Nick, Ramanathan, Sundra, Reynolds, John, Ong, Doen Ming, Tiong, Ing Soo, Wall, Meaghan, Murray, Michael, Rawling, Tristan, Leadbetter, Joanna, Rowley, Leesa, Latimer, Maya, Yuen, Sam, Ting, Stephen B., Fong, Chun Yew, Morris, Kirk, Bajel, Ashish, Seymour, John F., Levis, Mark J., Wei, Andrew H.

Source: In Blood 7 December 2023 142(23):1960-1971

Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells

Authors: Teh, Charis E., Peng, Hongke, Luo, Meng-Xiao, Tan, Tania, Trussart, Marie, Howson, Lauren J., Chua, Chong Chyn, Muttiah, Christine, Brown, Fiona, Ritchie, Matthew E., Wei, Andrew H., Roberts, Andrew W., Bryant, Vanessa L., Anderson, Mary Ann, Lindeman, Geoffrey J., Huang, David C. S., Thijssen, Rachel, Gray, Daniel H. D.

Source: In Blood Advances 27 June 2023 7(12):2733-2745

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Authors: Moujalled, Donia M. ^∗, Brown, Fiona C. ^∗, Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.

Source: In Blood 9 February 2023 141(6):634-644

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Authors: Thijssen, Rachel, Tian, Luyi, Anderson, Mary Ann, Flensburg, Christoffer, Jarratt, Andrew, Garnham, Alexandra L., Jabbari, Jafar S., Peng, Hongke, Lew, Thomas E., Teh, Charis E., Gouil, Quentin, Georgiou, Angela, Tan, Tania, Djajawi, Tirta M., Tam, Constantine S., Seymour, John F., Blombery, Piers, Gray, Daniel H.D., Majewski, Ian J., Ritchie, Matthew E., Roberts, Andrew W., Huang, David C.S.

Source: In Blood 17 November 2022 140(20):2127-2141

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL

Authors: Blombery, Piers, Lew, Thomas E., Dengler, Michael A., Thompson, Ella R., Lin, Victor S., Chen, Xiangting, Nguyen, Tamia, Panigrahi, Ashish, Handunnetti, Sasanka M., Carney, Dennis A., Westerman, David A., Tam, Constantine S., Adams, Jerry M., Wei, Andrew H., Huang, David C.S., Seymour, John F., Roberts, Andrew W., Anderson, Mary Ann

Source: Blood. 139(8):1198-1207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183249366.0x000001&indx=1&recIds=ETOCvdc_100183249366.0x000001

Germline MBD4 deficiency causes a multi-tumor predisposition syndrome

Authors: Palles, Claire, West, Hannah D., Chew, Edward, Galavotti, Sara, Flensburg, Christoffer, Grolleman, Judith E., Jansen, Erik A.M., Curley, Helen, Chegwidden, Laura, Arbe-Barnes, Edward H., Lander, Nicola, Truscott, Rebekah, Pagan, Judith, Bajel, Ashish, Sherwood, Kitty, Martin, Lynn, Thomas, Huw, Georgiou, Demetra, Fostira, Florentia, Goldberg, Yael, Adams, David J., van der Biezen, Simone A.M., Christie, Michael, Clendenning, Mark, Thomas, Laura E., Deltas, Constantinos, Dimovski, Aleksandar J., Dymerska, Dagmara, Lubinski, Jan, Mahmood, Khalid, van der Post, Rachel S., Sanders, Mathijs, Weitz, Jürgen, Taylor, Jenny C., Turnbull, Clare, Vreede, Lilian, van Wezel, Tom, Whalley, Celina, Arnedo-Pac, Claudia, Caravagna, Giulio, Cross, William, Chubb, Daniel, Frangou, Anna, Gruber, Andreas J., Kinnersley, Ben, Noyvert, Boris, Church, David, Graham, Trevor, Houlston, Richard, Lopez-Bigas, Nuria, Sottoriva, Andrea, Wedge, David, Jenkins, Mark A., Kuiper, Roland P., Roberts, Andrew W., Cheadle, Jeremy P., Ligtenberg, Marjolijn J.L., Hoogerbrugge, Nicoline, Koelzer, Viktor H., Rivas, Andres Dacal, Winship, Ingrid M., Ponte, Clara Ruiz, Buchanan, Daniel D., Power, Derek G., Green, Andrew, Tomlinson, Ian P.M., Sampson, Julian R., Majewski, Ian J., de Voer, Richarda M.

Source: American journal of human genetics. 109(5):953-960

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163384397.0x000001&indx=1&recIds=ETOCvdc_100163384397.0x000001

Geographic differences in community oncology provider and practice location characteristics in the central United States

Authors: Ellis, Shellie D., Thompson, Jeffrey A., Boyd, Samuel S., Roberts, Andrew W., Charlton, Mary, Brooks, Joanna Veazey, Birken, Sarah A., Wulff‐Burchfield, Elizabeth, Amponsah, Jonah, Petersen, Shariska, Kinney, Anita Y., Ellerbeck, Edward

Source: Journal of rural health. 38(4):865-875

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100162352086.0x000001&indx=1&recIds=ETOCvdc_100162352086.0x000001

Trajectories of glycemic control with clinical pharmacy specialist management of veterans with type 2 diabetes

Authors: Grabarczyk, Ted R., Roberts, Andrew W., Mahnken, Jonathan D., Grauer, Dennis

Source: Research in social and administrative pharmacy. 18(6):3064-3071

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161073928.0x000001&indx=1&recIds=ETOCvdc_100161073928.0x000001

Classification of myeloid neoplasms/acute leukemia: Global perspectives and the international consensus classification approach

Authors: Arber, Daniel A., Hasserjian, Robert P., Orazi, Attilio, Mathews, Vikram, Roberts, Andrew W., Schiffer, Charles A., Roug, Anne Stidsholt, Cazzola, Mario, Döhner, Hartmut, Tefferi, Ayalew

Source: American journal of hematology. 97(5):514-518

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151805546.0x000001&indx=1&recIds=ETOCvdc_100151805546.0x000001

Many Medicare Beneficiaries Do Not Fill High-Price Specialty Drug Prescriptions

Authors: Dusetzina, Stacie B., Huskamp, Haiden A., Rothman, Russell L., Pinheiro, Laura C., Roberts, Andrew W., Shah, Nilay D., Walunas, Theresa L., Wood, William A., Zuckerman, Autumn D., Zullig, Leah L.

Source: Health affairs. 41(4):487-496

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629052213&indx=1&recIds=ETOCRN629052213

Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies

Authors: Tam, Constantine S. ^*, Dimopoulos, Meletios, Garcia-Sanz, Ramon, Trotman, Judith, Opat, Stephen, Roberts, Andrew W., Owen, Roger, Song, Yuqin, Xu, Wei, Zhu, Jun, Li, Jianyong, Qiu, Lugui, D'Sa, Shirley, Jurczak, Wojciech, Cull, Gavin, Marlton, Paula, Gottlieb, David, Munoz, Javier, Phillips, Tycel, Du, Chenmu, Ji, Meng, Zhou, Lei, Guo, Haiyi, Zhu, Hongjie, Chan, Wai Y., Cohen, Aileen, Novotny, William, Huang, Jane, Tedeschi, Alessandra

Source: In Blood Advances 22 February 2022 6(4):1296-1308

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors

Authors: Thompson, Ella R. ^*, Nguyen, Tamia, Kankanige, Yamuna, Markham, John F., Anderson, Mary Ann, Handunnetti, Sasanka M., Thijssen, Rachel, Yeh, Paul Sung-Hao, Tam, Constantine S., Seymour, John F., Roberts, Andrew W., Westerman, David A., Blombery, Piers

Source: In Blood Advances 25 January 2022 6(2):503-508

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition

Authors: Lew, Thomas E. ^*, Lin, Victor S. ^*, Cliff, Edward R., Blombery, Piers, Thompson, Ella R., Handunnetti, Sasanka M., Westerman, David A., Kuss, Bryone J., Tam, Constantine S., Huang, David C.S., Seymour, John F., Roberts, Andrew W., Anderson, Mary Ann ^*

Source: In Blood Advances 26 October 2021 5(20):4054-4058

BCL2 and MCL1 inhibitors for hematologic malignancies

Authors: Roberts, Andrew W., Wei, Andrew H., Huang, David C.S.

Source: In Blood 30 September 2021 138(13):1120-1136

Efficacy of venetoclax plus rituximab for relapsed CLL: 5-year follow-up of continuous or limited- duration therapy

Authors: Ma, Shuo ^*, Seymour, John F. ^{*, *}, Brander, Danielle M., Kipps, Thomas J., Choi, Michael Y., Anderson, Mary Ann, Humphrey, Kathryn, Al Masud, Abdullah, Pesko, John, Nandam, Ruby, Salem, Ahmed Hamed, Chyla, Brenda, Arzt, Jennifer, Jacobson, Amanda, Kim, Su Young, Roberts, Andrew W.

Source: In Blood 9 September 2021 138(10):836-846

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Authors: Thijssen, Rachel ^*, Diepstraten, Sarah T. ^*, Moujalled, Donia ^*, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S. ^****, Brown, Fiona C. ^***, Kelly, Gemma L. ^**, Wei, Andrew H.

Source: In Blood 20 May 2021 137(20):2721-2735