Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks

Authors: Mabel Minji Jung, Siqi Shen, Giovanni A. Botten, Thomas Olender, Koichi R. Katsumura, Kirby D. Johnson, Alexandra A. Soukup, Peng Liu, Qingzhou Zhang, Zena D. Jensvold, Peter W. Lewis, Robert A. Beagrie, Jason K.K. Low, Lihua Yang, Joel P. Mackay, Lucy A. Godley, Marjorie Brand, Jian Xu, Sunduz Keles, Emery H. Bresnick

Source: The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)

Subject Terms: Genetics, Hematology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/0a1d39017eb14888912ea7fe69a08151

Reactivation of a developmentally silenced embryonic globin gene

Authors: Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb63b89aa9ae4973bb86a64000a9ce01

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

Authors: Damien J. Downes, Robert A. Beagrie, Matthew E. Gosden, Jelena Telenius, Stephanie J. Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q. Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel Roberts, Arun Shivalingam, Afaf El-Sagheer, A. Marieke Oudelaar, Tom Brown, Veronica J. Buckle, James O. J. Davies, Jim R. Hughes

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0197837fb40c491eb660e62c1a29c968

Dynamics of the 4D genome during in vivo lineage specification and differentiation

Authors: A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a68d72c62d2d48089c3be17071099d2e

Scalable in vitro production of defined mouse erythroblasts

Authors: Helena S. Francis, Caroline L. Harold, Robert A. Beagrie, Andrew J. King, Matthew E. Gosden, Joseph W. Blayney, Danuta M. Jeziorska, Christian Babbs, Douglas R. Higgs, Mira T. Kassouf

Source: PLoS ONE, Vol 17, Iss 1 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741028/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/baa5ea583f194f4d8f3af8a8cc7078c9

Scalable in vitro production of defined mouse erythroblasts.

Authors: Helena S Francis, Caroline L Harold, Robert A Beagrie, Andrew J King, Matthew E Gosden, Joseph W Blayney, Danuta M Jeziorska, Christian Babbs, Douglas R Higgs, Mira T Kassouf

Source: PLoS ONE, Vol 17, Iss 1, p e0261950 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261950&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/db43e7529cdc4c179b2fcd49af770d85