Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions

Authors: Xiong, Emily H. ^{1, 6}, Zhang, Xiang ^{2, 6}, Yan, Huijuan ³, Ward, Henry N. ^{2, 4}, Lin, Zhen-Yuan ⁵, Wong, Cassandra J. ⁵, Fu, Ci ¹, Gingras, Anne-Claude ^{1, 5}, Noble, Suzanne M. ³, Robbins, Nicole ¹, Myers, Chad L. ^{2, 4, ∗}, Cowen, Leah E. ^{1, 7, ∗∗}

Source: In Cell Reports 27 August 2024 43(8)

Interdisciplinary approaches for the discovery of novel antifungals

Authors: Yiu, Bonnie, Robbins, Nicole, Cowen, Leah E.

Source: In Trends in Molecular Medicine August 2024 30(8):723-735

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity

Authors: Puumala, Emily, Sychantha, David, Lach, Elizabeth, Reeves, Shawn, Nabeela, Sunna, Fogal, Meea, Nigam, AkshatKumar, Johnson, Jarrod W., Aspuru-Guzik, Alán, Shapiro, Rebecca S., Uppuluri, Priya, Kalyaanamoorthy, Subha, Magolan, Jakob, Whitesell, Luke, Robbins, Nicole, Wright, Gerard D., Cowen, Leah E.

Source: In Cell Chemical Biology 18 April 2024 31(4):760-775

Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathogen Candida Albicans

Authors: Robbins, Nicole, Ketela, Troy, Kim, Sang Hu, Cowen, Leah E.

Source: Methods in molecular biology. 2658:145-168

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633170332&indx=1&recIds=ETOCRN633170332

Bacterial‐fungal interactions and their impact on microbial pathogenesis

Authors: MacAlpine, Jessie, Robbins, Nicole, Cowen, Leah E.

Source: Molecular ecology. 32(10):2565-2581

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182058552.0x000001&indx=1&recIds=ETOCvdc_100182058552.0x000001

Expanding pediatric services to include adults during the COVID-19 pandemic

Authors: Gandora, Sara, Robbins, Nicole, Mulkey, David

Source: Journal of pediatric nursing. 68:68-73

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179844666.0x000001&indx=1&recIds=ETOCvdc_100179844666.0x000001

Roles of Hsp90 in Candida albicans morphogenesis and virulence

Authors: Robbins, Nicole, Cowen, Leah E

Source: In Current Opinion in Microbiology October 2023 75

Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity

Authors: Iyer, Kali R., Li, Sheena C., Revie, Nicole M., Lou, Jennifer W., Duncan, Dustin, Fallah, Sara, Sanchez, Hiram, Skulska, Iwona, Ušaj, Mojca Mattiazzi, Safizadeh, Hamid, Larsen, Brett, Wong, Cassandra, Aman, Ahmed, Kiyota, Taira, Yoshimura, Mami, Kimura, Hiromi, Hirano, Hiroyuki, Yoshida, Minoru, Osada, Hiroyuki, Gingras, Anne-Claude, Andes, David R., Shapiro, Rebecca S., Robbins, Nicole, Mazhab-Jafari, Mohammad T., Whitesell, Luke, Yashiroda, Yoko, Boone, Charles, Cowen, Leah E.

Source: In Cell Chemical Biology 20 July 2023 30(7):795-810

Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments

Authors: Lee, Yunjin ^{1, 2}, Hossain, Saif ^{1, 2}, MacAlpine, Jessie ¹, Robbins, Nicole ¹, Cowen, Leah E. ^{1, 3, ∗}

Source: In iScience 17 March 2023 26(3)

Antifungal discovery

Authors: Robbins, Nicole, Cowen, Leah E

Source: In Current Opinion in Microbiology October 2022 69

Downregulation of Essential Genes in the Fungal Pathogen Candida auris

Authors: Iyer, Kali R., Kim, Sang Hu, Robbins, Nicole, Cowen, Leah E.

Source: Methods in molecular biology. 2517:111-128

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629543221&indx=1&recIds=ETOCRN629543221

Functional analysis of the Candida albicans kinome reveals Hrr25 as a regulator of antifungal susceptibility

Authors: Lee, Yunjin ¹, Liston, Sean D. ¹, Lee, Dongyeob ¹, Robbins, Nicole ¹, Cowen, Leah E. ^{1, 2, ∗}

Source: In iScience 17 June 2022 25(6)

The role of Candida albicans stress response pathways in antifungal tolerance and resistance

Authors: Iyer, Kali R., Robbins, Nicole, Cowen, Leah E.

Source: In iScience 18 March 2022 25(3)

The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans

Authors: Case, Nicola T., Duah, Kwamaa, Larsen, Brett, Wong, Cassandra J., Gingras, Anne-Claude, O’Meara, Teresa R., Robbins, Nicole, Veri, Amanda O., Whitesell, Luke, Cowen, Leah E.

Source: In Cell Reports 24 August 2021 36(8)

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Authors: Lee, Yunjin, Puumala, Emily, Robbins, Nicole, Cowen, Leah E.

Source: Chemical reviews. 121(6):3390-3411

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631416103&indx=1&recIds=ETOCRN631416103

Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata

Authors: Robbins, Nicole, Cowen, Leah E.

Source: Current biology. 31(23):R1520-R1523

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152360476.0x000001&indx=1&recIds=ETOCvdc_100152360476.0x000001

The GARP complex is required for filamentation in Candida albicans.

Authors: Hossain, Saif¹, Robbins, Nicole¹, Cowen, Leah E.¹, leah.cowen@utoronto.ca

Source: Genetics; Dec2022, Vol. 222 Issue 4, p1-11, 11p

Antifungal drug resistance: evolution, mechanisms and impact

Authors: Revie, Nicole M, Iyer, Kali R, Robbins, Nicole, Cowen, Leah E

Source: In Current Opinion in Microbiology October 2018 45:70-76

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Authors: Whitesell, Luke, Robbins, Nicole, Huang, David, McLellan, Catherine, Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle, Nation, Catherine, Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin, Krysan, Damian, Lindquist, Susan, Porco, John, Tatu, Utpal, Brown, Lauren, Pizarro, Juan, Cowen, Leah

Source: Nature communications. 10(1):1-17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111632519.0x000001&indx=1&recIds=ETOCvdc_100111632519.0x000001

The Hsp90 Chaperone Network Modulates Candida Virulence Traits

Authors: O’Meara, Teresa R., Robbins, Nicole, Cowen, Leah E.

Source: In Trends in Microbiology October 2017 25(10):809-819