A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses

Authors: Kirsten L. Todd, Junyun Lai, Kevin Sek, Yu-Kuan Huang, Dane M. Newman, Emily B. Derrick, Hui-Fern Koay, Dat Nguyen, Thang X. Hoang, Emma V. Petley, Cheok Weng Chan, Isabelle Munoz, Imran G. House, Joel N. Lee, Joelle S. Kim, Jasmine Li, Junming Tong, Maria N. de Menezes, Christina M. Scheffler, Kah Min Yap, Amanda X. Y. Chen, Phoebe A. Dunbar, Brandon Haugen, Ian A. Parish, Ricky W. Johnstone, Phillip K. Darcy, Paul A. Beavis

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b9c76314c12142099494e8759d06a025

PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

Authors: Tirta M. Djajawi, Lizzy Pijpers, Akash Srivaths, David Chisanga, Kok Fei Chan, Simon J. Hogg, Liam Neil, Sarahi Mendoza Rivera, Nenad Bartonicek, Sarah L. Ellis, Terry C.C. Lim Kam Sian, Pouya Faridi, Yang Liao, Bhupinder Pal, Andreas Behren, Wei Shi, Stephin J. Vervoort, Ricky W. Johnstone, Conor J. Kearney

Source: Cell Reports, Vol 43, Iss 3, Pp 113831- (2024)

Subject Terms: CP: Cancer, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724001591; https://doaj.org/toc/2211-1247

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

Authors: Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis

Source: Cell Reports, Vol 43, Iss 2, Pp 113793- (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724001219; https://doaj.org/toc/2211-1247

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A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax

Authors: Hansen J. Kosasih, Gerry Healey, Margs S. Brennan, Stefan Bjelosevic, Teresa Sadras, Fatimah B. Jalud, Tasnia Ibnat, Ashley P. Ng, Chelsea Mayoh, Jie Mao, Gabor Tax, Louise E. A. Ludlow, Ricky W. Johnstone, Marco J. Herold, Seong L. Khaw, Charles E. deBock, Paul G. Ekert

Source: HemaSphere, Vol 8, Iss 2, Pp n/a-n/a (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/aa411753f44943afbf2d90c36c201409

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

Authors: Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis

Source: Cell Reports, Vol 42, Iss 8, Pp 113014- (2023)

Subject Terms: CP: Cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723010252; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/36f8c10bf54b436e8b3737f736a4464b

P1212: RATIONALLY DESIGNED CHIMERIC PI3K-BET BROMODOMAIN INHIBITORS ELICIT CURATIVE RESPONSES IN MYC-DRIVEN LYMPHOMA

Authors: Danielle H. Oh, Xiao MA, Jackson He, Conor Kearney, Simon J. Hogg, Andrea Newbold, Peter Fraser, Ian G. Jennings, Daniella Brasacchio, Olivia Susanto, Chun Yew Fong, Mark A. Dawson, Emily Gruber, Lev Kats, Ricky W. Johnstone, Philip E. Thompson, Jake Shortt

Source: HemaSphere, Vol 7, p e4369469 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971744.43694.69; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/93d888a242994fae978e83427bf5bb01

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Authors: Mayura V. Wagle, Stephin J. Vervoort, Madison J. Kelly, Willem Van Der Byl, Timothy J. Peters, Ben P. Martin, Luciano G. Martelotto, Simone Nüssing, Kelly M. Ramsbottom, James R. Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A. Miosge, Debbie R. Howard, Renee Gloury, Sarah S. Gabriel, Daniel T. Utzschneider, Jane Oliaro, Jonathan D. Powell, Fabio Luciani, Joseph A. Trapani, Ricky W. Johnstone, Axel Kallies, Christopher C. Goodnow, Ian A. Parish

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Authors: Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El-Ayoubi, Jezrael L. Revalde, Janith A. Seneviratne, Belamy B. Cheung, Laurence C. Cheung, Rishi S. Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M. Arndt, Richard B. Lock, Ricky W. Johnstone, Andrei V. Gudkov, Katerina V. Gurova, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Klaartje Somers

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: KMT2A-rearranged leukemia, infant leukemia, curaxin CBL0137, histone deacetylase inhibition, chromatin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.863329/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/030ef39db2a746f68cb7bcf2cf823422

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

Authors: Isabella Y. Kong, Joel S. Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A. Knight, Ylva E. Bergman, Simon J. Hogg, Hendrik Falk, Brendon J. Monahan, Paul A. Stupple, Ian P. Street, Susanne Heinzel, Philippe Bouillet, Ricky W. Johnstone, Philip D. Hodgkin, Stephin J. Vervoort, Edwin D. Hawkins

Source: Cell Reports, Vol 33, Iss 3, Pp 108290- (2020)

Subject Terms: B cells, cellular immunology, epigenetics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720312791; https://doaj.org/toc/2211-1247

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Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Authors: Madison J. Kelly, Joan So, Amy J. Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D. Gearhart, Vivian J. Bardwell, Ricky W. Johnstone, Stephin J. Vervoort, Lev M. Kats

Source: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a2e6698ad2f4471982b9c6935cb918b2

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Authors: Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Authors: Andrew J. Freeman, Stephin J. Vervoort, Kelly M. Ramsbottom, Madison J. Kelly, Jessica Michie, Lizzy Pijpers, Ricky W. Johnstone, Conor J. Kearney, Jane Oliaro

Source: Cell Reports, Vol 28, Iss 11, Pp 2784-2794.e5 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719310502; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/099c8c10b0f84d1e805bd39d02fcff16

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Authors: Marcus Lefebure, Richard W. Tothill, Elizabeth Kruse, Edwin D. Hawkins, Jake Shortt, Geoffrey M. Matthews, Gareth P. Gregory, Benjamin P. Martin, Madison J. Kelly, Izabela Todorovski, Maria A. Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, Micah D. Gearhart, Vivian J. Bardwell, Ross A. Dickins, Ross D. Hannan, Anthony T. Papenfuss, Ricky W. Johnstone

Source: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0c3aa501a43e4f4f934206118b33d4f2

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Authors: Simon J. Hogg, Stephin J. Vervoort, Sumit Deswal, Christopher J. Ott, Jason Li, Leonie A. Cluse, Paul A. Beavis, Phillip K. Darcy, Benjamin P. Martin, Andrew Spencer, Anna K. Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E. Bradner, Johannes Zuber, Jake Shortt, Ricky W. Johnstone

Source: Cell Reports, Vol 18, Iss 9, Pp 2162-2174 (2017)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717301766; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/7831449cccec4074b10637bac98536e0

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Authors: Liz J. Valente, Brandon J. Aubrey, Marco J. Herold, Gemma L. Kelly, Lina Happo, Clare L. Scott, Andrea Newbold, Ricky W. Johnstone, David C.S. Huang, Lyubomir T. Vassilev, Andreas Strasser

Source: Cell Reports, Vol 14, Iss 8, Pp 1858-1866 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716300377; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/52a55445e4b54bfcb568bd86fe2147c2

The Drug Vehicle and Solvent N-Methylpyrrolidone Is an Immunomodulator and Antimyeloma Compound

Authors: Jake Shortt, Andy K. Hsu, Benjamin P. Martin, Karen Doggett, Geoffrey M. Matthews, Maria A. Doyle, Jason Ellul, Tina E. Jockel, Daniel M. Andrews, Simon J. Hogg, Andrea Reitsma, David Faulkner, P. Leif Bergsagel, Marta Chesi, Joan K. Heath, William A. Denny, Philip E. Thompson, Paul J. Neeson, David S. Ritchie, Grant A. McArthur, Ricky W. Johnstone

Source: Cell Reports, Vol 7, Iss 4, Pp 1009-1019 (2014)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714002952; https://doaj.org/toc/2211-1247

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Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Authors: Michaela Waibel, Vanessa S. Solomon, Deborah A. Knight, Rachael A. Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith C.S. Sia, Lauryn S. Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B. Ramsey, Sara C. Meyer, Megumi Takiguchi, Ross A. Dickins, Ross Levine, Jacques Ghysdael, Mark A. Dawson, Richard B. Lock, Charles G. Mullighan, Ricky W. Johnstone

Source: Cell Reports, Vol 5, Iss 4, Pp 1047-1059 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713006372; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/038b13b134c84948ae45ebf210800b23

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

Authors: Piers Blombery, Ella R. Thompson, Kate Jones, Gisela Mir Arnau, Stephen Lade, John F. Markham, Jason Li, Anand Deva, Ricky W. Johnstone, Amit Khot, H. Miles Prince, David Westerman

Source: Haematologica, Vol 101, Iss 9 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7836; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/f6cbd610e341466eb56bd57bc3eca803

Overview of Histone Deacetylase Inhibitors in Haematological Malignancies

Authors: H. Miles Prince, Simon Harrison, Mark J. Bishton, Ricky W. Johnstone, Michael Dickinson

Source: Pharmaceuticals, Vol 3, Iss 8, Pp 2674-2688 (2010)

Subject Terms: Histone deacetylase inhibitors, Clinical studies, Haematology, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.mdpi.com/1424-8247/3/8/2674/; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/3dc18154665747c2bc354fc51f2437e6

The Role of p202 in Regulating Hematopoietic Cell Proliferation and Differentiation.

Authors: Louise E. Ludlow, Louise E. Purton, Kim Klarmann, Daniel J. Gough, Linda L. Hii, Joseph A. Trapani, Jonathan R. Keller, Christopher J.P. Clarke, Ricky W. Johnstone

Source: Journal of Interferon & Cytokine Research; Jan2008, Vol. 28 Issue 1, p5-11, 7p

Subject Terms: PROTEINS, INTERFERONS, CELL proliferation, CELL differentiation