Getting the dose right using physiologically-based pharmacokinetic modeling: dexamethasone to prevent post-extubation stridor in children as proof of concept

Authors: Joyce E. M. van der Heijden, Marika de Hoop-Sommen, Noa Hoevenaars, Jolien J. M. Freriksen, Koen Joosten, Rick Greupink, Saskia N. de Wildt

Source: Frontiers in Pediatrics, Vol 12 (2024)

Subject Terms: dexamethasone, modeling & simulation, pediatrics, pharmacokinetics, physiologically-based pharmacokinetic modeling, special populations, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2024.1416440/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/171193c1949d4eec9eea2f643a4373e1

Placental transfer of tofacitinib in the ex vivo dual-side human placenta perfusion model

Authors: Gaby A.M. Eliesen, Milou Fransen, Hedwig van Hove, Petra H.H. van den Broek, Rick Greupink

Source: Current Research in Toxicology, Vol 6, Iss , Pp 100149- (2024)

Subject Terms: Cotyledon perfusion, Drug disposition, Drug safety, Reproductive toxicology, Fetal drug exposure, Pharmacokinetics, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666027X24000021; https://doaj.org/toc/2666-027X

Access URL: https://doaj.org/article/0dd656059de5435ba0d70e631e0990d4

Pragmatic physiologically-based pharmacokinetic modeling to support clinical implementation of optimized gentamicin dosing in term neonates and infants: proof-of-concept

Authors: Marika A. de Hoop-Sommen, Joyce E. M. van der Heijden, Jolien J. M. Freriksen, Rick Greupink, Saskia N. de Wildt

Source: Frontiers in Pediatrics, Vol 11 (2023)

Subject Terms: term neonate, infant, PBPK, model-informed dose, gentamicin, pediatric pharmacology, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2023.1288376/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/b9186a5e5a144cfead80e41d4eccd928

Demystifying physiologically based pharmacokinetic modelling among non-modelers towards model-informed medicine use in under-served populations. [version 1; peer review: 3 approved, 2 approved with reservations]

Authors: Jolien Freriksen, Susan Cole, Joyce van der Heijden, Karen R Yeo, Trevor Johnson, Essam Kerwash, Marika de Hoop-Sommen, Rick Greupink, Janet Nooney, Saskia de Wildt, Ping Zhao

Source: Gates Open Research, Vol 7 (2023)

Subject Terms: Dosing, Under-served Populations, Model-informed Drug Development, Pediatrics, Pharmacokinetics, Pregnancy, eng, Medicine

File Description: electronic resource

Relation: https://gatesopenresearch.org/articles/7-128/v1; https://doaj.org/toc/2572-4754

Access URL: https://doaj.org/article/428afdfe2659434fa3aede8712f96746

Targeting 15d-Prostaglandin J2 to Hepatic Stellate Cells: Two Options Evaluated.

Authors: Werner Hagens, Adriana Mattos, Rick Greupink, Alie de Jager-Krikken, Catharina Reker-Smit, AnneMiek van Loenen-Weemaes, Annette Gouw, Klaas Poelstra, Leonie Beljaars

Source: Pharmaceutical Research; Mar2007, Vol. 24 Issue 3, p566-574, 9p

Subject Terms: PROSTAGLANDINS, APOPTOSIS, FIBROSIS, LIVER

Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptors may Represent a Target for the Selective Delivery of Mycophenolic Acid to Fibrogenic Cells.

Authors: Rick Greupink, Hester Bakker, Harry van Goor, Martin de Borst, Leonie Beljaars, Klaas Poelstra

Source: Pharmaceutical Research; Aug2006, Vol. 23 Issue 8, p1827-1834, 8p

Subject Terms: INSULIN, MANNOSE, CELLS, HORMONES