Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging

Authors: Strittmatter, Nicole, Richards, Frances M., Race, Alan M., Ling, Stephanie, Sutton, Daniel, Nilsson, Anna, Wallez, Yann, Barnes, Jennifer, Maglennon, Gareth, Gopinathan, Aarthi

Source: Analytical chemistry. 94(3):1795-1803

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628569380&indx=1&recIds=ETOCRN628569380

Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancerElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2nr00864e

Authors: Popov, Andrea Bistrović, Melle, Francesca, Linnane, Emily, González-López, Cristina, Ahmed, Ishtiaq, Parshad, Badri, Franck, Christoph O., Rahmoune, Hassan, Richards, Frances M., Muñoz-Espín, Daniel, Jodrell, Duncan I., Fairen-Jimenez, David, Fruk, Ljiljana

Source: Nanoscale. 14(17):6656-6669

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148857441.0x000001&indx=1&recIds=ETOCvdc_100148857441.0x000001

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response

Authors: Biasci, Daniele, Smoragiewicz, Martin, Connell, Claire M., Wang, Zhikai, Gao, Ya, Thaventhiran, James E. D., Basu, Bristi, Magiera, Lukasz, Johnson, T. Isaac, Bax, Lisa, Gopinathan, Aarthi, Isherwood, Christopher, Gallagher, Ferdia A., Pawula, Maria, Hudecova, Irena, Gale, Davina, Rosenfeld, Nitzan, Barmpounakis, Petros, Popa, Elizabeta Cristina, Brais, Rebecca, Godfrey, Edmund, Mirk, Fraz, Richards, Frances M., Fearon, Douglas T., Janowitz, Tobias, Jodrell, Duncan I.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Nov . 117(46), 28960-28970.

Access URL: https://www.jstor.org/stable/26971021

Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach

Authors: Johnson, Timothy I., Minteer, Christopher J., Kottmann, Daniel, Dunlop, Charles R., Fernández, Sandra Bernaldo de Quirós, Carnevalli, Larissa S., Wallez, Yann, Lau, Alan, Richards, Frances M., Jodrell, Duncan I.

Source: In EBioMedicine June 2021 68

A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown

Authors: Teplensky, Michelle H., Fantham, Marcus, Poudel, Chetan, Hockings, Colin, Lu, Meng, Guna, Alina, Aragones-Anglada, Marta, Moghadam, Peyman Z., Li, Peng, Farha, Omar K., Bernaldo de Quirós Fernández, Sandra, Richards, Frances M., Jodrell, Duncan I., Kaminski Schierle, Gabriele, Kaminski, Clemens F., Fairen-Jimenez, David

Source: In Chem 14 November 2019 5(11):2926-2941

SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer

Authors: Ramu, Iswarya, Buchholz, Sören M., Patzak, Melanie S., Goetze, Robert G., Singh, Shiv K., Richards, Frances M., Jodrell, Duncan I., Sipos, Bence, Ströbel, Philipp, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht

Source: In EBioMedicine October 2019 48:161-168

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

Authors: Patzak, Melanie S., Kari, Vijayalakshmi, Patil, Shilpa, Hamdan, Feda H., Goetze, Robert G., Brunner, Marius, Gaedcke, Jochen, Kitz, Julia, Jodrell, Duncan I., Richards, Frances M., Pilarsky, Christian, Gruetzmann, Robert, Rümmele, Petra, Knösel, Thomas, Hessmann, Elisabeth, Ellenrieder, Volker, Johnsen, Steven A., Neesse, Albrecht

Source: In EBioMedicine February 2019 40:394-405

Development of In Vitro Co-Culture Model in Anti-Cancer Drug Development Cascade

Authors: Xu, Ruiling, Richards, Frances M.

Source: Combinatorial chemistry & high throughput screening. 20(5):451-457

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077933148.0x000001&indx=1&recIds=ETOCvdc_100077933148.0x000001

Understanding the Complexity of Porous Graphitic Carbon (PGC) Chromatography: Modulation of Mobile-Stationary Phase Interactions Overcomes Loss of Retention and Reduces Variability

Authors: Bapiro, Tashinga E., Richards, Frances M., Jodrell, Duncan I.

Source: Analytical chemistry. 88(12):6190-6194

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606966660&indx=1&recIds=ETOCRN606966660

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

Authors: Watts, Ciorsdaidh A., Richards, Frances M., Bender, Andreas, Bond, Peter J., Korb, Oliver, Kern, Oliver, Riddick, Michelle, Owen, Paul, Myers, Rebecca M., Raff, Jordan, Gergely, Fanni, Jodrell, Duncan I., Ley, Steven V.

Source: In Chemistry & Biology 21 November 2013 20(11):1399-1410

Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

Authors: Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130624111.0x000001&indx=1&recIds=ETOCvdc_100130624111.0x000001

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

Authors: Latif, Farida, Tory, Kalman, Gnarra, James, Yao, Masahiro, Duh, Fuh-Mei, Orcutt, Mary Lou, Stackhouse, Thomas, Kuzmin, Igor, Modi, William, Geil, Laura, Schmidt, Laura, Zhou, Fangwei, Li, Hua, Wei, Ming Hui, Chen, Fan, Glenn, Gladys, Choyke, Peter, Walther, McClellan M., Weng, Yongkai, Duan, Dah-Shuhn R., Dean, Michael, Glavač, Damjan, Richards, Frances M., Crossey, Paul A., Ferguson-Smith, Malcolm A., Le Paslier, Denis, Chumakov, Iiya, Cohen, Daniel, Chinault, A. Craig, Maher, Eamonn R., Linehan, W. Marston, Zbar, Berton, Lerman, Michael I.

Source: Science, 1993 May . 260(5112), 1317-1320.

Access URL: https://www.jstor.org/stable/2881766

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

Authors: Berghmans, Stéphane, Butler, Paul, Goldsmith, Paul, Waldron, Gareth, Gardner, Iain, Golder, Zoe, Richards, Frances M., Kimber, Gillian, Roach, Alan, Alderton, Wendy, Fleming, Angeleen

Source: In Journal of Pharmacological and Toxicological Methods 2008 58(1):59-68

Anti-tumor effect of an oligosaccharide API in a Genetically Engineered Mouse- Derived Allograft (GEDA)

Authors: Rao, Shalini V., Steigedal, Tonje Strømmen, Gopinathan, Aarthi, Strand, Sabina P., Jodrell, Duncan I., Draget, Kurt I., Nordgård, Catherine Taylor, Richards, Frances M.

Source: Pancreatology. 20(8):e8-e8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112195951.0x000001&indx=1&recIds=ETOCvdc_100112195951.0x000001

Ataxia Telangiectasia Mutated and its value as a predictive biomarker of response to AZD6738 therapy in pancreatic cancer

Authors: Dunlop, Charles R., Wallez, Yann, Bernaldo de Quirós Fernández, Sandra, Lau, Alan, Richards, Frances M., Jodrell, Duncan I.

Source: Pancreatology. 20(8):e7-e7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111524942.0x000001&indx=1&recIds=ETOCvdc_100111524942.0x000001

An analysis of phenotypic variation in the familial cancer syndrome von Hippel-Lindau disease: evidence for modifier effects.

Authors: Webster, Andrew R., Richards, Frances M., MacRonald, Fiona E.

Source: American Journal of Human Genetics; October 1998, Vol. 63 Issue 4, p1025-1035, 11p

Anti-Tumour Efficacy of Capecitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer.

Authors: Courtin, Aurélie^1,2, Richards, Frances M.^1,2 fran.richards@cruk.cam.ac.uk, Bapiro, Tashinga E.^1,2, Bramhall, Jo L.^1,2, Neesse, Albrecht^2,3, Cook, Natalie^2,3, Krippendorff, Ben-Fillippo^1,2, Tuveson, David A.^2,3, Jodrell, Duncan I.^1,2

Source: PLoS ONE. Jun2013, Vol. 8 Issue 6, p1-9. 9p.

Subject Terms: *ANTINEOPLASTIC agents, *DRUG efficacy, *GENETIC engineering, *PANCREATIC cancer, *LABORATORY mice, *DRUG approval, *PHARMACOKINETICS

Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.

Authors: Dunlop, Charles R., Wallez, Yann, Johnson, Timothy Isaac, Bernaldo de Quirós Fernández, Sandra, Durant, Stephen T., Cadogan, Elaine B., Lau, Alan, Richards, Frances M., Jodrell, Duncan I.

Source: British Journal of Cancer; Oct2020, Vol. 123 Issue 9, p1424-1436, 13p

Subject Terms: THERAPEUTIC use of antineoplastic agents, PANCREATIC tumors, SULFUR compounds, QUINOLINE, PYRIDINE, PROTEIN kinases, RESEARCH, HETEROCYCLIC compounds, ANIMAL experimentation, RESEARCH methodology, DEOXYCYTIDINE, RNA, CELL physiology, MEDICAL cooperation, EVALUATION research, DUCTAL carcinoma, COMPARATIVE studies, DRUG synergism, GENETIC techniques, CELL lines, MICE, PHARMACODYNAMICS, CHEMICAL inhibitors

Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo.

Authors: Richards, Frances M.¹ frances.richards@cancer.org.uk, Tape, Christopher J.², Jodrell, Duncan I.¹, Murphy, Gillian²

Source: PLoS ONE. Jul2012, Vol. 7 Issue 7, p1-10. 10p.

Subject Terms: *TUMORS, *PATHOLOGY, *XENOGRAFTS, *CANCER treatment, *OVARIAN cancer, *CELL lines, *TUMOR growth

This result is not displayed to guests.
Login for full access.