Development of an efficient and sustainable synthesis of 2-(3-methyl-1H-1, 2, 4-triazol-1-yl) acetic acid under continuous-flow conditionsElectronic supplementary information (ESI) available: Experimental conditions and analysis of products. See DOI: 10.1039/c9gc04286e

Authors: Tortoioli, Simone, Friedli, Astrid, Prud'homme, Alice, Richard-Bildstein, Sylvia, Kohler, Philipp, Abele, Stefan, Vilé, Gianvito

Source: Green chemistry. 22(12):3748-3758

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108972650.0x000001&indx=1&recIds=ETOCvdc_100108972650.0x000001

A Novel and Efficient Continuous-Flow Route To Prepare Trifluoromethylated N-Fused Heterocycles for Drug Discovery and Pharmaceutical Manufacturing

Authors: Amini-Rentsch, Lara, Vanoli, Ennio, Richard-Bildstein, Sylvia, Marti, Roger, Vilé, Gianvito

Source: Industrial and engineering chemistry research. 58(24):10164-10171

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620703540&indx=1&recIds=ETOCRN620703540

Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases.

Authors: Meyer, Emmanuel A., Croxford, Andrew L., Gnerre, Carmela, Kulig, Paulina, Murphy, Mark J., Jacob, Elise M., Schäfer, Gabriel, Richard-Bildstein, Sylvia, Aissaoui, Hamed, Bouis, Patrick, Ertel, Eric A., de Kanter, Ruben, Keller, Marcel P., Lüthi, Urs, Caroff, Eva

Source: Journal of Medicinal Chemistry; 5/23/2024, Vol. 67 Issue 10, p8077-8098, 22p

Hydroxylated aminotriazole derivatives as ALX receptor agonists

Bridged Spiro[2.4]heptane ester derivatives

7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators

Oxazolyl-methylether derivatives as ALX receptor agonists

Electrophile, Substrate Functionality, and Catalyst Effects in the Synthesis of α‐Mono and Di‐Substituted Benzylamines via Visible‐Light Photoredox Catalysis in Flow.

Authors: Vilé, Gianvito¹ gianvito.vile@idorsia.com, Richard‐Bildstein, Sylvia¹, Lhuillery, Arnaud¹, Rueedi, Georg¹

Source: ChemCatChem. 9/7/2018, Vol. 10 Issue 17, p3786-3794. 9p.

Subject Terms: *BENZYLAMINES, *CHEMICAL synthesis, *ELECTROPHILES, *AMINO acids, *ARYLATION

3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators

Oxazole and thiazole derivatives as ALX receptor agonists

Fluorinated aminotriazole derivatives

1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D 2 receptor modulators

Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists

Aminotriazole derivatives as ALX agonists

Aminopyrazole derivatives

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS

FLUORINATED AMINOTRIAZOLE DERIVATIVES

Bicyclononene derivatives

Diazabicyclononene derivatives and use thereof