GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Authors: Nick Dand, Philip E. Stuart, John Bowes, David Ellinghaus, Joanne Nititham, Jake R. Saklatvala, Maris Teder-Laving, Laurent F. Thomas, Tanel Traks, Steffen Uebe, Gunter Assmann, David Baudry, Frank Behrens, Allison C. Billi, Matthew A. Brown, Harald Burkhardt, Francesca Capon, Raymond Chung, Charles J. Curtis, Michael Duckworth, Eva Ellinghaus, Oliver FitzGerald, Sascha Gerdes, Christopher E. M. Griffiths, Susanne Gulliver, Philip S. Helliwell, Pauline Ho, Per Hoffmann, Oddgeir L. Holmen, Zhi-ming Huang, Kristian Hveem, Deepak Jadon, Michaela Köhm, Cornelia Kraus, Céline Lamacchia, Sang Hyuck Lee, Feiyang Ma, Satveer K. Mahil, Neil McHugh, Ross McManus, Ellen H. Modalsli, Michael J. Nissen, Markus Nöthen, Vinzenz Oji, Jorge R. Oksenberg, Matthew T. Patrick, Bethany E. Perez White, Andreas Ramming, Jürgen Rech, Cheryl Rosen, Mrinal K. Sarkar, Georg Schett, Börge Schmidt, Trilokraj Tejasvi, Heiko Traupe, John J. Voorhees, Eike Matthias Wacker, Richard B. Warren, Rachael Wasikowski, Stephan Weidinger, Xiaoquan Wen, Zhaolin Zhang, BSTOP study group, Estonian Biobank research team, Anne Barton, Vinod Chandran, Tõnu Esko, John Foerster, Andre Franke, Dafna D. Gladman, Johann E. Gudjonsson, Wayne Gulliver, Ulrike Hüffmeier, Külli Kingo, Sulev Kõks, Wilson Liao, Mari Løset, Reedik Mägi, Rajan P. Nair, Proton Rahman, André Reis, Catherine H. Smith, Paola Di Meglio, Jonathan N. Barker, Lam C. Tsoi, Michael A. Simpson, James T. Elder

Source: Nature Communications, Vol 16, Iss 1, Pp 1-14 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f39f241152954aefa20c977332346595

Correction: Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Study

Authors: Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

Source: Dermatology and Therapy, Vol 15, Iss 2, Pp 477-481 (2025)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/4f93bbbdedfc4c43a55fd2a5ca002609

Bimekizumab Efficacy in High-Impact Areas: Pooled 2-Year Analysis in Scalp, Nail, and Palmoplantar Psoriasis from Phase 3/3b Randomized Controlled Trials

Authors: Joseph F. Merola, Alice B. Gottlieb, Andreas Pinter, Boni Elewski, Melinda Gooderham, Richard B. Warren, Stefano Piaserico, Krista Wixted, Nancy Cross, Nicola Tilt, Susanne Wiegratz, Ulrich Mrowietz

Source: Dermatology and Therapy, Vol 14, Iss 12, Pp 3291-3306 (2024)

Subject Terms: Bimekizumab, Clinical trial, Efficacy, High-impact areas, Nail, Palmoplantar, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/baf9bbc677c049fd857d3a8c7639ead5

Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Study

Authors: Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

Source: Dermatology and Therapy, Vol 14, Iss 12, Pp 3273-3290 (2024)

Subject Terms: Psoriasis, Efficacy, Safety, Risankizumab, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/34355c7facb14d3c80d5e8afaa8abaab

Long-Term Efficacy and Safety of Bimekizumab and Other Biologics in Moderate to Severe Plaque Psoriasis: Updated Systematic Literature Review and Network Meta-analysis

Authors: Richard B. Warren, Kerry Donnelly, Sandeep Kiri, Vanessa Taieb, Mahmoud Slim, Kyle Fahrbach, Binod Neupane, Marissa Betts, April Armstrong

Source: Dermatology and Therapy, Vol 14, Iss 11, Pp 3133-3147 (2024)

Subject Terms: Adalimumab, Bimekizumab, Guselkumab, Long-term efficacy, Long-term safety, Network meta-analysis, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/1b8b5aa9d0874f258cc203e0740e4093

Efficacy and Safety of Bimekizumab in Patients With Psoriatic Arthritis With or Without Methotrexate: 52‐Week Results From Two Phase 3 Studies

Authors: Iain B. McInnes, Philip J. Mease, Yoshiya Tanaka, Laure Gossec, M. Elaine Husni, Lars Erik Kristensen, Richard B. Warren, Barbara Ink, Rajan Bajracharya, Jason Coarse, Alice B. Gottlieb

Source: ACR Open Rheumatology, Vol 6, Iss 11, Pp 720-731 (2024)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2578-5745

Access URL: https://doaj.org/article/9bc82b35361540eca261704dc88423d0

Complete Skin Clearance is Associated with the Greatest Benefits to Health-Related Quality of Life and Perceived Symptoms for Patients with Psoriasis

Authors: Matthias Augustin, Alice B. Gottlieb, Mark Lebwohl, Andreas Pinter, Richard B. Warren, Luis Puig, Rhys Warham, Jérémy Lambert, Susanne Wiegratz, Balint Szilagyi, Andrew Blauvelt

Source: Dermatology and Therapy, Vol 14, Iss 10, Pp 2841-2857 (2024)

Subject Terms: Biologics, Clinical trials, Psoriasis, Quality of life, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/87932ef0b7d34aacbbdc912e39e468f6

Correction: Certolizumab Pegol for the Treatment of Plaque Psoriasis in Routine Clinical Practice: One-Year Results from the CIMREAL Study

Authors: Bernhard Korge, Olivier Vanhooteghem, Charles W. Lynde, Alena Machovcova, Marc Perrussel, Elisavet Lazaridou, Claudio Marasca, David Vidal Sarro, Ines Duenas Pousa, Frederik Fierens, Paulette Williams, Saori Shimizu, Tanja Heidbrede, Richard B. Warren

Source: Dermatology and Therapy, Vol 14, Iss 10, Pp 2923-2926 (2024)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/99b0aed743ab47f79d535ed54575f5a4

Progression of Quality of Life in Patients with Plaque Psoriasis Who Achieved Three or More Years of Complete Skin Clearance with Guselkumab Treatment: a Post hoc Analysis of the VOYAGE 1 Clinical Trial

Authors: Luis Puig, Antonio Costanzo, Elke M. G. J. de Jong, Tiago Torres, Richard B. Warren, Robert Wapenaar, Sven Wegner, Patricia Gorecki, Talia Gramiccia, Maria Jazra, Jozefien Buyze, Curdin Conrad

Source: Dermatology and Therapy, Vol 14, Iss 9, Pp 2539-2558 (2024)

Subject Terms: Psoriasis, Quality of life, Biologics, Clinical evaluation and treatment, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/ab526a4a99574512a77a238ef4a81a03

Comparative Effectiveness of Bimekizumab and Ustekinumab in Patients with Psoriatic Arthritis at 52 Weeks Assessed Using a Matching-Adjusted Indirect Comparison

Authors: Philip J. Mease, Richard B. Warren, Peter Nash, Jean-Marie Grouin, Nikos Lyris, Vanessa Taieb, Jason Eells, Iain B. McInnes

Source: Rheumatology and Therapy, Vol 11, Iss 5, Pp 1413-1423 (2024)

Subject Terms: ACR, Bimekizumab, Biologics, IL-17, IL-12/23, MAIC, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584

Access URL: https://doaj.org/article/4262254099cb40d39645fcfe05396997

Comparative Effectiveness of Bimekizumab and Risankizumab in Patients with Psoriatic Arthritis at 52 Weeks Assessed Using a Matching-Adjusted Indirect Comparison

Authors: Philip J. Mease, Richard B. Warren, Peter Nash, Jean-Marie Grouin, Nikos Lyris, Damon Willems, Vanessa Taieb, Jason Eells, Iain B. McInnes

Source: Rheumatology and Therapy, Vol 11, Iss 5, Pp 1403-1412 (2024)

Subject Terms: ACR, Bimekizumab, Biologics, IL-17, IL-23, MAIC, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584

Access URL: https://doaj.org/article/ce35de981e1147979941d6203e2e5191

Deucravacitinib onset of action and maintenance of response in phase 3 plaque psoriasis trials

Authors: Neil J. Korman, Richard B. Warren, Jerry Bagel, April W. Armstrong, Melinda Gooderham, Bruce Strober, Diamant Thaçi, Akimichi Morita, Shinichi Imafuku, Peter Foley, Howard Sofen, Min Zheng, Lauren Hippeli, Renata M. Kisa, Subhashis Banerjee, Andrew Blauvelt

Source: Journal of Dermatological Treatment, Vol 35, Iss 1 (2024)

Subject Terms: Clinical trials, deucravacitinib, maintenance of response, onset of action, phase 3, psoriasis, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/0954-6634; https://doaj.org/toc/1471-1753

Access URL: https://doaj.org/article/565ff6e9db3f40f3996833c3bba76026

Certolizumab Pegol for the Treatment of Plaque Psoriasis in Routine Clinical Practice: One-Year Results from the CIMREAL Study

Authors: Bernhard Korge, Olivier Vanhooteghem, Charles W. Lynde, Alena Machovcova, Marc Perrussel, Elisavet Lazaridou, Claudio Marasca, David Vidal Sarro, Ines Duenas Pousa, Frederik Fierens, Paulette Williams, Saori Shimizu, Tanja Heidbrede, Richard B. Warren

Source: Dermatology and Therapy, Vol 14, Iss 8, Pp 2077-2092 (2024)

Subject Terms: Anti-TNF biologic, Certolizumab pegol, Dermatology life quality index (DLQI), Health-related quality of life, Moderate to severe psoriasis, Psoriasis area and severity index (PASI), Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/9b8405ecefbc478e911d59e7b2e3c3c1

Comparative Effectiveness of Bimekizumab and Secukinumab in Patients with Psoriatic Arthritis at 52 Weeks Using a Matching-Adjusted Indirect Comparison

Authors: Philip J. Mease, Richard B. Warren, Peter Nash, Jean-Marie Grouin, Nikos Lyris, Damon Willems, Vanessa Taieb, Jason Eells, Iain B. McInnes

Source: Rheumatology and Therapy, Vol 11, Iss 3, Pp 817-828 (2024)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584

Access URL: https://doaj.org/article/f5c52a1be9d64789923ca497a0e9b3a0

Comparative Effectiveness of Bimekizumab and Guselkumab in Patients with Psoriatic Arthritis at 52 Weeks Assessed Using a Matching-Adjusted Indirect Comparison

Authors: Richard B. Warren, Iain B. McInnes, Peter Nash, Jean-Marie Grouin, Nikos Lyris, Damon Willems, Vanessa Taieb, Jason Eells, Philip J. Mease

Source: Rheumatology and Therapy, Vol 11, Iss 3, Pp 829-839 (2024)

Subject Terms: ACR, Bimekizumab, Biologics, Guselkumab, IL-17, IL-23, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584

Access URL: https://doaj.org/article/160b6ba0575d44a484ca18255390de4e

Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review

Authors: Andrew Blauvelt, Richard G. Langley, Kenneth B. Gordon, Jonathan I. Silverberg, Kilian Eyerich, Morten O. A. Sommer, Jakob Felding, Richard B. Warren

Source: Dermatology and Therapy, Vol 13, Iss 12, Pp 3031-3042 (2023)

Subject Terms: PDE4 inhibitors, PDE4B, PDE4D, Nerandomilast, Orismilast, PF-07038124, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/f2be335a118b4a2890d4421106a07e29

Short-, Mid-, and Long-Term Efficacy of Deucravacitinib Versus Biologics and Nonbiologics for Plaque Psoriasis: A Network Meta-Analysis

Authors: April W. Armstrong, Richard B. Warren, Yichen Zhong, Joe Zhuo, Allie Cichewicz, Ananth Kadambi, Daniela Junqueira, Tracy Westley, Renata Kisa, Carolin Daamen, Matthias Augustin

Source: Dermatology and Therapy, Vol 13, Iss 11, Pp 2839-2857 (2023)

Subject Terms: Biologics, Deucravacitinib, Indirect treatment comparison, Network meta-analysis, Non-biologics, Psoriasis, Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8210; https://doaj.org/toc/2190-9172

Access URL: https://doaj.org/article/7f35e0e59d49477a896a078e820ce12a

Clinical course, treatment and management of generalised pustular psoriasis from a United Kingdom extension of a global Delphi panel

Authors: Jonathan N. Barker, Gabrielle Becher, David A. Burden, Andrew E. Pink, Maria Zacharioudaki, Richard B. Warren

Source: Skin Health and Disease, Vol 4, Iss 3, Pp n/a-n/a (2024)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2690-442X

Access URL: https://doaj.org/article/2aae875e33de4ac7a37c266e7da3b82e

Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin typesCapsule Summary

Authors: Angela L. Bosma, MD, Wouter Ouwerkerk, PhD, Madeline J. Heidema, MD, David Prieto-Merino, PhD, Michael R. Ardern-Jones, MD, PhD, Paula Beattie, MD, Sara J. Brown, MD, PhD, John R. Ingram, MD, PhD, Alan D. Irvine, MD, DSc, Graham Ogg, MD, PhD, Prakash Patel, BSc, Nick J. Reynolds, MD, PhD, R.M. Ross Hearn, MD, Mandy Wan, PhD, Richard B. Warren, MD, PhD, Richard T. Woolf, MD, PhD, Ariënna M. Hyseni, Louise A.A. Gerbens, MD, PhD, Phyllis I. Spuls, MD, PhD, Carsten Flohr, MD, PhD, Maritza A. Middelkamp-Hup, MD, PhD

Source: JAAD International, Vol 10, Iss , Pp 14-24 (2023)

Subject Terms: atopic dermatitis, atopic eczema, ciclosporin, daily practice, dupilumab, effectiveness, Dermatology, RL1-803

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266632872200133X; https://doaj.org/toc/2666-3287

Access URL: https://doaj.org/article/a6000db7359b4ce99fcb0c5dc46847c7

Functional Genomics and Insights into the Pathogenesis and Treatment of Psoriasis

Authors: Elan May Shellard, Shraddha S. Rane, Stephen Eyre, Richard B. Warren

Source: Biomolecules, Vol 14, Iss 5, p 548 (2024)

Subject Terms: psoriasis, pathogenesis, tailored medicine, functional genomics, genetics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/5/548; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/33d477433b9b43ca93d617a4da90ccdf