High-Throughput Computing to Automate Population-Based Studies to Detect the 30-Day Risk of Adverse Outcomes After New Outpatient Medication Use in Older Adults with Chronic Kidney Disease: A Clinical Research Protocol

Authors: Sheikh S. Abdullah, Neda Rostamzadeh, Flory T. Muanda, Eric McArthur, Matthew A. Weir, Jessica M. Sontrop, Richard B. Kim, Sedig Kamran, Amit X. Garg

Source: Canadian Journal of Kidney Health and Disease, Vol 11 (2024)

Subject Terms: Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/2054-3581

Access URL: https://doaj.org/article/968e324d9f634da3ac9970efd1498e04

DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation

Authors: Theodore J. Wigle, Samantha Medwid, Cameron Ross, Ute I. Schwarz, Richard B. Kim

Source: Current Oncology, Vol 30, Iss 1, Pp 663-672 (2023)

Subject Terms: fluoropyrimidines, dihydropyrimidine dehydrogenase deficiency, adverse drug reactions, pharmacogenetics, copy number variation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/30/1/51; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/de525f99bb3b456bbd09e2b8d9d5124c

Adverse events with quetiapine and clarithromycin coprescription: A population‐based retrospective cohort study

Authors: Kevin Yau, Eric McArthur, Nivethika Jeyakumar, Flory Tsobo Muanda, Richard B. Kim, Kristin K. Clemens, Ron Wald, Amit X. Garg

Source: Health Science Reports, Vol 6, Iss 6, Pp n/a-n/a (2023)

Subject Terms: drug interactions, epidemiology, pharmacovigilance, polypharmacy, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2398-8835

Access URL: https://doaj.org/article/4e99223417a646f79855523607f24565

High oncostatin M predicts lack of clinical remission for patients with inflammatory bowel disease on tumor necrosis factor α antagonists

Authors: Angela Guo, Cameron Ross, Nilesh Chande, Jamie Gregor, Terry Ponich, Reena Khanna, Michael Sey, Melanie Beaton, Brian Yan, Richard B. Kim, Aze Wilson

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/86d16acd3ec34addbe877c36cffd23c0

Association of Sex With Stroke and Bleeding Risk of Apixaban and Rivaroxaban in Elderly Atrial Fibrillation Patients Using Propensity Score Weights

Authors: Markus Gulilat, PhD, Racquel Jandoc, MSc, Nivethika Jeyakumar, MSc, Eric McArthur, MSc, Amit X. Garg, MD, PhD, Richard B. Kim, MD, Rommel G. Tirona, PhD, Ute I. Schwarz, MD, PhD

Source: CJC Open, Vol 4, Iss 1, Pp 56-64 (2022)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589790X21002353; https://doaj.org/toc/2589-790X

Access URL: https://doaj.org/article/23571fb17bb1479d8b802dfb4989370d

Pharmacogenomic‐based personalized medicine: Multistakeholder perspectives on implementational drivers and barriers in the Canadian healthcare system

Authors: Mathushan Subasri, David Barrett, Jovana Sibalija, Lisa Bitacola, Richard B. Kim

Source: Clinical and Translational Science, Vol 14, Iss 6, Pp 2231-2241 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/eafb2eb5f6264a2591f92a50e7f25a9b

The CRTh2 polymorphism rs533116 G > A associates with asthma severity in older females

Authors: Nami Shrestha Palikhe, Constance A. Mackenzie, Christopher Licskai, Richard B. Kim, Harissios Vliagoftis, Lisa Cameron

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: CRTh2, asthma severity, polymorphism, female, sex difference, type 2 inflammation, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.970495/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/720add685ae844f5b73215019b163f59

Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events

Authors: Theodore J. Wigle, Brandi L. Povitz, Samantha Medwid, Wendy A. Teft, Robin M. Legan, John Lenehan, Stephanie Nevison, Veera Panuganty, Denise Keller, Jaymie Mailloux, Victoria Siebring, Sisira Sarma, Yun‐hee Choi, Stephen Welch, Eric Winquist, Ute I. Schwarz, Richard B. Kim

Source: Clinical and Translational Science, Vol 14, Iss 4, Pp 1338-1348 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/cb2d4022d64843098a58cd559aa1c31b

High infliximab trough concentrations are associated with sustained histologic remission in inflammatory bowel disease: a prospective cohort study

Authors: Aze Wilson, Bethany Choi, Michael Sey, Terry Ponich, Melanie Beaton, Richard B. Kim

Source: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-8 (2021)

Subject Terms: Inflammatory bowel disease, Histologic remission, Inflixmab trough concentrations, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1471-230X

Access URL: https://doaj.org/article/0f783ba7a2fe478cb741bf3d036fe8eb

Near Miss or Standard of Care? DPYD Screening for Cancer Patients Receiving Fluorouracil

Authors: Lauren E. Winquist, Michael Sanatani, Richard B. Kim, Eric Winquist

Source: Current Oncology, Vol 28, Iss 1, Pp 94-97 (2020)

Subject Terms: fluoropyrimidines, dihydropyrimidine dehydrogenase, cancer, adverse effects, single nucleotide polymorphisms, drug therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/28/1/12; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/db5c8ef7aed54c7993b28271286dccba

Targeted next generation sequencing as a tool for precision medicine

Authors: Markus Gulilat, Tyler Lamb, Wendy A. Teft, Jian Wang, Jacqueline S. Dron, John F. Robinson, Rommel G. Tirona, Robert A. Hegele, Richard B. Kim, Ute I. Schwarz

Source: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-17 (2019)

Subject Terms: Targeted exome sequencing, Next generation sequencing, Pharmacogenes, Copy number variation, In silico prediction, Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12920-019-0527-2; https://doaj.org/toc/1755-8794

Access URL: https://doaj.org/article/5ed343e32f6a4b0aacc825a9dc049fdc

Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates

Authors: Samantha Medwid, Hayley R. Price, Daniel P. Taylor, Jaymie Mailloux, Ute I. Schwarz, Richard B. Kim, Rommel G. Tirona

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: drug transporter, genetic variant, endogenous substrates, organic anion transporting polypeptide 2B1 (OATP2B1), pharmacogenenomics and personalised medicine, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.713567/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/3ea840111a064b66a5e3a81c5e38b44b

A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia

Authors: Lili Aslostovar, Allison L. Boyd, Mohammed Almakadi, Tony J. Collins, Darryl P. Leong, Rommel G. Tirona, Richard B. Kim, Jim A. Julian, Anargyros Xenocostas, Brian Leber, Mark N. Levine, Ronan Foley, Mickie Bhatia

Source: Blood Advances, Vol 2, Iss 15, Pp 1935-1945 (2018)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920309101; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/65462c7955b0444b8aa80b9a26bdee79

SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease

Authors: Brian D. Robertson, Abdullah S. Al Jaja, Alex A. MacDonald, Nole M. Hiebert, Ruzbeh Tamjeedi, Ken N. Seergobin, Ute I. Schwarz, Richard B. Kim, Penny A. MacDonald

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: Parkinson's disease, polymorphism, SLC6A3, overdose, dopamine, encoding, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.00693/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/314c8fd4b0544ebca4add52439955025

DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report

Authors: Theodore J. Wigle, Elena V. Tsvetkova, Stephen A. Welch, Richard B. Kim

Source: Pharmaceutics, Vol 11, Iss 5, p 199 (2019)

Subject Terms: dihydropyrimidine dehydrogenase, DPYD, 5-fluorouracil, fluoropyrimidine, therapeutic drug monitoring, orthotopic liver transplant, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/11/5/199; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/09b7bfd475fc4e559c3aa0aa9d6a0978

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Durable Complete Response of Refractory, Progressing Metastatic Melanoma After Treatment with a Patient-Specific Vaccine.

Authors: Robert O. Dillman, Andreea A. Nanci, Scott T. Williams, Richard B. Kim, Russell L. Hafer, Colleen L. Coleman, Peter C. Wang, Christopher M. Duma, Peter V. Chen, Senthamil R. Selvan, Andrew N. Cornforth, Carol DePriest

Source: Cancer Biotherapy & Radiopharmaceuticals; Oct2010, Vol. 25 Issue 5, p553-557, 5p

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Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

Authors: David W Haas, Heather J Ribaudo, Richard B Kim, Camlin Tierney, Grant R Wilkinson, Roy M Gulick, David B Clifford, Todd Hulgan, Catia Marzolini, Edward P Acosta

Source: AIDS (02699370); Dec2004, Vol. 18 Issue 18, p2391-2400, 10p

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide.

Authors: Keith A. Hoffmaster, Ryan Z. Turncliff, Edward L. LeCluyse, Richard B. Kim, Peter J. Meier, Kim L. R. Brouwer

Source: Pharmaceutical Research; Jul2004, Vol. 21 Issue 7, p1294-1302, 9p

Subject Terms: P-glycoprotein, NEUROPEPTIDES, CHELATION therapy, CARRIER proteins