Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes

Authors: Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Immune checkpoint therapy, T cells, T cell receptor (TCR) sequencing, tumour-infiltrating lymphocytes, immune repertoire, machine learning, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/f60545e051804f9796499b61db90824e

Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy

Authors: Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann

Source: Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/a6b9ffd96f4e40b6b71f12cbc7e2efb8

Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner

Authors: Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Cyclophosphamide, Tretinoin, Interferon, Sensitisation, Combination treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/604f2ab58dbd40a8bc1286fd39a00ca8

The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop

Authors: Scott A. Fisher, Kimberley Patrick, Tracy Hoang, Elly Marcq, Kiarash Behrouzfar, Sylvia Young, Timothy J. Miller, Bruce W. S. Robinson, Raphael Bueno, Anna K. Nowak, W. Joost Lesterhuis, Grant Morahan, Richard A. Lake

Source: Frontiers in Toxicology, Vol 6 (2024)

Subject Terms: mesothelioma, collaborative cross, MexTAg, asbestos related disease, host genetics, mouse model, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1373003/full; https://doaj.org/toc/2673-3080

Access URL: https://doaj.org/article/3d44dba5e34544bab7bb7980e494ea5c

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice

Authors: Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/59cfc35dd0fb4aa0a34e44f36234b216

Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action

Authors: Caitlin M. Tilsed, Scott A. Fisher, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: chemotherapy, tumor microenvironment, cell death, immune response, mechanism of action, cancer chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.960317/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e6d00f5ca20546b5b9b062d82fa200d8

Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model

Authors: Scott A. Fisher, Carolyn J. Peddle-McIntyre, Kimberley Burton, Robert U. Newton, Elly Marcq, Richard A. Lake, Anna K. Nowak

Source: BMC Research Notes, Vol 13, Iss 1, Pp 1-8 (2020)

Subject Terms: Asbestos, Mesothelioma, Exercise, MexTAg, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13104-020-05284-y; https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/d11f9550bc764e9584fb4a8af38d4896

Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

Authors: Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Scott A. Fisher, Louis Boon, Ian M. Dick, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Richard A. Lake, Jonathan Chee, Willem Joost Lesterhuis

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: chemo-immunotherapy combinations, immune checkpoint blockade (ICB) therapy, T cells, proinflammatory cytokine, TNFa = tumor necrosis factor–a, IL-1b, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.872295/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/eebc1cc11d8240f49cafed6001ba43c0

Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

Authors: Caitlin M. Tilsed, Thomas H. Casey, Emma de Jong, Anthony Bosco, Rachael M. Zemek, Joanne Salmons, Graeme Wan, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Willem Joost Lesterhuis

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: retinoic acid, immune checkpoint therapy, cancer, interferon, mesothelioma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.849793/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/19eeddb4bf7541cbb0eb578d199bb0ef

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

Authors: M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis

Source: iScience, Vol 25, Iss 1, Pp 103571- (2022)

Subject Terms: Biological sciences, Metabolomics, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221015418; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/6d9c2a0cd5324c82ad3d7f092e5dbba3

How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers

Authors: Kiarash Behrouzfar, Kimberley Burton, Steve E. Mutsaers, Grant Morahan, Richard A. Lake, Scott A. Fisher

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: thoracic malignancies, tumor immune microenvironment, mesothelioma, Collaborative Cross, MexTAg, host genetics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.679609/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/a82081bb8d03424fbee6db218af0ec59

Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?

Authors: Nicola Principe, Joel Kidman, Richard A. Lake, Willem Joost Lesterhuis, Anna K. Nowak, Alison M. McDonnell, Jonathan Chee

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: malignant pleural effusions (MPE), T cells, immune checkpoint therapy, checkpoint receptors, memory T cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.672747/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b452737bea3b422982a78da7a248010f

Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy

Authors: Nicola Principe, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Anna K. Nowak, Willem Joost Lesterhuis, Alison M. McDonnell, Jonathan Chee

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: immune checkpoint therapy, tumor-specific T cells, TCR repertoire, cytotoxic T lymphocytes, effector memory, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.584423/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/14028b32db2541389131a67ac973ccfb

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

Authors: Joel Kidman, Nicola Principe, Mark Watson, Timo Lassmann, Robert A. Holt, Anna K. Nowak, Willem Joost Lesterhuis, Richard A. Lake, Jonathan Chee

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: checkpoint immunotherapy, tumor immunology, T cell receptor, immunogenomics, dynamic analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.587014/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3fbe5a39f1c84d9fb46f15d98279e862

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors

Authors: Jonathan Chee, Mark W. Watson, Abha Chopra, Bella Nguyen, Alistair M. Cook, Jenette Creaney, Willem J. Lesterhuis, Bruce W. Robinson, Y. C. Gary Lee, Anna K. Nowak, Richard A. Lake, Alison M. McDonnell

Source: BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)

Subject Terms: Mesothelioma, Pleural effusion, T cell receptor, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13104-018-3953-x; https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/d41151ec53c34c3380c590cd7d030f32

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

Authors: Wayne J. Aston, Danika E. Hope, Anna K. Nowak, Bruce W. Robinson, Richard A. Lake, W. Joost Lesterhuis

Source: BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)

Subject Terms: Chemotherapy, Mice, Dose optimization, Maximum tolerated dose, MTD, Supportive care, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3677-7; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/23b7d93ee31743cab7a5c2ce88034ef9

Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters

Authors: Alison M. McDonnell, Alistair Cook, Bruce W. S. Robinson, Richard A. Lake, Anna K. Nowak

Source: BMC Cancer, Vol 17, Iss 1, Pp 1-15 (2017)

Subject Terms: Mesothelioma, Dendritic cells, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3403-5; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/ce8c9ba91b084192b71b0efaac8e4c66

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

Authors: Rachael M. Zemek, Wee Loong Chin, Anna K. Nowak, Michael J. Millward, Richard A. Lake, W. Joost Lesterhuis

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: cancer immunotherapy, immune checkpoints, sensitization, tumor microenvironment, PD-1, CTLA4, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00223/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c0ab4303f2fa4686a1db0102b6c02049

Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Authors: Wayne J. Aston, Danika E. Hope, Alistair M. Cook, Louis Boon, Ian Dick, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis

Source: OncoImmunology, Vol 8, Iss 11 (2019)

Subject Terms: dexamethasone, chemotherapy, immunotherapy, cancer, supportive care, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/e187f26bebde410e85dfd1051a98ed1f

Combination immune checkpoint blockade as an effective therapy for mesothelioma

Authors: Vanessa S. Fear, Caitlin Tilsed, Jonathan Chee, Catherine A. Forbes, Thomas Casey, Jessica N. Solin, Sally M. Lansley, Willem Joost Lesterhuis, Ian M. Dick, Anna K Nowak, Bruce W. Robinson, Richard A. Lake, Scott A. Fisher

Source: OncoImmunology, Vol 7, Iss 10 (2018)

Subject Terms: mesothelioma, immune checkpoint blockade, immunotherapy, anti-ctla-4, anti-ox40, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/8a7a9db118f44024bb28da87c1fdb035