CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

Authors: Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cathy Hou, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu

Source: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/27dd4928dbf643889186e8bd55e8a97e

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

Authors: Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson

Source: Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3ad164ee693049358f658929a36c0698

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

Authors: Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette McClure, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C. Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W. Poon, Ryan G. Lim, Leslie M. Thompson

Source: iScience, Vol 26, Iss 1, Pp 105732- (2023)

Subject Terms: Neurology, Omics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222020053; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/3051cef5c5b24f3ebdab019b1d8be6cf

Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

Authors: Charlene Smith-Geater, Sarah J. Hernandez, Ryan G. Lim, Miriam Adam, Jie Wu, Jennifer T. Stocksdale, Brook T. Wassie, Maxwell Philip Gold, Keona Q. Wang, Ricardo Miramontes, Lexi Kopan, Iliana Orellana, Shona Joy, Paul J. Kemp, Nicholas D. Allen, Ernest Fraenkel, Leslie M. Thompson

Source: Stem Cell Reports, Vol 14, Iss 3, Pp 406-419 (2020)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671120300369; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/ec7c074fe8934cefbe2687c75ff40f03

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