Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Authors: Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria ^*, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, Kraft, Peter, Hansen, John‐Bjarne, Heit, John A, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Pulit, Sara L, Rannikmäe, Kristiina, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, Dichgans, Martin

Source: In Journal of Thrombosis and Haemostasis June 2022 20(6):1331-1349

Kidney function changes and their relation with the progression of cerebral small vessel disease and cognitive decline

Authors: Jiménez-Balado, Joan, Riba-Llena, Iolanda, Pizarro, Jesús, Palasí, Antoni, Penalba, Anna, Ramírez, Clara, Maisterra, Olga, Espinel, Eugenia, Ramos, Natalia, Pujadas, Francesc, Serón, Daniel, Delgado, Pilar

Source: In Journal of the Neurological Sciences 15 February 2020 409

Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer's Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms.

Authors: Dakterzada, Farida, Cipriani, Raffaela, López-Ortega, Ricard, Arias, Alfonso, Riba-Llena, Iolanda, Ruiz-Julián, Maria, Huerto, Raquel, Tahan, Nuria, Matute, Carlos, Capetillo-Zarate, Estibaliz, Piñol-Ripoll, Gerard

Source: International Journal of Molecular Sciences; May2024, Vol. 25 Issue 9, p4594, 14p

Subject Terms: ALZHEIMER'S disease, CEREBROSPINAL fluid, CEREBROSPINAL fluid examination, BIOMARKERS, TAU proteins, MILD cognitive impairment

Plasma Matrix Metalloproteinases in Patients With Stroke During Intensive Rehabilitation Therapy

Authors: Ma, Feifei, Rodriguez, Susana, Buxo, Xavi, Morancho, Anna, Riba-Llena, Iolanda, Carrera, Ana, Bustamante, Alejandro, Giralt, Dolors, Montaner, Joan, Martinez, Carmen, Bori, Immaculada, Rosell, Anna

Source: In Archives of Physical Medicine and Rehabilitation November 2016 97(11):1832-1840

Role of lipoprotein-associated phospholipase A2 activity for the prediction of silent brain infarcts in women

Authors: Riba-Llena, Iolanda, Penalba, Anna, Pelegrí, Dolors, Vilar, Andrea, Jarca, Carme I., Filomena, Josefina, Montaner, Joan, Delgado, Pilar

Source: In Atherosclerosis December 2014 237(2):811-815

Silent brain infarcts, peripheral vascular disease and the risk of cardiovascular events in patients with hypertension.

Authors: Jiménez-Balado, Joan, Riba-Llena, Iolanda, Nafría, Cristina, Pizarro, Jesús, Rodríguez-Luna, David, Maisterra, Olga, Ballvé, Alejandro, Mundet, Xavier, Violan, Concepción, Ventura, Oriol, Montaner, Joan, Delgado, Pilar

Source: Journal of Hypertension; Aug2022, Vol. 40 Issue 8, p1469-1477, 9p

Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol design

Authors: Riba-Llena, Iolanda¹ (AUTHOR), Jarca, Carmen Ioana² (AUTHOR), Mundet, Xavier³ (AUTHOR), Tovar, Jose L.⁴ (AUTHOR), Orfila, Francesc³ (AUTHOR), López-Rueda, Antonio¹ (AUTHOR), Nafría, Cristina¹ (AUTHOR), Fernández, Jose L.⁵ (AUTHOR), Castañé, Xavier¹ (AUTHOR), Domingo, Mar³ (AUTHOR), Álvarez-Sabín, José⁶ (AUTHOR), Fernández-Cortiñas, Inés (AUTHOR), Maisterra, Olga⁶ (AUTHOR), Montaner, Joan^1,6 (AUTHOR), Delgado, Pilar¹ (AUTHOR) pilar.delgado@vhir.org

Source: BMC Neurology. 2013, Vol. 13 Issue 1, p1-8. 8p. 1 Black and White Photograph, 1 Diagram, 1 Chart.

Assessment of the Concordance and Diagnostic Accuracy Between Elecsys and Lumipulse Fully Automated Platforms and Innotest.

Authors: Dakterzada, Farida, López-Ortega, Ricard, Arias, Alfonso, Riba-Llena, Iolanda, Ruiz-Julián, Maria, Huerto, Raquel, Tahan, Nuria, Piñol-Ripoll, Gerard

Source: Frontiers in Aging Neuroscience; 3/4/2021, Vol. 13, pN.PAG-N.PAG, 12p

Subject Terms: CEREBROSPINAL fluid, DIAGNOSTIC imaging, AMYLOID, DIAGNOSIS, CEREBRAL amyloid angiopathy

Ambulatory Blood Pressure Levels in the Prediction of Progression of Cerebral Small Vessel Disease.

Authors: Jiménez‐Balado, Joan¹ (AUTHOR), Riba‐Llena, Iolanda¹ (AUTHOR), Maisterra, Olga^1,2 (AUTHOR), Pizarro, Jesús¹ (AUTHOR), Palasí, Antoni² (AUTHOR), Pujadas, Francesc² (AUTHOR), Mundet, Xavier³ (AUTHOR), Vinyoles, Ernest⁴ (AUTHOR), Delgado, Pilar^1,2 (AUTHOR) pilar.delgado@vhir.org

Source: Journal of the American Geriatrics Society. Oct2020, Vol. 68 Issue 10, p2232-2239. 8p.

Subject Terms: *AMBULATORY blood pressure monitoring, *CEREBRAL small vessel diseases, *BLOOD pressure measurement, *CEREBROVASCULAR disease, *MEDICAL care for older people, *HEALTH risk assessment of older people, *HYPERTENSION

Altered Levels of Acetylcholinesterase in Alzheimer Plasma.

Authors: García-Ayllón, María-Salud^1,2, Riba-Llena, Iolanda^1,2,3, Serra-Basante, Carol^1,2, Alom, Jordi^2,3, Boopathy, Rathnam⁴, Sáez-Valero, Javier^1,2 j.saez@umh.es

Source: PLoS ONE. 2010, Vol. 5 Issue 1, p1-11. 11p. 1 Black and White Photograph, 4 Graphs.

Subject Terms: *CHOLINESTERASES, *BLOOD, *ACETYLCHOLINESTERASE, *BLOOD plasma, *BUTYRYLCHOLINESTERASE, *SPECIES, *LIVER, *ERYTHROCYTES, *CEREBROSPINAL fluid

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Cognitive Impact of Cerebral Small Vessel Disease Changes in Patients With Hypertension.

Authors: Jiménez-Balado, Joan, Riba-Llena, Iolanda, Abril, Oscar, Garde, Edurne, Penalba, Anna, Ostos, Elena, Maisterra, Olga, Montaner, Joan, Noviembre, Maria, Ventura, Oriol, Pizarro, Jesus, Delgado, Pilar, Mundet, Xavier

Source: Hypertension (0194911X); Feb2019, Vol. 73 Issue 2, p342-349, 8p

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