A New Frontier in Cystic Fibrosis Pathophysiology: How and When Clock Genes Can Affect the Inflammatory/Immune Response in a Genetic Disease Model

Authors: Annalucia Carbone, Pamela Vitullo, Sante Di Gioia, Stefano Castellani, Massimo Conese

Source: Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 10396-10410 (2024)

Subject Terms: cystic fibrosis lung disease, clock genes, circadian rhythms, immune-inflammation, ex vivo and in vivo models, REV-ERBα agonists, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/46/9/618; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/340cbf11edcc41269a16cc1080176da2

REV-ERBα inhibitor rescues MPTP/MPP+-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway

Authors: Xiaoyu Wang, Mingmei Wang, Hui Zhi, Jingwei Li, Dongkai Guo

Source: Heliyon, Vol 10, Iss 23, Pp e40388- (2024)

Subject Terms: REV-ERBα, Ferroptosis, GPX4, FASN, SCD1, Science (General), Q1-390, Social sciences (General), H1-99

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Relation: http://www.sciencedirect.com/science/article/pii/S2405844024164195; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/228e266030734704a3b0923de8e3e9e9

Targeting NR1D1 in organ injury: challenges and prospects

Authors: Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang

Source: Military Medical Research, Vol 10, Iss 1, Pp 1-20 (2023)

Subject Terms: NR1D1, REV-ERBα, Circadian rhythms, Liver, Heart, Lung, Medicine (General), R5-920, Military Science

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Relation: https://doaj.org/toc/2054-9369

Access URL: https://doaj.org/article/ce3b1efade924902aba460f8773c47bd

REV-ERBα negatively regulates NLRP6 transcription and reduces the severity of Salmonella infection in mice

Authors: Sun, Lanqing ^{a, b, 1}, Huang, Kai ^{c, d, 1}, Deng, Qifeng ^e, Zhu, Yuan ^{a, f}, Cao, Yu ^{a, g}, Dong, Kedi ^{a, h}, Yang, Sidi ⁱ, Li, Yuanyuan ^a, Wu, Shuyan ^{a, ⁎⁎}, Huang, Rui ^{a, ⁎}

Source: In Heliyon 30 April 2024 10(8)

Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling

Authors: Zhong, Dandan ^{1, 9}, Chen, Jingshuo ^{1, 9}, Qiao, Ranran ^{1, 2, 3}, Song, Chang ^{1, 3}, Hao, Chang ^{1, 3}, Zou, Yingying ¹, Bai, Mi ², Su, Wen ^{4, 5}, Yang, Baoxue ^{6, 7}, Sun, Dong ^{8, ∗}, Jia, Zhanjun ^{1, 2, ∗∗}, Sun, Ying ^{1, 10, ∗∗∗}

Source: In Cell Reports 23 April 2024 43(4)

Targeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats

Authors: Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu, Shih-En Tang

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)

Subject Terms: Acute lung injury, Ischemia-reperfusion, Circadian clocks, Rev-Erbα, SR9009, SR8278, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/f44da4751f594f72b5e635fb11c22d30

Inhibiting Rev-erbα-mediated ferroptosis alleviates susceptibility to myocardial ischemia-reperfusion injury in type 2 diabetes

Authors: Huang, Qin ^a, Tian, Hao ^a, Tian, Liqun ^b, Zhao, Xiaoshuai ^a, Li, Lu ^a, Zhang, Yuxi ^a, Qiu, Zhen ^a, Lei, Shaoqing ^a, Xia, Zhongyuan ^{a, ∗}

Source: In Free Radical Biology and Medicine 20 November 2023 209 Part 1:135-150

Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis

Authors: Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang, Meirong Du

Source: Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-14 (2022)

Subject Terms: Sleep disturbance, Rev-erbα, Decidualization, Pregnancy, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/2d804b0eaf4a4e7f8f5e535b06c959f8

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome

Authors: Liang Kou, Xiaosa Chi, Yadi Sun, Chao Han, Fang Wan, Junjie Hu, Sijia Yin, Jiawei Wu, Yunna Li, Qiulu Zhou, Wenkai Zou, Nian Xiong, Jinsha Huang, Yun Xia, Tao Wang

Source: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)

Subject Terms: Parkinson’s disease, Circadian rhythm, Rev-erbα, NLRP3, Neuroinflammation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/0d3c0a38e4914f6b836f6675fe572282

Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway

Authors: Mingyue Sheng, Xun Chen, Yan Yu, Qi Wu, Junping Kou, Gangling Chen

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: cerebral ischemia, SR9009, REV-erbα, Nrf2, circadian rhythm, circadian gene, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1102567/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/8e4bf052e47d44cbb5fb1fa40e9d1709

Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia

Authors: Wang Z, Huang Y, Chu F, Ji S, Liao K, Cui Z, Chen J, Tang S

Source: Journal of Inflammation Research, Vol Volume 14, Pp 5901-5918 (2021)

Subject Terms: clock genes, rev-erbα, nr1d1, retinal inflammation, hmga2, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/clock-gene-nr1d1-alleviates-retinal-inflammation-through-repression-of-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/548ad5e59d19405b908573c89a7bbf66

Puerariae lobatae radix protects against UVB-induced skin aging via antagonism of REV-ERBα in mice

Authors: Luyao Ma, Meiping Huang, Guanghui Sun, Yanke Lin, Danyi Lu, Baojian Wu

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: Puerariae lobatae radix, skin aging, REV-ERBα, BMAL1, Nrf2, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1088294/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/3d1a42a898694c90a0a963019bea0b49

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

Authors: Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding, Meirong Du

Source: BMC Immunology, Vol 22, Iss 1, Pp 1-11 (2021)

Subject Terms: Rev-erbα, Decidual macrophages, M1/M2 polarization, Pregnancy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2172

Access URL: https://doaj.org/article/e731545981874919a9854a381b23f690

Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy

Authors: Qingxue Liu, Lei Xu, Meifei Wu, Yiwen Zhou, Junfa Yang, Cheng Huang, Tao Xu, Jun Li, Lei Zhang

Source: Cell & Bioscience, Vol 11, Iss 1, Pp 1-15 (2021)

Subject Terms: Rev-erbα, AFL, Autophagy, Bmal1, Lysosome, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/e177a0915ea04fd6aa80324be3d165cb

Scutellaria baicalensis Georgi regulates REV-ERBα/BMAL1 to protect against skin aging in mice

Authors: Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: scutellaria baicalensis georgi, skin aging, REV-erbα, BMAL1, photoaging, Therapeutics. Pharmacology, RM1-950

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Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.991917/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/7e34941146b44ae8a27dd68a51e0a72f

Helicobacter pylori–Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive DefenseSummary

Authors: Fang-Yuan Mao, Yi-Pin Lv, Chuan-Jie Hao, Yong-Sheng Teng, Yu-Gang Liu, Ping Cheng, Shi-Ming Yang, Weisan Chen, Tao Liu, Quan-Ming Zou, Rui Xie, Jing-Yu Xu, Yuan Zhuang

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 395-425 (2021)

Subject Terms: Helicobacter pylori, Rev-erbα, Gastric Epithelial Cells, Host Defense, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X21000515; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/78f2e7073bc74a87ad6a6a1c6dad1c20

REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

Authors: Shuo Huang, Chi-Hsiu Liu, Zhongxiao Wang, Zhongjie Fu, William R. Britton, Alexandra K. Blomfield, Theodore M. Kamenecka, Joshua L. Dunaief, Laura A. Solt, Jing Chen

Source: Redox Biology, Vol 51, Iss , Pp 102261- (2022)

Subject Terms: Retinal pigment epithelium, Aging, Age-related macular degeneration, REV-ERBα, Oxidative damage, NRF2, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231722000337; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/d3c8835aceba4b349400a9c669a90905

Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver

Authors: MengLin Chen, Min Chen, Danyi Lu, Yi Wang, Li Zhang, Zhigang Wang, Baojian Wu

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: PER2, Cyp2b10, REV-ERBα, cyclophosphamide, drug metabolism, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.764124/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/014a37401264465bb354052a0ed7740f

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Authors: Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang

Source: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)

Subject Terms: Temporal lobe epilepsy, Rev-Erbα, NLRP3 inflammasome, Neuroinflammation, Neuronal apoptosis, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/a24c5daa2e23441fb73fa685c2ac36bc

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

Authors: Berthier, Alexandre, Vinod, Manjula, Porez, Geoffrey, Steenackers, Agata, Alexandre, Jérémy, Yamakawa, Nao, Gheeraert, Céline, Ploton, Maheul, Maréchal, Xavier, Dubois-Chevalier, Julie, Hovasse, Agnès, Schaeffer-Reiss, Christine, Cianférani, Sarah, Rolando, Christian, Bray, Fabrice, Duez, Hélène, Eeckhoute, Jérôme, Lefebvre, Tony, Staels, Bart, Lefebvre, Philippe

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Nov . 115(47), E11033-E11042.

Access URL: https://www.jstor.org/stable/26564513