A tetracationic porphyrin with dual anti-prion activity

Authors: Masone, Antonio ^{1, 18}, Zucchelli, Chiara ^{2, 18}, Caruso, Enrico ³, Lavigna, Giada ¹, Eraña, Hasier ^{4, 5}, Giachin, Gabriele ⁶, Tapella, Laura ^{1, 15}, Comerio, Liliana ¹, Restelli, Elena ^{1, 16}, Raimondi, Ilaria ¹, Elezgarai, Saioa R. ¹, De Leo, Federica ^{2, 17}, Quilici, Giacomo ², Taiarol, Lorenzo ¹, Oldrati, Marvin ¹, Lorenzo, Nuria L. ⁷, García-Martínez, Sandra ⁴, Cagnotto, Alfredo ⁸, Lucchetti, Jacopo ⁹, Gobbi, Marco ⁹, Vanni, Ilaria ¹⁰, Nonno, Romolo ¹⁰, Di Bari, Michele A. ¹⁰, Tully, Mark D. ¹¹, Cecatiello, Valentina ^{12, 16}, Ciossani, Giuseppe ¹², Pasqualato, Sebastiano ^{12, 16}, Van Anken, Eelco ¹³, Salmona, Mario ⁸, Castilla, Joaquín ^{4, 5, 14}, Requena, Jesús R. ⁷, Banfi, Stefano ³, Musco, Giovanna ², Chiesa, Roberto ^{1, 19, ∗}

Source: In iScience 15 September 2023 26(9)

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice.

Authors: Lavigna, Giada, Grasso, Anna, Pasini, Chiara, Grande, Valentina, Mignogna, Laura, Restelli, Elena, Masone, Antonio, Fracasso, Claudia, Lucchetti, Jacopo, Gobbi, Marco, Chiesa, Roberto

Source: PLoS ONE; 1/13/2025, Vol. 20 Issue 1, p1-19, 19p

Subject Terms: CHEMICAL testing, PURKINJE cells, DRUG metabolism, DIBENZOYLMETHANE, TRAZODONE

Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice

Authors: Lavigna, Giada, Masone, Antonio, Bouybayoune, Ihssane, Bertani, Ilaria, Lucchetti, Jacopo, Gobbi, Marco, Porcu, Luca, Zordan, Stefano, Rigamonti, Mara, Imeri, Luca, Restelli, Elena, Chiesa, Roberto

Source: In Neurobiology of Disease October 2021 158

C. elegans detects toxicity of traumatic brain injury generated tau

Authors: Zanier, Elisa R., Barzago, Maria Monica, Vegliante, Gloria, Romeo, Margherita, Restelli, Elena, Bertani, Ilaria, Natale, Carmina, Colnaghi, Luca, Colombo, Laura, Russo, Luca, Micotti, Edoardo, Fioriti, Luana, Chiesa, Roberto, Diomede, Luisa

Source: In Neurobiology of Disease June 2021 153

Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells

Authors: Restelli, Elena, Capone, Vanessa, Pozzoli, Manuela, Ortolan, Davide, Quaglio, Elena, Corbelli, Alessandro, Fiordaliso, Fabio, Beznoussenko, Galina V., Artuso, Vladimiro, Roiter, Ignazio, Sallese, Michele, Chiesa, Roberto

Source: In Journal of Biological Chemistry January-June 2021 296

Forced diuresis oriented by point‐of‐care ultrasound in cardiorenal syndrome type 5 due to light chain myeloma—The role of hepatic venogram: A case report

Authors: Galassi, Andrea, Magagnoli, Lorenza, Fasulo, Eliana, Stucchi, Andrea, Restelli, Elena, Moro, Alessia, Violati, Martina, Cozzolino, Mario

Source: Clinical case reports. 9(4):2453-2459

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121118257.0x000001&indx=1&recIds=ETOCvdc_100121118257.0x000001

SARS‐CoV‐2–related ARDS in a maintenance hemodialysis patient: case report on tailored approach by daily hemodialysis, noninvasive ventilation, tocilizumab, anxiolytics, and point‐of‐care ultrasound

Authors: Galassi, Andrea, Casanova, Francesca, Gazzola, Lidia, Rinaldo, Rocco, Ceresa, Marco, Restelli, Elena, Giorgini, Alessia, Birocchi, Simone, Giovenzana, Marco, Zoni, Ulisse, Valli, Federica, Massironi, Laura, Belletti, Sebastiano, Magagnoli, Lorenza, Stucchi, Andrea, Ippolito, Michela, Carugo, Stefano, Parazzini, Elena, Cozzolino, Mario

Source: Clinical case reports. 9(2):694-703

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116920797.0x000001&indx=1&recIds=ETOCvdc_100116920797.0x000001

DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression

Authors: Appiah, Bismark, Fullio, Camila L, Ossola, Chiara, Bertani, Ilaria, Restelli, Elena, Cheffer, Arquimedes, Polenghi, Martina, Haffner, Christiane, Garcia‐Miralles, Marta, Zeis, Patrice, Treppner, Martin, Bovio, Patrick, Schlichtholz, Laura, Mas‐Sanchez, Aina, Zografidou, Lea, Winter, Jennifer, Binder, Harald, Grün, Dominic, Kalebic, Nereo, Taverna, Elena, Vogel, Tanja

Source: EMBO reports. 24(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196426774.0x000001&indx=1&recIds=ETOCvdc_100196426774.0x000001

PERK inhibition attenuates the abnormalities of the secretory pathway and the increased apoptotic rate induced by SIL1 knockdown in HeLa cells

Authors: Capone, Vanessa, Clemente, Emanuela, Restelli, Elena, Di Campli, Antonella, Sperduti, Samantha, Ornaghi, Francesca, Pietrangelo, Laura, Protasi, Feliciano, Chiesa, Roberto, Sallese, Michele

Source: In BBA - Molecular Basis of Disease October 2018 1864(10):3164-3180

Neuroprotective modulation of the unfolded protein response in Marinesco-Sjögren syndrome: PERK signaling inhibition and beyond

Authors: Restelli, Elena, Masone, Antonio, Sallese, Michele, Chiesa, Roberto

Source: Neural regeneration research. 14(1):62-64

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088812928.0x000001&indx=1&recIds=ETOCvdc_100088812928.0x000001

Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity.

Authors: Ghirardini, Elsa¹ (AUTHOR), Restelli, Elena² (AUTHOR), Morini, Raffaella¹ (AUTHOR), Bertani, Ilaria² (AUTHOR), Ortolan, Davide² (AUTHOR), Perrucci, Fabio¹ (AUTHOR), Pozzi, Davide¹ (AUTHOR), Matteoli, Michela^1,3 (AUTHOR) michela.matteoli@hunimed.eu, Chiesa, Roberto² (AUTHOR) michela.matteoli@hunimed.eu

Source: PLoS Pathogens. 7/16/2020, Vol. 16 Issue 7, p1-26. 26p.

Subject Terms: *AMPA receptors, *MUTANT proteins, *PRION diseases, *BRAIN degeneration, *CREUTZFELDT-Jakob disease, *GENETIC disorders, *BOVINE spongiform encephalopathy, *ORGANELLES

Transgenic mice recapitulate the phenotypic heterogeneity of genetic prion diseases without developing prion infectivity: Role of intracellular PrP retention in neurotoxicity

Authors: Chiesa, Roberto, Restelli, Elena, Comerio, Liliana, Del Gallo, Federico, Imeri, Luca

Source: Prion. 10(2):93-102

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100031996412.0x000001&indx=1&recIds=ETOCvdc_100031996412.0x000001

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit

Authors: Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B., Bertani, Ilaria, Mantovani, Susanna, Canovi, Mara, Micotti, Edoardo, Forloni, Gianluigi, Dolphin, Annette C., Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto

Source: In Neuron 26 April 2012 74(2):300-313

Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model

Authors: Dossena, Sara, Imeri, Luca, Mangieri, Michela, Garofoli, Anna, Ferrari, Loris, Senatore, Assunta, Restelli, Elena, Balducci, Claudia, Fiordaliso, Fabio, Salio, Monica, Bianchi, Susanna, Fioriti, Luana, Morbin, Michela, Pincherle, Alessandro, Marcon, Gabriella, Villani, Flavio, Carli, Mirjana, Tagliavini, Fabrizio, Forloni, Gianluigi, Chiesa, Roberto

Source: In Neuron 26 November 2008 60(4):598-609

Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction.

Authors: Tapella, Laura, Dematteis, Giulia, Moro, Marianna, Pistolato, Beatrice, Tonelli, Elisa, Vanella, Virginia Vita, Giustina, Daniele, La Forgia, Aleida, Restelli, Elena, Barberis, Elettra, Cali, Tito, Brini, Marisa, Villani, Salvatore, Del Grosso, Erika, Grilli, Mariagrazia, Manfredi, Marcello, Corazzari, Marco, Grolla, Ambra A., Genazzani, Armando A., Lim, Dmitry

Source: Cell Death & Disease; Oct2022, Vol. 13 Issue 10, p1-16, 16p

INFLUENCE OF INFLAMMATION ON COGNITIVE DEFICIT INDUCED BY α SYNUCLEIN OLIGOMERS INDEPENDENTLY OF CELLULAR PRION PROTEIN

Authors: La Vitola, Pietro, Balducci, Claudia, Beeg, Marten, Santamaria, Giulia, Restelli, Elena, Colombo, Laura, Caldinelli, Laura, Pollegioni, Loredano, Albani, Diego, Gobbi, Marco, Chiesa, Roberto, Forloni, Gianluigi

Source: Alzheimer's & dementia. 15(7):P275-P276

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091215327.0x000001&indx=1&recIds=ETOCvdc_100091215327.0x000001

Synaptic Dysfunction in Prion Diseases: A Trafficking Problem?

Authors: Senatore, Assunta¹, Restelli, Elena¹, Chiesa, Roberto¹ roberto.chiesa@marionegri.it

Source: International Journal of Cell Biology. 2013, p1-15. 15p.

Subject Terms: *PRION diseases, *NEURODEGENERATION, *PROTEIN folding, *ENDOPLASMIC reticulum, *CALCIUM channels, *GENETIC translation

Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction.

Authors: Quaglio, Elena^1,2, Restelli, Elena^1,2, Garofoli, Anna^1,2, Dossena, Sara^1,2, De Luigi, Ada³, Tagliavacca, Luigina⁴, Imperiale, Daniele⁵, Migheli, Antonio⁵, Salmona, Mario³, Sitia, Roberto⁴, Forloni, Gianluigi², Chiesa, Roberto^1,2 roberto.chiesa@marionegri.it

Source: PLoS ONE. 2011, Vol. 6 Issue 4, p1-14. 14p.

Subject Terms: *ENDOPLASMIC reticulum, *TRANSGENIC mice, *ORGANELLES, *SLOW virus diseases, *NEUROLOGICAL disorders, *IMMUNOHISTOCHEMISTRY

Cell Type-Specific Neuroprotective Activity of Untranslocated Prion Protein.

Authors: Restelli, Elena^1,2, Fioriti, Luana^1,2,3, Mantovani, Susanna^1,2, Airaghi, Simona^1,2, Forloni, Gianluigi², Chiesa, Roberto^1,2 roberto.chiesa@marionegri.it

Source: PLoS ONE. 2010, Vol. 5 Issue 10, p1-9. 9p.

Subject Terms: *PRION diseases, *PROTEINS, *NEUROPROTECTIVE agents, *ENDOPLASMIC reticulum, *BIOCHEMISTRY, *CELLS, *BIOMOLECULES, *PATHOGENIC microorganisms, *CYTOSOL

Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes.

Authors: Dematteis, Giulia¹ (AUTHOR) giulia.dematteis@uniupo.it, Restelli, Elena² (AUTHOR) elena.restelli@marionegri.it, Vanella, Virginia Vita³ (AUTHOR) virginia.vanella@uniupo.it, Manfredi, Marcello³ (AUTHOR) marcello.manfredi@uniupo.it, Marengo, Emilio⁴ (AUTHOR) emilio.marengo@uniupo.it, Corazzari, Marco⁵ (AUTHOR) marco.corazzari@uniupo.it, Genazzani, Armando A.¹ (AUTHOR) armando.genazzani@uniupo.it, Chiesa, Roberto² (AUTHOR) roberto.chiesa@marionegri.it, Lim, Dmitry¹ (AUTHOR) dmitry.lim@uniupo.it, Tapella, Laura¹ (AUTHOR) dmitry.lim@uniupo.it

Source: Cells (2073-4409). Apr2022, Vol. 11 Issue 4, p609. 1p.

Subject Terms: *PRION diseases, *PRIONS, *ASTROCYTES, *PROTEIN expression, *CALCINEURIN, *MUTANT proteins, *GOLGI apparatus, *PROTEIN synthesis