Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer

Authors: Tarazona, N., Gimeno-Valiente, F., Gambardella, V., Zuñiga, S., Rentero-Garrido, P., Huerta, M., Roselló, S., Martinez-Ciarpaglini, C., Carbonell-Asins, J.A., Carrasco, F., Ferrer-Martínez, A., Bruixola, G., Fleitas, T., Martín, J., Tébar-Martínez, R., Moro, D., Castillo, J., Espí, A., Roda, D., Cervantes, A. ^{*, †}

Source: In Annals of Oncology November 2019 30(11):1804-1812

74P Transcriptomic profile identifies biological differences in very young women with breast cancer

Authors: Garrido-Cano, I., Céspedes, M. Tapia, Carbonell-Asins, J.A., Peña, C., Burgues, O., Tebar, C., Terrádez, L., Àgreda-Roca, A., Torres, S., Segui-Manzaneque, V., Grimalt, N., Bartolomé, M.G., Melia, C. Hernando, Rentero-Garrido, P., Buch, E., Lluch, A., Gonzalez, I. Chirivella, Bermejo, B., Martinez, M.T.M., Cejalvo, J.M.

Source: In ESMO Open May 2023 8(1) Supplement 4

64P Integrative immune transcriptomic classification could improve patient selection for precision immunotherapy in advanced gastroesophageal adenocarcinoma

Authors: Cabeza Segura, M., Gambardella, V., Gimeno-Valiente, F., Carbonell-Asins, J.A., Alarcon-Molero, L., Gonzalez-Vilanova, A., Zuniga-Trejos, S., Rentero-Garrido, P., Villagrasa, R., Gil Raga, M., Richart, P., Huerta, M., Rosello Keranen, S., Roda Perez, D., Tarazona Llavero, N., Martínez-Ciarpaglini, C., Castillo, J., Cervantes, A., Fleitas, T.C.

Source: In Annals of Oncology October 2022 33 Supplement 8:S1402-S1403

379P Whole exome sequencing of plasma circulating tumor DNA identifies dynamic mutational changes to guide targeted therapies in colon cancer patients

Authors: Martín-Arana, J., Gimeno-Valiente, F., Tébar-Martínez, R., García-Mico, B., Gambardella, V., Huerta, M., Martínez-Ciarpaglini, C., Carbonell-Asins, J.A., Cabeza Segura, M., Martín-Arévalo, J., Casado, D., Pla, V., Pérez, L., Rentero-Garrido, P., Rosello Keranen, S., Fleitas, T.C., Castillo, J., Roda Perez, D., Cervantes, A., Tarazona Llavero, N.

Source: In Annals of Oncology September 2022 33 Supplement 7:S709-S709

360P Epigenetic engineering on CDX2 allows to determine the interplaying consequences with other genetic and transcriptomic events in colorectal cancer

Authors: Gimeno-Valiente, F., Duréndez, E., Badía, J., Martínez-Ciarpaglini, C., Iglesias, M., Linares, J.L., Huerta, M., Moro, D., Gambardella, V., Martín-Arana, J., Fleitas, T.C., Roselló Keränen, S., Cabeza Segura, M., García-Mico, B., Rentero-Garrido, P., Roda, D., Castillo, J., Cervantes, A., Calon, A., Tarazona Llavero, N.

Source: In Annals of Oncology September 2022 33 Supplement 7:S700-S700

464P Exome sequencing of ctDNA portrays the mutational landscape of patients with relapsing colon cancer and indicates new actionable targets

Authors: Tarazona, N., Martín-Arana, J., Tébar-Martínez, R., Gimeno-Valiente, F., Gambardella, V., Alvaro, M. Huerta, Martínez-Ciarpaglini, C., Alfaro-Cervello, C., Cabeza-Segura, M., García-Micó, B., Moragón, S., Tapia, M., Carbonell-Asins, J.A., Rentero-Garrido, P., Zuñiga, S., Roselló, S., Fleitas, T., Castillo, J., Perez, D. Roda, Cervantes, A.

Source: In Annals of Oncology September 2021 32 Supplement 5:S564-S564

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1493P An integrated analysis of gene expression profile and chromosomal aberrations highlighted the oxidative stress role in anti-HER2 drug-resistant gastric cancer models

Authors: Gambardella, V., Gimeno-Valiente, F., Cabeza, M., Papaccio, F., Zúñiga-Trejos, S., Carbonell-Asins, J.A., Rentero-Garrido, P., Huerta, M., Roselló Keränen, S., Cejalvo, J.M., Roda, D., Tarazona, N., Fleitas, T., Cervantes, A., Castillo, J.

Source: In Annals of Oncology September 2020 31 Supplement 4:S927-S927

1471P 3D patient-derived gastric cancer organoids as a tool for functional precision medicine for gastric cancer patients

Authors: Cabeza, M., Papaccio, F., Gutierrez Bravo, M.F., Gambardella, V., Alfaro-Cervello, C., Martínez-Ciarpaglini, C., Garzón-Lloría, Z., Rentero-Garrido, P., Zúñiga-Trejos, S., Seda-García, E., Gimeno-Valiente, F., Peña, A., Barrios, M., Tarazona, N., Roda, D., Cervantes, A., Fleitas, T., Castillo, J.

Source: In Annals of Oncology September 2020 31 Supplement 4:S919-S919

490P Metastatic colorectal cancer derived organoids recapitulate genomic profile and treatment response of the original tumor

Authors: Papaccio, F., Bravo, M.F. Gutierrez, Cabeza-Segura, M., Gimeno-Valiente, F., Gambardella, V., Garzón-Lloría, Z., García-Micó, B., Huerta, M., Martínez-Ciarpaglini, C., Alfaro-Cervello, C., Sabater, L., Lombardi, P., Rentero-Garrido, P., Zúñiga-Trejos, S., Keränen, S. Roselló, Fleitas, T., Tarazona, N., Roda, D., Cervantes, A., Castillo, J.

Source: In Annals of Oncology September 2020 31 Supplement 4:S449-S449

488P Patient-derived organoids as a tool for modelling localized colorectal cancer

Authors: Bravo, M.F. Gutierrez, Papaccio, F., Cabeza, M., Martínez-Ciarpaglini, C., Alfaro-Cervello, C., Garzón-Lloría, Z., Ferrer-Martínez, A., García-Micó, B., Gambardella, V., Rentero-Garrido, P., Fleitas, T., Moro-Valdezate, D., Huerta, M., Tarazona, N., Roda, D., Cervantes, A., Castillo, J.

Source: In Annals of Oncology September 2020 31 Supplement 4:S448-S448

406MO Sequencing paired tumor DNA and white blood cells (WBCs) increases sensitivity to track plasma circulating tumor DNA (ctDNA) for detecting minimal residual disease (MRD) in localized colon cancer (CC)

Authors: Tarazona, N., Martín-Arana, J., Tébar-Martínez, R., Lombardi, P., Moragón, S., Zuñiga, S., Rentero-Garrido, P., Carbonell-Asins, J.A., Gambardella, V., Huerta, M., Roselló, S., Martínez-Ciarpaglini, C., Alfaro-Cervello, C., Moro, D., Ferrer-Martínez, A., Ponce, M., Peña, A., Espí, A., Roda, D., Cervantes, A.

Source: In Annals of Oncology September 2020 31 Supplement 4:S413-S414

1201P The role of a mini tumour mutational burden (TMB) score generated with a customized NGS panel to predict benefit from immunotherapy

Authors: Lombardi, P., Gambardella, V., Tarazona, N., Carbonell-Asins, J.A., Martín-Arana, J., Rentero-Garrido, P., Montón-Bueno, J.V., Gonzalez-Barrallo, I., Bruixola, G., Cejalvo, J.M., Martín-Martorell, P., Tébar-Martínez, R., Blesa, S., Seda, E., Pérez-Fidalgo, J.A., Insa Mollá, A., Fleitas, T., Zúñiga-Trejos, S., Cervantes, A., Roda, D.

Source: In Annals of Oncology September 2020 31 Supplement 4:S789-S789

57P Benefit of CDK4/6 inhibitors beyond PIK3CA mutations in metastatic breast cancer patients

Authors: Tolosa Ortega, P., Cejalvo, J.M., Moragon Terencio, S., Carril-Ajuria, L., Bermejo, B., Ruiz, Á., Hernando Melia, C., Sánchez-Torre, A., Martínez, M.T., Herrera, M., Gambardella, V., Lema, L., Roda, D., Bernal, E., Rentero-Garrido, P., Lluch, A., Ciruelos, E.M., Cervantes, A., Manso, L.

Source: In Annals of Oncology May 2020 31 Supplement 2:S35-S35

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28P - CNAs concordance between CRC-PDOs and the original tissue reveals relevant oncogenic pathways alterations

Authors: Castillo, J., Papaccio, F., Valiente, F.G., Gutierrez-Bravo, M.F., Cabeza-Segura, M., Gambardella, V., Huerta, M.D.S., Martinez-Ciarpaglini, C., Alfaro-Cervello, C., Rentero-Garrido, P., Zúñiga-Trejos, S., Rosello Keranen, S., Fleitas, T., Tarazona, N., Roda Perez, D., Cervantes, A.

Source: In Annals of Oncology November 2019 30 Supplement 7:vii9-vii9

LBA24 - A multi-omic analysis for prospective patient stratification in localised colorectal cancer (CRC)

Authors: Tarazona Llavero, N., Fontana, E., Gambardella, V., Gimeno-Valiente, F., Castillo, J., Calon, A., Martínez-Ciarpaglini, C., Peiró-Chova, L., Huerta, M., Zuñiga, S., Rentero-Garrido, P., Montón-Bueno, J., Roda, D., Roselló, S., Bellosillo, B., Vivancos, A., Nyamundana, G., Montagut, C., Sadanandam, A., Cervantes, A.

Source: In Annals of Oncology October 2018 29 Supplement 8

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