Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1

Authors: Tao, Yongfeng, Remillard, David, Vinogradova, Ekaterina V., Yokoyama, Minoru, Banchenko, Sofia, Schwefel, David, Melillo, Bruno, Schreiber, Stuart L., Zhang, Xiaoyu, Cravatt, Benjamin F.

Source: Journal of the American Chemical Society. 144(40):18688-18699

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630409104&indx=1&recIds=ETOCRN630409104

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

Authors: Remillard, David, Savage, Nikolas A., Kedves, Alexia T., Paulk, Joshiawa, Chen, Xin, Garcia, Francisco J., Romanowski, Michael J., Horton, Patricia A., Murphy, Jason, Schirle, Markus

Source: ACS chemical biology. 16(11):2185-2192

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628094625&indx=1&recIds=ETOCRN628094625

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Authors: Vinogradova, Ekaterina V., Zhang, Xiaoyu, Remillard, David, Lazar, Daniel C., Suciu, Radu M., Wang, Yujia, Bianco, Giulia, Yamashita, Yu, Crowley, Vincent M., Schafroth, Michael A., Yokoyama, Minoru, Konrad, David B., Lum, Kenneth M., Simon, Gabriel M., Kemper, Esther K., Lazear, Michael R., Yin, Sifei, Blewett, Megan M., Dix, Melissa M., Nguyen, Nhan, Shokhirev, Maxim N., Chin, Emily N., Lairson, Luke L., Melillo, Bruno, Schreiber, Stuart L., Forli, Stefano, Teijaro, John R., Cravatt, Benjamin F.

Source: In Cell 20 August 2020 182(4):1009-1026

Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2.

Authors: Tao, Yongfeng¹, Felber, Jan G.^1,2, Zou, Zhongyu³, Njomen, Evert¹, Remsberg, Jarrett R.^1,4, Ogasawara, Daisuke¹, Ye, Chang³, Melillo, Bruno^1,5, Schreiber, Stuart L.^5,6, He, Chuan^3,7, chuanhe@uchicago.edu, Remillard, David^1,8, davidianremillard@gmail.com, Cravatt, Benjamin F.¹, cravatt@scripps.edu

Source: Angewandte Chemie International Edition; 12/18/2023, Vol. 62 Issue 51, p1-7, 7p

Collateral lethality between HDAC1and HDAC2exploits cancer-specific NuRD complex vulnerabilities

Authors: Zhang, Yuxiang, Remillard, David, Onubogu, Ugoma, Karakyriakou, Barbara, Asiaban, Joshua N., Ramos, Anissa R., Bowland, Kirsten, Bishop, Timothy R., Barta, Paige A., Nance, Stephanie, Durbin, Adam D., Ott, Christopher J., Janiszewska, Michalina, Cravatt, Benjamin F., Erb, Michael A.

Source: Nature Structural and Molecular Biology; 20230101, Issue: Preprints p1-12, 12p

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Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.

Authors: Remillard, David, Buckley, Dennis L., Seo, Hyuk-Soo, Ferguson, Fleur M., Dhe-Paganon, Sirano, Bradner, James E., Gray, Nathanael S.

Source: ACS Medicinal Chemistry Letters; 2019, Vol. 10 Issue 10, p1443-1449, 7p

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Tarbox v. Zoning Bd. of Review of Jamestown.

Authors: Remillard, David M.

Source: Roger Williams University Law Review; Summer2017, Vol. 22 Issue 3, p696-703, 8p

Subject Terms: SMALL business laws, LAND use laws, ZONING boards, ZONING law, ACTIONS & defenses (Law)

Geographic Terms: UNITED States

Company/Entity: RHODE Island. Supreme Court

Highway to the Danger Drone: Reconciling First Amendment Rights of Drone Owners and Privacy Rights of Individuals in Creating a Comprehensive Statutory Scheme in Rhode Island.

Authors: Remillard, David M.

Source: Roger Williams University Law Review; Summer2017, Vol. 22 Issue 3, p640-669, 30p

Subject Terms: RIGHT of privacy, AUTONOMOUS vehicles, DRONE aircraft, GOVERNMENT policy, SAFETY, LAW

Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1".

Authors: Tao, Yongfeng, Remillard, David, Vinogradova, Ekaterina V., Yokoyama, Minoru, Banchenko, Sofia, Schwefel, David, Melillo, Bruno, Schreiber, Stuart L., Zhang, Xiaoyu, Cravatt, Benjamin F.

Source: Journal of the American Chemical Society; 6/14/20\23, Vol. 145 Issue 23, p12948-12948, 1p

Chemical Tools to Study Bromodomains in Cancer

Authors: Remillard, David Ian

Contributors: Kadoch, Cigall, Gray, Nathanael S., Mazitschek, Ralph, Bradner, James E.

Source: Remillard, David Ian. 2018. Chemical Tools to Study Bromodomains in Cancer. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.

Subject Terms: Chemical Biology, Medicinal Chemistry, Bromodomain, Targeted Degradation, Cancer Biology

File Description: application/pdf; application/pdf

Access URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121222

Back Cover: Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET (ChemMedChem 23/2016).

Authors: Koblan, Luke W., Buckley, Dennis L., Ott, Christopher J., Fitzgerald, Mark E., Ember, Stuart W. J., Zhu, Jin‐Yi, Liu, Shuai, Roberts, Justin M., Remillard, David, Vittori, Sarah, Zhang, Wei, Schonbrunn, Ernst, Bradner, James E.

Source: ChemMedChem; 12/6/2016, Vol. 11 Issue 23, p2638-2638, 1p