Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Authors: Harber, Karl J., Neele, Annette E., van Roomen, Cindy PAA., Gijbels, Marion JJ., Beckers, Linda, Toom, Myrthe den, Schomakers, Bauke V., Heister, Daan AF., Willemsen, Lisa, Griffith, Guillermo R., de Goede, Kyra E., van Dierendonck, Xanthe AMH., Reiche, Myrthe E., Poli, Aurélie, L-H Mogensen, Frida, Michelucci, Alessandro, Verberk, Sanne GS., de Vries, Helga, van Weeghel, Michel, Van den Bossche, Jan, de Winther, Menno PJ.

Source: In Redox Biology April 2024 70

Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis

Authors: Poels, Kikkie, van Leent, Mandy M.T., Boutros, Celine, Tissot, Hubert, Roy, Séverine, Meerwaldt, Anu E., Toner, Yohana C.A., Reiche, Myrthe E., Kusters, Pascal J.H., Malinova, Tsveta, Huveneers, Stephan, Kaufman, Audrey E., Mani, Venkatesh, Fayad, Zahi A., de Winther, Menno P.J., Marabelle, Aurelien, Mulder, Willem J.M., Robert, Caroline, Seijkens, Tom T.P., Lutgens, Esther

Source: In JACC: CardioOncology November 2020 2(4):599-610

Microgravity Effect on Pancreatic Islets.

Authors: Zeger, Lukas, Barasa, Povilas, Han, Yilin, Hellgren, Josefin, Redwan, Itedale Namro, Reiche, Myrthe E., Florin, Gunnar, Christoffersson, Gustaf, Kozlova, Elena N.

Source: Cells (2073-4409); Sep2024, Vol. 13 Issue 18, p1588, 12p

Subject Terms: NEURAL stem cells, THREE-dimensional printing, ROCKETS (Aeronautics), REDUCED gravity environments, MASERS, PANCREATIC beta cells, ISLANDS of Langerhans

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.

Authors: Aarts, Suzanne A. B. M.¹, Reiche, Myrthe E.¹, den Toom, Myrthe¹, Beckers, Linda¹, Gijbels, Marion J. J.^1,2, de Winther, Menno P. J.^1,3, Lutgens, Esther^1,3, Gerdes, Norbert^3,4

Source: PLoS ONE. 8/10/2018, Vol. 13 Issue 8, p1-11. 11p.

Subject Terms: *MACROPHAGES, *ADIPOSE tissues, *CHOLESTEROL metabolism, *LEUKOCYTES

Lose the helpers… get 'remote' regulators!

Authors: Reiche, Myrthe E, Lutgens, Esther

Source: Cardiovascular research. 117(3):635-636

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130286332.0x000001&indx=1&recIds=ETOCvdc_100130286332.0x000001

Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis.

Authors: Ouweneel, Amber B.¹, Reiche, Myrthe E.², Snip, Olga S. C.¹, Wever, Robbert¹, van der Wel, Ezra J.¹, Schaftenaar, Frank H.¹, Kauerova, Soňa³, Lutgens, Esther², Van Eck, Miranda¹, Hoekstra, Menno¹ hoekstra@lacdr.leidenuniv.nl

Source: Journal of Cell Science. Mar2022, Vol. 135 Issue 5, p1-9. 9p.

Subject Terms: *BONE marrow cells, *T cells, *HIGH density lipoproteins, *LIPOPROTEIN receptors, *CELL populations, *STEM cells, *BONE marrow

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.

Authors: Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M.

Source: Nature Communications; 6/18/2021, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: VASCULAR diseases, CARDIOVASCULAR diseases, ATHEROSCLEROTIC plaque, ATHEROSCLEROSIS, MUSCLE cells

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.

Authors: Aarts, Suzanne ABM, Seijkens, Tom TP, Kusters, Pascal JH, van Tiel, Claudia M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy PAA, de Winther, Menno PJ, Kooij, Gijs, Lutgens, Esther

Source: Journal of Pathology; Apr2019, Vol. 247 Issue 4, p471-480, 10p

Lose the helpers... get 'remote' regulators!

Authors: Reiche, Myrthe E¹ (AUTHOR), Lutgens, Esther^1,2,3 (AUTHOR) E.Lutgens@amsterdamumc.nl

Source: Cardiovascular Research. Mar2021, Vol. 117 Issue 3, p635-636. 2p.

Subject Terms: *T helper cells, *SUPPRESSOR cells, *INTERLEUKIN-21, *B cells, *ATHEROSCLEROTIC plaque

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice.

Authors: Poels, Kikkie, van Leent, Mandy M. T., Reiche, Myrthe E., Kusters, Pascal J. H., Huveneers, Stephan, de Winther, Menno P. J., Mulder, Willem J. M., Lutgens, Esther, Seijkens, Tom T. P.

Source: Cells (2073-4409); Sep2020, Vol. 9 Issue 9, p1987, 1p

Subject Terms: ATHEROSCLEROTIC plaque, POSITRON emission tomography, T cells, THORACIC aorta, MUSCLE cells, AORTA, MONOCYTES, INFLAMMATION

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