ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance

Authors: Stüve, Philipp ^{1, 2, 3, 4, 20}, Godoy, Gloria J. ^{5, 20}, Ferreyra, Fernando N. ^{5, 6, 7}, Hellriegel, Florencia ^{5, 6, 7}, Boukhallouk, Fatima ⁴, Kao, Yu-San ⁴, More, Tushar H. ⁸, Matthies, Anne-Marie ^{9, 10, 11}, Akimova, Tatiana ¹², Abraham, Wolf-Rainer ^{8, 13}, Kaever, Volkhard ¹⁴, Schmitz, Ingo ^{9, 10, 11}, Hiller, Karsten ⁸, Lochner, Matthias ^{1, 2, 15}, Salomon, Benoît L. ¹⁶, Beier, Ulf H. ¹⁷, Rehli, Michael ^{3, 18}, Sparwasser, Tim ^{4, 19}, Berod, Luciana ^{5, 19, ⁎}

Source: In Molecular Metabolism April 2025 94

Expansions of circulating plasmablasts producing commensal-reactive IgA antibodies are predictors for chronic GVHD

Authors: Habenicht, Katharina M. ^{1, 2}, Wanzek, Jana ¹, Bootz, Anna ¹, Schäfer, Simon ^{1, 3}, Vollmer, Lara ^{1, 2}, Hiergeist, Andreas ⁴, Fante, Matthias ⁵, Hasenbank, Jakob ¹, Schneider, Andrea ¹, Vasova, Ingrid ², Spoerl, Silvia ², Brandt, Anna ², Rehli, Michael ^{5, 6}, Hoffmann, Petra ^{5, 6}, Wirtz, Stefan ⁷, Kotorri, Jesika ⁸, Gerlach, Roman G. ⁸, Gessner, André ⁴, Mackensen, Andreas ², Winkler, Julia ², Wolff, Daniel ⁵, Winkler, Thomas H. ^{1, ∗}

Source: In Blood April 2025

Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

Authors: Baldwin, Jeremy G., Heuser-Loy, Christoph, Saha, Tanmoy, Schelker, Roland C., Slavkovic-Lukic, Dragana, Strieder, Nicholas, Hernandez-Lopez, Inmaculada, Rana, Nisha, Barden, Markus, Mastrogiovanni, Fabio, Martín-Santos, Azucena, Raimondi, Andrea, Brohawn, Philip, Higgs, Brandon W., Gebhard, Claudia, Kapoor, Veena, Telford, William G., Gautam, Sanjivan, Xydia, Maria, Beckhove, Philipp, Frischholz, Sina, Schober, Kilian, Kontarakis, Zacharias, Corn, Jacob E., Iannacone, Matteo, Inverso, Donato, Rehli, Michael, Fioravanti, Jessica, Sengupta, Shiladitya, Gattinoni, Luca

Source: In Cell 14 November 2024 187(23):6614-6630

STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia

Authors: Fischer, Alexander ^{1, 2}, Hernández-Rodríguez, Benjamín ³, Mulet-Lazaro, Roger ^{4, 5}, Nuetzel, Margit ¹, Hölzl, Fabian ², van Herk, Stanley ^{4, 5}, Kavelaars, François G. ⁴, Stanewsky, Hanna ¹, Ackermann, Ute ¹, Niang, Amadou H. ³, Diaz, Noelia ^{3, 9}, Reuschel, Edith ⁶, Strieder, Nicholas ², Hernández-López, Inmaculada ², Valk, Peter J.M. ⁴, Vaquerizas, Juan M. ^{3, 7, 8}, Rehli, Michael ^{1, 2, 10}, Delwel, Ruud ^{4, 5, 10}, Gebhard, Claudia ^{2, 10, 11, ∗}

Source: In Cell Reports 27 August 2024 43(8)

Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

Authors: Simon, Malte, Stüve, Philipp, Schmidleithner, Lisa, Bittner, Sebastian, Beumer, Niklas, Strieder, Nicholas, Schmidl, Christian, Pant, Asmita, Gebhard, Claudia, Eigenberger, Andreas, Rehli, Michael, Prantl, Lukas, Hehlgans, Thomas, Brors, Benedikt, Imbusch, Charles D., Delacher, Michael, Feuerer, Markus

Source: In Immunity 13 August 2024 57(8):1975-1993

Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy

Authors: Bittner, Sebastian, Ruhland, Brigitte, Hofmann, Veronika, Schmidleithner, Lisa, Schambeck, Kathrin, Pant, Asmita, Stüve, Philipp, Delacher, Michael, Echtenacher, Bernd, Edinger, Matthias, Hoffmann, Petra, Rehli, Michael, Gebhard, Claudia, Strieder, Nicholas, Hehlgans, Thomas, Feuerer, Markus

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Oct 01. 119(40), 1-10.

Access URL: https://www.jstor.org/stable/27208469

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Authors: Mulet-Lazaro, Roger, van Herk, Stanley, Erpelinck, Claudia, Bindels, Eric, Sanders, Mathijs A., Vermeulen, Carlo, Renkens, Ivo, Valk, Peter, Melnick, Ari M., de Ridder, Jeroen, Rehli, Michael, Gebhard, Claudia, Delwel, Ruud ^*, Wouters, Bas J. ^{*, *}

Source: In Blood 15 July 2021 138(2):160-177

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

Authors: Delacher, Michael, Simon, Malte, Sanderink, Lieke, Hotz-Wagenblatt, Agnes, Wuttke, Marina, Schambeck, Kathrin, Schmidleithner, Lisa, Bittner, Sebastian, Pant, Asmita, Ritter, Uwe, Hehlgans, Thomas, Riegel, Dania, Schneider, Verena, Groeber-Becker, Florian Kai, Eigenberger, Andreas, Gebhard, Claudia, Strieder, Nicholas, Fischer, Alexander, Rehli, Michael, Hoffmann, Petra, Edinger, Matthias, Strowig, Till, Huehn, Jochen, Schmidl, Christian, Werner, Jens M., Prantl, Lukas, Brors, Benedikt, Imbusch, Charles D., Feuerer, Markus

Source: In Immunity 13 April 2021 54(4):702-720

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

Authors: Delacher, Michael, Imbusch, Charles D., Hotz-Wagenblatt, Agnes, Mallm, Jan-Philipp, Bauer, Katharina, Simon, Malte, Riegel, Dania, Rendeiro, André F., Bittner, Sebastian, Sanderink, Lieke, Pant, Asmita, Schmidleithner, Lisa, Braband, Kathrin L., Echtenachter, Bernd, Fischer, Alexander, Giunchiglia, Valentina, Hoffmann, Petra, Edinger, Matthias, Bock, Christoph, Rehli, Michael, Brors, Benedikt, Schmidl, Christian, Feuerer, Markus

Source: In Immunity 18 February 2020 52(2):295-312

Temporal autoregulation during human PU.1 locus SubTAD formation

Authors: Schuetzmann, Daniel, Walter, Carolin, van Riel, Boet, Kruse, Sabrina, König, Thorsten, Erdmann, Tabea, Tönges, Alexander, Bindels, Eric, Weilemann, Andre, Gebhard, Claudia, Wethmar, Klaus, Perrod, Chiara, Minderjahn, Julia, Rehli, Michael, Delwel, Ruud, Lenz, Georg, Gröschel, Stefan, Dugas, Martin, Rosenbauer, Frank ^*

Source: In Blood 20 December 2018 132(25):2643-2655

Oligoclonal CD4⁺CXCR5⁺ T cells with a cytotoxic phenotype appear in tonsils and blood.

Authors: Liang, Chunguang, Spoerl, Silvia, Xiao, Yin, Habenicht, Katharina M., Haeusl, Sigrun S., Sandner, Isabel, Winkler, Julia, Strieder, Nicholas, Eder, Rüdiger, Stanewsky, Hanna, Alexiou, Christoph, Dudziak, Diana, Rosenwald, Andreas, Edinger, Matthias, Rehli, Michael, Hoffmann, Petra, Winkler, Thomas H., Berberich-Siebelt, Friederike

Source: Communications Biology; 7/18/2024, p1-16, 16p

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Authors: Avellino, Roberto, Havermans, Marije, Erpelinck, Claudia, Sanders, Mathijs A., Hoogenboezem, Remco, van de Werken, Harmen J.G., Rombouts, Elwin, van Lom, Kirsten, van Strien, Paulina M.H., Gebhard, Claudia, Rehli, Michael, Pimanda, John, Beck, Dominik, Erkeland, Stefan, Kuiken, Thijs, de Looper, Hans, Gröschel, Stefan, Touw, Ivo, Bindels, Eric, Delwel, Ruud

Source: In Blood 16 June 2016 127(24):2991-3003

Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease.

Authors: Dittmar, David J., Pielmeier, Franziska, Strieder, Nicholas, Fischer, Alexander, Herbst, Michael, Stanewsky, Hanna, Wenzl, Niklas, Röseler, Eveline, Eder, Rüdiger, Gebhard, Claudia, Schwarzfischer-Pfeilschifter, Lucia, Albrecht, Christin, Herr, Wolfgang, Edinger, Matthias, Hoffmann, Petra, Rehli, Michael

Source: Nature Communications; 4/15/2024, Vol. 15 Issue 1, p1-16, 16p

Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10

Authors: Tausendschön, Michaela, Rehli, Michael, Dehne, Nathalie, Schmidl, Christian, Döring, Claudia, Hansmann, Martin-Leo, Brüne, Bernhard

Source: In BBA - Gene Regulatory Mechanisms January 2015 1849(1):10-22

Uterine enrichment of CD8+ T regulatory cells throughout pregnancy prevents fetal loss in mice

Authors: Hardardottir, Lilja, Bazzano, Maria Victoria, Shi, Wenqin, Thiele, Kristin, Tolosa, Eva, Nisthar, Sara, Strieder, Nicholas, Gebhard, Claudia, Rehli, Michael, Arck, Petra, Mittrücker, Hans-Willi, Köninger, Angela, Solano, Maria Emilia

Source: In Journal of Reproductive Immunology September 2023 159

Transcription and enhancer profiling in human monocyte subsets

Authors: Schmidl, Christian, Renner, Kathrin, Peter, Katrin, Eder, Ruediger, Lassmann, Timo, Balwierz, Piotr J., Itoh, Masayoshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Andreesen, Reinhard, Hume, David A., Hoffmann, Petra, Forrest, Alistair R.R., Kreutz, Marina P., Edinger, Matthias, Rehli, Michael

Source: In Blood 24 April 2014 123(17):e90-e99

The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations

Authors: Schmidl, Christian, Hansmann, Leo, Lassmann, Timo, Balwierz, Piotr J., Kawaji, Hideya, Itoh, Masayoshi, Kawai, Jun, Nagao-Sato, Sayaka, Suzuki, Harukazu, Andreesen, Reinhard, Hayashizaki, Yoshihide, Forrest, Alistair R.R., Carninci, Piero, Hoffmann, Petra, Edinger, Matthias, Rehli, Michael

Source: In Blood 24 April 2014 123(17):e68-e78

Changes in adenoviral chromatin organization precede early gene activation upon infection.

Authors: Schwartz, Uwe, Komatsu, Tetsuro, Huber, Claudia, Lagadec, Floriane, Baumgartl, Conradin, Silberhorn, Elisabeth, Nuetzel, Margit, Rayne, Fabienne, Basyuk, Eugenia, Bertrand, Edouard, Rehli, Michael, Wodrich, Harald, Laengst, Gernot

Source: EMBO Journal; 10/4/2023, Vol. 42 Issue 19, p1-19, 19p

Subject Terms: GENETIC regulation, GENETIC vectors, GENE expression, NUCLEOTIDE sequence, CYTOSKELETAL proteins, CHROMATIN, VIRAL genes, NUCLEOPROTEINS

Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states

Authors: Pham, Thu-Hang, Benner, Christopher, Lichtinger, Monika, Schwarzfischer, Lucia, Hu, Yuhui, Andreesen, Reinhard, Chen, Wei, Rehli, Michael

Source: In Blood 14 June 2012 119(24):e161-e171

A Gene Necessary for Reproductive Suppression in Termites

Authors: Korb, Judith, Weil, Tobias, Hoffmann, Katharina, Foster, Kevin R., Rehli, Michael

Source: Science, 2009 May 01. 324(5928), 758-758.

Access URL: https://www.jstor.org/stable/20493892