Structure–function relationship of dynorphin B variants using naturally occurring amino acid substitutions

Authors: Luca Zangrandi, Barbara Fogli, Anna Mutti, René Staritzbichler, Victoria Most, Peter W. Hildebrand, Regine Heilbronn, Christoph Schwarzer

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: opioid receptors, epilepsy, functional selectivity, G-protein-coupled receptors, selectivity, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1484730/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/f369c9268e654a14b335b6273d0e7f09

Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector

Authors: Jeanette Zanker, Daniela Hüser, Adrien Savy, Sara Lázaro-Petri, Eva-Maria Hammer, Christoph Schwarzer, Regine Heilbronn

Source: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Subject Terms: adeno-associated virus, gene therapy, neuropeptide, SH-SY5Y, differentiation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2023.1280556/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/0008ca48e46b43d6a58a16fb4f210f2f

Dynorphin‐based 'release on demand' gene therapy for drug‐resistant temporal lobe epilepsy

Authors: Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer

Source: EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-16 (2019)

Subject Terms: adeno‐associated virus, learning, memory, neuropeptide, seizure, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/480489b3db774418b348f8ecb6933d15

CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis

Authors: Jackie Lau, Aitak Farzi, Yue Qi, Regine Heilbronn, Mario Mietzsch, Yan-Chuan Shi, Herbert Herzog

Source: Molecular Metabolism, Vol 7, Iss , Pp 102-118 (2018)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877817308141; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/c9797eabe3dc4a67bdd5670806031a4a

Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking

Authors: Bridget Lins-Austin, Saajan Patel, Mario Mietzsch, Dewey Brooke, Antonette Bennett, Balasubramanian Venkatakrishnan, Kim Van Vliet, Adam N. Smith, Joanna R. Long, Robert McKenna, Mark Potter, Barry Byrne, Sanford L. Boye, Brian Bothner, Regine Heilbronn, Mavis Agbandje-McKenna

Source: Viruses, Vol 12, Iss 6, p 668 (2020)

Subject Terms: AAV, trafficking, capsid, liposomes, PLA2, thermostability, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/6/668; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/c53fc790c6d747268e96cc1198cbcd18

Methylation Status of the Adeno-Associated Virus Type 2 (AAV2)

Authors: Renáta Tóth, István Mészáros, Daniela Hüser, Barbara Forró, Szilvia Marton, Ferenc Olasz, Krisztián Bányai, Regine Heilbronn, Zoltán Zádori

Source: Viruses, Vol 11, Iss 1, p 38 (2019)

Subject Terms: AAV2, adeno-associated virus, bisulfite PCR, CpG methylation, DNA virus, Parvoviridae, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4915/11/1/38; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/a795cd22baa4496184f4f9c93fb25dfa

Comprehensive Small RNA-Seq of Adeno-Associated Virus (AAV)-Infected Human Cells Detects Patterns of Novel, Non-Coding AAV RNAs in the Absence of Cellular miRNA Regulation.

Authors: Catrin Stutika, Mario Mietzsch, Andreas Gogol-Döring, Stefan Weger, Madlen Sohn, Wei Chen, Regine Heilbronn

Source: PLoS ONE, Vol 11, Iss 9, p e0161454 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5017669?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d2713c58ea904d12a7e5e3628cdb3622

A simplified purification protocol for recombinant adeno-associated virus vectors

Authors: Mark Potter, Bridget Lins, Mario Mietzsch, Regine Heilbronn, Kim Van Vliet, Paul Chipman, Mavis Agbandje-McKenna, Brian D Cleaver, Nathalie Clément, Barry J Byrne, Sergei Zolotukhin

Source: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Subject Terms: Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050116301012; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/c17f51f63f434046bfc638662e57c782

Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.

Authors: Anna Osiak, Frank Radecke, Eva Guhl, Sarah Radecke, Nadine Dannemann, Fabienne Lütge, Silke Glage, Cornelia Rudolph, Tobias Cantz, Klaus Schwarz, Regine Heilbronn, Toni Cathomen

Source: PLoS ONE, Vol 6, Iss 12, p e28911 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3237556?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/368166d969e343d6b3056ac64ca6a795

Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.

Authors: Daniela Hüser, Andreas Gogol-Döring, Timo Lutter, Stefan Weger, Kerstin Winter, Eva-Maria Hammer, Toni Cathomen, Knut Reinert, Regine Heilbronn

Source: PLoS Pathogens, Vol 6, Iss 7, p e1000985 (2010)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2900306?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/eb0261c9c280413a82730aee381124c9

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Fate of Recombinant Adeno-Associated Viral Vector Genomes During DNA Double-Strand Break-Induced Gene Targeting in Human Cells.

Authors: Katharina Gellhaus, Tatjana I. Cornu, Regine Heilbronn, Toni Cathomen

Source: Human Gene Therapy; May2010, Vol. 21 Issue 5, p543-553, 11p

This result is not displayed to guests.
Login for full access.

Adeno-Associated Virus Type 2 Wild-Type and Vector-Mediated Genomic Integration Profiles of Human Diploid Fibroblasts Analyzed by Third-Generation PacBio DNA Sequencing.

Authors: Daniela Hüser¹, Andreas Gogol-Döring^2,3,4, Wei Chen², Regine Heilbronn¹ regine.heilbronn@charite.de

Source: Journal of Virology. Oct2014, Vol. 88 Issue 19, p11253-11263. 11p.

Subject Terms: *ADENO-associated virus, *FIBROBLASTS, *NUCLEOTIDE sequencing, *HELA cells, *HUMAN chromatin