Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

Authors: McFaline-Figueroa, José L., Srivatsan, Sanjay, Hill, Andrew J., Gasperini, Molly, Jackson, Dana L., Saunders, Lauren, Domcke, Silvia, Regalado, Samuel G., Lazarchuck, Paul, Alvarez, Sarai, Monnat, Raymond J., Jr., Shendure, Jay, Trapnell, Cole

Source: In Cell Genomics 14 February 2024 4(2)

Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita

Authors: Choo, Seunga ^*, Lorbeer, Franziska K. ^*, Regalado, Samuel G., Short, Sarah B., Wu, Shannon, Rieser, Gabrielle, Bertuch, Alison A., Hockemeyer, Dirk ^*

Source: In Blood 11 August 2022 140(6):608-618

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.

Authors: Chardon, Florence M., McDiarmid, Troy A., Page, Nicholas F., Daza, Riza M., Martin, Beth K., Domcke, Silvia, Regalado, Samuel G., Lalanne, Jean-Benoît, Calderon, Diego, Li, Xiaoyi, Starita, Lea M., Sanders, Stephan J., Ahituv, Nadav, Shendure, Jay

Source: Nature Communications; 9/18/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: GENETIC regulation, GENE expression, CRISPRS, RNA sequencing, AUTISM spectrum disorders

A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility

Authors: Cusanovich, Darren A., Hill, Andrew J., Aghamirzaie, Delasa, Daza, Riza M., Pliner, Hannah A., Berletch, Joel B., Filippova, Galina N., Huang, Xingfan, Christiansen, Lena, DeWitt, William S., Lee, Choli, Regalado, Samuel G., Read, David F., Steemers, Frank J., Disteche, Christine M., Trapnell, Cole, Shendure, Jay

Source: In Cell 23 August 2018 174(5):1309-1324

Retinoic acid induces human gastruloids with posterior embryo-like structures

Authors: Hamazaki, Nobuhiko, Yang, Wei, Kubo, Connor A., Qiu, Chengxiang, Martin, Beth K., Garge, Riddhiman K., Regalado, Samuel G., Nichols, Eva K., Pendyala, Sriram, Bradley, Nicholas, Fowler, Douglas M., Lee, Choli, Daza, Riza M., Srivatsan, Sanjay, Shendure, Jay

Source: Nature Cell Biology; October 2024, Vol. 26 Issue: 10 p1790-1803, 14p

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

Authors: Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk

Source: In Stem Cell Reports 3 June 2014 2(6):838-852

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

Authors: Sinha, Manisha, Jang, Young C., Oh, Juhyun, Khong, Danika, Wu, Elizabeth Y., Manohar, Rohan, Miller, Christine, Regalado, Samuel G., Loffredo, Francesco S., Pancoast, James R., Hirshman, Michael F., Lebowitz, Jessica, Shadrach, Jennifer L., Cerletti, Massimiliano, Kim, Mi-Jeong, Serwold, Thomas, Goodyear, Laurie J., Rosner, Bernard, Lee, Richard T., Wagers, Amy J.

Source: Science, 2014 May 01. 344(6184), 649-652.

Access URL: http://www.jstor.org/stable/24743885

Multiplex profiling of developmental cis-regulatory elements with quantitative single-cell expression reporters

Authors: Lalanne, Jean-Benoît, Regalado, Samuel G., Domcke, Silvia, Calderon, Diego, Martin, Beth K., Li, Xiaoyi, Li, Tony, Suiter, Chase C., Lee, Choli, Trapnell, Cole, Shendure, Jay

Source: Nature Methods; 20240101, Issue: Preprints p1-11, 11p

A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells.

Authors: Turkalo, Timothy K., Maffia, Antonio, Schabort, Johannes J., Regalado, Samuel G., Bhakta, Mital, Blanchette, Marco, Spierings, Diana C. J., Lansdorp, Peter M., Hockemeyer, Dirk

Source: Nature Communications; 2/20/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: EMBRYONIC stem cells, HUMAN stem cells, RECOMBINANT DNA, TELOMERES, PLURIPOTENT stem cells, STEM cells, CELL differentiation

A time-resolved, multi-symbol molecular recorder via sequential genome editing.

Authors: Choi, Junhong, Chen, Wei, Minkina, Anna, Chardon, Florence M., Suiter, Chase C., Regalado, Samuel G., Domcke, Silvia, Hamazaki, Nobuhiko, Lee, Choli, Martin, Beth, Daza, Riza M., Shendure, Jay

Source: Nature; Aug2022, Vol. 608 Issue 7921, p98-107, 10p

Automotive anti-theft device which disables the distributor by fracturing its rotor

Genetic Dissection of Dyskeratosis Congenita-Causing Mutations in TINF2 Using Human Pluripotent and Hematopoietic Stem Cell Models

Authors: Choo, Seunga, Lorbeer, Franziska K., Regalado, Samuel G., Short, Sarah B., Wu, Shannon, Rieser, Gabrielle, Bertuch, Alison A., Hockemeyer, Dirk

Source: In Blood 23 November 2021 138 Supplement 1:2178-2178

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

Authors: Boyle, John M., Hennick, Kelsey M., Regalado, Samuel G., Vogan, Jacob M., Zhang, Xiaozhu, Collins, Kathleen, Hockemeyer, Dirk

Source: Molecular Biology of the Cell; November 2020, Vol. 31 Issue: 23 p2583-2596, 14p

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Editing TINF2as a therapeutic approach to restore telomere length in dyskeratosis congenita

Authors: Choo, Seunga, Lorbeer, Franziska K., Regalado, Samuel G., Short, Sarah B., Wu, Shannon, Rieser, Gabrielle, Bertuch, Alison A., Hockemeyer, Dirk

Source: Blood; 20240101, Issue: Preprints

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Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle.

Authors: Manisha Sinha^1,2,3,4, Jang, Young C.^1,2,4, Juhyun Oh^1,2,4, Danika Khong^1,2,4, Wu, Elizabeth Y.^1,2,4, Manohar, Rohan^1,2,4, Miller, Christine^1,2,4, Regalado, Samuel G.^1,5, Loffredo, Francesco S.^1,6, Pancoast, James R.^1,6, Hirshman, Michael F.², Lebowitz, Jessica^1,2,4, Shadrach, Jennifer L.^1,2,3, Cerletti, Massimiliano^1,2,7, Mi-Jeong Kim², Serwold, Thomas², Goodyear, Laurie J.^2,8, Rosner, Bernard⁹, Lee, Richard T.^1,6, Wagers, Amy J.^1,2,3,4, amy_wagers@harvard.edu

Source: Science; 5/9/2014, Vol. 344 Issue 6184, p649-652, 4p

Genetic Dissection of Dyskeratosis Congenita-Causing Mutations in TINF2Using Human Pluripotent and Hematopoietic Stem Cell Models

Authors: Choo, Seunga, Lorbeer, Franziska K., Regalado, Samuel G., Short, Sarah B., Wu, Shannon, Rieser, Gabrielle, Bertuch, Alison A., Hockemeyer, Dirk

Source: Blood; November 2021, Vol. 138 Issue: 1, Number 1 Supplement 1 p2178-2178, 1p