The 4th NextGen therapies for SJIA and MAS: part 3 clinical trials in refractory SJIA: historic controls as an alternative to a withdrawal design study

Authors: Fabrizio de Benedetti, Alexei A. Grom, Hermine Brunner

Source: Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-4 (2024)

Subject Terms: Refractory SJIA, Refractory SJIA trial design, Historical controls, MAS, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1546-0096

Access URL: https://doaj.org/article/a701bfd93a34490baa23aa947625826b

The 4th NextGen therapies for SJIA and MAS: part 2 phenotypes of refractory SJIA and the landscape for clinical trials in refractory SJIA

Authors: Grant Schulert, Sebastiaan J. Vastert, Alexei A. Grom

Source: Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-5 (2024)

Subject Terms: IL-1, IL-6, IL-18, Refractory SJIA, Refractory SJIA Trial Design, Persistent partial MAS, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1546-0096

Access URL: https://doaj.org/article/d5ef467d5ddc43e1a600f84c6143d7b8

The 4th NextGen therapies of SJIA and MAS, part 4: it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?

Authors: Scott W. Canna, Fabrizio De Benedetti

Source: Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-6 (2024)

Subject Terms: IL-18, IL-18 blocker, Refractory SJIA, Biomarker driven trials, IL-18ophathies, Inflammasopathies, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1546-0096

Access URL: https://doaj.org/article/537d6e32416e48f980b48ea3ec208ea9

Part 5: Allogeneic HSCT in refractory SJIA with lung disease; recent cases from centers in North America & Europe

Authors: Alexei A. Grom, Scott W. Canna, Rolla F. Abu-Arja, Rashmi Sinha, Luciana Peixoto, Elvira Cannizzaro, Shanmuganathan Chandrakasan, Kyla Driest, Rebecca Marsh, Bénédicte Neven, Karen Onel, Sampath Prahalad, Susan Prockop, Pierre Quartier, Johannes Roth, Grant Schulert, Juliana M.F. Silva, Donna Wall, Ulrike Zeilhofer

Source: Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-13 (2024)

Subject Terms: Allogeneic HSCT, Refractory SJIA, SJIA-LD, MAS, HLA DRB1*15 alleles, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1546-0096

Access URL: https://doaj.org/article/f82d150206794485be3d6684b703536d