High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization

Authors: Thomas, Peter, Rees-Spear, Chloe, Griffith, Sarah, Muir, Luke, Touizer, Emma, Andrabi, Raiees, Priest, Richard, Percival-Alwyn, Jennifer, Hayward, Darryl, Buxton, Amanda, Traylen, William, Chain, Benny, Wattam, Trevor, Nandin, Irene Sanjuan, McCoy, Laura E.

Source: In iScience 19 April 2024 27(4)

Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles

Authors: Touizer, Emma, Alrubayyi, Aljawharah, Ford, Rosemarie, Hussain, Noshin, Gerber, Pehuén Pereyra, Shum, Hiu-Long, Rees-Spear, Chloe, Muir, Luke, Gea-Mallorquí, Ester, Kopycinski, Jakub, Jankovic, Dylan, Jeffery-Smith, Anna, Pinder, Christopher L., Fox, Thomas A., Williams, Ian, Mullender, Claire, Maan, Irfaan, Waters, Laura, Johnson, Margaret, Madge, Sara, Youle, Michael, Barber, Tristan J., Burns, Fiona, Kinloch, Sabine, Rowland-Jones, Sarah, Gilson, Richard, Matheson, Nicholas J., Morris, Emma, Peppa, Dimitra, McCoy, Laura E.

Source: In iScience 20 January 2023 26(1)

Neutralizing Antibody Responses After SARS-CoV-2 Infection in End-Stage Kidney Disease and Protection Against Reinfection

Authors: Muir, Luke, Jaffer, Aneesa, Rees-Spear, Chloe, Gopalan, Vignesh, Chang, Fernando Y., Fernando, Raymond, Vaitkute, Gintare, Roustan, Chloe, Rosa, Annachiara, Earl, Christopher, Rajakaruna, Gayathri K., Cherepanov, Peter, Salama, Alan, McCoy, Laura E., Motallebzadeh, Reza

Source: In Kidney International Reports July 2021 6(7):1799-1809

Influence of IL-6 levels on patient survival in COVID-19

Authors: Arulkumaran, Nishkantha, Snow, Timothy A.C., Kulkarni, Adarsh, Brealey, David, Rickman, Hannah M., Rees-Spear, Chloe, Spyer, Moira J., Heaney, Judith, Garr, Edmund, Williams, Bryan, Cherepanov, Peter, Kassiotis, George, Lunn, Michael P., Ambler, Gareth, Houlihan, Catherine, McCoy, Laura E., Nastouli, Eleni, Singer, Mervyn

Source: Journal of critical care. 66:123-125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144157919.0x000001&indx=1&recIds=ETOCvdc_100144157919.0x000001

TIGIT⁺ Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre.

Authors: Edner, Natalie M., Houghton, Luke P., Ntavli, Elisavet, Rees-Spear, Chloe, Petersone, Lina, Chunjing Wang, Fabri, Astrid, Elfaki, Yassin, Gonzalez, Andrea Rueda, Brown, Rachel, Kisand, Kai, Peterson, Pärt, McCoy, Laura E., Walker, Lucy S. K.

Source: Frontiers in Immunology; 2024, p01-14, 14p

Subject Terms: ANTIBODY titer, T helper cells, B cells, ANTIBODY formation, PHENOTYPIC plasticity

Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1.

Authors: Alrubayyi, Aljawharah, Touizer, Emma, Hameiri-Bowen, Dan, Charlton, Bethany, Gea-Mallorquí, Ester, Hussain, Noshin, da Costa, Kelly A. S., Ford, Rosemarie, Rees-Spear, Chloe, Fox, Thomas A., Williams, Ian, Waters, Laura, Barber, Tristan J., Burns, Fiona, Kinloch, Sabine, Morris, Emma, Rowland-Jones, Sarah, McCoy, Laura E., Peppa, Dimitra

Source: Scientific Reports; 11/3/2023, Vol. 13 Issue 1, p1-17, 17p

Subject Terms: KILLER cells, B cells, SARS-CoV-2, HIV, T cells, CELL physiology, HIV-positive persons

Sex differences in immunological responses to COVID-19: a cross-sectional analysis of a single-centre cohort

Authors: Arulkumaran, Nishkantha, Snow, Timothy A.C., Kulkarni, Adarsh, Brealey, David, Rickman, Hannah M., Rees-Spear, Chloe, Spyer, Moira J., Heaney, Judith, Garr, Edmund, Williams, Bryan, Cherepanov, Peter, Kassiotis, George, Lunn, Michael P., Houlihan, Catherine, McCoy, Laura E., Nastouli, Eleni, Singer, Mervyn

Source: In British Journal of Anaesthesia August 2021 127(2):e75-e78

The effect of spike mutations on SARS-CoV-2 neutralization

Authors: Rees-Spear, Chloe, Muir, Luke, Griffith, Sarah A., Heaney, Judith, Aldon, Yoann, Snitselaar, Jonne L., Thomas, Peter, Graham, Carl, Seow, Jeffrey, Lee, Nayung, Rosa, Annachiara, Roustan, Chloe, Houlihan, Catherine F., Sanders, Rogier W., Gupta, Ravindra K., Cherepanov, Peter, Stauss, Hans J., Nastouli, Eleni, Doores, Katie J., van Gils, Marit J., McCoy, Laura E.

Source: In Cell Reports 23 March 2021 34(12)

Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort

Authors: Arulkumaran, Nishkantha, Snow, Timothy Arthur Chandos, Kulkarni, Adarsh, Brealey, David, Rickman, Hannah, Rees-Spear, Chloe, Spyer, Moira J., Heaney, Judith, Garr, Edmund, Williams, Bryan, Cherepanov, Peter, Kassiotis, George, Lunn, Michael, Houlihan, Catherine, McCoy, Laura E., Nastouli, Eleni, Singer, Mervyn

Source: Critical care explorations. 3(8):e0488-e0488

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156964803.0x000001&indx=1&recIds=ETOCvdc_100156964803.0x000001

Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in a patient with uncontrolled HIV

Authors: Touizer, Emma, Alrubayyi, Aljawharah, Rees-Spear, Chloe, Fisher-Pearson, Natasha, Griffith, Sarah A, Muir, Luke, Pellegrino, Pierre, Waters, Laura, Burns, Fiona, Kinloch, Sabine, Rowland-Jones, Sarah, Gupta, Ravindra K, Gilson, Richard, Peppa, Dimitra, McCoy, Laura E

Source: In The Lancet HIV June 2021 8(6):e317-e318

Vaccine responses in ageing and chronic viral infection.

Authors: Rees-Spear, Chloe, McCoy, Laura E

Source: Oxford Open Immunology; 2021, Vol. 2 Issue 1, p1-14, 14p

Subject Terms: VACCINE effectiveness, VIRUS diseases, OLDER patients, HIV infections, IMMUNE response

Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies

Authors: King, Lloyd D.W., Pulido, David, Barrett, Jordan R., Davies, Hannah, Quinkert, Doris, Lias, Amelia M., Silk, Sarah E., Pattinson, David J., Diouf, Ababacar, Williams, Barnabas G., McHugh, Kirsty, Rodrigues, Ana, Rigby, Cassandra A., Strazza, Veronica, Suurbaar, Jonathan, Rees-Spear, Chloe, Dabbs, Rebecca A., Ishizuka, Andrew S., Zhou, Yu, Gupta, Gaurav, Jin, Jing, Li, Yuanyuan, Carnrot, Cecilia, Minassian, Angela M., Campeotto, Ivan, Fleishman, Sarel J., Noe, Amy R., MacGill, Randall S., King, C. Richter, Birkett, Ashley J., Soisson, Lorraine A., Long, Carole A., Miura, Kazutoyo, Ashfield, Rebecca, Skinner, Katherine, Howarth, Mark R., Biswas, Sumi, Draper, Simon J.

Source: Cell Reports Medicine; July 2024, Vol. 5 Issue: 7

SARS-CoV-2 evolution during treatment of chronic infection

Authors: Kemp, Steven A., Collier, Dami A., Datir, Rawlings P., Ferreira, Isabella A. T. M., Gayed, Salma, Jahun, Aminu, Hosmillo, Myra, Rees-Spear, Chloe, Mlcochova, Petra, Lumb, Ines Ushiro, Roberts, David J., Chandra, Anita, Temperton, Nigel, Sharrocks, Katherine, Blane, Elizabeth, Modis, Yorgo, Leigh, Kendra E., Briggs, John A. G., van Gils, Marit J., Smith, Kenneth G. C., Bradley, John R., Smith, Chris, Doffinger, Rainer, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Pollock, David D., Goldstein, Richard A., Smielewska, Anna, Skittrall, Jordan P., Gouliouris, Theodore, Goodfellow, Ian G., Gkrania-Klotsas, Effrossyni, Illingworth, Christopher J. R., McCoy, Laura E., Gupta, Ravindra K.

Source: Nature; 20210101, Issue: Preprints p1-10, 10p

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Authors: Kemp, Steven A., Collier, Dami A., Datir, Rawlings P., Ferreira, Isabella A. T. M., Gayed, Salma, Jahun, Aminu, Hosmillo, Myra, Rees-Spear, Chloe, Mlcochova, Petra, Lumb, Ines Ushiro, Roberts, David J., Chandra, Anita, Temperton, Nigel, Sharrocks, Katherine, Blane, Elizabeth, Modis, Yorgo, Leigh, Kendra E., Briggs, John A. G., van Gils, Marit J., Smith, Kenneth G. C., Bradley, John R., Smith, Chris, Doffinger, Rainer, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Pollock, David D., Goldstein, Richard A., Smielewska, Anna, Skittrall, Jordan P., Gouliouris, Theodore, Goodfellow, Ian G., Gkrania-Klotsas, Effrossyni, Illingworth, Christopher J. R., McCoy, Laura E., Gupta, Ravindra K.

Source: Nature; August 2022, Vol. 608 Issue: 7922 pE23-E23, 1p

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SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies.

Authors: Jeffery-Smith, Anna, Burton, Alice R., Lens, Sabela, Rees-Spear, Chloe, Davies, Jessica, Patel, Monika, Gopal, Robin, Muir, Luke, Aiano, Felicity, Doores, Katie J., Chow, J. Yimmy, Ladhani, Shamez N., Zambon, Maria, McCoy, Laura E., Maini, Mala K.

Source: Journal of Clinical Investigation. 1/18/2022, Vol. 132 Issue 2, p1-12. 12p.

Subjects: IMMUNOLOGIC memory, OLDER people, IMMUNOGLOBULINS, COVID-19 pandemic, ELDER care

SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.

Authors: Rosa, Annachiara¹, Pye, Valerie E.¹, Graham, Carl², Muir, Luke³, Seow, Jeffrey², Ng, Kevin W.⁴, Cook, Nicola J.¹, Rees-Spear, Chloe³, Parker, Eleanor⁵, Silva dos Santos, Mariana⁶, Rosadas, Carolina⁵, Susana, Alberto⁷, Rhys, Hefin⁸, Nans, Andrea⁹, Masino, Laura⁹, Roustan, Chloe⁹, Christodoulou, Evangelos⁹, Ulferts, Rachel¹⁰, Wrobel, Antoni G.¹¹, Short, Charlotte-Eve⁵

Source: Science Advances. 5/26/2021, Vol. 7 Issue 22, p1-14. 14p.

Subject Terms: *SARS-CoV-2, *GLYCANS, *VIRAL envelope proteins, *CYTOCHROME oxidase, *COVID-19