Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

Authors: Koh, Eun-Ik, Oluoch, Peter O., Ruecker, Nadine, Proulx, Megan K., Soni, Vijay, Murphy, Kenan C., Papavinasasundaram, Kadamba, Reames, Charlotte J., Trujillo, Carolina, Zaveri, Anisha, Zimmerman, Matthew D., Aslebagh, Roshanak, Baker, Richard E., Shaffer, Scott A., Guinn, Kristine M., Fitzgerald, Michael, Dartois, Véronique, Ehrt, Sabine, Hung, Deborah T., Ioerger, Thomas R., Rubin, Eric J., Rhee, Kyu Y., Schnappinger, Dirk, Sassetti, Christopher M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Apr 01. 119(15), 1-12.

Access URL: https://www.jstor.org/stable/27151819

Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.

Authors: Oluoch, Peter O., Koh, Eun-Ik, Proulx, Megan K., Reames, Charlotte J., Papavinasasundaram, Kadamba G., Murphy, Kenan C., Zimmerman, Matthew D., Dartois, Véronique, Sassetti, Christopher M.

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/4/2025, Vol. 122 Issue 9, p1-9, 16p

Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection.

Authors: Pullen, Krista M., Finethy, Ryan, Ko, Seung-Hyun B., Reames, Charlotte J., Sassetti, Christopher M., Lauffenburger, Douglas A.

Source: NPJ Systems Biology & Applications; 2/15/2025, Vol. 11 Issue 1, p1-13, 13p

Subject Terms: UNFOLDED protein response, MYCOBACTERIUM tuberculosis, MYCOBACTERIAL diseases, MEDICAL sciences, TYPE I interferons

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.

Authors: Eun-Ik Koh, Oluoch, Peter O., Ruecker, Nadine, Proulx, Megan K., Soni, Vijay, Murphy, Kenan C., Papavinasasundaram, Kadamba, Reames, Charlotte J., Trujillo, Carolina, Zaveri, Anisha, Zimmerman, Matthew D., Aslebagh, Roshanak, Baker, Richard E., Shaffer, Scott A., Guinn, Kristine M., Fitzgerald, Michael, Dartois, Véronique, Ehrt, Sabine, Hung, Deborah T., Ioerger, Thomas R.

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/12/2022, Vol. 119 Issue 15, p1-12, 12p

Subject Terms: CARBON metabolism, DRUG efficacy, CELL metabolism, ANTITUBERCULAR agents, TUBERCULOSIS, COMMERCIAL products

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

Authors: Smith, Clare M., Baker, Richard E., Proulx, Megan K., Mishra, Bibhuti B., Long, Jarukit E., Sae Woong Park, Ha-Na Lee, Kiritsy, Michael C., Bellerose, Michelle M., Olive, Andrew J., Murphy, Kenan C., Papavinasasundaram, Kadamba, Boehm, Frederick J., Reames, Charlotte J., Meade, Rachel K., Hampton, Brea K., Linnertz, Colton L., Shaw, Ginger D., Hock, Pablo, Bell, Timothy A.

Source: eLife; 2/15/2022, p1-31, 31p