A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma

Authors: Sacco, Joseph J., Jackson, Richard, Corrie, Pippa, Danson, Sarah, Evans, T.R. Jeffry, Ochsenreither, Sebastian, Kumar, Satish, Goodman, Andrew, Larkin, James, Karydis, Ioannis, Steven, Neil, Lorigan, Paul, Plummer, Ruth, Patel, Poulam, Psarelli, Eftychia, Olsson-Brown, Anna, Shaw, Heather, Leyvraz, Serge, Handley, Louise, Rawcliffe, Charlotte, Nathan, Paul

Source: In European Journal of Cancer May 2024 202

Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial

Authors: Ghaneh, Paula ^*, Palmer, Daniel, Cicconi, Silvia, Jackson, Richard, Halloran, Christopher Michael, Rawcliffe, Charlotte, Sripadam, Rajaram, Mukherjee, Somnath, Soonawalla, Zahir, Wadsley, Jonathan, Al-Mukhtar, Ahmed, Dickson, Euan, Graham, Janet, Jiao, Long, Wasan, Harpreet S, Tait, Iain S, Prachalias, Andreas, Ross, Paul, Valle, Juan W, O'Reilly, Derek A, Al-Sarireh, Bilal, Gwynne, Sarah, Ahmed, Irfan, Connolly, Kate, Yim, Kein-Long, Cunningham, David, Armstrong, Thomas, Archer, Caroline, Roberts, Keith, Ma, Yuk Ting, Springfeld, Christoph, Tjaden, Christine, Hackert, Thilo, Büchler, Markus W, Neoptolemos, John P

Source: In The Lancet Gastroenterology & Hepatology February 2023 8(2):157-168

The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma

Authors: Ghaneh, Paula, Kleeff, Jorg, Halloran, Christopher M., Raraty, Michael, Jackson, Richard, Melling, James, Jones, Owain, Palmer, Daniel H., Cox, Trevor F., Smith, Chloe J., O'Reilly, Derek A., Izbicki, Jakob R., Scarfe, Andrew G., Valle, Juan W., McDonald, Alexander C., Carter, Ross, Tebbutt, Niall C., Goldstein, David, Padbury, Robert, Shannon, Jennifer, Dervenis, Christos, Glimelius, Bengt, Deakin, Mark, Anthoney, Alan, Lerch, Markus M., Mayerle, Julia, Oláh, Attila, Rawcliffe, Charlotte L., Campbell, Fiona, Strobel, Oliver, Büchler, Markus W., Neoptolemos, John P.

Source: Annals of surgery. 269(3):520-529

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180881911.0x000001&indx=1&recIds=ETOCvdc_100180881911.0x000001

Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial

Authors: Middleton, Gary, Palmer, Daniel H, Greenhalf, William, Ghaneh, Paula, Jackson, Richard, Cox, Trevor, Evans, Anthony, Shaw, Victoria E, Wadsley, Jonathan, Valle, Juan W, Propper, David, Wasan, Harpreet, Falk, Stephen, Cunningham, David, Coxon, Fareeda, Ross, Paul, Madhusudan, Srinivasan, Wadd, Nick, Corrie, Pippa, Hickish, Tamas, Costello, Eithne, Campbell, Fiona, Rawcliffe, Charlotte, Neoptolemos, John P

Source: In The Lancet Oncology April 2017 18(4):486-499

What are the main inefficiencies in trial conduct: a survey of UKCRC registered clinical trials units in the UK

Authors: Duley, Lelia, Gillman, Alexa, Duggan, Marian, Belson, Stephanie, Knox, Jill, McDonald, Alison, Rawcliffe, Charlotte, Simon, Joanne, Sprosen, Tim, Watson, Jude, Wood, Wendy

Source: Trials. 19(1):1-7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161562312.0x000001&indx=1&recIds=ETOCvdc_100161562312.0x000001

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

Authors: Middleton, Gary, Silcocks, Paul, Cox, Trevor, Valle, Juan, Wadsley, Jonathan, Propper, David, Coxon, Fareeda, Ross, Paul, Madhusudan, Srinivasan, Roques, Tom, Cunningham, David, Falk, Stephen, Wadd, Nick, Harrison, Mark, Corrie, Pippa, Iveson, Tim, Robinson, Angus, McAdam, Karen, Eatock, Martin, Evans, Jeff, Archer, Caroline, Hickish, Tamas, Garcia-Alonso, Angel, Nicolson, Marianne, Steward, William, Anthoney, Alan, Greenhalf, William, Shaw, Victoria, Costello, Eithne, Naisbitt, Dean, Rawcliffe, Charlotte, Nanson, Gemma, Neoptolemos, John

Source: In Lancet Oncology July 2014 15(8):829-840

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Biomarker predication of efficacy to gemcitabine plus vandetanib in phase II, double blind multicentre randomised controlled trial of gemcitabine placebo in locally advanced or metastatic pancreatic carcinoma

Authors: Evans, Anthony, Jackson, Richard, Shaw, Victoria E., Ghaneh, Paula, Wadsley, Jonathan, Valle, Juan W., Wasan, Harpreet, Falk, Stephen, Cunningham, David, Coxon, Fareeda Y., Ross, Paul J., Wadd, Nick, Hickish, Tamas, Costello, Eithne, Campbell, Fiona, Rawcliffe, Charlotte, Neoptolemos, John P., Palmer, Daniel H., Greenhalf, William, Middleton, Gary

Source: In Pancreatology June 2018 18(4) Supplement:S127-S128

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The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic ductal adenocarcinoma

Authors: Kleeff, Jorg, Costello, Eithne, Jackson, Richard, Halloran, Chris, Greenhalf, William, Ghaneh, Paula, Lamb, Richard F., Lerch, Markus, Mayerle, Julia, Palmer, Daniel, Cox, Trevor, Rawcliffe, Charlotte L., Strobel, Oliver, Büchler, Markus W., Neoptolemos, John P.

Source: In Pancreatology June 2016 16(3) Supplement 1:S67-S67

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