Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Authors: Lee, Sangeun, Nasr, Sarah, Rasheed, Sari, Liu, Yun, Hartwig, Olga, Kaya, Cansu, Boese, Annette, Koch, Marcus, Herrmann, Jennifer, Müller, Rolf, Loretz, Brigitta, Buhler, Eric, Hirsch, Anna K.H., Lehr, Claus-Michael

Source: Journal of controlled release. 353:915-929

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180181529.0x000001&indx=1&recIds=ETOCvdc_100180181529.0x000001

Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization

Authors: Girardini, Miriam, Ferlenghi, Francesca, Annunziato, Giannamaria, Degiacomi, Giulia, Papotti, Bianca, Marchi, Cinzia, Sammartino, José Camilla, Rasheed, Sari S., Contini, Anna, Pasca, Maria Rosalia, Vacondio, Federica, Evans, Joanna C., Dick, Thomas, Müller, Rolf, Costantino, Gabriele, Pieroni, Marco

Source: In European Journal of Medicinal Chemistry 5 January 2023 245 Part 2

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents

Authors: Aboushady, Dina, Rasheed, Sari S., Herrmann, Jennifer, Maher, Ahmed, El-Hossary, Ebaa M., Ibrahim, Eslam S., Abadi, Ashraf H., Engel, Matthias, Müller, Rolf, Abdel-Halim, Mohammad, Hamed, Mostafa M.

Source: In Bioorganic Chemistry December 2021 117

Incidence, outcome, and risk factors for recurrence of nosocomial Clostridioides difficile infection in adults: A prospective cohort study

Authors: Karaoui, Walid R., Rustam, Louma Basma O., Bou Daher, Halim, Rimmani, Hussein H., Rasheed, Sari S., Matar, Ghassan M., Mahfouz, Rami, Araj, George F., Zahreddine, Nada, Kanj, Souha S., Berger, Fabian K., Gärtner, Barbara, El Sabbagh, Rana, Sharara, Ala I.

Source: In Journal of Infection and Public Health April 2020 13(4):485-490

Pineapple Lectin AcmJRL Binds SARS‐CoV‐2 Spike Protein in a Carbohydrate‐Dependent Fashion**

Authors: Meiers, Joscha, Dastbaz, Jan, Adam, Sebastian, Rasheed, Sari, Kirsch, Susanne H., Meiser, Peter, Gross, Peter, Müller, Rolf, Titz, Alexander

Source: Chembiochem. 24(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173053131.0x000001&indx=1&recIds=ETOCvdc_100173053131.0x000001

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models.

Authors: Schippers, Philip^1,2 (AUTHOR), Rasheed, Sari^2,3 (AUTHOR), Park, Yu Mi² (AUTHOR), Risch, Timo^2,3 (AUTHOR), Wagmann, Lea¹ (AUTHOR), Hemmer, Selina¹ (AUTHOR), Manier, Sascha K.¹ (AUTHOR), Müller, Rolf^2,3 (AUTHOR), Herrmann, Jennifer^2,3 (AUTHOR), Meyer, Markus R.¹ (AUTHOR) markus.meyer@uks.eu

Source: Scientific Reports. 5/9/2023, Vol. 13 Issue 1, p1-15. 15p.

Subject Terms: *EVALUATION methodology, *BRACHYDANIO, *LARVAE, *MYCOBACTERIAL diseases, *METABOLOMICS

Molecular characterization, toxin detection and resistance testing of human clinical Clostridium difficile isolates from Lebanon

Authors: Berger, Fabian K., Rasheed, Sari S., Araj, George F., Mahfouz, Rami, Rimmani, Hussein H., Karaoui, Walid R., Sharara, Ala I., Dbaibo, Ghassan, Becker, Sören L., von Müller, Lutz, Bischoff, Markus, Matar, Ghassan M., Gärtner, Barbara

Source: In International Journal of Medical Microbiology April 2018 308(3):358-363

Novel 2, 4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

Authors: Megahed, Sarah H., Rasheed, Sari, Herrmann, Jennifer, El-Hossary, Ebaa M., El-Shabrawy, Yahia I., Abadi, Ashraf H., Engel, Matthias, Müller, Rolf, Abdel-Halim, Mohammad, Hamed, Mostafa M.

Source: Bioorganic & medicinal chemistry letters. 59

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155128574.0x000001&indx=1&recIds=ETOCvdc_100155128574.0x000001

The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.

Authors: Mashayekhi, Vida, Schomisch, Annika, Rasheed, Sari, Aparicio-Puerta, Ernesto, Risch, Timo, Yildiz, Daniela, Koch, Marcus, Both, Simon, Ludwig, Nicole, Legroux, Thierry M., Keller, Andreas, Müller, Rolf, Fuhrmann, Gregor, Hoppstädter, Jessica, Kiemer, Alexandra K.

Source: Cell Communication & Signaling; 6/27/2024, Vol. 22 Issue 1, p1-25, 25p

Subject Terms: RNA-binding proteins, COATED vesicles, EXTRACELLULAR vesicles, MACROPHAGES, CANCER cell migration, GENE expression

The Peptide Antibiotic Corramycin Adopts a β‑Hairpin-like Structure and Is Inactivated by the Kinase ComG.

Authors: Adam, Sebastian, Fries, Franziska, von Tesmar, Alexander, Rasheed, Sari, Deckarm, Selina, Sousa, Carla F., Reberšek, Roman, Risch, Timo, Mancini, Stefano, Herrmann, Jennifer, Koehnke, Jesko, Kalinina, Olga V., Müller, Rolf

Source: Journal of the American Chemical Society; 4/3/2024, Vol. 146 Issue 13, p8981-8990, 10p

Development and evaluation of 2,4‐disubstituted‐5‐aryl pyrimidine derivatives as antibacterial agents.

Authors: Khalifa, Hend, Rasheed, Sari, Haupenthal, Jörg, Herrmann, Jennifer, Mandour, Yasmine M., Abadi, Ashraf H., Engel, Matthias, Müller, Rolf, Hirsch, Anna K. H., Abdel‐Halim, Mohammad, Hamed, Mostafa M.

Source: Archiv der Pharmazie; Apr2024, Vol. 357 Issue 4, p1-20, 20p

Molecular Characteristics of Colistin Resistance in Acinetobacter baumannii and the Activity of Antimicrobial Combination Therapy in a Tertiary Care Medical Center in Lebanon.

Authors: Abou Fayad, Antoine, Haraoui, Louis-Patrick, Sleiman, Ahmad, Hussein, Hadi, Grenier, Frédéric, Derbaj, Ghada, Itani, Dana, Iweir, Sereen, Sherri, Nour, Bazzi, Wael, Rasheed, Sari, Tanelian, Arax, Miari, Mariam, el Hafi, Bassam, Kanj, Souha S., Kanafani, Zeina A., Daoud, Ziad, Araj, George F., Matar, Ghassan M.

Source: Microorganisms; Feb2024, Vol. 12 Issue 2, p349, 11p

Subject Terms: TERTIARY care, ACINETOBACTER baumannii, MEDICAL centers, COLISTIN, ANTI-infective agents, WHOLE genome sequencing

Geographic Terms: LEBANON, BEIRUT (Lebanon)

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.

Authors: Fu, Chengzhang, Liu, Yunkun, Walt, Christine, Rasheed, Sari, Bader, Chantal D., Lukat, Peer, Neuber, Markus, Haeckl, F. P. Jake, Blankenfeldt, Wulf, Kalinina, Olga V., Müller, Rolf

Source: Nature Communications; 1/26/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: BIOSYNTHESIS, MULTIDRUG-resistant tuberculosis, MYCOBACTERIAL diseases, MYCOBACTERIUM tuberculosis, DNA polymerases

Novel 2, 4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2, 4-substituents

Authors: Aboushady, Dina, Rasheed, Sari S., Herrmann, Jennifer, Maher, Ahmed, El-Hossary, Ebaa M., Ibrahim, Eslam S., Abadi, Ashraf H., Engel, Matthias, Müller, Rolf, Abdel-Halim, Mohammad, Hamed, Mostafa M.

Source: Bioorganic chemistry. 117

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148071937.0x000001&indx=1&recIds=ETOCvdc_100148071937.0x000001

Natural products and polysorbates: Potential Inhibitors of biofilm formation in Pseudomonas aeruginosa.

Authors: Miari, Mariam^1,2,3, Rasheed, Sari S.^1,2,3, Ahmad, Nathaline Haidar^1,2,3, Itani, Dana^1,2,3, Fayad, Antoine Abou^1,2,3, Matar, Ghassan M.^1,2,3 gmatar@aub.edu.lb

Source: Journal of Infection in Developing Countries. Jun2020, Vol. 14 Issue 6, p580-588. 10p.

Subject Terms: *NATURAL products, *PSEUDOMONAS aeruginosa, *QUORUM sensing, *GINGER, *GENE expression, *RHAMNOLIPIDS

Chapter Five - Targeting the bacterial β-sliding clamp (DnaN): A promising strategy for novel antibiotics

Authors: Elgaher, Walid A.M., Hapko, Uladzislau, Rasheed, Sari, Müller, Rolf, Hirsch, Anna K.H.

Source: In Annual Reports in Medicinal Chemistry 2023 61:163-195

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos.

Authors: Fries, Franziska, Kany, Andreas M., Rasheed, Sari, Hirsch, Anna K. H., Müller, Rolf, Herrmann, Jennifer

Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 16, p12791, 17p

Subject Terms: DRUG administration routes, STAPHYLOCOCCUS aureus infections, BRACHYDANIO, NATURAL products, DRUG discovery, EMBRYOS

Correction: Fries et al. Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin A Using a Staphylococcus aureus Infection Model in Zebrafish Embryos. Int. J. Mol. Sci. 2023, 24 , 12791.

Authors: Fries, Franziska, Kany, Andreas M., Rasheed, Sari, Hirsch, Anna K. H., Müller, Rolf, Herrmann, Jennifer

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 4, p2011, 3p

Subject Terms: STAPHYLOCOCCUS aureus infections, DRUG administration routes, BRACHYDANIO, NATURAL products, EMBRYOS, STAPHYLOCOCCUS aureus

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

Authors: Megahed, Sarah H., Rasheed, Sari, Herrmann, Jennifer, El-Hossary, Ebaa M., El-Shabrawy, Yahia I., Abadi, Ashraf H., Engel, Matthias, Müller, Rolf, Abdel-Halim, Mohammad, Hamed, Mostafa M.

Source: In Bioorganic & Medicinal Chemistry Letters 1 March 2022 59

A Prospective Study on the Incidence, Risk Factors for Relapse, and Outcome of Nosocomial Clostridium Difficile Infection in Adults

Authors: Sharara, Ala I., Karaoui, Walid, Shayto, Rani, Rimmani, Hussein H., Chalhoub, Jean M., Kara, Nada, Rasheed, Sari, El Sabbagh, Rana, Kanj, Souha S., Mahfouz, Rami, Araj, George, Matar, Ghassan

Source: Gastroenterology. 152(5):S348-S349

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100052925968.0x000001&indx=1&recIds=ETOCvdc_100052925968.0x000001