Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Authors: Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, Zucchini Stefano

Source: Frontiers in Endocrinology, Vol 15 (2024)

Subject Terms: adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2024.1387537/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/04c5d7ea5bbf4c18b2fce4857d7be15d

Sulfonylurea-Insensitive Permanent Neonatal Diabetes Caused by a Severe Gain-of-Function Tyr330His Substitution in Kir6.2

Authors: McClenaghan, Conor, Rapini, Novella, De Rose, Domenico Umberto, Gao, Jian, Roeglin, Jacob, Bizzarri, Carla, Schiaffini, Riccardo, Tiberi, Eloisa, Mucciolo, Mafalda, Deodati, Annalisa, Perri, Alessandro, Vento, Giovanni, Barbetti, Fabrizio, Nichols, Colin G., Cianfarani, Stefano

Source: Hormone research in pædiatrics. 95(3):215-223

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157415841.0x000001&indx=1&recIds=ETOCvdc_100157415841.0x000001

The application of precision medicine in monogenic diabetes

Authors: Barbetti, Fabrizio, Rapini, Novella, Schiaffini, Riccardo, Bizzarri, Carla, Cianfarani, Stefano

Source: Expert review of endocrinology & metabolism. 17(2):111-129

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146778284.0x000001&indx=1&recIds=ETOCvdc_100146778284.0x000001

School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology

Authors: Schiaffini, Riccardo, Barbetti, Fabrizio, Rapini, Novella, Inzaghi, Elena, Deodati, Annalisa, Patera, Ippolita P., Matteoli, Maria C., Ciampalini, Paolo, Carducci, Chiara, Lorubbio, Antonella, Schiaffini, Gabriele, Cianfarani, Stefano

Source: In Diabetes Research and Clinical Practice August 2020 166

Time In Range in Children with Type 1 Diabetes Using Treatment Strategies Based on Nonautomated Insulin Delivery Systems in the Real World

Authors: Cherubini, Valentino, Bonfanti, Riccardo, Casertano, Alberto, De Nitto, Elena, Iannilli, Antonio, Lombardo, Fortunato, Maltoni, Giulio, Marigliano, Marco, Bassi, Marta, Minuto, Nicola, Mozzillo, Enza, Rabbone, Ivana, Rapini, Novella, Rigamonti, Andrea, Salzano, Giuseppina, Scaramuzza, Andrea, Schiaffini, Riccardo, Tinti, Davide, Toni, Sonia, Zagaroli, Luca, Zucchini, Stefano, Maffeis, Claudio, Gesuita, Rosaria

Source: Diabetes technology & therapeutics. 22(7):509-515

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150493782.0x000001&indx=1&recIds=ETOCvdc_100150493782.0x000001

The Changing Landscape of Neonatal Diabetes Mellitus in Italy Between 2003 and 2022.

Authors: Rapini, Novella, Delvecchio, Maurizio, Mucciolo, Mafalda, Ruta, Rosario, Rabbone, Ivana, Cherubini, Valentino, Zucchini, Stefano, Cianfarani, Stefano, Prandi, Elena, Schiaffini, Riccardo, Bizzarri, Carla, Piccini, Barbara, Maltoni, Giulio, Predieri, Barbara, Minuto, Nicola, Paola, Rossella Di, Giordano, Mara, Tinto, Nadia, Grasso, Valeria, Russo, Lucia

Source: Journal of Clinical Endocrinology & Metabolism; Sep2024, Vol. 109 Issue 9, p2349-2357, 9p

Subject Terms: PANCREATIC enzymes, MOLECULAR genetics, INSULIN resistance, DIABETES, NUCLEOTIDE sequencing

Time In Tight Range in children and adolescents with type 1 diabetes: A cross‐sectional observational single centre study evaluating efficacy of new advanced technologies.

Authors: Schiaffini, Riccardo, Lumaca, Alessandra, Martino, Mariangela, Rapini, Novella, Deodati, Annalisa, Amodeo, Maria Elisa, Ciampalini, Paolo, Matteoli, Maria Cristina, Pampanini, Valentina, Cianfarani, Stefano

Source: Diabetes/Metabolism Research & Reviews; Jul2024, Vol. 40 Issue 5, p1-8, 8p

Subject Terms: TYPE 1 diabetes, CONTINUOUS glucose monitoring, GLYCEMIC control, TEENAGERS

Editorial: Personalized therapies for monogenic diabetes.

Authors: Delvecchio, Maurizio, Ming Liu, Rapini, Novella, Barbetti, Fabrizio

Source: Frontiers in Genetics; 2024, p1-3, 3p

Subject Terms: MATURITY onset diabetes of the young, TYPE 1 diabetes, TYPE 2 diabetes, GESTATIONAL diabetes, METABOLIC syndrome, INSULIN

COVID-19 forced restrictions did not affect metabolic control in youth with T2D in Italy

Authors: Zucchini, Stefano, Iafusco, Dario, Cherubini, Valentino, De Sanctis, Luisa, Maltoni, Giulio, Lenzi, Lorenzo, Mozzillo, Enza, Calcaterra, Valeria, Gallo, Francesco, Arnaldi, Claudia, Delvecchio, Maurizio, Rabbone, Ivana, Minuto, Nicola, Predieri, Barbara, Zanfardino, Angela, Piscopo, Alessia, Tiberi, Valentina, Tinti, Davide, Rapini, Novella, Toni, Sonia, Schiaffini, Riccardo

Source: Nutrition, metabolism, and cardiovascular diseases. 33(1):232-233

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190941658.0x000001&indx=1&recIds=ETOCvdc_100190941658.0x000001

Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D

Authors: Petrelli, Arianna, Ravà, Lucilla, Mascali, Alberto, Rapini, Novella, Massoud, Michela, Manca Bitti, Maria Luisa, Cianfarani, Stefano, Manco, Melania

Source: Diabetes/metabolism research and reviews. 38(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140394250.0x000001&indx=1&recIds=ETOCvdc_100140394250.0x000001

Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia.

Authors: Zucchini, Stefano, Tumini, Stefano, Scaramuzza, Andrea Enzo, Bonfanti, Riccardo, Delvecchio, Maurizio, Franceschi, Roberto, Iafusco, Dario, Lenzi, Lorenzo, Mozzillo, Enza, Passanisi, Stefano, Piona, Claudia, Rabbone, Ivana, Rapini, Novella, Rigamonti, Andrea, Ripoli, Carlo, Salzano, Giuseppina, Savastio, Silvia, Schiaffini, Riccardo, Zanfardino, Angela, Cherubini, Valentino

Source: Frontiers in Endocrinology; 2024, p01-14, 14p

Subject Terms: HYPOGLYCEMIA, CONTINUOUS glucose monitoring, CLOSED loop systems, BLOOD sugar, PEOPLE with diabetes, HONEY, FRUIT juices, HYPERGLYCEMIA, SUCROSE

Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years.

Authors: Rapini, Novella, Martino, Mariangela, Arnaldi, Claudia, Deodati, Annalisa, Anagnostopoulou, Lilian, Amodeo, Maria Elisa, Ciampalini, Paolo, Pampanini, Valentina, Lorubbio, Antonella, Tosini, Davide, Cianfarani, Stefano, Schiaffini, Riccardo

Source: Frontiers in Endocrinology; 2024, p1-6, 6p

Subject Terms: TYPE 1 diabetes, GLYCEMIC control, INSULIN therapy, PRESCHOOL children, DISEASE duration

The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey.

Authors: Zanfardino, Angela, Bruzzi, Patrizia, Trada, Michela, Rapini, Novella, Laudani, Emanuela, Tornese, Gianluca, Ortolani, Federica, Piccolo, Gianluca, Matonti, Lorena, Saltarelli, Maria Alessandra, Timpanaro, Tiziana, D'Annunzio, Giuseppe, Predieri, Barbara, Rossi, Francesca, Mura, Rossella, Barat, Veronica, Prete, Arcangelo, Schiaffini, Riccardo, Zucchini, Stefano

Source: Pediatric Hematology & Oncology; 2024, Vol. 41 Issue 3, p198-210, 13p

Subject Terms: BLOOD diseases, GLUCOSE, HYPERGLYCEMIA, TECHNOLOGICAL innovations, GLUCOSE tolerance tests, IRON overload

Increased incidence of childhood type 1 diabetes during the COVID‐19 pandemic. Figures from an Italian tertiary care center

Authors: Schiaffini, Riccardo, Deodati, Annalisa, Rapini, Novella, Pampanini, Valentina, Cianfarani, Stefano

Source: Journal of diabetes. 14(8):562-563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158981894.0x000001&indx=1&recIds=ETOCvdc_100158981894.0x000001

Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report.

Authors: Iavarone, Sonia, Massoud, Michela, Di Felice, Giovina, Pulcinelli, Fabio, Rapini, Novella, Luciani, Matteo

Source: Children; Dec2023, Vol. 10 Issue 12, p1839, 7p

Subject Terms: BREASTFEEDING techniques, BLOOD platelet aggregation, MELATONIN, DIETARY supplements, BLOOD coagulation disorders, PLATELET aggregation inhibitors, BLOOD testing, HEMOSTATICS

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

Authors: Fiorillo, Edoardo, Orrú, Valeria, Stanford, Stephanie M., Liu, Yingge, Salek, Mogjiborahman, Rapini, Novella, Schenone, Aaron D., Saccucci, Patrizia ^**, Delogu, Lucia G., Angelini, Federica, Manca Bitti, Maria Luisa, Schmedt, Christian, Chan, Andrew C., Acuto, Oreste, Bottini, Nunzio

Source: In Journal of Biological Chemistry 20 August 2010 285(34):26506-26518

Monogenic diabetes clinic (MDC): 3-year experience.

Authors: Rapini, Novella¹ (AUTHOR), Patera, Patrizia I.¹ (AUTHOR), Schiaffini, Riccardo¹ (AUTHOR), Ciampalini, Paolo¹ (AUTHOR), Pampanini, Valentina¹ (AUTHOR), Cristina, Matteoli M.¹ (AUTHOR), Deodati, Annalisa¹ (AUTHOR), Bracaglia, Giorgia² (AUTHOR), Porzio, Ottavia^2,3 (AUTHOR), Ruta, Rosario⁴ (AUTHOR), Novelli, Antonio⁴ (AUTHOR), Mucciolo, Mafalda⁴ (AUTHOR), Cianfarani, Stefano^1,5,6 (AUTHOR), Barbetti, Fabrizio² (AUTHOR) fabrizio.barbetti@uniroma2.it

Source: Acta Diabetologica. Jan2023, Vol. 60 Issue 1, p61-70. 10p.

Subject Terms: *TYPE 1 diabetes, *DIABETES in children, *DIABETES complications, *DIABETES, *ASSISTED suicide

Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study.

Authors: Levi Mortera, Stefano, Marzano, Valeria, Vernocchi, Pamela, Matteoli, Maria Cristina, Guarrasi, Valerio, Gardini, Simone, Del Chierico, Federica, Rapini, Novella, Deodati, Annalisa, Fierabracci, Alessandra, Cianfarani, Stefano, Putignani, Lorenza

Source: International Journal of Molecular Sciences; Dec2022, Vol. 23 Issue 24, p15982, 15p

Subject Terms: TYPE 1 diabetes, DIABETES in children, GUT microbiome, VOXEL-based morphometry, HUMAN microbiota, AUTOIMMUNE diseases

Pathophysiology of Type 1 Diabetes and Gut Microbiota Role.

Authors: Del Chierico, Federica¹ (AUTHOR), Rapini, Novella² (AUTHOR), Deodati, Annalisa² (AUTHOR), Matteoli, Maria Cristina² (AUTHOR), Cianfarani, Stefano^2,3,4 (AUTHOR), Putignani, Lorenza⁵ (AUTHOR) lorenza.putignani@opbg.net

Source: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 23, p14650. 12p.

Subject Terms: *TYPE 1 diabetes, *PATHOLOGICAL physiology, *IMMUNOLOGICAL tolerance, *MICROBIAL metabolites, *AUTOIMMUNE diseases, *GUT microbiome

Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset.

Authors: Del Chierico, Federica, Conta, Giorgia, Matteoli, Maria Cristina, Fierabracci, Alessandra, Reddel, Sofia, Macari, Gabriele, Gardini, Simone, Guarrasi, Valerio, Levi Mortera, Stefano, Marzano, Valeria, Vernocchi, Pamela, Sciubba, Fabio, Marini, Federico, Deodati, Annalisa, Rapini, Novella, Cianfarani, Stefano, Miccheli, Alfredo, Putignani, Lorenza

Source: International Journal of Molecular Sciences; Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG, 17p

Subject Terms: GUT microbiome, TYPE 1 diabetes, IMMUNOGLOBULINS, SYMPTOMS