Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin

Authors: Ola Al-Diab, Christin Sünkel, Eric Blanc, Rusan Ali Catar, Muhammad Imtiaz Ashraf, Hongfan Zhao, Pinchao Wang, Markus M. Rinschen, Raphaela Fritsche-Guenther, Florian Grahammer, Sebastian Bachmann, Dieter Beule, Jennifer A. Kirwan, Nikolaus Rajewsky, Tobias B. Huber, Dennis Gürgen, Angelika Kusch

Source: Biology of Sex Differences, Vol 15, Iss 1, Pp 1-24 (2024)

Subject Terms: Podocytes, Sex differences, Transcriptome, Proteome, Metabolome, mTOR, Medicine, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2042-6410

Access URL: https://doaj.org/article/6486c593796f4fa4bf8ff685f8544f3b

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Authors: Morgan Essex, Belén Millet Pascual-Leone, Ulrike Löber, Mathias Kuhring, Bowen Zhang, Ulrike Brüning, Raphaela Fritsche-Guenther, Marta Krzanowski, Facundo Fiocca Vernengo, Sophia Brumhard, Ivo Röwekamp, Agata Anna Bielecka, Till Robin Lesker, Emanuel Wyler, Markus Landthaler, Andrej Mantei, Christian Meisel, Sandra Caesar, Charlotte Thibeault, Victor M. Corman, Lajos Marko, Norbert Suttorp, Till Strowig, Florian Kurth, Leif E. Sander, Yang Li, Jennifer A. Kirwan, Sofia K. Forslund, Bastian Opitz

Source: npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)

Subject Terms: Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5008

Access URL: https://doaj.org/article/3800ac4d0de04e14b83d18bba159a41d

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung

Authors: Patrick J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Ulrike Brüning, Raphaela Fritsche-Guenther, Lennart Pfannkuch, Florian Kurth, Miha Milek, Vanessa Igbokwe, Ulrike Löber, Birgitt Gutbier, Markus Holstein, Gitta Anne Heinz, Mir-Farzin Mashreghi, Leon N. Schulte, Ann-Brit Klatt, Sandra Caesar, Sandra-Maria Wienhold, Stefan Offermanns, Matthias Mack, Martin Witzenrath, Stefan Jordan, Dieter Beule, Jennifer A. Kirwan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Markus M. Heimesaat, Bastian Opitz

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/41a8a643c26b41c0b66352c312b98b9b

Promising results of a clinical feasibility study: CIRBP as a potential biomarker in pediatric cardiac surgery

Authors: Jana Lücht, Raphael Seiler, Alexa Leona Herre, Liliya Brankova, Raphaela Fritsche-Guenther, Jennifer Kirwan, Dörte Huscher, Hanna Münzfeld, Felix Berger, Joachim Photiadis, Giang Tong, Katharina R. L. Schmitt

Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Subject Terms: pediatric cardiology, pediatric cardiac surgery, cold inducible RNA-binding protein (CIRBP), inflammation, endothelial dysfunction, biomarker, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1247472/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/a721b03d05814911a1d1c18bf739fe41

Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia

Authors: Leonard D. Kuhrt, Edyta Motta, Nirmeen Elmadany, Hannah Weidling, Raphaela Fritsche-Guenther, Ibrahim E. Efe, Olivia Cobb, Jit Chatterjee, Lucy G. Boggs, Marina Schnauß, Sebastian Diecke, Marcus Semtner, Corina Anastasaki, David H. Gutmann, Helmut Kettenmann

Source: Disease Models & Mechanisms, Vol 16, Iss 12 (2023)

Subject Terms: microglia, neurofibromatosis 1, human induced pluripotent stem cells, purinergic receptors, phagocytosis, motility, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/16/12/dmm049861; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/27ffcc79016247599283cd70ac5c43af

Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit

Authors: Raphaela Fritsche-Guenther, Yoann Gloaguen, Alina Eisenberger, Jennifer A. Kirwan

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/42ba3dc87f6e49cdb509e3ac058ca684

A Comparison of Solvent-Based Extraction Methods to Assess the Central Carbon Metabolites in Mouse Bone and Muscle

Authors: Daniela B. Dias, Raphaela Fritsche-Guenther, Friederike Gutmann, Georg N. Duda, Jennifer Kirwan, Patrina S. P. Poh

Source: Metabolites, Vol 12, Iss 5, p 453 (2022)

Subject Terms: muscle, bone, metabolites, GC-MS, central carbon metabolism, metabolomics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/5/453; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/75f3879b38034311a2629ea7b4a2af29

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations

Authors: Raphaela Fritsche-Guenther, Christin Zasada, Guido Mastrobuoni, Nadine Royla, Roman Rainer, Florian Roßner, Matthias Pietzke, Edda Klipp, Christine Sers, Stefan Kempa

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ba89ec86c64648e088f3642d09599e61

Optimized Workflow for On-Line Derivatization for Targeted Metabolomics Approach by Gas Chromatography-Mass Spectrometry

Authors: Raphaela Fritsche-Guenther, Yoann Gloaguen, Anna Bauer, Tobias Opialla, Stefan Kempa, Christina A. Fleming, Henry Paul Redmond, Jennifer A. Kirwan

Source: Metabolites, Vol 11, Iss 12, p 888 (2021)

Subject Terms: automated derivatization, on-line derivatization, optimization, gas-chromatography mass spectrometry, validation, metabolomics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/11/12/888; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/db8e5fdfd03041df90e19cc6b7d1ff98

An immediate–late gene expression module decodes ERK signal duration

Authors: Florian Uhlitz, Anja Sieber, Emanuel Wyler, Raphaela Fritsche‐Guenther, Johannes Meisig, Markus Landthaler, Bertram Klinger, Nils Blüthgen

Source: Molecular Systems Biology, Vol 13, Iss 5, Pp 1-15 (2017)

Subject Terms: ERK signalling, immediate–late genes, mRNA half‐life, signal decoding, signal duration, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/e1c853c3b713463086a68edb107c858b

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

Authors: Anna R. Malik, Kinga Szydlowska, Karolina Nizinska, Antonino Asaro, Erwin A. van Vliet, Oliver Popp, Gunnar Dittmar, Raphaela Fritsche-Guenther, Jennifer A. Kirwan, Anders Nykjaer, Katarzyna Lukasiuk, Eleonora Aronica, Thomas E. Willnow

Source: Cell Reports, Vol 26, Iss 10, Pp 2792-2804.e6 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719301986; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/549dda87d7d14f30bc0d079ad6b0d64c

An immediate–late gene expression module decodes ERK signal duration

Authors: Florian Uhlitz, Anja Sieber, Emanuel Wyler, Raphaela Fritsche‐Guenther, Johannes Meisig, Markus Landthaler, Bertram Klinger, Nils Blüthgen

Source: Molecular Systems Biology, Vol 13, Iss 9, Pp n/a-n/a (2017)

Subject Terms: Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/da5119290c764cf3bd6f2218403291c5

Network quantification of EGFR signaling unveils potential for targeted combination therapy

Authors: Bertram Klinger, Anja Sieber, Raphaela Fritsche‐Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers, Nils Blüthgen

Source: Molecular Systems Biology, Vol 9, Iss 1, Pp 1-14 (2013)

Subject Terms: cancer, EGFR signaling, mathematical modeling, modular response analysis, signal transduction, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/a4ed5dbe243d4ea28f53fa9649700665

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Authors: Raphaela Fritsche‐Guenther, Franziska Witzel, Anja Sieber, Ricarda Herr, Nadine Schmidt, Sandra Braun, Tilman Brummer, Christine Sers, Nils Blüthgen

Source: Molecular Systems Biology, Vol 7, Iss 1, Pp 1-13 (2011)

Subject Terms: expression noise, MAPK signalling, negative feedback, Raf, robustness, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/89ef771c22b44fc196560c75b2a4eca5