Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery

Authors: Krakovka, Sascha, Ranjbarian, Farahnaz, Luján, Lucas A., Saura, Alicia, Larsen, Nicolai B., Jiménez-González, Alejandro, Reggenti, Anna, Luján, Hugo D., Svärd, Staffan G., Hofer, Anders

Source: In Journal of Biological Chemistry June 2022 298(6)

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro.

Authors: Petersen, Inga, Morrison, Jamie I., Petrovic, Alex, Babic, Neira, Metzendorf, Nicole G., Godec, Ana, de la Rosa, Andrés, Rofo, Fadi, Bondza, Sina, Buijs, Jos, Ranjbarian, Farahnaz, Hofer, Anders, Sehlin, Dag, Hultqvist, Greta

Source: Scientific Reports; 12/23/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: TRANSFERRIN receptors, TRANSCYTOSIS, BRAIN diseases, THERAPEUTICS, ENDOTHELIAL cells, BLOOD-brain barrier, BISPECIFIC antibodies

Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis.

Authors: Ranjbarian, Farahnaz, Rafie, Karim, Shankar, Kasturika, Krakovka, Sascha, Carlson, Lars-Anders, Hofer, Anders

Source: Nucleic Acids Research; 12/11/2024, Issue 22, p14061-14076, 16p

A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils.

Authors: Petersen, Inga, Godec, Ana, Ranjbarian, Farahnaz, Hofer, Anders, Mirabello, Claudio, Hultqvist, Greta

Source: PLoS ONE; 8/29/2024, Vol. 19 Issue 8, p1-15, 15p

Subject Terms: PEPTIDES, PARKINSON'S disease, EXTRACELLULAR space, ELECTROSTATIC interaction, PROTEOGLYCANS, IMMUNOGLOBULINS

Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family

Authors: Ngahang Kamte, Stephane L., Ranjbarian, Farahnaz, Cianfaglione, Kevin, Sut, Stefania, Dall’Acqua, Stefano, Bruno, Maurizio, Afshar, Fariba Heshmati, Iannarelli, Romilde, Benelli, Giovanni, Cappellacci, Loredana, Hofer, Anders, Maggi, Filippo, Petrelli, Riccardo

Source: In Ecotoxicology and Environmental Safety 30 July 2018 156:154-165

Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation

Authors: Sut, Stefania, Dall'Acqua, Stefano, Baldan, Valeria, Ngahang Kamte, Stephane L., Ranjbarian, Farahnaz, Biapa Nya, Prosper C., Vittori, Sauro, Benelli, Giovanni, Maggi, Filippo, Cappellacci, Loredana, Hofer, Anders, Petrelli, Riccardo

Source: Fitoterapia. 124:145-151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100055316021.0x000001&indx=1&recIds=ETOCvdc_100055316021.0x000001

Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES

Alternate Title: T. brucei Methylthioadenosine Phosphorylase (English)

Authors: Vodnala, Munender, Ranjbarian, Farahnaz, Pavlova, Anna, de Koning, Harry P., Hofer, Anders

Source: In Journal of Biological Chemistry 27 May 2016 291(22):11717-11726

An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis

Authors: Petrelli, Riccardo, Ranjbarian, Farahnaz, Dall'Acqua, Stefano, Papa, Fabrizio, Iannarelli, Romilde, Ngahang Kamte, Stephane L., Vittori, Sauro, Benelli, Giovanni, Maggi, Filippo, Hofer, Anders, Cappellacci, Loredana

Source: Parasitology international. 66(2):146-151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100056946885.0x000001&indx=1&recIds=ETOCvdc_100056946885.0x000001

Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine

Authors: Vande Voorde, Johan, Sabuncuoğlu, Suna, Noppen, Sam, Hofer, Anders, Ranjbarian, Farahnaz, Fieuws, Steffen, Balzarini, Jan, Liekens, Sandra

Source: In Journal of Biological Chemistry 9 May 2014 289(19):13054-13065

Trypanosoma brucei Thymidine Kinase Is Tandem Protein Consisting of Two Homologous Parts, Which Together Enable Efficient Substrate Binding

Authors: Ranjbarian, Farahnaz, Vodnala, Munender, Vodnala, Sharvani Munender, Rofougaran, Reza, Thelander, Lars, Hofer, Anders

Source: In Journal of Biological Chemistry 18 May 2012 287(21):17628-17636

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Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples.

Authors: Ranjbarian, Farahnaz, Sharma, Sushma, Falappa, Giulia, Taruschio, Walter, Chabes, Andrei, Hofer, Anders

Source: Nucleic Acids Research; 2/22/2022, Vol. 50 Issue 3, pe18-e18, 1p

Activating AMPK improves pathological phenotypes due to mtDNA depletion.

Authors: Carvalho, Gustavo¹ (AUTHOR), Nguyen, Tran V. H.¹ (AUTHOR), Repolês, Bruno¹ (AUTHOR), Forslund, Josefin M. E.¹ (AUTHOR), Wijethunga, W. M. Ruchitha Rukmal¹ (AUTHOR), Ranjbarian, Farahnaz¹ (AUTHOR), Mendes, Isabela C.¹ (AUTHOR), Gorospe, Choco Michael¹ (AUTHOR), Chaudhari, Namrata¹ (AUTHOR), Falabella, Micol² (AUTHOR), Doimo, Mara³ (AUTHOR), Wanrooij, Sjoerd¹ (AUTHOR), Pitceathly, Robert D. S.^2,4 (AUTHOR), Hofer, Anders¹ (AUTHOR), Wanrooij, Paulina H.¹ (AUTHOR) paulina.wanrooij@umu.se

Source: FEBS Journal. Feb2025, p1. 22p. 9 Illustrations.

Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents.

Authors: Baldassarri, Cecilia, Falappa, Giulia, Mazzara, Eugenia, Acquaticci, Laura, Ossoli, Elena, Perinelli, Diego Romano, Bonacucina, Giulia, Dall'Acqua, Stefano, Cappellacci, Loredana, Maggi, Filippo, Ranjbarian, Farahnaz, Hofer, Anders, Petrelli, Riccardo

Source: Antibiotics (2079-6382); Nov2021, Vol. 10 Issue 11, p1413, 1p

Subject Terms: ESSENTIAL oils, ADENOSINE triphosphate, ADENOSINE diphosphate, TRYPANOSOMA brucei, MASS spectrometry

Geographic Terms: ITALY

9-(2′-Deoxy-2′-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance

Authors: Ranjbarian, Farahnaz, Vodnala, Munender, Alzahrani, Khalid J. H., Ebiloma, Godwin U., de Koning, Harry P., Hofer, Anders

Source: Antimicrobial Agents and Chemotherapy; April 2017, Vol. 61 Issue: 6