Renin-angiotensin system and inflammation update

Authors: Cantero-Navarro, Elena, Fernández-Fernández, Beatriz, Ramos, Adrian M., Rayego-Mateos, Sandra, Rodrigues-Diez, Raúl R., Sánchez-Niño, María Dolores, Sanz, Ana B., Ruiz-Ortega, Marta, Ortiz, Alberto

Source: In Molecular and Cellular Endocrinology 1 June 2021 529

Ferroptosis and kidney disease

Alternate Title: Ferroptosis y nefropatía (Spanish; Castilian)

Authors: Martin-Sanchez, Diego, Fontecha-Barriuso, Miguel, Martinez-Moreno, Julio M., Ramos, Adrian M., Sanchez-Niño, Maria D., Guerrero-Hue, Melania, Moreno, Juan A., Ortiz, Alberto, Sanz, Ana B.

Source: In NEFROLOGIA (English Edition) July-August 2020 40(4):384-394

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

Authors: Zimmermann, Silke, Rädisch, Brit, Hävemeier, Anika, Busmann, Annette, Wittkop, Ulrike, Neuhaus, Barbara, Ax-Smolarski, Regina, Zieglschmid, Veit, Bollweber, Eva, Wölk, Heidrun, Curovic, Viktor R., Tougaard, Ninna H., Eickhoff, Mie K., Pilemann-Lyberg, Sascha, Winther, Signe A., Rosenlund, Signe V., Hansen, Tine W., von Scholten, Bernt J., Hansen, Christian S., Zobel, Emilie H., Laursen, Jens C., Theilade, Simone, Jelstrup, Lone, Juhl, Tina R., Riis, Dorthe, Hermann, Jessie A., Lundgaard, Anne G., Halkjær, Maja L.D., Aabo, Lene, Frost Lerche, Therese, Lajer, Maria, Stefansen, Rikke J., Campbell, Maria A., Durban, Annika, Raad, Julia, Prigge, Michael, Schiemann, Marco, Wilson, Robbie, Kean, Sharon, Douglas, Elizabeth, Surtees, Pamela, Gant, Christina, Yeung, Stanley M.H., Hagedoorn, Ilse, Flynn, Joanne, Galloway, Joe, Brooksbank, Katriona, Aparicio, Carolina, Iliev, Ilian P., Nones, Francesco, Lo Bue, Francesca, Melacini, Daniela, Cugini, Daniela, Prandini, Silvia, Lecchi, Verusca, Yakymchuk, Svitlana, Gherardi, Giulia, Villa, Alessandro, Villa, Davide, Gaspari, Flavio, Cannata, Antonio N., Ferrari, Silvia, Stucchi, Nadia, Albrechtová, Šárka, Eldeik, Elina, Amanaki, Renata, Fernandez-Fernandez, Beatriz, Sanchez-Rodriguez, Jinny, Vázquez, Clotilde, Sanz, Ana B., Sanchez-Niño, Maria D., Ramos, Adrian M., Gonzalo, Maria Á., Schmidt, Ulrike, Selim, Gjulsen, Gjorgovski, Tatjana, Stratrova, Slavica S., Stojceva-Taneva, Olivera, Schutten-Westerneng, Petra, Wierbos, Brenda, Huvers, Frank, De Bruin, Anneke K., Lapauw, Bruno, de Man, Elsie, Rokegem, Kelly, Inion, Sabien, Kreutzmann, Kristin, Dewettinck, Isabelle, Boukens-de Graaf, Caroline, Clerc-de Jong, Ferrina, Entius, Jannet, Nannings, Marian, van Steenderen, Suzy, Petry, Friedrich W., Kilic, Ceyda, Tofte, Nete ^*, Lindhardt, Morten ^*, Adamova, Katarina, Bakker, Stephan J L, Beige, Joachim, Beulens, Joline W J, Birkenfeld, Andreas L, Currie, Gemma, Delles, Christian, Dimos, Ingo, Francová, Lidmila, Frimodt-Møller, Marie, Girman, Peter, Göke, Rüdiger, Havrdova, Tereza, Heerspink, Hiddo J L, Kooy, Adriaan, Laverman, Gozewijn D, Mischak, Harald, Navis, Gerjan, Nijpels, Giel, Noutsou, Marina, Ortiz, Alberto, Parvanova, Aneliya, Persson, Frederik, Petrie, John R, Ruggenenti, Piero L, Rutters, Femke, Rychlík, Ivan, Siwy, Justyna, Spasovski, Goce, Speeckaert, Marijn, Trillini, Matias, Zürbig, Petra, von der Leyen, Heiko, Rossing, Peter ^*

Source: In The Lancet Diabetes & Endocrinology April 2020 8(4):301-312

Statins: Could an old friend help in the fight against COVID‐19?

Authors: Rodrigues‐Diez, Raul R., Tejera‐Muñoz, Antonio, Marquez‐Exposito, Laura, Rayego‐Mateos, Sandra, Santos Sanchez, Laura, Marchant, Vanessa, Tejedor Santamaria, Lucía, Ramos, Adrian M., Ortiz, Alberto, Egido, Jesus, Ruiz‐Ortega, Marta

Source: British journal of pharmacology. 177(21):4873-4886

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108626491.0x000001&indx=1&recIds=ETOCvdc_100108626491.0x000001

Renoprotective effect of Limonium duriusculum (de Girard) Kuntze via modulation of oxidative stress/UPR markers and inflammation during cyclosporine-induced nephrotoxicity in rats.

Authors: Redouane-Salah, Azzedine, Souad, Ameddah, Kerkatou, Wafa, Wojnicki, Kamil, Ramos, Adrian M., Ortiz, Alberto, Kaminska, Bozena, Menad, Ahmed

Source: Iranian Journal of Basic Medical Sciences; Aug2024, Vol. 27 Issue 8, p1023-1032, 10p

Subject Terms: TRANSCRIPTION factors, OXIDATIVE stress, NEPHROTOXICOLOGY, ORAL drug administration, RATS, VITAMIN E

Out of the TWEAKlight: Elucidating the Role of Fn14 and TWEAK in Acute Kidney Injury

Authors: Sanz, Ana B., Ruiz-Andres, Olga, Sanchez-Niño, Maria Dolores, Ruiz-Ortega, Marta, Ramos, Adrian M., Ortiz, Alberto

Source: In Seminars in Nephrology May 2016 36(3):189-198

Regulated necrosis role in inflammation and repair in acute kidney injury.

Authors: Guerrero-Mauvecin, Juan, Villar-Gómez, Natalia, Rayego-Mateos, Sandra, Ramos, Adrian M., Ruiz-Ortega, Marta, Ortiz, Alberto, Sanz, Ana B.

Source: Frontiers in Immunology; 2023, p1-9, 9p

Subject Terms: ACUTE kidney failure, NECROSIS, CHRONIC kidney failure, SHEAR waves, KIDNEY physiology

BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress.

Authors: Marchant, Vanessa, Trionfetti, Flavia, Tejedor-Santamaria, Lucia, Rayego-Mateos, Sandra, Rotili, Dante, Bontempi, Giulio, Domenici, Alessandro, Menè, Paolo, Mai, Antonello, Martín-Cleary, Catalina, Ortiz, Alberto, Ramos, Adrian M., Strippoli, Raffaele, Ruiz-Ortega, Marta

Source: Antioxidants; Dec2023, Vol. 12 Issue 12, p2055, 19p

Subject Terms: NUCLEAR factor E2 related factor, OXIDATIVE stress, FETAL hemoglobin, CHRONIC kidney failure

Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells

Authors: González-Guerrero, Cristian, Ocaña-Salceda, Carlos, Berzal, Sergio, Carrasco, Susana, Fernández-Fernández, Beatriz, Cannata-Ortiz, Pablo, Egido, Jesús, Ortiz, Alberto, Ramos, Adrián M.

Source: In Toxicology and Applied Pharmacology 1 November 2013 272(3):825-841

Mitochondrial Dysfunction in the Cardio-Renal Axis.

Authors: Barbero, Nerea Mendez, Oller, Jorge, Sanz, Ana B., Ramos, Adrian M., Ortiz, Alberto, Ruiz-Ortega, Marta, Rayego-Mateos, Sandra

Source: International Journal of Molecular Sciences; May2023, Vol. 24 Issue 9, p8209, 26p

Subject Terms: HOMEOSTASIS, CARDIO-renal syndrome, MITOCHONDRIA, CHRONIC kidney failure, CARDIOVASCULAR diseases, KIDNEY diseases

Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines

Authors: Ramos, Adrián M., Aller, Patricio

Source: In Biochemical Pharmacology 2008 75(10):1912-1923

Regulated cell death pathways in kidney disease

Authors: Sanz, Ana B., Sanchez-Niño, Maria Dolores, Ramos, Adrian M., Ortiz, Alberto

Source: Nature Reviews Nephrology; May 2023, Vol. 19 Issue: 5 p281-299, 19p

Arsenic trioxide sensitizes promonocytic leukemia cells to TNFα-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways

Authors: Amrán, Donna, Sánchez, Yolanda, Fernández, Carlos, Ramos, Adrián M., de Blas, Elena, Bréard, Jacqueline, Calle, Consuelo, Aller, Patricio

Source: In BBA - Molecular Cell Research 2007 1773(11):1653-1663

Tubular Mitochondrial Dysfunction, Oxidative Stress, and Progression of Chronic Kidney Disease.

Authors: Fontecha-Barriuso, Miguel, Lopez-Diaz, Ana M., Guerrero-Mauvecin, Juan, Miguel, Veronica, Ramos, Adrian M., Sanchez-Niño, Maria D., Ruiz-Ortega, Marta, Ortiz, Alberto, Sanz, Ana B.

Source: Antioxidants; Jul2022, Vol. 11 Issue 7, p1356-N.PAG, 21p

Subject Terms: PGC-1 protein, CHRONIC kidney failure, DIABETIC nephropathies, OXIDATIVE stress, ACUTE kidney failure

Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells

Authors: Ramos, Adrián M., Fernández, Carlos, Amrán, Donna, Sancho, Patricia, de Blas, Elena, Aller, Patricio ^*

Source: In Blood 15 May 2005 105(10):4013-4020

Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation

Authors: Amrán, Donna, Sancho, Patricia, Fernández, Carlos, Esteban, Diego, Ramos, Adrián M., de Blas, Elena, Gómez, Milagros, Palacios, María A., Aller, Patricio ^*

Source: In BBA - Molecular Cell Research 2005 1743(3):269-279

12-O-Tetradecanoylphorbol-13-acetate May Both Potentiate and Decrease the Generation of Apoptosis by the Antileukemic Agent Arsenic Trioxide in Human Promonocytic Cells: REGULATION BY EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASES AND GLUTATHIONE

Authors: Fernández, Carlos ^{*, ‡}, Ramos, Adrián M. ^{*, §}, Sancho, Patricia ^{*, ¶}, Amrán, Donna ^*, de Blas, Elena ^*, Aller, Patricio ^{*, ∥}

Source: In Journal of Biological Chemistry 30 January 2004 279(5):3877-3884

Trypanosoma cruzi: cruzipain and membrane-bound cysteine proteinase isoform(s) interacts with human α 2-macroglobulin and pregnancy zone protein

Authors: Ramos, Adrián M., Duschak, Vilma G., Gerez de Burgos, Nelia M., Barboza, Mariana, Remedi, Marı́a S., Vides, Miguel A., Chiabrando, Gustavo A.

Source: In Experimental Parasitology 2002 100(2):121-130

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Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

Authors: Tofte, Nete, Lindhardt, Morten, Adamova, Katarina, Bakker, Stephan J L, Beige, Joachim, Beulens, Joline W J, Birkenfeld, Andreas L, Currie, Gemma, Delles, Christian, Dimos, Ingo, Francová, Lidmila, Frimodt-Møller, Marie, Girman, Peter, Göke, Rüdiger, Havrdova, Tereza, Heerspink, Hiddo J L, Kooy, Adriaan, Laverman, Gozewijn D, Mischak, Harald, Navis, Gerjan, Nijpels, Giel, Noutsou, Marina, Ortiz, Alberto, Parvanova, Aneliya, Persson, Frederik, Petrie, John R, Ruggenenti, Piero L, Rutters, Femke, Rychlík, Ivan, Siwy, Justyna, Spasovski, Goce, Speeckaert, Marijn, Trillini, Matias, Zürbig, Petra, von der Leyen, Heiko, Rossing, Peter, Zimmermann, Silke, Rädisch, Brit, Hävemeier, Anika, Busmann, Annette, Wittkop, Ulrike, Neuhaus, Barbara, Ax-Smolarski, Regina, Zieglschmid, Veit, Bollweber, Eva, Wölk, Heidrun, Curovic, Viktor R., Tougaard, Ninna H., Eickhoff, Mie K., Pilemann-Lyberg, Sascha, Winther, Signe A., Rosenlund, Signe V., Hansen, Tine W., von Scholten, Bernt J., Hansen, Christian S., Zobel, Emilie H., Laursen, Jens C., Theilade, Simone, Jelstrup, Lone, Juhl, Tina R., Riis, Dorthe, Hermann, Jessie A., Lundgaard, Anne G., Halkjær, Maja L.D., Aabo, Lene, Frost Lerche, Therese, Lajer, Maria, Stefansen, Rikke J., Campbell, Maria A., Durban, Annika, Raad, Julia, Prigge, Michael, Schiemann, Marco, Wilson, Robbie, Kean, Sharon, Douglas, Elizabeth, Surtees, Pamela, Gant, Christina, Yeung, Stanley M.H., Hagedoorn, Ilse, Flynn, Joanne, Galloway, Joe, Brooksbank, Katriona, Aparicio, Carolina, Iliev, Ilian P., Nones, Francesco, Lo Bue, Francesca, Melacini, Daniela, Cugini, Daniela, Prandini, Silvia, Lecchi, Verusca, Yakymchuk, Svitlana, Gherardi, Giulia, Villa, Alessandro, Villa, Davide, Gaspari, Flavio, Cannata, Antonio N., Ferrari, Silvia, Stucchi, Nadia, Albrechtová, Šárka, Eldeik, Elina, Amanaki, Renata, Fernandez-Fernandez, Beatriz, Sanchez-Rodriguez, Jinny, Vázquez, Clotilde, Sanz, Ana B., Sanchez-Niño, Maria D., Ramos, Adrian M., Gonzalo, Maria Á., Schmidt, Ulrike, Selim, Gjulsen, Gjorgovski, Tatjana, Stratrova, Slavica S., Stojceva-Taneva, Olivera, Schutten-Westerneng, Petra, Wierbos, Brenda, Huvers, Frank, De Bruin, Anneke K., Lapauw, Bruno, de Man, Elsie, Rokegem, Kelly, Inion, Sabien, Kreutzmann, Kristin, Dewettinck, Isabelle, Boukens-de Graaf, Caroline, Clerc-de Jong, Ferrina, Entius, Jannet, Nannings, Marian, van Steenderen, Suzy, Petry, Friedrich W., Kilic, Ceyda

Source: The Lancet Diabetes & Endocrinology; April 2020, Vol. 8 Issue: 4 p301-312, 12p