Covalent targeting of splicing in T cells

Authors: Scott, Kevin A. ^{1, 10}, Kojima, Hiroyuki ^{1, 10}, Ropek, Nathalie ^{1, 10}, Warren, Charles D. ^{2, 3, 10}, Zhang, Tiffany L. ^{1, 3}, Hogg, Simon J. ^{4, 8}, Sanford, Henry ¹, Webster, Caroline ¹, Zhang, Xiaoyu ^{5, 9}, Rahman, Jahan ⁴, Melillo, Bruno ^{5, 6}, Cravatt, Benjamin F. ⁵, Lyu, Jiankun ⁷, Abdel-Wahab, Omar ⁴, Vinogradova, Ekaterina V. ^{1, 11, ∗}

Source: In Cell Chemical Biology 16 January 2025 32(1):201-218

GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

Authors: Benbarche, Salima, Pineda, Jose Mario Bello, Galvis, Laura Baquero, Biswas, Jeetayu, Liu, Bo, Wang, Eric, Zhang, Qian, Hogg, Simon J., Lyttle, Kadeen, Dahi, Ariana, Lewis, Alexander M., Sarchi, Martina, Rahman, Jahan, Fox, Nina, Ai, Yuxi, Mehta, Sanjoy, Garippa, Ralph, Ortiz-Pacheco, Juliana, Li, Zhuoning, Monetti, Mara, Stanley, Robert F., Doulatov, Sergei, Bradley, Robert K., Abdel-Wahab, Omar

Source: In Molecular Cell 16 May 2024 84(10):1886-1903

Proteomic discovery of chemical probes that perturb protein complexes in human cells

Authors: Lazear, Michael R., Remsberg, Jarrett R., Jaeger, Martin G., Rothamel, Katherine, Her, Hsuan-lin, DeMeester, Kristen E., Njomen, Evert, Hogg, Simon J., Rahman, Jahan, Whitby, Landon R., Won, Sang Joon, Schafroth, Michael A., Ogasawara, Daisuke, Yokoyama, Minoru, Lindsey, Garrett L., Li, Haoxin, Germain, Jason, Barbas, Sabrina, Vaughan, Joan, Hanigan, Thomas W., Vartabedian, Vincent F., Reinhardt, Christopher J., Dix, Melissa M., Koo, Seong Joo, Heo, Inha, Teijaro, John R., Simon, Gabriel M., Ghosh, Brahma, Abdel-Wahab, Omar, Ahn, Kay, Saghatelian, Alan, Melillo, Bruno, Schreiber, Stuart L., Yeo, Gene W., Cravatt, Benjamin F.

Source: In Molecular Cell 18 May 2023 83(10):1725-1742

Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia

Authors: Wang, Eric, Pineda, Jose Mario Bello, Kim, Won Jun, Chen, Sisi, Bourcier, Jessie, Stahl, Maximilian, Hogg, Simon J., Bewersdorf, Jan Phillipp, Han, Cuijuan, Singer, Michael E., Cui, Daniel, Erickson, Caroline E., Tittley, Steven M., Penson, Alexander V., Knorr, Katherine, Stanley, Robert F., Rahman, Jahan, Krishnamoorthy, Gnana, Fagin, James A., Creger, Emily, McMillan, Elizabeth, Mak, Chi-Ching, Jarvis, Matthew, Bossard, Carine, Beaupre, Darrin M., Bradley, Robert K., Abdel-Wahab, Omar

Source: In Cancer Cell 9 January 2023 41(1):164-180

Automated design of CRISPR prime editors for 56,000 human pathogenic variants

Authors: Morris, John A., Rahman, Jahan A., Guo, Xinyi, Sanjana, Neville E.

Source: In iScience 19 November 2021 24(11)

Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens

Authors: Guo, Xinyi, Rahman, Jahan A., Wessels, Hans-Hermann, Méndez-Mancilla, Alejandro, Haro, Daniel, Chen, Xinru, Sanjana, Neville E.

Source: In Cell Genomics 13 October 2021 1(1)

Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial

Authors: Horwitz, Steven M., Nirmal, Ajit J., Rahman, Jahan, Xu, Ran, Drill, Esther, Galasso, Natasha, Ganesan, Nivetha, Davey, Theresa, Hancock, Helen, Perez, Leslie, Maccaro, Catherine, Bahgat, Alexandra, Marzouk, Evan, Cathcart, Elizabeth, Moskowitz, Alison, Noy, Ariela, Kumar, Anita, Jacobsen, Eric, Fisher, David C., Mehta-Shah, Neha, Kim, Youn H., Khodadoust, Michael, Kotlov, Nikita, Nikitina, Anastasia, Kudryashova, Olga, Zubareva, Valeria, Zornikova, Ksenia, Shin, Nara, Sorokina, Maria, Degryse, Sandrine, Postovalova, Ekaterina, Bagaev, Aleksander, Hosszu, Kinga, McAvoy, Devin, Boelens, Jaap J., Wu, Wenchao, Ciantra, Zoe, Appelt, Jackson W., Trevisani, Christopher, Amaka, Sam, Weinstock, David M., Vardhana, Santosha A.

Source: Nature Medicine; September 2024, Vol. 30 Issue: 9 p2517-2527, 11p

RAF-Independent MEK Mutations Drive Histiocytic Neoplasms In Vivo and Are Sensitive to Single-Agent ERK Inhibition in Patients

Authors: Durham, Benjamin H, Singer, Michael E ^*, Benbarche, Salima, Erickson, Caroline ^*, Rahman, Jahan ^*, Solit, David B. ^*, Witkowski, Matthew ^*, Rosen, Neal ^*, Abdel-Wahab, Omar, Diamond, Eli L ^*

Source: In Blood 15 November 2022 140 Supplement 1:1098-1100

CRISPR arrays as high-resolution markers to track microbial transmission during influenza infection.

Authors: Zhang, Lingdi, Rahman, Jahan, Chung, Matthew, Lashua, Lauren, Gordon, Aubree, Balmaseda, Angel, Kuan, Guillermina, Bonneau, Richard, Ghedin, Elodie

Source: Microbiome; 6/17/2023, Vol. 11 Issue 1, p1-11, 11p

Subject Terms: METAGENOMICS, RESPIRATORY infections, CRISPRS, WHOLE genome sequencing

Geographic Terms: MANAGUA (Nicaragua)

Ruxolitinib Promotes Clinical Responses in Large Granular Lymphocytic Leukemia Via Suppression of JAK/STAT-Dependent Inflammatory Cascades

Authors: Moskowitz, Alison, Rahman, Jahan, Ganesan, Nivetha, Hannigan, Kelly, Ksanznak, Katie, Bitton, Hadassah, Lin, Ya-Hui, Davey, Theresa, Hancock, Helen, Perez, Leslie, Miller, Tayler, Brutus, Jamila, Dogan, Ahmet, Geyer, Mark Blaine, Jacobsen, Eric, Kumar, Anita, Moreira, Jonathan, Park, Jae H., Thompson, Meghan C., Torka, Pallawi, Zelenetz, Andrew D., Vardhana, Santosha A, Horwitz, Steven M.

Source: In Blood 28 November 2023 142 Supplement 1:183-183

Distinct Patterns of CD4+ and CD8+ T-Cell Clonal Expansion Enable Broad Clinical Responses to Pembrolizumab + GVD in Patients with Relapsed Hodgkin Lymphoma

Authors: Wills, Beatriz, Rahman, Jahan, Ganesan, Nivetha, Shah, Gunjan L., Noy, Ariela, Schoder, Heiko, Yahalom, Joachim, Kumar, Anita, Falchi, Lorenzo, Hamlin, Paul A., Palomba, Maria Lia, Johnson, William, Intlekofer, Andrew M., Caron, Philip, Davey, Theresa, Hancock, Helen, Galasso, Natasha, Munayirji, Brittney, Hui Lin, Ya, Santarosa, Alayna, Casper, Ellie, Pongas, Georgio, Zelenetz, Andrew D., Moskowitz, Craig H., Salles, Gilles, Vardhana, Santosha A, Moskowitz, Alison

Source: In Blood 28 November 2023 142 Supplement 1:1623-1623

E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: a phase II clinical trial

Authors: Bewersdorf, Jan Philipp, Stahl, Maximilian, Taylor, Justin, Mi, Xiaoli, Chandhok, Namrata Sonia, Watts, Justin, Derkach, Andriy, Wysocki, Mateusz, Lu, Sydney X., Bourcier, Jessie, Hogg, Simon J., Rahman, Jahan, Chaudhry, Sana, Totiger, Tulasigeri M., Abdel-Wahab, Omar, Stein, Eytan M.

Source: Leukemia; 20230101, Issue: Preprints p1-5, 5p

A genome-scale screen for synthetic drivers of T cell proliferation.

Authors: Legut, Mateusz, Gajic, Zoran, Guarino, Maria, Daniloski, Zharko, Rahman, Jahan A., Xue, Xinhe, Lu, Congyi, Lu, Lu, Mimitou, Eleni P., Hao, Stephanie, Davoli, Teresa, Diefenbach, Catherine, Smibert, Peter, Sanjana, Neville E.

Source: Nature; Mar2022, Vol. 603 Issue 7902, p728-735, 8p

Systematic Evaluation of AML-Associated Antigens Identifies Novel Anti-U5 snRNP200 Therapeutic Antibodies for the Treatment of AML

Authors: Knorr, Katherine, Erickson, Caroline ^*, Wang, Eric ^*, Rahman, Jahan ^*, Mi, Xiaoli ^*, Lu, Sydney ^*, Fox, Nina ^*, Penson, Alex ^*, Hogg, Simon ^*, Stanley, Robert ^*, Inoue, Daichi, Knorr, David, Ravetch, Jeffrey ^*, Abdel-Wahab, Omar

Source: In Blood 15 November 2022 140 Supplement 1:2247-2248

Author Correction: Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial

Authors: Horwitz, Steven M., Nirmal, Ajit J., Rahman, Jahan, Xu, Ran, Drill, Esther, Galasso, Natasha, Ganesan, Nivetha, Davey, Theresa, Hancock, Helen, Perez, Leslie, Maccaro, Catherine, Bahgat, Alexandra, Marzouk, Evan, Cathcart, Elizabeth, Moskowitz, Alison, Noy, Ariela, Kumar, Anita, Jacobsen, Eric, Fisher, David C., Mehta-Shah, Neha, Kim, Youn H., Khodadoust, Michael, Kotlov, Nikita, Nikitina, Anastasia, Kudryashova, Olga, Zubareva, Valeria, Zornikova, Ksenia, Shin, Nara, Sorokina, Maria, Degryse, Sandrine, Postovalova, Ekaterina, Bagaev, Aleksander, Hosszu, Kinga, McAvoy, Devin, Boelens, Jaap J., Wu, Wenchao, Ciantra, Zoe, Appelt, Jackson W., Trevisani, Christopher, Amaka, Sam, Weinstock, David M., Vardhana, Santosha A.

Source: Nature Medicine; December 2024, Vol. 30 Issue: 12 p3778-3778, 1p

Development of Novel CAR Therapies for Diffuse Large B-Cell Lymphoma Using Genome-Wide Overexpression Screens

Authors: Legut, Mat, Gajic, Zoran, Guarino, Maria, Mimitou, Eleni, Hao, Stephanie, Rahman, Jahan, Davoli, Teresa, Smibert, Peter, Diefenbach, Catherine S., Sanjana, Neville

Source: In Blood 23 November 2021 138 Supplement 1:1726-1726

RAF-Independent MEK Mutations Drive Histiocytic Neoplasms In Vivoand Are Sensitive to Single-Agent ERK Inhibition in Patients

Authors: Durham, Benjamin H, Singer, Michael E, Benbarche, Salima, Erickson, Caroline, Rahman, Jahan, Solit, David B., Witkowski, Matthew, Rosen, Neal, Abdel-Wahab, Omar, Diamond, Eli L

Source: Blood; November 2022, Vol. 140 Issue: 1, Number 1 Supplement 1 p1098-1100, 3p

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